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黄海波 《中国预防兽医学报》1988,(6)
猪血凝性脑脊髓炎(Hemaagglutinatingencephaloye litis)是由猪血凝性脑脊髓炎病毒(HEV)引起的猪的传染病。HEV 最早由 Greig 等(1962)以患有脑脊髓炎吮乳仔猪的脑组织中分离而得。后来,Cart wright等(1969)又从厌食、呕吐、精神沉郁、无任何脑脊髓炎症状的吮乳仔猪体内分离到另一株病毒,经鉴定与前者是同种病毒。实验感染都能够得以复制。 相似文献
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1病毒性疾病
猪血凝性脑脊髓炎由猪血凝性脑脊髓炎病毒引起,主要感染3周龄以下的仔猪。病猪主要表现厌食,剧烈呕吐或干呕,精神沉郁,肌肉震颤,脱水,呼吸困难,发绀、虚弱、昏迷而死亡。耐过猪成为永久性侏儒。通过病毒分离、血凝及血凝抑制试验进行确诊。猪传染性胃肠炎由传染性胃肠炎病毒引起的急性胃肠道传染病。各种年龄的猪均易感,10日龄以内的仔猪最敏感,如与猪呼吸道冠状病毒混合感染,则病情恶化。 相似文献
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《北方牧业》2006,(24)
<正> 神经症状在临床上比较多见,从精神状态上看,主要表现为兴奋或抑制;从运动机能上看,主要表现为共济运动失调、痉挛、瘫痪,更多地表现为强制运动,如转圈运动、盲目运动、暴进暴退、滚转运动等。猪患脑脊髓炎、伪狂犬病、李氏杆菌病、食盐中毒等疾病后,都可能会表现出神经症状,主要的表现有:共济失调、阵发性痉挛、转圈运动、角弓反张、四肢呈游泳样划动等,临床上应注意进行仔细的鉴别,才能确保不会出现误诊、误治。1 鉴别要点1.1 脑脊髓炎引发猪脑脊髓炎的病原有两种,即传染性脑脊髓炎病毒和血凝性脑脊髓炎病毒,前者引起猪的传染性脑脊髓炎,后者引起猪的血凝性脑脊髓炎。传染性脑脊髓炎主要发生于仔猪,尤其是4～5周龄的仔猪最易感染,病初体温高达40℃～41℃,不久即出现各种神经症状,严重者眼球震颤、头颈后弯、肌肉抽搐、昏迷不醒,随即发生麻痹,呈犬坐姿势或一侧横卧,有响声出现或触摸机体时,四肢会出现不胁调运动或头颈后弯。轻型病例主要出现兴奋、发抖、平衡失调、运动失控、肢体麻痹等症状。少数病例为最急性型,在24小时内死亡,多数为急性型,于3～4日内死亡。血凝性脑脊髓炎多发生于2周龄以下的仔猪,更多见于 相似文献
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猪血凝性脑脊髓炎是由红细胞凝集性脑脊髓炎病毒（HEV）引起的猪的急性传染病。以主要引起仔猪呕吐、食欲废绝、便秘、进行性消瘦及中枢神经系统功能障碍为特征，临诊上又称仔猪呕吐一消瘦病。初发病地区，病死率高。疫区的新生仔猪通常从初乳中获得被动保护，随后建立了日龄相关的抵抗力。 相似文献
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仔猪繁殖与呼吸综合征病毒和血凝性脑脊髓炎病毒混合感染的诊断 总被引：1，自引：0，他引：1
对辽宁省某规模化猪场发病的哺乳仔猪,通过临床症状、血清学、病理学、动物试验和反转录多聚酶链式反应(PCR)方法进行综合诊断,确诊为猪繁殖与呼吸综合征(porcine reproductive and respiratory syndrone virus,PRRSV)与猪血凝性脑脊髓炎病毒(HEV)混合感染。RT-PCR检测结果证明,所感染的PRRSV为美洲型毒株,猪血凝性脑脊髓炎病毒多呈隐性感染,本猪场哺乳仔猪发生二者混合感染,可能与PRRSV感染猪免疫力降低,容易感染HEV而混合发病有关。 相似文献
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近年来随着养猪业的持续发展,特别是规模养殖的快速发展,以前不常见的猪病近年来发病率也逐渐增多,猪传染性脑脊髓炎就是其中之一。猪传染性脑脊髓炎是由猪肠病毒引起的中枢神经系统受损继而出现一系列神经症状的传染病。又称为塔番病、猪脑脊髓灰质炎、猪病毒性脑脊髓炎等。临诊上以四肢麻痹和感觉过敏、震颤、轻瘫、惊厥等脑神经症状为主要特征。常可导致哺乳仔猪死亡。 相似文献
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Two day old piglets were inoculated intravenously with 1 ml of swine vesicular disease virus UK-G 27-72 isolate. Using infectivity tests, immunofluorescent staining and gross and histopathological examination, pathogenesis of the infection was studied in tissue specimens collected daily from one through seven days postinoculation. Swine vesicular disease virus had a strong affinity for the epithelia of the tongue, snout, coronary band and lips, the myocardium and the lymphoid elements of the tonsil and the brain stem. The virus had the greatest affinity for the epithelium of the tongue. However, there was no evidence that the tongue was the initial replication site for swine vesicular disease virus. Prickle cells in the stratum spinosum appear to be the primary targets for the virus. The necrotic foci in the stratum spinosum appeared first, followed the next day by reticular degeneration and multilocular intraepidermal vesicular formation. In the digestive tract and most of the other visceral organs the short duration