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1.
L Prozesky T S Kellerman W G Welman 《The Onderstepoort journal of veterinary research》1986,53(1):9-12
The hepatotoxicity of Pteronia pallens was demonstrated in 5 sheep which developed lesions that ranged from centrilobular necrosis to diffuse hepatocellular degeneration. Botanical, clinical and pathological data are given and the lesions are briefly compared with those caused by other hepatotoxic plants in South Africa. 相似文献
2.
Francili A. Molossi Bianca S. de Cecco Camila B. Pohl Rogrio B. Borges Luciana Sonne Saulo P. Pavarini David Driemeier 《Journal of veterinary diagnostic investigation》2021,33(4):677
We determined the prevalence of diseases and pathogens associated with mortality in beef cattle in the State of Rio Grande do Sul, Brazil, based on pathology laboratory submissions. Postmortem examinations were conducted on 1,277 beef cattle that died between 2008 and 2018. Information regarding age, time of the year, breed, and regional location were analyzed statistically. Most cattle were from the surrounding region of Porto Alegre, and 78.7% of the analyzed cases had diagnostic value. The diagnostic category with most cases was infectious and/or parasitic diseases (60%), followed by toxic and toxicoinfectious (25%). Most cases occurred in the fall. Major disease conditions identified included hemoprotozoal infection (18.2%), rabies (8.2%), and plant intoxications by Senecio spp. (8.5%) and Pteridium arachnoideum (4.6%). Hemoprotozoal infection occurred at a higher frequency in young cattle, mainly in animals up to 1 y old. Intoxication by Senecio spp. was more frequent in cattle 2–3 y old. 相似文献
3.
Akifumi OHTANI Masahito KUBO Hiroshi SHIMODA Kenji OHYA Tadashi IRIBE Daiki OHISHI Daiji ENDOH Tsutomu OMATSU Tetsuya MIZUTANI Hideto FUKUSHI Ken MAEDA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(7):777-782
Chlamydia pecorum (designated 22–58) was isolated in 2010 in
HmLu-1 cells from the jejunum of a calf which died of necrotizing enterocolitis in
Yamaguchi Prefecture, Japan. Immunohistochemical staining identified C.
pecorum positive reactions in the jejunal villi. C. pecorum,
designated 24–100, was isolated from the feces of a calf with diarrhea in another farm in
Yamaguchi Prefecture in 2012. A significant increase in neutralizing antibody titers
against C. pecorum was confirmed in paired sera. Nucleotide sequence
identities of omp1 genes of the 2 isolates were 100%. The isolates were
genetically and antigenically more closely related to C. pecorum
Bo/Yokohama strain isolated from cattle with enteritis in Japan than to the other
prototype strains, Bo/Maeda isolated from cattle with pneumonia and Ov/IPA isolated from
sheep with polyarthritis. These results indicate that C. pecorum strains
similar to 22–58 and 24–100 might be endemic in Yamaguchi Prefecture and cause enteric
disease in cattle. 相似文献
4.
Denis Rwabiita MUGIZI Sofia BOQVIST George William NASINYAMA Charles WAISWA Kokas IKWAP Kim ROCK Elisabeth LINDAHL Ulf MAGNUSSON Joseph ERUME 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(5):557-564
Brucellosis is a key zoonosis of major public health, animal welfare and
economic significance, and is endemic in livestock in Uganda. A cross-sectional
epidemiological study was carried out to estimate the sero-prevalence of brucellosis and
identify factors associated with sero-positivity in cattle in urban and peri-urban Gulu
and Soroti towns of Northern and Eastern Uganda, respectively. A total of 1007 sera and
data on biologically plausible risk factors from 166 herds and their spatial locations,
were collected from cattle reared in urban and peri-urban Gulu and Soroti towns of Uganda.
