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牛传染性鼻气管炎(IBR)是由牛疱疹病毒1型(BoHV-1)引起牛的一种接触性传染病,表现为上呼吸道感染及气管黏膜炎症、呼吸困难等症状,还可引起生殖道感染、脑膜炎、结膜炎、流产等多种病型。该病呈世界性流行,我国部分地区也有发生。BoHV-1感染造成的免疫抑制,容易使其他病原体侵入引发继发感染,从而导致牛呼吸道疾病综合征(BRDC)的发生,给世界养牛业造成了巨大经济损失。论文围绕IBR病原学、流行病学、诊断、防控等方面阐述了近年来牛传染性鼻气管炎的研究进展,以期为牛传染性鼻气管炎的诊断及防控提供参考。 相似文献
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牛传染性鼻气管炎(IBR)是由牛疱疹病毒I型(BoHV-I)引起的一种急性接触性疾病。主要从临床症状、流行病学特点、疫病动态、病原学、分子生物学、诊断和防控措施等方面来论述牛传染性鼻气管炎,以期为该病诊断、防控、疫苗研究提供参考。 相似文献
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牛传染性鼻气管炎诊断方法研究进展 总被引：1，自引：0，他引：1
牛传染性鼻气管炎(IBR)是由牛传染性鼻气管炎病毒(IBRV),即牛疱疹病毒1型(BoHV-1)所引起的以上呼吸道炎症为主的一种牛的急性、热性、接触性传染病,呈世界性流行。IBR的早期准确诊断,对该病的防控具有不可忽视的作用。目前,IBR的诊断方法主要包括病原学诊断和血清学诊断方法。病原学诊断具有特异和敏感及准确等特点,而血清学诊断具有敏感、快速、方便和价廉等特点。为了实施IBR的净化和根除计划,部分国家和地区已逐渐采用IBR基因缺失疫苗,配套使用鉴别诊断方法来鉴别IBR疫苗免疫和自然感染。论文就牛传染性鼻气管炎常用诊断方法的研究进展进行综述,以期为IBR的诊断和防控提供参考。 相似文献
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<正>牛传染性鼻气管炎是由牛疱疹病毒Ⅰ型牛传染性鼻气管炎病毒引起的一种具有高度传染性的疾病。本病最常表现为鼻气管炎、结膜炎、发热,病程短和康复率高。根据临床表现可将该病分为呼吸道型、生殖道感染型、脑膜脑炎型、眼炎型和流产型。1流行病学特点用病毒进行实验攻击时,各种年龄和品种的牛均易感,但6月龄以上的动物常自然发病,很可能与它们更多暴露于传染源有关。 相似文献
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牛传染性鼻气管炎是由牛传染性鼻气管炎病毒引起的急性接触性传染病,又称牛疱疹病毒Ⅰ型感染、红鼻病或牛传染性坏死性鼻炎.患牛临床特征表现为呼吸困难和发热,有鼻炎、鼻窦炎、喉炎和气管炎.世界动物卫生组织(OIE)将牛传染性鼻气管炎列为B类疫病.
1 病原
牛传染性鼻气管炎病毒属于疱疹病毒,病毒呈球状,直径约200毫微米.可在牛肾、牛胎肾、猪肾、羊肾及马肾细胞上生长,并可发生细胞病变,均产生核内包涵体. 相似文献
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牛传染性鼻气管炎是由Ⅰ型牛疱疹病毒感染后引起牛的一种传染性疾病,主要表现为鼻气管炎、体温升高以及母牛流产等症状,发病较为严重的病牛还可能会出现死亡。本病原的传播范围广,给养牛业造成较大的影响,使得养殖场遭受经济损失。本文将对牛传染性鼻气管炎进行归纳总结,以为养殖场提供参考。 相似文献
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Glucocorticoid treatment of imported red deer (Cervus elaphus), seropositive to Infectious Bovine Rhinotracheitis (IBR) virus, reactivated a latent herpesvirus infection, which was transmitted to a seronegative deer with a fatal outcome. However the virus did not spread to cattle housed in close contact with the infected deer, and serological indication og infection in the cattle was observed only on direct nasal installation of virus. The virus isolate had characteristics in common with other Alpha herpesviruses and especially the Bovid Herpesvirus type 1 (BHV-1) but distinguished itself from the latter by its host specificity, serological reaction and genomic restriction fragment pattern (RFP). The host specific red deer herpesvirus was tentatively designated Cervid Herpesvirus type 1 (CHV-1). It was concluded that CHV-1 seropositive deer can be a threat to red deer farming, while in cattle the infection may only cause minor inconvenience through interference with the serological IBR diagnosis. 相似文献
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An outbreak of severe conjunctivitis involved approximately 30% of a dairy herd of 118 cattle. Infectious Bovine Rhinotracheitis (IBR) virus was identified by cytopathic effects and fluorescent antibody techniques from conjunctival swabs of affected animals. The disease typically presented as a unilateral ocular disease with systemic signs of pyrexia, inappetance, decreased milk production, and some subsequent abortions. 相似文献
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G. Florent A. Wiseman 《Comparative immunology, microbiology and infectious diseases》1990,13(4):203-208
A capture ELISA for the detection of IgM antibodies to Infectious Bovine Rhinotracheitis (IBR) and to Bovine Respiratory Syncytial (BRS) viruses was developed. In these assays, the first monoclonal antibody to bovine IgM is used as the catching antibody while the second monoclonal detects specific antiviral antibodies. The test was evaluated on serum samples originating from both experimentally and naturally infected animals. From these studies, it has been shown that primary IBR and BRS virus infections can be confirmed using serum samples collected 5–10 days after the appearance of the clinical signs of disease. 相似文献