and sudden drop of the virus titres and the negative fluorescence and pathological findings suggest that these are not important sites for the replication of swine vesicular disease virus in this experiment. The virus was recovered from most of the central nervous tissue specimens. Although the piglets had significant central nervous system lesions, signs of impaired central nervous system function were not detected. However, subtle nervous signs could have been obscured by difficulties in locomotion resulting from severe lesions of the feet. 相似文献
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猪伪狂犬病(Porcine Pseudorabies, PRV)是一种引发神经系统功能障碍的病毒性传染病,主要危害妊娠期母猪和哺乳期仔猪,母猪感染后表现繁殖障碍,仔猪则以神经症状为主要表现,病死率高;预防本病需对易感猪群科学接种疫苗,加强全场综合消毒工作,提升猪场生物安全管理水平;目前猪伪狂犬病尚无特效化学药物能够治疗,病猪可通过对症用药来降低病死率。 相似文献
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A plaquing system and plaque neutralization test in porcine thyroid cells were used to study different transmissible gastroenteritis isolates and hemagglutinating encephalomyelitis virus. Among transmissible gastroenteritis virus isolates, plaque size varied considerably and mixed size ranges sometimes occurred. The most recently isolated viruses produced smaller plaques than the laboratory viruses or hemagglutinating encephalomyelitis virus. All transmissible gastroenteritis virus isolates reacted in the plaque neutralization test with a transmissible gastroenteritis virus antiserum which showed no activity against hemagglutinating encephalomyelitis virus. Plaque neutralization results both from experimentally infected pigs and following a field outbreak demonstrated the reliability of this test and its greater sensitivity than the conventional tube test. 相似文献
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Encephalomyelitis, reproductive failure and corneal opacity (blue eye) in pigs, associated with a paramyxovirus infection 总被引：2，自引：0，他引：2
A new clinicopathological disorder associated with a paramyxovirus infection in pigs is described. Central nervous system manifestations and corneal opacity are the main features in piglets two to 21 days old. Older pigs seem to be more resistant and only corneal opacity is commonly observed. In pregnant sows the virus appears to be responsible for reproductive disturbances such as stillbirth, mummification and a return to oestrus. The changes are mainly microscopic and characterised by a non-suppurative encephalomyelitis, interstitial pneumonia and anterior uveitis with corneal oedema. Experimental infection of one-day-old piglets with the virus reproduced clinical signs similar to those described in naturally infected piglets. The virus was recovered from the tonsils, lung and brain of the experimentally infected piglets between the fourth and 20th day after infection. 相似文献
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不同途径感染猪血球凝集性脑脊髓炎病毒的比较病理学 总被引：6，自引：0，他引：6
