Cell-mediated immunity in cytomegalovirus infections —A review |
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| Authors: | GV Quinnan FA Ennis |
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| Institution: | Department of Health, Education and Welfare, Food and Drug Administration, Bureau of Biologics, Division of Virology, 8800 Rockville Pike, Bethesda, MD 20014, U.S.A. |
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| Abstract: | Cell-mediated immunity is of critical significance in the host response to cytomegalovirus infection. This fact is evidenced by numerous reports of disease in immunosuppressed hosts and by other clinical and experimental observations. Methodologies are now available for elucidation of the specific role of the various facets of cell-mediated immunity in normal and susceptible individuals during different stages of infection. Most progress has been made recently using assays of lymphocyte transformation and cell-mediated immune lysis, but other areas also deserve specific attention. A comprehensive picture of the function of cellular immunity should greatly advance understanding of disease pathogenesis as well as direct the development of future models for immunotherapy. |
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| Keywords: | Cytomegalovirus cell-mediated immunity Virus cytomégalique cytomégalovirus immunité à médiation cellulaire |
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