The sera were analyzed using indirect ELISA and sero-positive reactors confirmed by
competitive ELISA. Multivariable models were used to investigate for risk factors. The
overall animal-level and herd-level sero-prevalence was 7.5% (76/1007, 95% Confidence
Interval (CI): 6.15–9.4%) and 27.1% (45/166, 95% CI: 20.9–34.3%), respectively. Herd-level
sero-prevalence was significantly (P<0.001) higher in Soroti than
Gulu. In Gulu town, sero-positivity increased with an increase in herd size
(P=0.03) and age (P=0.002), and was higher in cattle
brought in from western Uganda (P<0.0001). In Soroti town,
introduction of new cattle into a herd was significantly (P=0.027)
associated with herd sero-positivity. There was a geographically differential risk
(clustering) of Brucella sero- positivity in herds in Soroti, while
sero-positivity was homogeneously distributed in Gulu. The data highlight brucellosis
occurrence and major risk factors for its transmission in cattle in urban and peri-urban
areas. 相似文献
5.
6.
Relationship of bovine NOS2 gene polymorphisms to the risk of bovine
tuberculosis in Holstein cattle
Yafen CHENG ChenShen HUANG Hsiang-Jung TSAI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2016,78(2):281-286
Many studies suggest significant genetic variation in the resistance of cattle and humans to infection with
Mycobacterium bovis, the causative agent of zoonotic tuberculosis. The inducible nitric
oxide synthase (iNOS which is encoded by the NOS2 gene) plays a key role in the immunological
control of a broad spectrum of infectious agents. This study aimed to investigate the influence of genetic
variations in the promoter of the NOS2 gene on bovine tuberculosis (bTB) susceptibility. In
this study, the NOS2 genes of 74 bTB-infected Holstein cows and 90 healthy controls were
genotyped using PCR followed by nucleotide sequencing. Polymorphisms at rs207692718, rs109279434, rs209895548,
rs385993919, rs433717754, rs383366213, rs466730386, rs715225976, rs525673647, rs720757654 and g.19958101T>G
in the promoter region of the NOS2 gene were detected. The g.19958101T>G SNP produced two
different conformation patterns (TT and TG) and the TG genotype was over-represented in the bTB group (20.27%)
compared with the control group (2.22%). The TG genotype frequency of the g.19958101T>G variant was
significantly higher in bTB cattle than in healthy controls (OR, 11.19; 95% CI, 2.47–50.73;
P=0.0002). The G allele of the g.19958101T>G polymorphism was more frequent in bTB group
when compared to control group (10.14% versus 1.11%). Furthermore, the G allele was a risk factor for bTB
susceptibility (OR, 10.04; 95% CI, 2.26–44.65; P=0.0002). In conclusion, the g.19958101T>G
polymorphism of the NOS2 gene may contribute to the susceptibility of Holstein cattle to
bTB. 相似文献
7.
Eve M. Manthorpe Ian V. Jerrett Grant T. Rawlin Lucy Woolford 《Journal of veterinary diagnostic investigation》2021,33(5):875
Acute bovine liver disease (ABLD) is a sporadic hepatic disease affecting cattle in southern Australia, characterized histologically by striking periportal hepatocellular necrosis. The cause of ABLD is unknown; however, the seasonality and acute presentation of outbreaks suggest mycotoxin involvement. We describe here the clinical and pathologic findings of ABLD in 45 naturally affected cattle from 13 outbreaks occurring from 2010 to 2019 in Victoria, Australia. Outbreaks occurred in herds located along the southern coastal plain of Victoria and were observed most frequently in lactating dairy cattle. Clinical signs commonly included a combination of mild photosensitization, progressive neurologic signs, and hypogalactia, which preceded death by ≤ 48 h. All affected animals had marked elevations in activities of glutamate dehydrogenase, aspartate aminotransferase, and gamma-glutamyl transferase. At autopsy, the most common lesions were serosal petechiae and/or gastrointestinal hemorrhage, and hepatomegaly with a pronounced hepatic reticular pattern. The principal histologic lesion was widespread—severe periportal hepatocellular coagulative necrosis and erythrocyte pooling—which often extended to massive necrosis. Lesions in other organs were uncommon. Our study of ABLD suggests involvement of a potent hepatotoxin that is either directly cytopathic or requires bioactivation by periportal-specific enzymes. 相似文献
8.
