| 腺病毒载体狂犬病疫苗研究进展 |
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| 引用本文： | 王林栋,张守峰,扈荣良.腺病毒载体狂犬病疫苗研究进展[J].动物医学进展,2012,33(8):69-73. |
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| 作者姓名： | 王林栋 张守峰 扈荣良 |
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| 作者单位： | 中国人民解放军军事医学科学院军事兽医研究所,吉林省人兽共患病预防与控制重点实验室,吉林长春130122 |
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| 摘 要： | 狂犬病是一种古老的人兽共患传染病。世界上已有部分国家和地区成功地消灭了狂犬病。在我国,每年有约3 000人死于狂犬病。腺病毒作为载体的优点包括高效的入核机制、优良的转染性、较低的病原性、较高的基因表达量及清楚的基因背景。目前,腺病毒已广泛应用于基础研究、基因治疗和疫苗研发。20世纪末,以腺病毒为载体的表达狂犬病病毒糖蛋白的疫苗就已诞生,一直发展至今。以腺病毒载体狂犬病疫苗作为口服疫苗,可望在控制和消除狂犬病中发挥着巨大的作用。
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| 关 键 词： | 狂犬病病毒 腺病毒载体 口服疫苗 |
Advance in Rabies Vaccine Based on Adenovirus Vector |
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| WANG Lin-dong
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ZHANG Shou-feng
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HU Rong-liang.Advance in Rabies Vaccine Based on Adenovirus Vector[J].Progress In Veterinary Medicine,2012,33(8):69-73. |
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| Authors: | WANG Lin-dong ZHANG Shou-feng HU Rong-liang |
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| Institution: | (Military Veterinary Research Institute,Academy of Military Medical Sciences,PLA,Key Laboratory of Jilin Province for Zoonosis Control and Prevention,Changchun,Jilin,130122,China) |
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| Abstract: | Rabies is an age-old infectious zoonosis.Some countries and regions in the world have eliminated rabies successfully.In our country,about 3000 people died of rabies every year.Adenovirus as vector possesses some merits as follows: efficient nuclear entry mechanism,excellent ability to transduce cells,low pathogenicity,robust transgene expression and clear genetic background.Now,adenovirus-based vectors have been widely used for basic research,for gene therapy applications,and in vaccine development.As early as the end of the 20 century,the vaccine based on adenovurs expressing glycoprotein has been born,and developing up to now.Rabies vaccine,based on adenovirus develpoing for use as an oral vaccine,plays an important role in control and elimination.Here,we reviewed the research of rabies vaccine based on adenovirus vector in recent years. |
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| Keywords: | Rabies virus adenovirus vector oral vaccine |
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