| 山羊痘灭活疫苗免疫保护试验 |
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| 引用本文： | 赵利平,魏学峰,陈九连,刘棋,郭建刚,巴特,苏丽琼,王家福.山羊痘灭活疫苗免疫保护试验[J].中国兽药杂志,2005,39(8):21-23. |
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| 作者姓名： | 赵利平 魏学峰 陈九连 刘棋 郭建刚 巴特 苏丽琼 王家福 |
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| 作者单位： | 1. 金宇集团内蒙古生物药品厂,内蒙古呼和浩特,010030
2. 广西兽医防检站,广西南宁,530001 |
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| 摘 要： | 将山羊痘GT4-STV42-56种毒在犊牛睾丸细胞上繁殖,收获毒液,用0.1%甲醛溶液灭活,加适量206佐剂,制成山羊痘油佐剂灭活疫苗.将疫苗以不同剂量皮下免疫接种不同种群的山羊.免疫后21 d,用AV40株强毒进行攻毒保护试验.结果显示,免疫剂量达0.5 mL时,疫苗对内蒙绒山羊的保护率为100%,对广西黑山羊的保护率为80%.实验表明,山羊痘灭活疫苗对山羊的免疫效果确实可靠.
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| 关 键 词： | 山羊痘 灭活疫苗 免疫保护 |
| 文章编号： | 1002-1280(2005)08-0021-03 |
| 修稿时间： | 2005年3月25日 |
The immune protection test of inactivated capripoxvirus vaccine |
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| ZHAO Li-ping,WEI Xue-feng,CHEN Jiu-lian,LIU Qi,GUO Jian-gang,BA Te,SU Li-qiong,WANG Jia-fu.The immune protection test of inactivated capripoxvirus vaccine[J].Chinese Journal of Veterinary Drug,2005,39(8):21-23. |
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| Authors: | ZHAO Li-ping WEI Xue-feng CHEN Jiu-lian LIU Qi GUO Jian-gang BA Te SU Li-qiong WANG Jia-fu |
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| Abstract: | GT_ 4 -STV_ 42-56 strain of capripoxvirus was inoculated on the bovine testicle cells, and reproduced and harvested. Add formaldehyde (0.1%) to inactivated the virus and mixed with the adjuvant Montanide ISA 206 to prepare the oil vaccine. With different doses, the vaccine was vaccinated subcutaneously to different goats. 21 days after vaccination, these goats were challenged with 1 000 ID_ 50 capripox virus AV40 strain. The results showed that the protective rate of animals which vaccinated with 0.5 mL inactivated vaccine were 100% to the Inner Mongolia group and 80% to the Guangxi group. Based on the results, we concluded that the inactivated capripoxvirus vaccine has an excellent protective efficacy. |
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| Keywords: | capripoxvirus inactivated vaccine protective efficacy |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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