Acute hepatic necrosis and death in a subadult southern white rhinoceros (Ceratotherium simum) associated with exposure to sterigmatocystin in forage contaminated with Aspergillus nidulans
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A young male southern white rhinoceros (Ceratotherium simum), which was resident in a zoo as part of a multi‐rhinoceros group, died suddenly. Necropsy and histopathological findings supported a diagnosis of death from acute hepatic necrosis. The microscopic distribution of liver lesions was suggestive of hepatotoxicosis. Further investigation revealed potential exposure to a mycotoxin, sterigmatocystin, present in spoiled lucerne hay contaminated with Aspergillus nidulans. It was concluded that mycotoxicosis was the likely cause of the hepatic necrosis and death in this animal. 相似文献
9.
Sota KOBAYASHI Toshiyuki TSUTSUI Takehisa YAMAMOTO Yoko HAYAMA Norihiko MUROGA Misako KONISHI Ken-ichiro KAMEYAMA Kenji MURAKAMI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(7):861-863
A cohort study was conducted to evaluate the risk of bovine leukemia virus (BLV)
transmission to uninfected cattle by adjacent infected cattle in 6 dairy farms. Animals
were initially tested in 2010–2011 using a commercial ELISA kit. Uninfected cattle were
repeatedly tested every 4 to 6 months until fall of 2012. The Cox proportional hazard
model with frailty showed that uninfected cattle neighboring to infected cattle (n=53) had
a significant higher risk of seroconversion than those without any infected neighbors
(n=81) (hazard ratio: 12.4, P=0.001), implying that neighboring infected
cattle were a significant risk factor for BLV transmission. This finding provides
scientific support for animal health authorities and farmers to segregate infected cattle
on farms to prevent spread of BLV. 相似文献
10.
P. M. BANDARRA S. P. PAVARINI D. L. RAYMUNDO A. M. R. CORRÊA P. M. O. PEDROSO D. DRIEMEIER 《Equine veterinary journal》2010,42(5):456-459
After ingesting green leaves of T. micrantha, 2 horses showed apathy, locomotor deficit, blindness, recumbency, paddling, coma and death. The main gross findings were scattered haemorrhages, enhanced lobular pattern of the liver, and cerebral oedema. Histological changes included disseminated haemorrhages, massive hepatocellular necrosis, neuronal degeneration, Alzheimer type II astrocytes and cerebral perivascular oedema. Clinicopathological findings which were comparable with those observed in Trema micrantha poisoned ruminants, associated with epidemiological evidence suggested the diagnosis.Trema micrantha poisoning should be evaluated as a possible cause in the diagnosis of equine hepatopathy and occasional secondary encephalopathy. 相似文献
11.
Laura B. A. Williams Steven E. Edmonds Susan R. Kerr Liam E. Broughton-Neiswanger Kevin R. Snekvik 《Journal of veterinary diagnostic investigation》2021,33(4):732
Rabbit hemorrhagic disease virus 2 (RHDV2) causes an often-fatal disease of rabbits that has resulted in outbreaks in rabbitries in Europe, Africa, Australia, and Asia. RHD has historically been characterized as a foreign animal disease in the United States. In July 2019, RHDV2 was detected in rabbits on Orcas Island along the northwestern coast of Washington (WA) State following reports of deaths in multiple feral and domestic rabbits. We document and highlight here the unique clinical presentation and gross and histologic lesions observed in this recent WA outbreak. Affected rabbits died without premonitory signs or displayed hyporexia and/or lethargy for ≤1 d prior to death. The most consistent pathologic finding was random, multifocal hepatocellular necrosis, often with concurrent multifocal-to-diffuse splenic necrosis. The lack of significant clinical signs in conjunction with the random distribution of hepatic necrosis in the WA outbreak contrasts with previous reports of RHDV2 disease progression. 相似文献
12.
