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1.
Reichling J Fitzi J Fürst-Jucker J Bucher S Saller R 《Schweizer Archiv für Tierheilkunde》2003,145(5):223-231
An open multi-centered veterinary clinical trial, comparing conditions before and after treatment with a herbal preparation, containing the powdered root of Echinacea purpurea, was conducted by 6 practicing veterinarians in Switzerland. The plant-based immune stimulant was administered to 41 dogs with manifestations of chronic and seasonal upper respiratory tract infections, including pharyngitis/tonsillitis, bronchitis and kennel cough. Each animal was at an individual stage of the disease, with various symptoms and different severity scores, at start of treatment. There was no control group. Echinacea powder (1:3) was administered with the food at a dose of 1.0 g/10 kg body weight once daily for 8 weeks. Overall efficacy showed significant improvement for 92% of 39 dogs after 4 weeks of treatment and this was confirmed after 8 weeks. Significant reductions of severity and resolution of typical clinical symptoms, of clear nasal secretions, enlargement of lymph nodes, dry cough, dyspnea and dry lung sounds, were evident after 4 weeks. Only two adverse effects, not suspected to be attributable to the study drug, were recorded. Because quality and stability of the Echinacea powder were defined, using an analytical standard and purity tests, these data suggest, that the Echinacea preparation can be recommended as a well tolerated alternative treatment of canine upper respiratory tract infections. 相似文献
2.
Moore I Horney B Day K Lofstedt J Cribb AE 《The Canadian veterinary journal. La revue veterinaire canadienne》2004,45(7):594-601
The effect of oral treatment with natural or recombinant human interferon alpha (HIA) on inflammatory airway disease in young standardbreds was assessed in a double-blind, randomized clinical trial. A total of 34 horses with nasal discharge, excess mucus in the trachea, and a persistent cough of at least 2 weeks' duration that interfered with training completed the trial. Horses were rested for 1 week and received oral treatment with either a saline placebo, recombinant human interferon alpha (rHIA; 90 U/horse/day), or natural human interferon alpha (nHIA: 50 U/horse/day) for 5 days. There was a significant decline in nasal discharge and cough scores in all groups and the apparent response rate was similar. However, significantly fewer horses relapsed within 2 weeks once treatment was ceased when interferon rather than placebo was used (P = 0.012). Seventeen of 22 horses treated with rHIA or nHIA were cough-free 4 weeks after treatment, compared with only 4 of 12 after treatment with the placebo. Treatment with oral interferon is a useful adjunct to rest in standardbreds with inflammatory airway disease. 相似文献
3.
Talavera J del Palacio MJ Bayon A Buendia AJ Sanchez J 《Journal of Feline Medicine and Surgery》2008,10(1):95-101
A 14-year-old neutered male Persian cat was evaluated because of an acute exacerbation of a chronic cough of 2-3 years of duration. Physical examination was normal except for the auscultation of accentuated breath sounds and wheezes cranially on both sides of the chest. Complete blood count, biochemical parameters and urinalysis were normal. Thoracic radiographs showed a generalised nodular pattern with multiple mineral opacities. Oral prednisone and doxycycline were prescribed. Two weeks later, the frequency of the cough was significantly reduced. Terbutaline was recommended for relief of acute exacerbations. Three years later the cat was evaluated again due to a non-related disease that led to the euthanasia of the cat. Concerning its respiratory disease, the cat had experienced nearly asymptomatic periods of 3-6 weeks of duration punctuated by acute exacerbation periods of 7-10 days, during which terbutaline was useful to relieve the cough. Thoracic radiographs showed a mild increase in the size and extent of the pulmonary mineralisation. Histopathologically, mild bronchitis and bronchiectasis were evident, accompanied by calcified bronchial plugs and marked hyperplasia and hypertrophy of the seromucinous glands. Based on clinical and pathoanatomical findings, a final diagnosis of miliary broncholithiasis and bronchiectasis was made. Broncholithiasis should be considered in differential diagnosis of pulmonary mineralisation in cats. When no concomitant diseases are present, this rare disease appears to have a slowly progressive evolution that does not appear to carry a bad prognosis and may be satisfactorily managed with combinations of bronchodilators and corticosteroids. 相似文献
4.
G M Longbottom 《The Veterinary record》1977,101(3):54-55
An eight-year-old male Yorkshire terrier which had had a cough for two years was presented and a diagnosis of tracheal collapse was made after examination with a bronchoscope. It was decided to try to correct the tracheal defect by plication. Two weeks after the operation the dog was examined under general anaesthesia. Although traction had exposed a part of the thoracic trachea it was not sufficient in this case to achieve a complete repair. In view of a grave prognosis, the dog was destroyed. 相似文献
5.
