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1.
日本血吸虫病的病理基础是在肝、肠所形成的虫卵肉芽肿,其形成机理已被证明是免疫反应。吡喹酮对血吸虫成虫、童虫、尾蚴和毛蚴均有强大的杀灭或抑制作用,对虫卵作用尚有争论,在生产中还发现一些植物具有灭螺作用。笔者等筛选了抑制钉螺繁殖的高蛋白牧草进行了研究。本实验对比观察吡喹酮与灭螺牧草对小鼠肝脏内日本血吸虫虫卵肉芽肿的作用及对肉芽肿内嗜酸性粒细胞的影响。 相似文献
2.
血吸虫病的主要致病因素是虫卵在组织中形成的虫卵肉芽肿。深入研究虫卵肉芽肿的形成、发展和转归,有助于了解血吸虫病发病机理及病程发展规律,进而为防治实践探讨新的途径及方法。此外血吸虫虫卵肉芽肿还可作为模型,研究其它慢性感染性疾病及其肿瘤免疫病理问题,基于此,对血吸虫虫卵肉芽肿的研究将日益受到重视。本文仅就近年来国内外关于血吸虫虫卵肉芽肿的研究方法、形成、调节及影响因素等作一综述。 相似文献
3.
对感染18条毛毕吸虫尾蚴的50日龄雏鸭分别于感染后41d起喂服阿魏倍半萜类及吡喹酮，两组用药组雏鸭肝内虫卵肉芽肿平均直径减小与对照组比较差异显著（P〈0．os）、肉芽肿内嗜酸粒细胞数目减少与对照组无差异差异显著（P〈0．05），表明阿魏倍半萜类与吡喹酮对血吸虫虫卵肉芽肿的发展具有明显的抑制作用。 相似文献
4.
对人工感染18条日本血吸虫尾蚴的雌性小鼠分别于感染后41 d起灌服羊角拗甙及吡喹酮,观察其对小鼠肝内虫卵肉芽肿和肉芽肿内嗜酸性粒细胞的影响。结果表明,小鼠肝内虫卵肉芽肿平均直径和肉芽肿内嗜酸性粒细胞明显减少,羊角拗甙与吡喹酮对血吸虫虫卵肉芽肿具有明显抑制作用。 相似文献
5.
牛血吸虫病是由裂体属血吸虫或裂体虫所引起的一种人兽共患寄生虫病.通常引起我国人畜血吸虫病流行的主要是日本血吸虫.其成虫寄生于终宿主门静脉和肠系膜静脉,虫卵聚集于肝脏、肠道等器官组织中,引起特征性虫卵结节. 相似文献
6.
对感染15条日本血吸虫尾蚴的雌性小鼠分别于感染后45 d起灌胃羊踯躅提取物及吡喹酮,结果小鼠肝内虫卵肉芽肿平均直径和肉芽肿内嗜酸性粒细胞明显减少。试验结果表明,羊踯躅提取物与吡喹酮对血吸虫虫卵肉芽肿的发展具有明显抑制作用。 相似文献
7.
日本血吸虫病是由人或哺乳动物感染血吸虫后所引起的一种疾病,钉螺为日本血吸虫的惟一中间宿主,灭螺是阻止血吸虫病传播的有效途径。目前,化学灭螺对环境污染较大。提倡植物灭螺。新疆阿魏系伞形科阿魏属植物,具有消积、杀虫、治疗疟疾等功效。笔者等利用阿魏倍半萜类化合物对钉螺进行浸泡、喷粉、投喂等方法处理,并比较了这3种方法的灭螺效果。 相似文献
8.
为了探讨新疆阿魏杀灭血吸虫的功效,分别用新疆阿魏蒸馏萃取物以0.1、0.2、0.3、0.4 g/kg浓度药液灌服治疗感染血吸虫病家兔,每隔3 d灌服1次,4次后停止给药,4周后剖检,门静脉灌注法收集虫体、计算减虫率,并以组织切片检查该药对血吸虫感染兔肝脏的治疗作用。结果显示,减虫率分别为12.30%、17.20%、46.40%、40.80%;经组织切片观察,家兔肝脏肉芽肿明显减小。表明新疆阿魏具有很强的杀灭血吸虫活性的作用,最佳杀虫剂量为0.3 g/kg。 相似文献
9.