Sileshi BELEW Jin-Yoon KIM Md.Akil HOSSAIN Ji-Yong PARK Seung-Jin LEE Yong-Soo PARK Joo-Won SUH Jong-Choon KIM Seung-Chun PARK 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(3):327-329
Pharmacokinetic (PK) parameters of marbofloxacin (MRFX) in Korean cattle, Hanwoo, were
determined following its intravenous (i.v.) or intramuscular (i.m.) administration at a
dose of 2 mg/kg. Area under the curve (AUC0–24 hr), half-life (t1/2)
and total body clearance (CLB) of i.v. MRFX were 6.87
hr∙µg/ml, 2.44 hr and 0.29 l/kg∙hr,
respectively, and the corresponding values for i.m. administration of MRFX were 5.07
hr∙µg/ml, 2.44 hr and 0.39 l/kg∙hr.
The suggested optimal doses of MRFX in Hanwoo cattle, calculated by integration of PK data
obtained in the present study and previously reported minimum inhibitory concentration
(MIC) for MRFX against susceptible (MIC ≤1 µg/ml) and
intermediate (MIC ≤2 µg/ml) pathogenic bacteria, were
2.1 and 4.2 mg/kg/day by i.v. route and 3.9 and 7.8 mg/kg/day by i.m. route. 相似文献
13.
Muhammet Eren ASLAN Ahmet Kursat AZKUR Serkal GAZYAGCI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(11):1371-1377
The aim of the study was to determine the epidemiological data of bovine viral diarrhea
virus (BVDV), bovine herpesvirus-1 (BHV-1), bovine herpesvirus-4 (BHV-4), bovine
herpesvirus-5 (BHV-5) and Brucella–associated cattle that were previously
reported to have abortion and infertility problems in Ankara, Corum, Kirikkale and Yozgat
provinces, Turkey. Whole blood and sera samples were obtained from 656 cattle, and
antibodies against Brucella spp. were detected in 45 (6.86%) and 41
(6.25%) animals by Rose Bengal plate and serum tube agglutination tests, respectively. The
seropositivity rates against BVDV, BHV-1 and BHV-4 were 70.89%, 41.3% and 28.78%,
respectively. RT-PCR and PCR were performed to detect RNA and DNA viruses in blood
samples, respectively. The BVDV 5′-untranslated region and BHV-1 gB gene detected in this
study were phylogenetically analyzed. The BVDV strains analyzed in this study were closely
related to those previously reported from Turkey. The nucleotide sequence from the BHV-1
strain detected in this study is the first nucleotide sequence of BHV-1 circulating in
this area of Turkey deposited in the GenBank. The presence of Brucella
spp. and prevalence of BHV-1, BHV-4 and BVDV in cattle should be further investigated
throughout these regions. 相似文献
14.
Du Plessis EC Prozesky L Botha CJ 《Journal of the South African Veterinary Association》2011,82(3):144-149
Toxicity in cattle by the shrub Nolletia gariepina was induced experimentally by intraruminal administration of 3 g/kg dried, milled plant material as a single dose. The animals had to be starved for 24 hours before dosing, as dosing on a full rumen did not induce any signs of toxicity during 5 days of observation and clinical pathology monitoring. Clinical signs were not specific and varied according to the duration (acute versus subacute) of the toxicological process. Clinical pathological parameters indicated renal and to a lesser extent hepatic damage, with raised serum concentrations of urea, creatinine, aspartate aminotransferase (AST) and gamma glutamyl transferase (GGT). Increased urinary sodium and potassium concentration and GGT activity, as well as proteinuria, were evident. Histological and electron microscopic examinations revealed acute renal tubular epithelial cell degeneration and necrosis, especially of the proximal convoluted tubules. Mild hepatocellular degeneration was also noticeable. 相似文献
15.
Kimberly A. Thompson Ronan Eustace Vengai Mavangira Colleen Turner Colleen F. Monahan 《Journal of veterinary diagnostic investigation》2021,33(5):1023
A 10-y-old giraffe (Giraffa camelopardalis reticulata) bull developed colic after a 3-mo history of reduced feed consumption. Physical examination and management were performed with 2 standing sedations. The giraffe developed metabolic alkalosis and progressive pre-renal azotemia followed by compensatory respiratory acidosis and paradoxical aciduria. A metallic “ping” sound was auscultated on the left side near ribs 10–12. The giraffe was euthanized given the grave prognosis, and postmortem examination confirmed left displacement of the abomasum (LDA) with fluid sequestration (150–190 L [40–50 gal]) within the rumen. Dental disease was evident at postmortem examination and perimortem skull computed tomography. To ensure cases of LDA are not overlooked, the position of the abomasum must be noted during postmortem examination prior to removal of the gastrointestinal tract. The risk factors for the development of LDA in giraffes are not known, and associations such as those of dairy cattle (hypocalcemia, high-concentrate low-fiber diet, and indoor housing) remain to be elucidated. 相似文献
16.
