Cross-protective immunity and the serological classification system for Bacteroides nodosus |
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| Authors: | DJ STEWART JA VAUGHAN TC ELLEMAN† PA HOYNE† KJ BURNS JH DUFTY |
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| Institution: | CSIRO Division of Animal Health, Animal Health Research Laboratory, Parkville, Victoria. |
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| Abstract: | The relationship between the serological classification system for serogroup B and for serogroup H of Bacteroides nodosus and cross-protection between subgroups within these serogroups was examined. Protection against ovine footrot following vaccination was achieved against other subgroup strains provided sufficient cross-reactive antibody was induced by shared pilus antigens. Within serogroup B, better cross-protection against one subgroup was obtained with a pili vaccine than a whole cell vaccine which correlated with higher pilus antibody titres induced by the former. For serogroup H, a lack of cross-protection and serological reactivity between subgroups was demonstrated, which indicates that the prototype strain of subgroup H2 should be designated a new serogroup. |
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