| 模拟低压低氧环境对小鼠肺组织形态结构的影响 |
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| 引用本文： | 申什菊,张勤文.模拟低压低氧环境对小鼠肺组织形态结构的影响[J].畜牧与饲料科学,2019,40(2):6-8. |
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| 作者姓名： | 申什菊 张勤文 |
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| 作者单位： | [1]青海省海东市农发委畜牧科,青海海东810699;[2]青海大学农牧学院动物医学系,青海西宁810016 |
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| 基金项目： | 国家自然科学基金项目(31660699)。 |
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| 摘 要： | 以肺组织显微结构、超微结构及部分血氧值为指标,以雄性昆明系小鼠为实验对象,观察了低压氧舱模拟不同海拔环境对小鼠肺组织形态结构的影响。结果表明,试验组小鼠肺泡隔厚度,肺气—血屏障算术平均厚度,动、静脉氧分压差和动、静脉血氧饱和度差均高于对照组,且差异显著(P<0.05)。这是低氧环境对小鼠肺组织造成的改变,这种改变可保证其适应低氧环境。
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| 关 键 词： | 低压低氧 小鼠 肺组织 形态结构 |
| 收稿时间： | 2018-11-21 |
Effects of Simulated Hypobaric Hypoxia Environment on Morphological Structure of Lung Tissues in Mice |
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| SHEN Shi-ju,ZHANG Qin-wen.Effects of Simulated Hypobaric Hypoxia Environment on Morphological Structure of Lung Tissues in Mice[J].Animal Husbandry and Feed Science,2019,40(2):6-8. |
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| Authors: | SHEN Shi-ju ZHANG Qin-wen |
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| Institution: | [1]Animal Husbandry Department of the Agricultural Development Committee in Haidong of Qinghai Province,Haidong 810699,China;[2]Veterinary Medicine Department of Agricultural and Animal Husbandry College,Qinghai University,Xining 810016,China |
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| Abstract: | In the present study, the effects of different altitudes environment simulated in hypobaric cabin on morphological structure of lung tissues in male Kunming mice was assessed using microstructure and ultrastructure of lung tissues and selected blood oxygen values. The results showed that the mice in the simulated hypobaric hypoxia environment had significantly higher thickness of alveolar septum, arithmetic mean thickness of the lung air-blood barrier, arteriovenous oxygen difference, and arterial and venous blood oxygen saturation difference (p<0.05). The morphological structure changes of the lung tissues in mice was caused by the hypobaric hypoxia environment, providing the adaptability to the hypobaric hypoxia environment. |
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