Experimental Alkylmercurial Poisoning in Swine. Lesions in the Peripheral and Central Nervous Systems 下载免费PDF全文
K. M. Charlton 《Canadian journal of veterinary research》1974,38(1):75-81
The effects of alkylmercurial poisoning were studied in 16 pigs poisoned with daily oral doses of a fungicide containing methylmercury 2, 3-dihydroxy propyl mercaptide and methylmercury acetate. Clinical signs included weakness, wobbling gait, blindness, recumbency and death. Microscopic studies of the peripheral nervous system revealed Wallerian degeneration in sensory fibers and neuronal degeneration in dorsal root ganglia. In the central nervous system, there were neuronal degeneration of ischemic type, glial degeneration, gliosis and necrosis of the media of meningeal arterioles. The last mentioned lesion was not extensive.
The sequential development o lesions and the absence of segmental demyelination suggest that the primary lesion in the peripheral nervous system was neuronal-axonal degeneration rather than degeneration of the Schwann cell and myelin sheath.
相似文献17.
Tomohito ISHIZUKA Jun TAMURA Tsukasa NAGARO Kanako SUDO Takaharu ITAMI Mohammed Ahamed UMAR Kenjirou MIYOSHI Tadashi SANO Kazuto YAMASHITA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2014,76(12):1577-1582
Effects of intermittent
positive pressure ventilation (IPPV) on cardiopulmonary function were evaluated in horses
anesthetized with total intravenous anesthesia using constant rate infusions of
medetomidine (3.5 µg/kg/hr), lidocaine (3 mg/kg/hr), butorphanol (24
µg/kg/hr) and propofol (0.1 mg/kg/min) (MLBP-TIVA). Five horses were
anesthetized twice using MLBP-TIVA with or without IPPV at 4-week interval (crossover
study). In each occasion, the horses breathed 100% oxygen with spontaneous ventilation
(SB-group, n=5) or with IPPV (CV-group, n=5), and changes in cardiopulmonary parameters
were observed for 120 min. In the SB-group, cardiovascular parameters were maintained
within acceptable ranges (heart rate: 33–35 beats/min, cardiac output: 27–30
l/min, mean arterial blood pressure [MABP]: 114–123 mmHg, mean
pulmonary arterial pressure [MPAP]: 28–29 mmHg and mean right atrial pressure [MRAP]:
19–21 mmHg), but severe hypercapnea and insufficient oxygenation were observed (arterial
CO2 pressure [PaCO2]: 84–103 mmHg and arterial O2
pressure [PaO2]: 155–172 mmHg). In the CV-group, normocapnea (PaCO2:
42–50 mmHg) and good oxygenation (PaO2: 395–419 mmHg) were achieved by the IPPV
without apparent cardiovascular depression (heart rate: 29–31 beats/min, cardiac output:
17–21 l /min, MABP: 111–123 mmHg, MPAP: 27–30 mmHg and MRAP: 15–16 mmHg).
MLBP-TIVA preserved cardiovascular function even in horses artificially ventilated. 相似文献
18.
