| 乳酸杆菌益生作用机制的研究进展 |
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| 引用本文： | 章文明,汪海峰,刘建新.乳酸杆菌益生作用机制的研究进展[J].动物营养学报,2012(3):389-396. |
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| 作者姓名： | 章文明 汪海峰 刘建新 |
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| 作者单位： | 浙江大学动物科学学院，生物饲料安全与污染防控国家工程实验室，杭州 ３１００５８;浙江农林大学，林业与生物技术学院，临安 ３１１３００ |
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| 基金项目： | 国家自然科学基金（３０９０１０４３，３０９０１０４３）；中国博士后科学基金（２００９０４６１３８７）；浙江省自然科学基金（Ｙ３０９００５０） |
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| 摘 要： | 乳酸杆菌作为益生菌广泛用于人和动物。本文综述了乳酸杆菌改善宿主健康的机制。乳酸杆菌可通过产生抗菌物质如乳酸、过氧化氢、细菌素，或者通过竞争营养或肠道黏附位点来抑制致病菌；通过诱导黏附素的分泌或阻止细胞凋亡而增强肠道的屏障功能，从而保护肠道。文章重点讨论了乳酸杆菌表面成分（表面蛋白、脂磷壁酸和肽聚糖）与肠道受体（Ｃ型凝集素受体、Ｔｏｌｌ样受体和 Ｎｏｄ样受体），阐述了他们结合后启动免疫调节信号，调控肠道免疫功能以发挥改善健康作用的机制。
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| 关 键 词： | 乳酸杆菌 抗菌物质 竞争黏附 免疫调节 益生作用 |
Mechanism of Action of Probiotic Function of Lactobacilli |
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| ZHANG Wenming,WANG Haifeng,LIU Jianxin.Mechanism of Action of Probiotic Function of Lactobacilli[J].Acta Zoonutrimenta Sinica,2012(3):389-396. |
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| Authors: | ZHANG Wenming WANG Haifeng LIU Jianxin |
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| Institution: | 1(1.National Engineering Laboratory of Biofeed Safety & Pollution Control,College of Animal Sciences,Zhejiang University,Hangzhou 310058,China;2.College of Forestry and Biotechnology,Zhejiang A & F University,Lin’an 311300,China) |
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| Abstract: | Lactobacilli have been widely applied to exert health benefits for human and animals.This article reviewed the recent advances in the mechanisms underlying the health-promoting functions of Lactobacilli.Lactobacilli can secrete antimicrobial compounds(lactic acid,H2O2 or bacteriocin),or compete with pathogenic bacteria for nutrient or attachment site in the intestinal tract.Probiotic Lactobacilli are suggested to strengthen the epithelial barrier by induction of mucin secretion or prevention of epithelial cell apoptosis.This review focused on Lactobacilli surface factors such as surface protein,teichoic acids and peptidoglycan,and their intestinal receptors(C-type lectin receptor,toll-like receptor,and nucleotide binding oligomerization domain-like receptors,NLRs).Their combination may modulate immune signaling pathways and promote immune function in the gut,resulting in beneficial effects on host. |
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| Keywords: | Lactobacilli antimicrobial compounds competitive attachment immune modulation probiotic function |
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