From June to October 1978 four pony mares and foals and two donkey mares and foals grazed a paddock contaminated with Dictyocaulus arnfieldi larvae. No signs of respiratory disease were seen in the foals but within 11 weeks of exposure to the paddock all six developed patent lungworm infections. In October 1978 one donkey and two pony foals were killed. At post mortem examination parasites in various stages of development and measuring up to 8 cm in length were found in the lungs. At this time the three surviving foals were stabled for the remainder of the experiment. Two of these ceased passing D arnfieldi larvae during the winter months but in one pony foal patency persisted until the study ended in August 1979. Patent lungworm infections were not seen in the pony mares, although two started to cough four to six weeks after starting to graze the infected paddock. One of the affected mares was killed in October 1978 when seven small (less than 7 mm) D arnfieldi were recovered. The other continued to cough until the end of the study over a year later. 相似文献
6.
Campbell D Holmberg DL 《The Canadian veterinary journal. La revue veterinaire canadienne》1984,25(11):414-416
A one year old cat, with a history of respiratory dyspnea since it was eight weeks of age, was found to have abnormal function of the larynx. A castellated laryngofissure and bilateral ventriculocordectomy was performed. The respiratory distress was alleviated and the cat's personality changed from being apprehensive and elusive to that of a friendly, social animal. A slight cough remained and a fiberoptic examination four months postoperatively revealed that the right arytenoid drooped medially. Thirteen months after the arytenoid was sutured to the lateral wall of the pharynx, the cat is coughing less frequently and appears to be doing well. 相似文献
7.
"Kennel cough" in dogs in animal shelters is readily transmissible, reduces adoption rates, and commonly leads to the euthanasia of affected dogs. In cats, tracheobronchitis, conjunctivitis, and pneumonia have been associated with Bordetella bronchiseptica infection-but most cases of upper-respiratory infection (URI) probably are caused by herpesvirus and calicivirus, and many B. bronchiseptica culture-positive cats are clinically normal. Our prospective observational study was undertaken to document the contribution of B. bronchiseptica to disease in cats and dogs from two animal shelters undergoing outbreaks of canine kennel cough, to evaluate whether cross-species transmission might have occurred, and to determine if the presence of infected cats represented a risk to dogs. Clinically defined cases of kennel cough in dogs and URI in cats were investigated in two shelters by calculating clinical-disease incidence, alveolar-lavage cytological examination, bacterial and viral cultures, antibiotic-susceptibility testing, and molecular fingerprinting by pulsed-field gel electrophoresis.In a 40-cat and 40-dog "no-kill" shelter, the prevalences of culture positivity were 47% for B. bronchiseptica and 36% for calicivirus at the same time as two resident dogs demonstrated clinical cough. When no dogs had kennel cough 3 months later, 10% of cats were B. bronchiseptica-culture-positive and 63% calicivirus positive. In a large traditional shelter, the incidence of kennel cough in dogs increased over 12 weeks to a maximum of 19 cases/week/120 dogs, during which time the culture prevalence was 23% for B. bronchiseptica in dogs and 47% in cats. Three to 6 months before the kennel-cough epidemic, no dogs or cats were B. bronchiseptica positive. Very little genetic variability was detected in isolates from these shelters; all isolates except one corresponded to a single strain type which was identical to the pattern in a vaccine used in these shelters. Isolates from other cats, a horse, a llama, and a sea otter were genetically distinct from the shelter isolates. There was widespread resistance to cephalosporins and ampicillin, but low or no resistance to amoxicillin/clavulanate, trimethoprim-sulfamethoxazole, tetracycline, and enrofloxacin. Greater percent resistance was observed in the traditional shelter than in the no-kill shelter and feline isolates were more likely to be resistant than canine isolates. 相似文献
8.
Eight mature horses which had been affected with a moist cough for six weeks were found to have large numbers of eosinophils in tracheal mucus samples taken by transtracheal washing. These horses were kept on irrigated pasture and fed a hay-free diet. A companion yearling donkey was found to be passing Dictyocaulus arnfieldi larvae in its faeces. Two oral treatments with a dose of thiabendazole (440 mg/kg) resulted in the resolution of the clinical signs and the disappearance of eosinophils from transtracheal washings. The eosinophilic bronchitis seen in these horses was presumed to be a manifestation of prepatent D arnfieldi infestation. 相似文献
9.
