| 潮霉素B预混剂的临床驱虫试验研究 |
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| 引用本文： | 费陈忠.潮霉素B预混剂的临床驱虫试验研究[J].中国兽药杂志,2017,51(1):30-34. |
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| 作者姓名： | 费陈忠 |
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| 作者单位： | 中国农业科学院上海兽医研究所 |
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| 基金项目： | 国家自然科学基金项目（31272607），国家重点研发计划专项（2016YFD0501303），农业部公益性行业专项（201303038-9） |
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| 摘 要： | 为了解潮霉素B预混剂临床驱除绦虫线虫的有效性和给药时间的合理性,依据兽药临床试验规范,试验选择了蠕虫自然感染皖西麻黄鸡824只,按要求随机分为3组,分别为潮霉素B预混剂治疗组284只,芬苯哒唑粉对照药物组284只,不治疗的感染对照组256只,试验周期根据临床治疗效果确定。结果显示,潮霉素B预混剂,推荐剂量10 mg/kg混饲,连续饲喂21 d,对鸡蛔虫和绦虫的粗计驱虫率分别为63%和26%,表现明显的驱除蛔虫作用(P0.05),连续饲喂42 d,对鸡蛔虫和绦虫的粗计驱虫率分别为100%和-13%,驱蛔虫效果极显著(P0.01);对照药物芬苯哒唑粉,50 mg/kg混饲,连续饲喂6 d,对鸡蛔虫和绦虫的粗计驱虫率分别为100%和44%,同样具有极显著的驱除蛔虫作用(P0.01),本试验中2种药物的驱蛔虫效果相当,对绦虫的驱除作用不明显(P0.05)。潮霉素B预混剂10 mg/kg混饲,连续饲喂42 d,可以驱净鸡蛔虫的感染,但对鸡绦虫感染无明显的驱除作用。
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| 关 键 词： | 鸡蛔虫 潮霉素B 临床试验 |
| 收稿时间： | 2016/9/18 0:00:00 |
| 修稿时间： | 2017/1/3 0:00:00 |
Clinical deworming trial on hygromycin B premixes |
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| Institution: | Shanghai Veterinary Research Institute,Chinese Academy of Agricultural Sciences/Key Laboratory of Veterinary Drug Safety Evaluation and Residues Research/Key Laboratory of Animal Parasitology of Ministry of Agriculture |
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| Abstract: | To understand the clinical effect and rational administration time of hygromycin B premixs expelling the Taenia and Nematodes. 824 Wanxi partridge chicken naturally infected by worms were selected and randomly assigned to three groups: the hygromycin B premixes treatment group (n=284), the fenbendazole powder control drug group (n=284) and the no treatment and infected control group (n=256). The test period is determined according to the clinical effect. The results showed that when 10mg/kg hygromycin B premixes was fed continuously for 21 days, the deworming rate in chicken roundworms and tapeworms was about 63% and 26%, respectively, showing a significant effect on expelling roundworms (p<0.05). When fed continuously for 42 days, the rough deworming rate in chicken roundworms and tapeworms was 100% and -13%, respectively, showing an extremely significant effect on expelling roundworms(p<0.01). The coarse deworming rate in chicken roundworms and tapeworms with 50mg/kg control drug fenbendazole powder feeding continuously for six days was 100% and 44%, respectively, also showing an extremely significant role in expelling roundworms (p<0.01). In the test, the effect of these two drugs driving out roundworms was similar, while their role in expelling tapeworms was not obvious (p>0.05). 10mg/kg hygromycin B Premixs with feeding continuously for 42 days can dispel chicken roundworms completely, but has no obvious effect on expelling chicken tapeworms. |
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| Keywords: | Chicken Ascaris Hygromycin B Clinical Trials |
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