| 喹赛多的合成工艺研究 |
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| 引用本文： | 薛克友.喹赛多的合成工艺研究[J].中国兽药杂志,2013,47(8):42-44. |
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| 作者姓名： | 薛克友 |
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| 作者单位： | 1. 武汉回盛生物科技有限公司,湖北省兽药工程技术研究中心,武汉430042
2. 华中农业大学国家兽药残留基准实验室/农业部食品安全评价重点开放实验室,武汉,430070 |
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| 摘 要： | 以苯并呋咱-N-氧化物和丙酮醛缩二甲醇为起始原料,N,N-二甲基甲酰胺为溶剂,吡咯烷为催化剂,经过Beirut反应得到喹噁啉-1,4-二氧-2-甲醛缩二甲醇,喹噁啉-1,4-二氧-2-甲醛缩二甲醇在以甲醇为溶剂、浓盐酸为催化剂的条件下与氰乙酰肼反应生成喹赛多.终产物喹赛多经核磁共振氢谱、核磁共振碳谱、质谱、红外光谱进行确证.总收率为55.8％.
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| 关 键 词： | 喹赛多 合成工艺研究 苯并呋咱-N-氧化物 Beirut反应 |
| 收稿时间： | 2013/4/16 0:00:00 |
| 修稿时间： | 2013/5/16 0:00:00 |
The Synthesis Technologic Study of Cyadox |
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| XUE Ke-you
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YUAN Zong-hui
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ZHANG Wei-yuan
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LIU Jie.The Synthesis Technologic Study of Cyadox[J].Chinese Journal of Veterinary Drug,2013,47(8):42-44. |
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| Authors: | XUE Ke-you YUAN Zong-hui ZHANG Wei-yuan LIU Jie |
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| Institution: | Wuhan Hvsen Biotechnology Co,Ltd,Hubei Province Veterinary Drug Engineering Research Center; |
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| Abstract: | 2-formylquinoxaline-1, 4-dioxide dimethylacetal was obtained by benzofuroxan-N-oxide and pyruvaldehyde dimethylacetal which were dissolved in N,N-dimethyl formamide and pyrrolidine was used as catalyzer. 2-formylquinoxaline-1, 4-dioxide dimethylacetal was dissolved in methanol and concentrated hydrochloric acid, then reacted with cyanoacetylhydrazine to obtain cyadox. Cyadox was identified by 1H-NMR, 13C-NMR, MS, and IR. The total yield was 55.8%. |
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| Keywords: | cyadox synthesis study benzofuroxan-N-oxide Beirut reaction Hydrazoning reaction |
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