本研究将日本血吸虫单克隆抗独特型抗体（抗－Ｉｄ）结合佐剂ＦＣＡ／ＦＩＡ免疫的绵羊设为抗－Ｉｄ免疫组，将在攻击感染日本血吸虫尾蚴前２小时肌注低剂量吡喹酮（ＰＺＱ）的绵羊设为ＰＺＱ组，将既用抗－Ｉｄ免疫又在攻击感染前肌注ＰＺＱ的绵羊设为协同组，同时设空白和ＦＣＡ对照组。在攻击感染血吸虫后的第１２周，剖杀各组绵羊，收集肝脏病理组织块，经切片和染色后，用显微镜测量各组肝脏单个虫卵肉芽肿直径。结果发现，抗－Ｉｄ组、ＰＺＱ组和协同组的肉芽肿直径分别为０．４１、０．４２和０．４０ｍｍ，均明显小于空白对照组（０．５１ｍｍ，Ｐ＜０．０５），也小于ＦＣＡ对照组。组织病理观察结果表明，试验组虫卵周围的多核巨细胞数量明显高于对照组。实验结果提示，抗－Ｉｄ免疫和预防性注射ＰＺＱ均能直接影响虫卵肉芽肿的形成，并且二者存在协同作用，对探讨血吸虫病免疫预防机理的研究具有一定的意义。 相似文献
10.
研究表明,辐照致弱血吸虫尾蚴疫苗能够诱导宿主产生较高的免疫保护作用,是所有血吸虫候选疫苗中保护力最强的,且辐照致弱尾蚴在宿主体内不能发育成熟,不会对宿主造成严重的病理损害。单性感染的血吸虫同样不能在宿主体内发育成熟,其发育状态停留在童虫阶段,也不会对宿主造成严重的病理损害,在童虫状态下对宿主持续进行的免疫刺激,是否也能诱导宿主对继发血吸虫病产生较高的免疫保护作用呢？为此,本研究通过让宿主携带单性血吸虫雄虫的带虫免疫方式来检测其对继发血吸虫病的影响。选用雄性血吸虫尾蚴感染BALB/c小鼠（100条/只）,于单性血吸虫尾蚴攻击后第5、7 w用吡喹酮进行治疗（300mg/kg）,第9 w进行雌雄血吸虫混合尾蚴攻击实验动物（40条/只）,第15 w剖杀实验动物,收集宿主荷虫、宿主肝卵负荷、肝卵孵化、宿主肝单卵肉芽肿体积数据,并检测宿主血清特异性抗体变化趋势。结果表明单性带虫免疫可以引起宿主肝虫卵孵化率及组织病理损伤显著降低,对宿主有一定的免疫保护效果。 相似文献
11.
In late December 1985, 1485 institutional veterinarians and small and mixed animal clinics across Canada were sent a questionnaire in order to assess the status of Dirofilaria immitis in Canada in 1985 and 44% of them responded. Veterinarians reported that 137,300 dogs were blood-tested to check for microfilariae and 1210 dogs were found with heartworm. Another 36 dogs were amicrofilaremic but diagnosed with heartworm disease to give the total number diagnosed in 1985 as 1247 (0.91%). Heartworm was reported from all provinces except Prince Edward Island, Newfoundland and Saskatchewan but most (1126) of the cases were in Ontario. Southwestern Ontario continued to be the primary focus of the infection in Canada. From Quebec, 91 cases were reported mostly from and around Montreal. From Manitoba, 19 cases were reported from Winnipeg and surrounding areas. Heartworm was found most frequently in companion dogs over three years of age maintained mainly outdoors in rural areas. About 28% of the cases were observed with clinical signs of heartworm disease and 78% had a history of not having left Canada. 相似文献
12.
In late November 1988, 1581 small and mixed animal clinics and institutional veterinarians across Canada were sent a questionnaire in order to assess the status of Dirofilaria immitis in Canada in 1988, and 46% of them responded. Veterinarians reported that 181,577 dogs were blood-tested for heartworm disease and 367 dogs were found with D. immitis microfilariae. Another 60 dogs were amicrofilaremic but diagnosed with heartworm disease to give the total number of cases diagnosed in 1988 as 441 (0.24%). 相似文献
13.
In late December 1984, 1853 institutional veterinarians and small and mixed animal clinics across Canada were sent a questionnaire in order to assess the status of Dirofilaria immitis in Canada in 1984 and 35% of them responded. Veterinarians reported that 97,794 dogs were blood-tested to check for microfilariae and 1417 dogs (1.45% of those tested) were found with heartworm. Another 34 dogs were amicrofilaremic, but were diagnosed as having heartworm disease, to give the total number diagnosed in 1984 as 1451 (1.48%). Heartworm was reported from all provinces except Prince Edward Island and Newfoundland but most (1310) of the cases were in Ontario. In Quebec, 126 cases were reported mostly from west of Montreal. Heartworm was found most frequently in companion dogs over three years of age maintained mainly outdoors in rural areas. About 27% of the cases were observed with clinical signs of heartworm disease and 72% had a history of not having left Canada. Southwestern Ontario continued to be the primary focus of the infection. 相似文献
15.
