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Shichang Li Cunzhou Shen Wenyuan Guo Xuefei Zhang Shixin Liu Fengyin Liang Zhongliang Xu Zhong Pei Huacan Song Liqin Qiu Yongcheng Lin Jiyan Pang 《Marine drugs》2013,11(12):5159-5189
Parkinson’s disease (PD) is the second most common neurodegenerative disease affecting people over age 55. Oxidative stress actively participates in the dopaminergic (DA) neuron degeneration of PD. Xyloketals are a series of natural compounds from marine mangrove fungus strain No. 2508 that have been reported to protect against neurotoxicity through their antioxidant properties. However, their protection versus 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity is only modest, and appropriate structural modifications are necessary to discover better candidates for treating PD. In this work, we designed and synthesized 39 novel xyloketal derivatives (1–39) in addition to the previously reported compound, xyloketal B. The neuroprotective activities of all 40 compounds were evaluated in vivo via respiratory burst assays and longevity-extending assays. During the zebrafish respiratory burst assay, compounds 1, 9, 23, 24, 36 and 39 strongly attenuated reactive oxygen species (ROS) generation at 50 μM. In the Caenorhabditis elegans longevity-extending assay, compounds 1, 8, 15, 16 and 36 significantly extended the survival rates (p < 0.005 vs. dimethyl sulfoxide (DMSO)). A total of 15 compounds were tested for the treatment of Parkinson’s disease using the MPP+-induced C. elegans model, and compounds 1 and 8 exhibited the highest activities (p < 0.005 vs. MPP+). In the MPP+-induced C57BL/6 mouse PD model, 40 mg/kg of 1 and 8 protected against MPP+-induced dopaminergic neurodegeneration and increased the number of DA neurons from 53% for the MPP+ group to 78% and 74%, respectively (p < 0.001 vs. MPP+ group). Thus, these derivatives are novel candidates for the treatment of PD. 相似文献
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Jinghua Liu Arjun H. Banskota Alan T. Critchley Jeff Hafting Balakrishnan Prithiviraj 《Marine drugs》2015,13(4):2250-2266
Parkinson’s disease (PD) is the second most common neurodegenerative disorder in the elderly people, currently with no cure. Its mechanisms are not well understood, thus studies targeting cause-directed therapy or prevention are needed. This study uses the transgenic Caenorhabditis elegans PD model. We demonstrated that dietary supplementation of the worms with an extract from the cultivated red seaweed Chondrus crispus decreased the accumulation of α-synulein and protected the worms from the neuronal toxin-, 6-OHDA, induced dopaminergic neurodegeneration. These effects were associated with a corrected slowness of movement. We also showed that the enhancement of oxidative stress tolerance and an up-regulation of the stress response genes, sod-3 and skn-1, may have served as the molecular mechanism for the C. crispus-extract-mediated protection against PD pathology. Altogether, apart from its potential as a functional food, the tested red seaweed, C. crispus, might find promising pharmaceutical applications for the development of potential novel anti-neurodegenerative drugs for humans. 相似文献
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Baranowska-Wójcik Ewa Szwajgier Dominik Winiarska-Mieczan Anna 《Plant foods for human nutrition (Dordrecht, Netherlands)》2020,75(1):30-32
Plant Foods for Human Nutrition - Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized, among others by abnormal levels of acetyl- and butyrylcholinesterase in... 相似文献
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Chien-Wei Feng Han-Chun Hung Shi-Ying Huang Chun-Hong Chen Yun-Ru Chen Chun-Yu Chen San-Nan Yang Hui-Min David Wang Ping-Jyun Sung Jyh-Horng Sheu Kuan-Hao Tsui Wu-Fu Chen Zhi-Hong Wen 《Marine drugs》2016,14(10)
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by tremor, rigidity, bradykinesia, and gait impairment. In a previous study, we found that the marine-derived compound 11-dehydrosinulariolide (11-de) upregulates the Akt/PI3K pathway to protect cells against 6-hydroxydopamine (6-OHDA)-mediated damage. In the present study, SH-SY5Y, zebrafish and rats were used to examine the therapeutic effect of 11-de. The results revealed the mechanism by which 11-de exerts its therapeutic effect: the compound increases cytosolic or mitochondrial DJ-1 expression, and then activates the downstream Akt/PI3K, p-CREB, and Nrf2/HO-1 pathways. Additionally, we found that 11-de could reverse the 6-OHDA-induced downregulation of total swimming distance in a zebrafish model of PD. Using a rat model of PD, we showed that a 6-OHDA-induced increase in the number of turns, and increased time spent by rats on the beam, could be reversed by 11-de treatment. Lastly, we showed that 6-OHDA-induced attenuation in tyrosine hydroxylase (TH), a dopaminergic neuronal marker, in zebrafish and rat models of PD could also be reversed by treatment with 11-de. Moreover, the patterns of DJ-1 expression observed in this study in the zebrafish and rat models of PD corroborated the trend noted in previous in vitro studies. 相似文献
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Patrizia Russo Aliaksei Kisialiou Palma Lamonaca Rossana Moroni Giulia Prinzi Massimo Fini 《Marine drugs》2016,14(1)
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder. Current approved drugs may only ameliorate symptoms in a restricted number of patients and for a restricted period of time. Currently, there is a translational research challenge into identifying the new effective drugs and their respective new therapeutic targets in AD and other neurodegenerative disorders. In this review, selected examples of marine-derived compounds in neurodegeneration, specifically in AD field are reported. The emphasis has been done on compounds and their possible relevant biological activities. The proposed drug development paradigm and current hypotheses should be accurately investigated in the future of AD therapy directions although taking into account successful examples of such approach represented by Cytarabine, Trabectedin, Eribulin and Ziconotide. We review a complexity of the translational research for such a development of new therapies for AD. Bryostatin is a prominent candidate for the therapy of AD and other types of dementia in humans. 相似文献
