| 多糖类化合物的抗菌作用及其机制研究进展 |
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| 引用本文： | 吴香云,刘亚娜,周喆麒,潘源虎,郝海红,程古月,王玉莲.多糖类化合物的抗菌作用及其机制研究进展[J].畜牧兽医学报,2020,51(6):1167-1176. |
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| 作者姓名： | 吴香云 刘亚娜 周喆麒 潘源虎 郝海红 程古月 王玉莲 |
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| 作者单位： | 华中农业大学动物医学院 国家兽药残留基准实验室(HZAU), 武汉 430070 |
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| 基金项目： | 政府间国际科技创新合作重点专项（2018YFE0101600） |
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| 摘 要： | 多糖类化合物根据来源可分为植物多糖、动物多糖以及微生物多糖三大类。其不仅具有高效低毒、来源广泛的特点，还具有调节免疫功能、抗肿瘤、抗病毒、抗氧化、抗糖尿病、抗菌等多种生理功能。目前，人们已成功从高等植物、动物细胞膜以及微生物细胞壁中提取了大量多糖并广泛应用于食品、饲料、医药等行业中。随着细菌耐药性的不断产生，多糖类作为一种抗生素替代品已经成为国内外研究的热点。本文拟通过对多糖类化合物的抗菌活性以及主要机制进行详细阐述，为进一步深入开展多糖类化合物的生物活性及其作用机理研究，开发出更加安全、绿色高效的抗生素替代品提供理论依据。
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| 关 键 词： | 多糖类 抗生素替代品 抗菌作用 作用机制 |
| 收稿时间： | 2020-01-09 |
Research Progress on Antibacterial Effect and Mechanism of Polysaccharides |
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| WU Xiangyun,LIU Yana,ZHOU Zheqi,PAN Yuanhu,HAO Haihong,CHENG Guyue,WANG Yulian.Research Progress on Antibacterial Effect and Mechanism of Polysaccharides[J].Acta Veterinaria et Zootechnica Sinica,2020,51(6):1167-1176. |
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| Authors: | WU Xiangyun LIU Yana ZHOU Zheqi PAN Yuanhu HAO Haihong CHENG Guyue WANG Yulian |
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| Institution: | Reference Laboratory for the Test of Veterinary Drug Residues(HZAU), College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China |
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| Abstract: | According to the sources, polysaccharides can be divided into plant polysaccharides, animal polysaccharides and microbial polysaccharides. They not only have the characteristics of high efficiency, low toxicity and wide sources, but also have various physiological functions, such as regulating immune function, anti-tumor, anti-virus, anti-oxidation, anti-diabetes, anti-bacterial and so on. At present, people have been successfully extracted a large number of polysaccharides from higher plants, animal cell membranes and microbial cell walls and they are widely used in food, feed, medicine and other industries. With the continuous development of bacterial drug resistance, polysaccharides have become the focus of research at home and abroad as a class of antibiotic alternatives. This review intends to elaborate on the antibacterial activity and main mechanisms of polysaccharides, in order to provide a theoretical basis for further research on the biological activities of polysaccharides and their mechanism, and to develop safer, greener and more efficient antibiotic alternatives. |
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| Keywords: | polysaccharides antibiotic alternatives antibacterial effect mechanism of action |
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