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G. Regev-Shoshani S. Vimalanathan D. Prema J.S. Church M.W. Reudink N. Nation C.C. Miller 《Research in veterinary science》2014
Bovine Respiratory Disease Complex (BRDc), a multi-factorial disease, negatively impacts the cattle industry. Nitric oxide (NO), a naturally occurring molecule, may have utility controlling incidence of BRDc. Safety, bioavailability, toxicology and tolerance/stress of administering NO to cattle is evaluated herein. Thirteen, crossbred, multiple-sourced, commingled commercial weaned beef calves were treated multiple times intranasally over a 4 week period with either a nitric oxide releasing solution (treatment) or saline (control). Exhaled NO, methemoglobin percent (MetHg) and serum nitrites demonstrated biological availability as a result of treatment. Cortisol levels, tissue nitrites, behavior and gross and macroscopic pathology of organs were all normal. Moreover, preliminary in vitro studies using Mannheimia haemolytica, Infectious Bovine Rhinotracheitis, Bovine Parainfluenza-3 and Bovine Respiratory Syncytial Virus, suggest a potential explanation for the previously demonstrated efficacy for BRDc. These data confirm the bioavailability, safety and lack of residual of NO treatment to cattle, along with the bactericidal and virucidal effects. 相似文献
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建立一种PCR技术,既能快速检测疱疹病毒1型成员牛传染性鼻气管炎病毒(bovine infectious rhinotracheitisvirus,IBRV),又能区分牛疱疹病毒5型和伪狂犬病毒。根据基因库中牛传染性鼻气管炎病毒的gD基因序列,应用primer 5.0软件设计了gD PCR引物,建立PCR方法,反应条件是:94℃预变性5min,94℃1min,58℃1min,72℃1min,30个循环,72℃7min,4℃5min。该方法能从IBRV阳性样本和参考毒株中扩增出372bp的目的片段,而从同属的牛疱疹病毒5型中扩增出440bp和206bp两条目的片段,从同属的伪狂犬病毒中扩增出303bp的目的片段,但不能从非疱疹病毒属成员猪呼吸与繁殖综合征病毒中扩增出目的条带。该PCR检测IBRV的灵敏度可达1PFU/mL以上。鉴于其灵敏度高、特异性好,可望在牛疱疹病毒感染快速鉴别检测方面发挥重要作用。 相似文献
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为了快速检测牛传染性鼻气管炎,采用SDS-蛋白酶K法,提取病毒模板DNA。根据IBRV gB基因序列设计了1对特异引物,在其上下游引物的内侧又分别设计了1对引物,以这4条引物对IBRV模板进行扩增。结果成功扩增出预期目的片段,建立了巢式PCR检测方法。敏感性、特异性等检测试验结果表明该方法能特异检测IBR病毒。本方法具有快速、灵敏、特异的优点,适用于在牛及其遗传物质的进出口检疫中进行牛传染性鼻气管炎快速病原鉴定。 相似文献
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Gür Sibel Erol Nural Yapıcı Orhan Kale Mehmet Tan Mehmet Tolga Turan Turhan Çakmak Mehmet Atilla Tosun Cemil Yılmaz Simay Acar Abuzer Özenli Işınsu Gür Coşkun 《Tropical animal health and production》2019,51(4):753-758
Bovine herpesvirus 1 (BoHV1) is the cause of economically significant viral infections in cattle. Respiratory symptoms associated with the infection are known as Infectious Bovine Rhinotracheitis (IBR). Sheep and goats are less sensitive to the infection although their role in inter-species viral transmission under field conditions is subject to controversy. The objective of this study was to investigate seroprevalence of BoHV1 infections in cattle, sheep, and goats raised together for at least a year. Blood serum samples were taken from 226 cattle, 1.053 sheep, and 277 goats from 17 small- to medium-scale farms. BoHV1-specific antibody presence and titers were determined using virus neutralization test. In total, 73 of the 226 cattle (32.3%) were seropositive. The infection was detected in 13 of the 17 farms. Infection rates ranged from 5.8 to 88.8%. Only one of the 1053 sheep (0.09%) was seropositive. However, 58 of the 277 (20.9%) goats were seropositive. Goat samples taken from 8 of the 17 farms were seropositive with infection rates ranging from 17 to 38.9%. Statistical analysis showed a significant correlation in infection rates between cattle and goats but not sheep. These results suggest that goats may be more sensitive to the BHV1 infection than sheep and the role of goats as possible reservoirs for BoHV1 in the control and eradication of BHV1 in cattle should be considered in future studies.