Cricopharyngeal achalasia in Cocker Spaniels 总被引：1，自引：0，他引：1
A. D. WEAVER 《The Journal of small animal practice》1983,24(4):209-214
Cricopharyngeal achalasia is described in three Cocker Spaniel puppies, two being male littermates, the other a bitch from a litter comprising two bitches and two dogs. From 3 weeks of age, solid food was consistently regurgitated, while some fluids were returned via the nares. Diagnosis was made on fluoroscopic demonstration of failure of relaxation of the cricopharyngeal sphincter dorsal to the larynx. Myotomy of the cricopharyngeus muscle and partial section of the thyropharyngeus and oesophageal musculature resulted in considerable improvement. One animal with aspiration pneumonia remained with an occasional cough and all three animals were liable occasionally to regurgitate if eating fast. 相似文献
10.
Wyse CA Skeldon K Hotchkiss JW Gibson G Yam PS Christley RM Preston T Cumming DR Padgett M Cooper JC Love S 《The Veterinary record》2005,157(14):408-412
The aim of this study was to assess the effects of changes to the stable environment on exhaled markers of respiratory inflammation in six horses with clinical histories of recurrent airway obstruction. The horses were maintained for two weeks under conventional stable management (straw bedding and hay) and for two weeks on a reduced-dust regimen (paper bedding and ensiled grass), in a crossover study design. Exhaled ethane and carbon monoxide (CO) and exhaled breath condensate hydrogen peroxide (H(2)O(2)) were measured every three days under each regimen. The presence of clinical signs of airway inflammation (nasal discharge and cough) was monitored daily. The reduced-dust regimen was associated with fewer clinical signs of airway inflammation than the conventional regimen. Exhaled ethane and CO were significantly lower on the reduced-dust regimen and these markers were correlated with clinical signs of respiratory inflammation, but exhaled H(2)O(2) was not affected by the management regimen. 相似文献
11.
Bihr T Conboy GA 《The Canadian veterinary journal. La revue veterinaire canadienne》1999,40(8):555-559
Crenosoma vulpis is a nematode lungworm that is highly prevalent in the red fox population of Atlantic Canada. Dogs are susceptible to infection with clinical signs consisting primarily of a chronic cough. A recent report of C. vulpis infection in 3 dogs on Prince Edward Island prompted an investigation into the importance of this parasite as a cause of chronic respiratory disease in Island dogs. A general prevalence was determined through the necropsy of dogs euthanized at the local humane society. Lungs were removed and examined for parasites using a lung flush technique. Rectal feces was collected and examined for first-stage larvae using the Baermann technique and zinc sulfate centrifugal flotation. Ten of 310 dogs (3.2%) were positive with 0-35 worms (mean = 11.0 +/- 13.4) recovered. First-stage larvae of C. vulpis were recovered in the rectal feces of the one animal in which no worms were recovered on lung flush. A second survey was conducted examining fecal samples with the Baermann technique from afebrile dogs with presenting signs of chronic cough that had no history of recent anthelmintic treatment and showed no signs of cardiac disease, based on physical examination. Fifteen of 55 dogs examined (27.3%) were definitively diagnosed as C. vulpis-positive. All of the infected dogs were treated with fenbendazole (50 mg/kg body weight, p.o. q24 h for 3-7 days). Clinical signs resolved in all of the dogs and fecal samples were negative 2-4 weeks posttreatment. It was concluded that C. vulpis infection was a significant cause of upper respiratory disease in dogs on Prince Edward Island and should be considered in all dogs with presenting signs of chronic cough. 相似文献
12.
Hawkins EC Rogala AR Large EE Bradley JM Grindem CB 《American journal of veterinary research》2006,67(1):160-167
OBJECTIVE: To determine whether bronchial brushings from dogs with chronic cough have increased numbers of goblet cells and WBCs, compared with numbers for healthy dogs, or have differing WBC populations, compared with populations in bronchoalveolar lavage (BAL) fluid obtained from dogs with chronic cough. ANIMALS: 9 healthy dogs and 10 dogs with chronic cough. PROCEDURE: Specimens were collected by use of bronchoscopy. Cellular composition was determined for brushings, and results from dogs with chronic cough were compared with those from healthy dogs. Cellular composition of brushings was compared with composition of BAL obtained from dogs with chronic cough. RESULTS: Brushings from healthy dogs contained a median of 2.9 x 10(6) epithelial cells, comprising 100% epithelial cells (96% ciliated, 3% goblet, and 1% other) and no WBCs. Brushings from dogs with chronic cough had 4.5 x 10(6) epithelial cells, comprising 93% epithelial cells (86% ciliated, 2% goblet, and 12% other). Dogs with chronic cough had significantly greater percentages of WBCs (7%) and neutrophils (6%), compared with values for healthy dogs. Five dogs with chronic cough had no neutrophilic inflammation evident in BAL, but 4 of these had evidence of neutrophilic inflammation in brushings. CONCLUSIONS AND CLINICAL RELEVANCE: Neutrophils, but not goblet cells, were increased in brushings from dogs with chronic cough. Analysis of bronchial brushings provides information about airway inflammation that differs from that found by examination of BAL in some dogs with chronic cough and is a more sensitive indicator of airway inflammation than cytologic examination of BAL in these dogs. 相似文献
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14.
