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鸡胆汁有效成分Tau和CA的抗炎抗菌作用研究 总被引：5，自引：1，他引：4
采用比较药理学研究方法对鸡胆汁的有效成分牛磺酸（Tau）和胆酸（CA）进行了抗炎作用及抗菌作用研究。结果显示，Tau和CA均能极显著地抑制二甲苯所致小鼠耳壳炎症及小鼠皮肤毛细血管通透性；对棉球所致小鼠肉芽肿、角叉莱胶所致大鼠足跖肿胀、甲醛所致大鼠足跖肿胀以及炎性组织中PGE2的含量增有极显著地抑制作用。因而表明Tau和CA对急慢性炎症均有很强的抑制作用。Tau和CA对体外培养的革兰氏阴性菌、大肠杆菌均无抗菌作用；对体外培养的革兰氏阳性菌、金黄色葡萄球菌Tau无抗菌作用，而CA却有明显的抗菌作用。 相似文献
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实验研究证明,按0.5g/kg,0.2g/kg的剂量口服鸡胆汁均可显著地抑制小鼠皮肤毛细血管通透性,二甲苯所致耳壳炎症,大鼠角叉菜胶和甲醛致炎后不同时间的足跖肿胀以及小鼠棉球肉芽组织增生。实验结果揭示,鸡胆汁对炎症的各个阶段均有明显的抑制作用。 相似文献
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鸡胆汁的抗炎药理作用研究 总被引：1，自引：0，他引：1
实验研究证明，按０．５ｇ／ｋｇ，０．２ｇ／ｋｇ的剂量口服鸡胆汁均可显著地抑制小鼠皮肤毛细血管通透性，二甲苯所致耳壳炎症，大鼠角叉菜胶和甲醛致炎后不同时间的足跖肿胀以及小鼠棉球肉芽组织增生。实验结果揭示，鸡胆汁对炎症的各个阶段均有明显的抑制作用。 相似文献
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以鸡胆汁为原料,通过不和谐梭菌（Ｃ．ａｂｓｏｎｕｍ）的转化作用,使鸡胆汁中部分鹅去氧胆酸（ＣＤＣＡ）转化为熊去氧胆酸（ＵＤＣＡ）,并在薄层板上表现为与熊胆相同的胆汁酸组成。该结果为通过细菌转化作用制备ＵＤＣＡ及熊胆替代品研究提供了实验依据。 相似文献
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为了探讨牛磺鹅去氧胆酸(TCDcA)对有丝分裂原刺激的小鼠脾淋巴细胞免疫功能的影响,设计了TCDCA的0.01,0.05,0.1,1,10μg/mL5个剂量浓度梯度,开展了TCDCA对有丝分裂原刺激的小鼠脾淋巴细胞增殖反应、分泌IL-2和IgG的影响研究。结果表明:TCDCA对ConA刺激的脾淋巴细胞增殖反应表现出调节作用,对LPS刺激的脾淋巴细胞无明显作用;TCDCA对ConA和LPS刺激的脾淋巴细胞的分泌IL-2表现出向上抛物线形式的明显的调节作用;TCDCA对LPS刺激的脾淋巴细胞分泌IgG具有向下抛物线形式的明显的调节作用。说明TCDCA对有丝分裂原刺激的小鼠脾淋巴细胞免疫功能具有明显的调节作用。 相似文献
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本试验旨在研究牛磺鹅去氧胆酸（taurochenodeoxycholic acid,TCDCA）对环磷酰胺致免疫抑制小鼠免疫功能的影响。给小鼠腹腔注射环磷酰胺(CTX,50 mg/kg),建立免疫功能抑制模型,灌服TCDCA（100 mg/（kg·d））,共灌服7 d。采用重量法和分光光度法分别测定TCDCA对免疫器官指数及对血清中抗体含量、单核—巨噬细胞吞噬功能和溶菌酶含量的影响。〖JP2〗TCDCA对免疫抑制小鼠胸腺指数、脾指数和血清溶血素水平无显著性影响;TCDCA可显著提高免疫抑制小鼠单核—巨噬细胞吞噬功能和血清中溶菌酶含量。TCDCA能够增强CTX免疫抑制小鼠的免疫功能,对免疫失衡机体具有一定的保护作用。 相似文献
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牛磺酸鹅去氧胆酸对小鼠体内氧自由基代谢的影响 总被引：2，自引：0，他引：2
研究了牛磺酸鹅去氧胆酸（TCDCA）对小鼠体内氧自由基代谢的影响.分别采用黄嘌呤氧化酶化学发光法、化学比色法、紫外分光光度法、硫代巴比妥酸法及酶标法测定了小鼠血浆、肝脏、脑组织中的超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、过氧化氢酶（CAT）的活性和丙二醛（MDA）的含量及血浆中一氧化氮合成酶（NOS）的活性.结果显示,高、低剂量的TCDCA均能显著提高小鼠血浆和肝组织中的SOD活性,显著提高小鼠肝组织中CAT的活性,显著提高小鼠血浆中NOS活性,显著降低小鼠肝组织中GSH-Px活性;高剂量TCDCA能极显著提高小鼠脑组织中GSH-Px活性;低剂量TCDCA能显著提高小鼠血浆中CAT活性;高、低剂量的TCD-CA能分别显著降低小鼠血浆和脑组织、肝脏中的MDA含量.试验表明TCDCA具有显著的抗氧化作用. 相似文献
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《畜牧与饲料科学》2021,42(5)
[目的]进一步探讨牛磺鹅去氧胆酸(taurochenodeoxycholic acid,TCDCA)在抗炎免疫方面的潜在调节作用。[方法]以AA大鼠成纤维样滑膜细胞作为研究对象,采用ELISA方法检测TCDCA和IL-1β作用下AA大鼠成纤维样滑膜细胞上清液中PGE_2的含量,分析TCDCA对IL-1β刺激下AA大鼠成纤维样滑膜细胞中PGE_2分泌情况的影响。[结果]TCDCA能够对IL-1β刺激下AA大鼠纤维样滑膜细胞PGE_2的分泌产生下调作用(P0.05)。[结论]TCDCA对IL-1β刺激下AA大鼠成纤维样滑膜细胞中PGE_2的分泌具有抑制作用,为TCDCA在兽医临床应用提供依据。 相似文献
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Beran GW 《Preventive veterinary medicine》2008,86(3-4):198-207
When early people made their appearance, zoonotic infectious diseases were already waiting, but epidemic diseases did not appear in human history until people began to live in large numbers under conditions of close contact, mainly during the last 10,000 years. Disease has decimated urban populations, conquered armies, and disrupted society. The focus here is on (1) the plague of Athens and the Black Death; (2) smallpox, influenza, and rabies; (3) avian influenza prion diseases, and foot & mouth disease; and (4) emerging and