Comparative studies of strains of infectious bovine rhinotracheitis virus isolated from latently infected calves |
| |
| Authors: | G Castrucci F Frigeri S Ranucci M Ferrari V Cilli B Pedini P Nettleton F Caleffi V Aldrovandi A J Herring |
| |
| Institution: | 1. Istituto di Malattie Infettive, Profilassi e Polizia Veterinaria dell''Universita'' di Perugia, Italy;2. Istituto di Semeiotica Medica e Metodologia Clinica Veterinaria dell''Universita'' di Perugia, Perugia, Italy;3. Istituto Zooprofilattico Sperimentale della Lombardia e dell''Emilia, Brescia, Italy;4. Animal Diseases Research Association, Moredun Institute, Edinburgh, Scotland;5. Centro Provinciale Svezzamento Vitelli, Tripoli San Giorgio, Mantova, Italy |
| |
| Abstract: | Three strains (479 C, 778 TL, 982 LE) of infectious bovine rhinotracheitis (IBR) virus isolated from latently infected calves were compared with the prototype strain of IBR virus (LA strain) in studies which included restriction endonuclease analysis, experimental infection, and reciprocal cross protection tests in cattle. From the restriction endonuclease analysis it appeared that the 3 "latent" viruses were derived from the same isolate, and that it differed slightly from the LA strain. However, latency does not seem to have affected the pathogenicity or the immunogenicity of the virus. This is demonstrated by the identical clinical and virologic response of calves subjected to experimental infection with the various strains under study, and by the finding that when the LA strain and a "latent" strain (982 LE) were tested in cross protection tests in cattle, they proved to be mutually protective. |
| |
| Keywords: | Infectious bovine rhinotracheitis virus latent strains comparison pathogenicity immunogenicity calves Rhinotracheite infectieuse bovine virus souches latentes pathogénicité immunogénicité veaux |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