用传代鼠血球凝集性脑脊髓炎病毒接种液，经不同途径感染12头5日龄仔猪作比较病理学研究。结果表明，经脑内注射、前后肢肌肉注射、口服、口服兼滴鼻等途径接种的仔猪全部感染发病，并在接种后36～98h死亡。发病猪出现脑、脊髓的小静脉和毛细管充血、出血、水肿，神经原水肿、急性肿胀、急性液化及中央染色质溶解，胶质细胞轻微增生等非化脓性脑脊髓炎特征。口服兼滴鼻接种猪脑脊髓出血、脑水肿最明显，神经原变质也最重。脑内接种猪脑膜的血管周围出现明显的免疫细胞反应。 相似文献
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R E Werdin D K Sorensen W C Stewart 《Journal of the American Veterinary Medical Association》1976,168(3):240-246
Six epizootics of encephalomyeltis in suckling pigs in Minnesota were attributed to infection with hemagglutinating encephalomyelitis virus. The disease occurred in 74 litters of pigs and was characterized by sudden onset of tremors, inappetence, weakness, atazia, and hyperesthesia, with high morbidity and case fatality rate. Pathologic changes consisted of marked nonsuppurative, nondemyelinating encephalomyelitis characterized by perivascular mononuclear cuffing, gliosis, neuronal death, and satellitosis. Clinical disease was limited principally to suckling pigs during a single farrowing period and did not recur in the herds involved during the ensuing 18 months. 相似文献
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J B Derbyshire 《Canadian journal of veterinary research》1989,53(1):52-55
The objective of this study was to compare the sensitivity of 11 porcine viruses to the antiviral effects of porcine interferon-alpha in serum from piglets which had been infected 19 h previously with transmissible gastroenteritis virus, and of porcine interferon-beta prepared in PK-15 cells by induction with polyinosinic:polycytidylic acid, in yield reduction assays in pig kidney cells which were treated with interferon before virus challenge, and both before and after virus challenge. The most sensitive virus to both types of interferon was vesicular stomatitis. A porcine isolate of bovine herpesvirus type 1, hemagglutinating encephalomyelitis virus and porcine enterovirus types 1 and 2 were also highly sensitive to interferon-alpha. There was little reduction in the yield of porcine parvovirus or porcine rotavirus, while swinepox, swine influenza and transmissible gastroenteritis viruses were intermediate in their sensitivity to interferon-alpha. In addition to vesicular stomatitis virus, porcine adenovirus type 3, swine influenza, hemagglutinating encephalomyelitis and porcine rotavirus were highly sensitive to interferon-beta, while swinepox, bovine herpesvirus type 1, porcine parvovirus, transmissible gastroenteritis and porcine enteroviruses were less sensitive than the above viruses to interferon-beta, although all showed significant reductions in virus yield. 相似文献
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为研究血凝性脑脊髓炎病毒(HEY)在人工感染仔猪体内的侵袭过程和分布规律,本实验采用滴鼻的方式感染5头1日龄未食初乳仔猪,并在感染后每隔24 h迫杀1头仔猪,采集鼻黏膜、气管、口腔黏膜、舌、食管、胃、肠、心肌、肝、脾、肺、肾、各段脊髓和脑等组织脏器制作切片,通过间接免疫组织化学方法检测HEV在仔猪体内的动态侵袭过程.此外,采用SYBR Green Ⅰ实时荧光定量PCR(Real-time PCR)方法检测病毒在各组织脏器中的分布情况.结果显示:感染病毒后2 d～3 d,仔猪出现精神沉郁、全身震颤等中枢神经系统症状,免疫组织化学检测可见病毒抗原首先出现于脑桥,并进一步蔓延至延髓和各段脊髓,最后进入小脑浦肯野氏细胞和大脑皮层锥体细胞中;Real-time PCR检测结果显示病毒广泛分布于大脑皮层、脑桥、延髓、脊髓和小脑等中枢神经系统的组织中,其中大脑皮层的检出率最高. 相似文献