re-emerging diseases. All have veterinary public health associations. In Athens, Greece, in 430 BC, when the Spartans ravaged the countryside, hordes crowded into Athens so that orderly movements, space in which to live, and adequate supplies of food became impossible. Crowding of any population fosters disease transmission; chaos and disorder enhance it all the more. Out of northern Egypt came a terrible plague from across the Mediterranean Sea. The identity of the plague of Athens remains unsure, but the well-considered conclusion is Rift Valley Fever, a mosquito borne, viral zoonosis. The Black Death, also called the Plague, raged in Asia for centuries. In 1347, the Black Death was brought by a ship out of Asia to Sicily. The scenes of devastation were repeated throughout Europe, with 90% or more of the people dying in city after city. Influenza, too, has been a cause of periodic human epidemics, but the great pandemic of influenza occurred in the last months of World War I. In the years of highest occurrence, more than half the world's population became clinically infected. If veterinary public health had been born earlier, it could have led to elucidating the epidemiology of influenza and the plagues of Athens, Europe, and Asia. In turn, smallpox had also caused continual tragedy. In 1796, Edward Jenner began to harvest pustules of cowpox from children or infected cows and inject them into susceptible children. In 1980, the World Health Organization declared that smallpox had been eliminated from the world. Rabies, though, still strikes terror. A number of animal diseases, broadly termed emerging and re-emerging diseases, need surveillance because they have the potential to impact human health. From late in 2003 to 2007, the highly pathogenic H5N1 influenza virus in poultry infected at least 121 people and caused 62 deaths in four countries. The prion diseases, too, all have very high numbers in concentrated contacts. To control these diseases, veterinary public health is essential, with diagnosis, epidemiological surveillance, clinical manifestations, and prevention as primary measures. 相似文献
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Dekker A Dercksen D Snoep J van Wuyjckhuise L 《Tijdschrift voor diergeneeskunde》2007,132(18):695-701
On 26th of july 2007 a new case of bluetongue was notified in the Netherlands and on 2nd of august 2007 foot-and-mouth disease was diagnosed in Surrey, England, which raised the threat of having both infections simultaniously in one area. Bluetongue and foot-and-mouth disease have a different pathogenesis, but symptoms may resemble each other at a later stage of infection. The pathogenesis and possible clinical symptoms of both infections are discussed and illustrated with pictures. 相似文献
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在动物的异常行为中以刻板行为最为常见,而咽气癖又是马最常见的口部刻板行为之一。作者就咽气癖在生理方面和心智方面对马体产生的影响、行为基础、诱因的研究进展及常见的防治措施进行综述。 相似文献
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近几年,世界饲用添加剂市场增长较快,预计今后将进一步增长,据世界粮农组织(FAO)首领会议的倡议,到2015年,将使世界营养不良的人口削减一半,其间,肉制品将会以每年2％的速度增长,特别是加快猪肉和禽肉增长。这将促进世界添加剂,尤其是蛋氨酸和赖氨酸需求量的增加。 相似文献
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