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<正> 猪断奶后多系统衰弱综合征(PMWS)是一种严重影响养猪生产的疾病综合征,是由圆环病毒2型(PCV2)感染引起的,主要发生于断奶仔猪。同时 PCV2经常和猪繁殖与呼吸综合征病毒(PRRSV)、细小病毒(PPV)混合感染,PMWS 的发生还常常有其他细菌如:副猪嗜血杆菌、衣原体、支原体、胸膜肺炎放线杆菌、多杀性巴氏杆菌以及链球菌等继发感染。除此之外,PMWS 相似文献
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猪圆环病毒病是由猪圆环病毒(Porcinecir-covirus,PVC)引起猪的一种多系统功能障碍性疾病,临床上以新生仔猪先天震颤和断奶仔猪多系统衰弱综合征为主要症状。猪断奶后衰竭综合征(PMWS)的病原体已被世界各国学者公认为猪圆环病毒(PCV-2),所以PMWS应属于猪圆环病毒病。另外,猪皮炎与肾炎综合征(PDNS)、增生性坏死性肺炎(PNP)等其他许多猪病也于PCV-2感染有极其重要的关系。本病最早发现于加拿大(1991),以后此病很快蔓延至美国、西班牙、英国、丹麦、德国、荷兰、比利时等国家。近年来中国以及台湾地区也有此病发生和流行,1999年,我… 相似文献
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《畜牧兽医科技信息》2017,(10)
<正>猪圆环病毒病是由猪Ⅱ型圆环病毒(PCV-2)引起的一种免疫抑制性疾病。猪圆环病毒病是继猪繁殖与呼吸综合征(PRRS)之后近年来对养猪业造成巨大损失的一种传染病。猪Ⅱ型圆环病毒(PCV-2)感染所引起的疾病包括:断奶仔猪多系统衰竭综合征(PMWS)、猪皮炎与肾病综合征(PDNS)、增生性坏死性肺炎(PNP)、猪呼吸道综合征(PRDC)、繁殖障碍、先天性颤抖、肠炎。感染圆环病毒后容易继发细菌性疾病,副 相似文献
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猪圆环病毒2型(PCV-2)所引起的断奶猪多系统衰弱综合征(PMWS)已给世界各国养猪业造成巨大的经济损失,且近年来呈现不断扩散的趋势.5～12周龄仔猪是猪圆环病毒感染的主要对象,症状表现为生长缓慢、精神不振、食欲减退、咳嗽、呼吸困难等,少数伴有腹泻和中枢神经症状.可依据临床症状和病理变化给出初步的诊断,进一步确诊需运... 相似文献
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近年来断奶仔猪多系统衰竭综合征(PMWS)在全世界范围内呈不断流行和蔓延的趋势。猪圆环病毒Ⅱ型(PCV-2),目前已被世界各国学者确认为是引起PMWS的主要病原体,许多对PCV-2的研究也主要是针对PMWS的。本文就近年来对猪圆环病毒的病原及致病性、流行病学、诊断及防制等方面的研究进展作一综述。 相似文献
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董海亮 《国外畜牧学(猪与禽)》2003,23(2):50-52
自从1991年首次报告了加拿大萨斯卡彻温的断奶后多系统消耗性综合征(PMWS)以来,现在全世界都已报告了这一综合征。1997年证实了PMWS患猪的病变中存在猪圆环病毒。对于与PMWS有关的猪圆环病毒进行核苷酸序列分析,结果表明该病毒与以前已知的猪圆环病毒相比有重要差异,所以建议将获自细胞培养的病毒称为Ⅰ型猪圆环病毒(PCV1),而将与这一新疾病有关的病毒称为Ⅱ型猪圆环病毒(PCV2)。 相似文献
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自从1991年首次报告了加拿大萨斯卡彻温的断奶后多系统消耗性综合征(PMWS)以来,现在全世界都已报告了这一综合征.1997年证实了PMWS患猪的病变中存在猪圆环病毒.对于与PMWS有关的猪圆环病毒进行核苷酸序列分析,结果表明该病毒与以前已知的猪圆环病毒相比有重要差异,所以建议将获自细胞培养的病毒称为Ⅰ型猪圆环病毒(PCV1),而将与这一新疾病有关的病毒称为Ⅱ型猪圆环病毒(PCV2). 相似文献
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猪圆环病毒病的流行病学调查及综合防治措施 总被引：1，自引：0，他引：1
猪圆环病毒(Porcine circovirus,PCV)属于圆环病毒科(Circoviridae)圆环病毒属(Circovirus),无囊膜,基因组为单链DNA,直径为17nm,是迄今发现的最小的一种动物病毒。其中,PCV-2是引发猪断奶后多系统衰弱综合征(Post-weaning multisystemicwasting syndrome,PMWS)的主要病原。该病主要以患畜生长迟缓、进行性消瘦和多系统病理损伤为特征。除了引发PMWS外,PCV-2还与猪皮炎与肾病综合征(Porcine dermatitis and nephropathy syndrome,PDNS)、新生仔猪先天性脑震颤(Congenital tremors,CT)、增生性坏死肺炎(Proliferative and necr… 相似文献
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仔猪断奶后多系统衰弱综合征(postweaningmultisystemic wasting syndrome,PMWS)最早发生于1991年,1997年首次证实[1],是近年来新发生的仔猪的一种新病,给养猪业造成了重大的经济损失。PMWS主要发生在5至12周龄的仔猪,最常见的临床症状包括生长衰竭或停滞、呼吸困难、淋巴结肿大、腹泻、皮肤苍白及黄疸、渐进性消瘦和腹泻。研究表明PMWS在中国普遍存在[2-3]。猪圆环病毒2型(porcine circovirus type 2,PCV2)目前被认为是PMWS的主要病原,该病毒属于圆环病毒科,是单股环状DNA病毒,直径17nm,呈二十面体对称,无囊膜。基因组全长1 767bp… 相似文献
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Case-control study on the association of porcine circovirus type 2 and other swine viral pathogens with postweaning multisystemic wasting syndrome. 总被引：19，自引：0，他引：19
Roman M Pogranichniy Kyoung-Jin Yoon Perry A Harms Steven D Sorden Michael Daniels 《Journal of veterinary diagnostic investigation》2002,14(6):449-456
A field-based case-control study was conducted to assess the strength of association of porcine circovirus type 2 (PCV2) and some major swine viruses with postweaning multisystemic wasting syndrome (PMWS). Cases were defined as individual pigs with a clinical history of progressive weight loss and histopathological lesions characteristic of PMWS. Controls were pigs without clinical signs and histopathological lesions typical of PMWS. A total of 31 cases and 56 controls was identified from diagnostic submissions. Serum and various tissues were collected from all animals and assayed for PCV, porcine reproductive and respiratory syndrome virus (PRRSV), porcine parvovirus, porcine enterovirus types 1-3, swine influenza virus, porcine