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Newman Rachel Waterland Nicole Moon Youyoun Tou Janet C. 《Plant foods for human nutrition (Dordrecht, Netherlands)》2019,74(4):449-460
Plant Foods for Human Nutrition - Selenium supplementation in humans has been suggested for the prevention of chronic diseases including cardiovascular disease, cancer, and neurodegenerative... 相似文献
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SUN Dai-zhen JIANG Ling ZHANG Ying-xin CHENG Xia-nian ZHAI Hu-qu WAN Jian-min 《水稻科学》2007,14(2):157-160
In order to map the quantitative trait loci for rice stripe resistance, a molecular linkage map was constructed based on the F2 population derived from a cross between Zhaiyeqing 8 and Wuyujing 3. Reactions of the two parents, F1 individual and 129 F2:3 lines to rice stripe were investigated by both artificial inoculation at laboratory and natural infection in the field, and the ratios of disease rating index were scored. The distribution of the ratios of disease rating index in Zhaiyeqing 8/Wuyujing 3 F2:3 population ranged from 0 to 134.08 and from 6.25 to 133.6 under artificial inoculation at laboratory and natural infection in the field, respectively, and showed a marked bias towards resistant parent (Zhaiyeqing 8), indicating that the resistance to rice stripe was controlled by quantitative trait loci (QTL). QTL analysis showed that the QTLs detected by the two inoculation methods were completely different. Only one QTL, qSTV7, was detected under artificial inoculation, at which the Zhaiyeqing 8 allele increased the resistance to rice stripe, while two QTLs, qSTV5 and qSTV1, were detected under natural infection, in which resistant alleles came from Zhaiyeqing 8 and Wuyujing 3, respectively. These results showed that resistant parent Zhaiyeqing 8 carried the alleles associated with the resistance to rice stripe virus and the small brown planthopper, and susceptible parent Wuyujing 3 also carried the resistant allele to rice stripe virus. In comparison with the results previously reported, QTLs detected in the study were new resistant genes to rice stripe disease. This will provide a new resistant resource for avoiding genetic vulnerability for single utilization of the resistant gene Stvb-i. 相似文献
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In saline paddy soil in the north of China, the technique of immunization of rice nursery (IRN) was applied in 1990‘s and succesfuully met the production needs. It had more advantages than paddy soil land nursery (PSLN). 相似文献
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To use common differential varietiesin the world, a set of internationaldifferential varieties, including 6 in-dica and 2 japonica rice varieties,were set up in the midddle of 1960s;in 1976, a set of differential varietiescmposed of 9 japonica varieties withknown resistance gene were estab-lished; and later a set ofnear-isogenic lines (NILs), 4 lines 相似文献
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Kosová Klára Leišová-Svobodová Leona Dvořáček Václav 《Plant foods for human nutrition (Dordrecht, Netherlands)》2020,75(2):131-141
Plant Foods for Human Nutrition - Oats represent a promising alternative to small-grain cereals from Triticeae group (wheat, barley, rye) for persons suffering from any form of gluten intolerance,... 相似文献
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TANGuangxuan 《中国水稻研究通报》1998,6(4):6-7
Wild rice is an important resource of useful genes to rice breeders. However, low regeneration frequency is an obstacle to use the valuable genes. We used desiccation to improve the regeneration frequency and studied the biochemical changes of calli of wild rice after desiccation, 相似文献
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Some locally available fruits and vegetables of the arid zone of Rajasthanwere analyzed for their -carotene content; the selected fruits and vegetables were: Dansra (Rhus myserensis), Kachri (Cucumis collosus), fruit Kachri (Cucumis collosus), Kair (Capparisdecidua) and Sanghri (Prosopis cineriria). The -carotene contents of the samples were estimated in fresh and various processed states (blanched, dried and roasted). The results showed the heat lability of -carotene. Among the samples, kair was found to be the richest source of -carotene. Variety, too, had an impact on the content of this fat soluble vitamin. 相似文献
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ZENGXianming LAIWenjiang XUDong 《中国水稻研究通报》1996,4(2):7-7
The leaf streak of rice is one of the seedborne and quarantine bacterial disease in China. The rice seeds must be strictly inspected to prevent the disease from spreading. The serological test is a rapid and accurate method of identifying seedborne bacterial plant pathogens. But the specificity and thus reliability of any serological method depend first on the specificity of the antiserum. Therefore, a high specificity of antiserum is always required for and has become a key in detecting the leaf streak pathogen in rice seeds. The present study was conducted on the method of improving the specificity. Two group of antigen, the yellow and white proteins, were extracted from the cells of Xanthornonas oryzae pv. oryzicola by the methods of stepwise precipitation with ammonium sulfate and differential centrifugation. Antiserum A and B against the yellow and white proteins were each produced in white rabbit immunized with the proteins respectively. The tittle of the two antiserum were the same(1: 6400). 相似文献
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《中国水稻研究通报》1997,(1)
Chalkiness is an unpleasant trait for rice con-sumer. which is known to be controlled geneti-cally and affected by environment during grainmaturing. We used the model of Additive MainEffects and Multiplieative Interaction (AMMI)for interpreting the result of genotype by env-iornment interaction (G×E) in the chalkinessof indica rice varieties. 相似文献
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《中国水稻研究通报》2002,(Z1)
Rice blast, caused by Magnaporthe grisea, is one of the most important rice diseases in China. Resistance breakdown often happened, especially in the field supplied with high nitrogen fertilizer. In the simulation study on race dynamics and cultivar-race interaction on population level, the influence of nitrogen on the relative parasitic fittness of cultivar-race combinations should be realized quantitative-ly. 相似文献