In late November 1991, 1883 clinics in Canada were sent a questionnaire to assess the status of Dirofilaria immitis in dogs in 1991 and there was a 60.0% response. There were 344,031 dogs tested for heart-worm (HW), 627 were found infected and the prevalence of HW infection was 0.18%. There were 417 dogs with HW in Ontario, 116 in Manitoba, 38 in Quebec, 53 in British Columbia, three in Alberta, and one in Nova Scotia. In British Columbia, all of the infected dogs but one were from the Okanagan valley which, as from 1991, is a new focus of infection in Canada. Most dogs with HW had not been on preventive medication in 1990, and the prevalence among dogs tested and unprotected was 0.59%. That prevalence was considerably higher in endemic areas. Companion dogs, over three years of age and maintained primarily outdoors in rural areas, were most frequently infected. One cat was diagnosed with D. immitis and 33 dogs had Dipetalonema reconditium. 相似文献
16.
In late November 1989, 1732 clinics and institutional veterinarians were sent a questionnaire to assess the status of Dirofilaria immitis, and 51.7% responded. Of 247,716 dogs tested, 394 had D. immitis microfilariae and 51 were amicrofilaremic for a total of 445 cases and heartworm prevalence of 0.17%. Most (408) of these dogs had no preventive medication and the prevalence among dogs tested and unprotected was 1.01%. That prevalence was considerably higher in endemic areas. Thirty-seven dogs with heartworm had preventive medication. Heartworm was most frequent in companion dogs over three years of age maintained outdoors in rural areas. About 75% of the cases had never left Canada, 26% had clinical signs and 125 were not treated. Heartworm was reported from British Columbia, Manitoba, Ontario, Quebec, Nova Scotia and Newfoundland, but 383 cases were in Ontario. South-western Ontario was the primary focus of infection. There were 33 cases in Quebec and 24 in Manitoba, mainly found in and around Metropolitan Montreal and Winnipeg respectively. 相似文献
17.
In late November 1987, 1246 institutional veterinarians and small and mixed animal clinics across Canada were sent a questionnaire in order to assess the status of Dirofilaria immitis in Canada in 1987, and 50% of them responded. Veterinarians reported that 165,428 dogs were blood tested for heartworm disease and 511 dogs were found with D. immitis microfilariae. Another 78 dogs were amicrofilaremic but diagnosed with heartworm disease to give the total number of cases diagnosed in 1987 as 589 (0.35%). 相似文献
18.
In late December 1986, 1224 institutional veterinarians and small and mixed animal clinics across Canada were sent a questionnaire in order to assess the status of Dirofilaria immitis in Canada in 1986; 46% of them responded. Veterinarians reported that 150,989 dogs were blood-tested for microfilariae and 869 dogs were found with heartworm. Another 65 dogs were amicrofilaremic but diagnosed with heartworm disease and one was found with heartworm at necropsy to give the total number diagnosed in 1986 as 935 (0.62%). Heartworm was reported from Manitoba, New Brunswick, Ontario and Quebec, but most (810) of the cases were from Ontario. South-western Ontario continued to be the primary focus of the infection in Canada. There were 103 cases reported from Quebec, mostly from and around Montreal, and 21 cases from Manitoba, from Winnipeg and surrounding areas. Heartworm was found most frequently in companion dogs over three years of age maintained mainly outdoors in rural areas. About 33% of the cases were observed with clinical signs of heartworm disease and 81% had a history of not having left Canada. 相似文献
20.
In late December 1983, 2 800 veterinarians across Canada were sent a questionnaire in order to assess the status of heartworm disease in Canada in 1983 and 26% of them responded. Veterinarians reported that 59 504 dogs were blood-tested to check for microfilariae and 771 dogs (1.30% of those tested) were found with Dirofilaria immitis. Heartworm disease was diagnosed in all provinces except New Brunswick and Newfoundland but most (733) of the cases were in Ontario. Heartworm disease was found most frequently in companion dogs over three years of age maintained mainly outdoors in rural areas. About 31% of the cases were observed with clinical signs of heartworm disease and 64% had a history of not having left Canada. Southwestern Ontario continues to be the focus of the infection and most of the dogs there had not left the province previously. 相似文献
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