respiratory coronavirus, transmissible gastroenteritis virus, porcine endogenous retrovirus, porcine lymphotropic herpesvirus type 1, and bovine viral diarrhea virus. The proportion of case and control pigs positive for each virus was determined and statistically compared for determining the strength of the association that each virus had with PMWS individually or in combinations. Porcine circovirus type 2 had the strongest association (OR = 9.3, P = 0.006) with PMWS among the viruses tested for. Risk for PWMS was much higher (OR = 31.2, P = 0.0009) if the animal was concurrently infected with PCV2 and PRRSV, suggesting that development of PMWS may be enhanced by cofactor(s). Because PCV2 was also found in 62.5% of the controls, PCV2 from 5 cases and 4 controls were selected and genetically compared. No significant genetic difference was observed between PCV2 from PMWS and control pigs. 相似文献
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猪圆环病毒免疫学研究进展 总被引：1，自引：0，他引：1
猪圆环病毒(PCV)在世界范围内广泛存在,可引起断奶仔猪多系统衰竭综合征(PMWS)、猪皮炎-肾病综合征(PDNS)和猪呼吸系统疾病症候群,给养猪业造成重大经济损失.已有研究表明,PCV-2感染和免疫刺激作用在PMWS发生中起关键作用,母源抗体对PMWS发生有被动保护作用,通过对初产母猪和经产母猪进行PCV-2免疫,增加母源性免疫和降低病毒血症的措施可以减少PMWS对仔猪死亡的影响.PCV-2疫苗现在已经在商业上应用,疫苗对PCV-2复制和PCVD的诱导增强作用似乎依赖于疫苗佐剂的类型和疫苗的接种时间.因此,基于有效的试验,在发生过PMWS感染的猪群,应该根据PCV-2感染的时间有目的地制定免疫接种方案,以控制或者减少PMWS的发生. 相似文献
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猪圆环病毒2型致病机制研究进展 总被引：3，自引：1，他引：2
猪圆环病毒2型(PCV-2)感染可导致一系列病征,包括断奶仔猪多系统衰竭征(PMWS)、仔猪先天性震颤(CT)、母猪繁殖障碍、猪皮炎肾病综合征(PDNS)及猪呼吸道综合征(PRDC),其中以PMWS对养猪业危害最大.PCV-2具有自身特有生物学特性.PCV-2可感染不同年龄段猪而产生临床上症状不同的疾病,能诱发仔猪产生免疫抑制后继发感染和混合感染其他病原.论文结合PCV-2的分子生物学特性和发病特征,从分子生物学角度、病毒组织嗜性、宿主细胞增殖特性及免疫刺激方面,对PCV-2致病机制进行综述,为防控PCV-2感染提供参考. 相似文献
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Postweaning multisystemic wasting syndrome (PMWS) is a worldwide emerging disease of weaned piglets. The objective of this review is to summarize the current knowledge regarding PMWS, its causative agent, mode of transmission, diagnostic techniques to detect PCV-2, the possible control measures, and the association of PMWS and PCV-2 with porcine dermatitis and nephropathy syndrome (PDNS). The causative agent of PMWS is porcine circovirus type 2 (PCV-2), however, not all pigs infected with PCV-2 develop the syndrome. PCV-2 is consistently associated with PMWS and PMWS is considered not to occur without it. Both the syndrome and the virus are not regarded as new. Co-factors that could activate PCV-2 to cause PMWS are considered. This enigmatic nature of both the syndrome and the virus is triggering a concern towards uncertainties of the viral transmission, its introduction in to the herd, effective tools of diagnosis, and control strategies. 相似文献
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The presence of co-infections in pigs with clinical signs of PMWS in The Netherlands: a case-control study 总被引：8，自引：0，他引：8
Wellenberg GJ Stockhofe-Zurwieden N Boersma WJ De Jong MF Elbers AR 《Research in veterinary science》2004,77(2):177-184
In this study, 60 pigs with clinical signs of post-weaning multisystemic wasting syndrome (PMWS) from 20 different pig herds and 180 control pigs (without clinical signs of PMWS) were examined to get more insights into the frequencies of porcine circovirus 2 infections and the presence of co-infections in pigs with and without clinical signs of PMWS in the Netherlands. Porcine circovirus type 2 was detected in 100% of the pigs with clinical signs of PMWS by virus isolation and/or PCR and in 50% of the pigs from PMWS-free herds. There was an association between the levels of infectious PCV2 and/or PCV2 DNA load and the severity of clinical signs as described for PMWS. A high variation in PCV2 antibody titres was found in the clinically affected pigs, and 27% of these pigs did not mount PCV2 antibody titres higher than 1:200. A concurrent infection of PCV2 and porcine reproductive and respiratory syndrome virus (PRRSV) was found in at least 83% of the pigs with clinical signs of PMWS and in 35% of the pigs from PMWS-free herds. Co-infections of European- and American-type PRRSV were detected only in PMWS herds and in one control herd with a history of PMWS clinical signs. 相似文献