Manabu KOIKE Yasutomo YUTOKU Aki KOIKE 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(9):1109-1114
Clinically, many chemotherapeutics and ionizing radiation (IR) have been
applied for the treatment of various types of human and animal malignancies. These
treatments kill tumor cells by causing DNA double-strand breaks (DSBs). Core factors of
classical nonhomologous DNA-end joining (C-NHEJ) play a vital role in DSB repair. Thus, it
is indispensable to clarify the mechanisms of C-NHEJ in order to develop next-generation
chemotherapeutics for cancer. The XRCC4-like factor (XLF; also called Cernunnos or NHEJ1)
is the lastly identified core NHEJ factor. The localization of core NHEJ factors might
play a critical role in regulating NHEJ activity. The localization and function of XLF
have not been elucidated in animal species other than mice and humans. Domestic cattle
(Bos taurus) are the most common and vital domestic animals in many
countries. Here, we show that the localization of cattle XLF changes dynamically during
the cell cycle. Furthermore, EYFP-cattle XLF accumulates quickly at microirradiated sites
and colocalizes with the DSB marker γH2AX. Moreover, nuclear localization and accumulation
of cattle XLF at DSB sites are dependent on 12 amino acids (288–299) of the C-terminal
region of XLF (XLF CTR). Furthermore, basic amino acids on the XLF CTR are highly
conserved among domestic animals including cattle, goat and horses, suggesting that the
CTR is essential for the function of XLF in domestic animals. These findings might be
useful to develop the molecular-targeting therapeutic drug taking XLF as a target molecule
for human and domestic animals. 相似文献
19.
Yusuf Madaki LEKKO Azlan CHE-AMAT Peck Toung OOI Sharina OMAR Dhabitah Tatiyana MOHD-HAMDAN Liya Syahila LINAZAH Zakirawaranis ZAKARIA Siti Zubaidah RAMANOON Mazlina MAZLAN Faez Firdaus Abdullah JESSE Mohd Firdaus Ariff ABDUL-RAZAK Sabri JASNI Norhamizah ABDUL-HAMID 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(11):1702
Tuberculosis (TB) is a chronic inflammatory and zoonotic disease caused by Mycobacterium tuberculosis complex (MTBC) members, affecting several domestic animals, wildlife species and humans. The preliminary investigation was aimed to detect antibody against MTBC among indigenous wildlife which are free-ranged wild boar, free-ranged wild macaques and captive Asian elephants in selected areas of Selangor and elephant conservation centre in Pahang, respectively. The results indicate that MTBC serodetection rate in wild boar was 16.7% (7.3–33.5 at 95% confidence interval (CI)) using an in-house ELISA bPPD IgG and 10% (3.5–25.6 at 95% CI) by DPP®VetTB assay, while the wild macaques and Asian elephant were seronegative. The univariate analysis indicates no statistically significant difference in risk factors for sex and age of wild boar but there was a significant positive correlation (P<0.05) between bovine TB in dairy cattle and wild boar seropositivity in the Sepang district. 相似文献
20.
Prevalence and risk factor investigation of Campylobacter species in beef cattle feces from seven large commercial feedlots in Alberta,Canada 下载免费PDF全文
Sherry J. Hannon Brenda Allan Cheryl Waldner Margaret L. Russell Andrew Potter Lorne A. Babiuk Hugh G.G. Townsend 《Canadian journal of veterinary research》2009,73(4):275-282
This fecal prevalence study targeted cattle from 7 large (10 000 to > 40 000 head) commercial feedlots in Alberta as a means of establishing Campylobacter levels in cattle just prior to animals entering the food chain. Overall, 87% [95% confidence interval (CI) = 86–88] of 2776 fresh pen-floor fecal samples were culture positive for Campylobacter species, with prevalences ranging from 76% to 95% among the 7 feedlots. Campylobacter spp. prevalence was 88% (95% CI = 86–90) in the summer (n = 1376) and 86% (95% CI = 85–88) in the winter (n = 1400). In addition, 69% (95% CI = 66–71) of 1486 Campylobacter spp. positive samples were identified as Campylobacter jejuni using hippurate hydrolysis testing. Of those, 64% (95% CI = 58–70) of 277 and 70% (95% CI = 67–72) of 1209 Campylobacter isolates were identified as C. jejuni in winter and summer, respectively. After accounting for clustering within pen and feedlot, feedlot size and the number of days on feed were associated with Campylobacter spp. isolation rates. The high isolation rates of Campylobacter spp. and C. jejuni in feedlot cattle feces in this study suggest a potential role for feedlot cattle in the complex epidemiology of campylobacters in Alberta. 相似文献