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Influence of induced disease states on the disposition kinetics of imidocarb in goats 总被引：2，自引：0，他引：2
The influence of fever, induced by different agents, on the disposition kinetics of imidocarb was determined in goats. Escherichia coli endotoxin (0.2 microgram/kg), Trypanosoma evansi (10(7) in 1 ml sterile glucose citrate), and Infectious Bovine Rhinotracheitis virus (10(6.5)TCID50) were the agents administered to induce the febrile state. In control and febrile animals the two-compartment model was used to describe the disposition kinetics of the drug. Fever caused significant changes to occur in the apparent volume of distribution and the body (systemic) clearance of imidocarb, but the half-life remained unchanged. The statistical significance of the changes in these pharmacokinetic parameters varied with the etiology of the febrile state. E. coli endotoxin and IBR virus caused corresponding decreases in apparent volume of distribution and clearance of imidocarb, while fever induced with T. evansi caused highly significant increases in both pharmacokinetic parameters. It was concluded that the alterations in the disposition kinetics of imidocarb that occurred in the febrile goats were related not only to the febrile reaction per se but also to the pathophysiology of the disease condition. 相似文献
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用犊牛睾丸细胞培养传染性牛鼻气管炎病毒（IBRV），反复冻融，差速离心提取病毒，用Triton X-100溶解，超声波处理，制成IBRV TritonX-100亚单位抗原，经SDS－PAGE电泳，其分子量在176kD-53kD之间，其中有6条清晰的蛋白带。该抗原与一定比例的白油－司盘佐剂乳化，接种育成年，经间接ELISA检测，可使接种的育成牛产生高效价的血清抗体（OD492mm=1.57)。2种不同剂量（80mg/头，40mg／头）的IBRV亚单位疫苗接种育成牛，体内抗体效价相差不显著，抗体可在体内持续12周，用IBRV TrionX-100亚单位疫苗2次接种育成牛，其体内抗体效价显著高于用灭活疫苗2次接种育成牛体内的效价。试验结果表明：提取的IBRV多肽制作的亚单位疫苗具有良好的免疫原性，且抗体持续时间较长。 相似文献
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The health risks for both domestic animals and humans caused by large herbivores in self-sustaining ecosystems are largely unknown. The aim of this article is to make an inventory of these risks, to explore ways to manage them in practice, and to make recommendations for the quantification of risks. Potential hazards from herbivores in and around Europe are listed using the data of the OIE (Office International des Epizooties). The desired health status and the implementation of control or surveillance measures are important factors when assessing the risks. Results indicate that a regular yearly system of health monitoring of herbivores is necessary. To get more insight into the importance of certain risks (Infectious Bovine Rhinotracheitis, biodegradation of carrion in the field) epidemiological investigations have to be carried out to assess the risk of transmission in different situations (with or without intervention). Analysing and managing risks enable decision-makers to formulate the conditions for the development of nature reserves. In Europe more has to be done to increase the quality of nature in terms of de-fragmentation and de-isolation, but regulations concerning the health of large herbivores also have to be improved. 相似文献