| 兽药人工抗原合成的研究进展 |
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| 引用本文： | 张泽英,袁宗辉.兽药人工抗原合成的研究进展[J].中国兽药杂志,2006,40(5):44-47. |
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| 作者姓名： | 张泽英 袁宗辉 |
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| 作者单位： | 华中农业大学兽药研究所,国家兽药残留基准实验室,农业部食品安全评价重点开放实验室,湖北,武汉,430070 |
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| 摘 要： | 在兽药的免疫化学残留分析中,能否合成稳定的具有良好免疫原性的人工抗原是制备抗体和建立免疫分析方法的最关键步骤.综述了国内外兽药人工抗原合成过程中载体的选择、半抗原的设计（强调偶联部位和间隔臂的引入）、半抗原与载体的偶联方法、人工抗原的纯化与鉴定等方面的研究进展.
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| 关 键 词： | 兽药 半抗原 人工抗原 合成 进展 |
| 文章编号： | 1002-1280（2006）05-0044-04 |
| 收稿时间： | 2005-12-16 |
| 修稿时间： | 2005-12-16 |
Research Progress on Synthesis of Artificial Antigens for Veterinary Drugs |
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| ZHANG Ze-ying,YUAN Zong-hui.Research Progress on Synthesis of Artificial Antigens for Veterinary Drugs[J].Chinese Journal of Veterinary Drug,2006,40(5):44-47. |
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| Authors: | ZHANG Ze-ying YUAN Zong-hui |
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| Institution: | National Reference Laboratory for Test of Veterinary Drug Residues, National Key Laboratory of Food Safety Evaluation, Institute of Veterinary Pharmaceuticals, Wuhan, Hubei 430070; China |
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| Abstract: | The key to using immunoassay method in veterinary drug residue analysis is the synthesis of veterinary drug artificial antigen.The progress of carrier selection,design of hapten(emphasizing hapten-carrier coupling position,attachment of connecting arm),methods for the synthesis of hapten-protein conjugation,purification and identification of artificial antigens were introduced in this paper. |
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| Keywords: | veterinary drug hapten artificial antigens synthesis progress |
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