| 桉油溶液剂的急性毒性和安全药理学研究 |
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| 引用本文： | 阳刚,殷中琼,魏琴,周黎军,杨仕群.桉油溶液剂的急性毒性和安全药理学研究[J].中国兽药杂志,2018,52(1):28-35. |
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| 作者姓名： | 阳刚 殷中琼 魏琴 周黎军 杨仕群 |
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| 作者单位： | 宜宾职业技术学院,四川农业大学动物医学院,,, |
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| 基金项目： | 香料植物资源开发与利用四川省高校重点实验室开放基金资助项目资助（2016XLZ004）；四川高校科研创新团队建设计划资助（14TD0031） |
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| 摘 要： | 灌胃给药(ig)研究桉油溶液剂对大鼠的急性毒性。安全药理学试验以高剂量(30%)、中剂量(18%)、低剂量(6%)分别给予大鼠0.3 m L/只涂抹桉油溶液剂,观察其对大鼠神经系统、心血管系统和呼吸系统的影响。桉油溶液剂对大鼠的经口半数致死量(LD50)为3811.5 mg/kg。桉油溶液剂对大鼠的中枢神经系统、呼吸系统和心率等均无明显影响。桉油溶液剂是一种较安全的局部外用药,适合在临床上推广应用。桉油溶液剂经生产实践和兽医临床试验证明具有良好的治疗动物疥螨病效果。
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| 关 键 词： | 桉油溶液剂 急性毒性 安全药理学 |
| 收稿时间： | 2017/7/14 0:00:00 |
| 修稿时间： | 2017/7/29 0:00:00 |
Pharmacology Studies on Acute Toxicity and Safety of Eucalyptus oil Solution |
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| Abstract: | It has been proved that eucalyptus oil solution produced in our laboratory presenting good results in treating sarcoptidosis. In order to study the clinical effect and the acute toxicity of Eucalyptus oil solution, the acute toxicity and the safety pharmacology was tested. We observed the acute toxicity of imperatorin by perfusing intragastric administration(ig) to rats. In safety pharmacology experiments, high dose group(30%), middle dose group(18%) and low dose group(6%) of eucalyptus oil solution were respectively applied on the skin of rats 0.3 ml/ench and then we observed the influences on the nervous system, cardiovascular and respiratory systems of targeted rats. The LD50 of eucalyptus oil solution to rats is 3811.5 mg/kg by ig. There is no significant effect on the nervous system, cardiovascular and respiratory systems of targeted rats according to the experiment. Eucalyptus oil solution is a comparatively safe foreign agents and suitable for further clinical promotion. |
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| Keywords: | Eucalyptus oil solution Acute toxicity Safety pharmacology |
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