为了研究芩黄口服液在止咳平喘方面的疗效,选用组胺喷雾法、氨水引咳法,观察对豚鼠引喘潜伏期、小鼠咳嗽次数的影响。结果显示芩黄口服液能明显延长组胺诱发豚鼠出现哮喘反应的潜伏期;能明显的抑制氨水引起的小鼠咳嗽。芩黄口服液具有平喘、止咳作用。 相似文献
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16.
J R Snyder J R Pascoe J W Williams 《Journal of the American Veterinary Medical Association》1985,187(4):421-422
A 7-year-old burro jack was examined because of recurrent rectal prolapse and severe cough. The prolapse was reduced manually and a cough associated with bronchopneumonia responded to antimicrobial therapy. The rectal prolapse recurred and again was reduced manually. During exploratory celiotomy a cystic calculus was identified and removed. Severe protracted cough and cystic calculus were thought to be contributing factors to recurrent rectal prolapse in this burro. 相似文献
17.
Cahalane AK Flanders JA Steffey MA Rassnick KM 《Journal of the American Veterinary Medical Association》2007,230(4):527-531
CASE DESCRIPTION: 3 dogs (9 to 12 years old) were evaluated because of recurrent pleural effusion that was refractory to treatment of the underlying cause. CLINICAL FINDINGS: Dogs were evaluated because of cough, dyspnea, tachypnea, or lethargy or a combination of these clinical signs. Radiography, ultrasonography, or thoracocentesis were used to confirm the presence of pleural fluid in each dog. A neoplastic cause of pleural effusion was confirmed in 2 dogs. In 1 dog, fasciitis of the mediastinum and the left parietal pleura was diagnosed, with no evidence of neoplasia. TREATMENT AND OUTCOME: Each dog was anesthestized, and thoracotomy was performed with manual perforation of the mediastinum. Permanent, subcutaneously placed vascular access ports were attached to intrathoracic, Jackson-Pratt drain tubing for repeated drainage of pleural fluid. Drains were used successfully in the 3 dogs for periods of 6 weeks, 11 weeks, and > 3 years. CLINICAL RELEVANCE: Findings suggest that subcutaneous vascular access ports attached to intrathoracic drain tubing may be an effective way to remove recurrent pleural effusion in dogs. 相似文献
18.
目的:考察射干地龙颗粒对动物发病模型的止咳祛痰效果。方法:采用小白鼠浓氨水诱咳法和酚红祛痰法。结果:生理盐水对照组和药物组引起半数小白鼠咳嗽所需的浓氨水喷雾时间(ET50)分别为19.2 s和30.43 s,R值为158.50%;以酚红标准溶液(X)对其吸收度(A值)(Y)作标准曲线为:Y=0.074 7 X-0.003 6,在0.1-10.0μg/mL浓度范围内呈线性关系,其相关系数为0.999 8,3个药物剂量组小鼠气管酚红排泌量与生理盐水对照组比较均呈显著性差异;3个药物剂量组之间无显著性差异。结论:射干地龙颗粒对小白鼠具有明显的止咳作用;对小白鼠气管分泌功能有显著增强作用。 相似文献
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R D Pinckney A D Studer R M Genta 《Journal of the American Veterinary Medical Association》1988,193(10):1287-1288
Filaroides hirthi infection was diagnosed in 2 related Yorkshire Terriers. Dog 1 had a chronic nonproductive cough, but results of fecal flotation examination were negative. Dog 2 was a 1-year-old female progeny of dog 1. Both dogs came from the same kennel and were raised together for 8 weeks. Dog 2 had generalized demodicosis accompanied by secondary bacterial infection and had been treated with corticosteroids. Dog 2 also was given 68 micrograms of ivermectin, PO, and then 50 mg of fenbendazole/kg, PO, q 24 h for 14 days. After the 14-day treatment, results of 3 fecal examinations were negative for Filaroides sp and other parasites, and the dog improved without complications. Fecal examination of the other dogs in the kennel were negative for F hirthi. 相似文献