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Chianini F Majó N Segalés J Domínguez J Domingo M 《Veterinary immunology and immunopathology》2003,94(1-2):63-75
The lymphoid, renal, pulmonary, and hepatic lesions of naturally occurring postweaning multisystemic wasting syndrome (PMWS) affected pigs have been studied by means of immunohistology. Ten conventionally reared pigs showing acute clinical signs of PMWS were selected from a farm on which animal were seronegative to porcine reproductive and respiratory virus and to Aujeszky's disease virus. All pigs were positive in tests for porcine circovirus type 2 by ISH and IHC. Monoclonal and polyclonal antibodies to CD3, CD79alpha, CD45RA (3C3/9), lysozyme, SLA-II-DQ (BL2H5), and MAC387 were used to characterise cells in PMWS lesions. The most relevant changes were reduction or loss of B and T lymphocytes, increased numbers of macrophages, and partial loss and redistribution of antigen presenting cells throughout lymphoid tissues compared to uninfected controls. The characteristics of lymphoid lesions in the present study strongly suggest an immunosuppressive effect of PMWS in affected pigs. 相似文献
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A review of porcine circovirus 2-associated syndromes and diseases 总被引：25，自引：0，他引：25
Chae C 《Veterinary journal (London, England : 1997)》2005,169(3):2012-336
Clinical expression of porcine circovirus 2 (PCV2) infection in swine may result in several distinct syndromes and diseases including post-weaning multisystemic wasting syndrome (PMWS), porcine dermatitis and nephropathy syndrome (PDNS), reproductive failure, porcine respiratory disease complex, granulomatous enteritis, necrotizing lymphadenitis, and possibly exudative epidermitis. Association of PCV2 with congenital tremor in piglets is still controversial. The extent of the involvement of PCV2 in swine disease other than PMWS is currently poorly understood. This review concentrates on PCV-2-associated syndromes and diseases other than PMWS. 相似文献
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Pathological findings associated with naturally acquired porcine circovirus type 2 associated disease 总被引：1，自引：0，他引：1
Porcine circovirus type 2 (PCV2) is a novel virus of the Circoviridae family which is considered the cause of postweaning multisystemic wasting syndrome (PMWS). PCV2 has also been associated to a number of pathological conditions of pigs, including porcine dermatitis and nephropathy syndrome, reproductive failure, porcine respiratory disease complex, proliferative and necrotising pneumonia and congenital tremor type AII. Pathological studies have been used to describe and characterise PMWS and these emerging conditions associated with PCV2. The objective of this review is to concentrate on the gross, microscopic and ultrastructural pathology associated with natural cases of PCV2 associated disease, along with some speculations on the pathogenesis of naturally occurring PMWS. 相似文献
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上海地区出现猪繁殖与呼吸综合征和2型猪圆环病毒混合感染 总被引：21，自引：2，他引：19
上海地区6个规模化猪场断奶后仔猪出现全身消耗性综合征，剖检的18头病仔猪都表现肺脏严重病变和淋巴结肿大出血。分别设计针对猪繁殖与呼吸综合征病毒(porcine reproductive and respiratory syndrome virus，PRRSV)N蛋白和2型猪圆环病毒(porcine circovirus type2，PCV-2)部分基因的特异性PCR引物，通过RT—PCR和PCR技术从患病猪肺脏组织均扩增出PRRSV和PCV-2的特异基因片段。结合临床症状和流行病学调查，证实上海地区出现PRRSV和PCV-2的混合感染。 相似文献