共查询到20条相似文献，搜索用时 7 毫秒
1.
M H Crawford 《Science (New York, N.Y.)》1966,154(747):398-399
Four hemoglobin phenotypes have been noted in the pigtailed monkey ( Macaca nemestrina). Pedigree studies suggest a simple codominant Mendelian explanation for inheritance of three of these phenotypes, including one electrophoretically identical with human type A. The fourth type occurred in only one animal in this series. 相似文献
2.
采用原子吸收或原子荧光分光光度法,对分别生活于人工圈笼、猴园和野外的3组猕猴(每组10只)被毛中的6种微量元素(Cu,Fe,Mn,Zn,Pb与As)进行测定和分析。结果发现,Cu和Fe的含量无差异(P>0.05),但人工饲养(猴园和笼养)猕猴被毛中Mn,Pb和As的含量均极显著高于野外猕猴(P<0.01),而野外猕猴被毛中Zn的含量显著高于人工饲养猕猴(P<0.05)。将上述结果与已报道的川金丝猴和人类毛发相应元素的含量做比较分析,提示适当调整人工饲养猴饲料中Mn,Zn,Pb的添加量可作为改善猕猴被毛质量的尝试方法。 相似文献
3.
Transfer factor: delayed hypersensitivity to Schistosoma mansoni and tuberculin in Macaca mulatta 总被引：4，自引：0，他引：4
Delayed hypersensitivity in Macaca mulatta infected with either Schistosoma mansoni or mycobacteria was demonstrated by biopsies of skin test sites. Both dialyzable and nondialyzable leukocyte extracts from infected donors transferred delayed hypersensitivity to recipient monkeys. In two recipients, skin test conversion was associated with in vitro transformation of the recipients' lymphocytes. 相似文献
4.
Naturally occurring primate hybrid 总被引：2，自引：0，他引：2
I S Bernstein 《Science (New York, N.Y.)》1966,154(756):1559-1560
Two members of a troop of wild Macaca irus in Malaysia have been tentatively identified as hybrids of M. irus and M. nemestrina. Mechanisms prohibiting such hybridization in the natural habitat may have broken down under heavy predation pressure which finally resulted in the local extermination of M. nemestrinia. 相似文献
5.
Three rhesus monkeys Macaca mulatta, formerly dependent on morphine, had increased sensitivity to nalorphine's effect of suppressing operant responding for food, as compared with two monkeys with no history of morphine exposure. Within the dose range employed, nalorphine injections produced emesis, salivation, and hyperirritability in formerly morphine-dependent monkeys but not in controls. 相似文献
6.
P A Marx D H Maul K G Osborn N W Lerche P Moody L J Lowenstine R V Henrickson L O Arthur R V Gilden M Gravell 《Science (New York, N.Y.)》1984,223(4640):1083-1086
A type D retrovirus related to but distinct from Mason-Pfizer monkey virus was isolated in vitro from the blood of two rhesus monkeys (Macaca mulatta) with simian acquired immunodeficiency syndrome (SAIDS). Three juvenile rhesus monkeys that were injected intravenously with tissue culture fluids containing this virus developed SAIDS after 2 to 4 weeks. 相似文献
7.
食蟹猴耳部成纤维细胞体外培养体系的初步建立 总被引：2，自引：0，他引：2
建立食蟹猴耳部成纤维细胞的体外培养体系,为食蟹猴体细胞核移植、转基因技术及治疗性克隆做准备.通过组织块培养法进行原代培养,成功分离了食蟹猴耳部成纤维细胞;原代培养后用0.25%胰蛋白酶+0.02%EDTA消化液消化细胞,用含10%FBS的DMEM对细胞进行培养,细胞在体外传至第25代;用含10%FBS和10%DMSO的DMEM为冷冻液对细胞进行冷冻保存,解冻传代后,细胞形态和生长速度没有明显变化;用细胞技术法绘制细胞的生长曲线显示,符合体外细胞生长规律;用吉姆萨染色法对不同代数细胞的染色体倍性进行分析,二倍体细胞所占比例为80%以上. 相似文献
8.
M D Daniel N W King N L Letvin R D Hunt P K Sehgal R C Desrosiers 《Science (New York, N.Y.)》1984,223(4636):602-605
Macaque monkeys with the recently described acquired immunodeficiency syndrome show a marked defect in T-lymphocyte function and die with opportunistic infections and lymphoproliferative abnormalities. In the study described here a new type D retrovirus was isolated from two Macaca cyclopis with this syndrome. This virus is related to, but distinct from, Mason-Pfizer monkey virus, a type D retrovirus previously isolated from a mammary tumor of a rhesus monkey (Macaca mulatta). 相似文献
9.
Operant conditioning of cortical unit activity 总被引：6，自引：0，他引：6
E E Fetz 《Science (New York, N.Y.)》1969,163(870):955-958
The activity of single neurons in precentral cortex of unanesthetized monkeys (Macaca mulatta) was conditioned by reinforcing high rates of neuronal discharge with delivery of a food pellet. Auditory or visual feedback of unit firing rates was usually provided in addition to food reinforcement. After several training sessions, monkeys could increase the activity of newly isolated cells by 50 to 500 percent above rates before reinforcement. 相似文献
10.
[目的]研究太行山猕猴掌、跖骨的重量在生长发育过程中与颅长（体重）的关系。[方法]运用SPSS13．0统计分析软件,对26例（♀16,♂10）成年太行山猕猴掌、跖骨所测量的重量数据,用Linear和Power两种模型进行异速生长分析。[结果]使用Power模型的拟合程度不比Linear模型拟合程度高,而且只有雄性掌骨的拟合效果较好;掌、跖骨的重量与颅长均呈负异速生长（b〈1．0000）。[结论]在生长发育过程中,掌、跖骨的重量变化与颅长有密切关系;利用雄性5Mc的重量变量来推测颅长的应用价值较高。 相似文献
11.
Long-term exposure of sexually mature female rhesus monkeys (Macaca mulata) to thrice weekly injections of delta 9-tetrahydrocannabinol resulted in a disruption of menstrual cycles that lasted for several months. This period was marked by an absence of ovulation and decreased basal concentrations of gonadotropin and sex steroids in the plasma. After this period, normal cycles and hormone concentrations were reestablished. These studies demonstrate that in rhesus monkeys subjected to long-term treatment with delta 9-tetrahydrocannabinol tolerance develops to the disruptive effects of the drug on the menstrual cycle. 相似文献
12.
Transmission of simian acquired immunodeficiency syndrome (SAIDS) with blood or filtered plasma 总被引：4，自引：0，他引：4
M Gravell W T London S A Houff D L Madden M C Dalakas J L Sever K G Osborn D H Maul R V Henrickson P A Marx 《Science (New York, N.Y.)》1984,223(4631):74-76
Simian acquired immunodeficiency syndrome (SAIDS), a disease clinically and pathologically similar to acquired immunodeficiency syndrome in humans, was transmitted from diseased rhesus monkeys (Macaca mulatta) to normal monkeys by inoculation with heparinized whole blood or plasma that had been passed through filters of 0.45 micrometer pore size. This suggests that the causative agent is small and most probably a virus. No viruses, however, were isolated by standard cell culture techniques from the blood or filtered plasma which caused SAIDS. Both cellular and humoral immunity were markedly depressed in animals with advanced SAIDS. 相似文献
13.
14.
Neuronal correlates of subjective visual perception 总被引：10，自引：0，他引：10
Neuronal activity in the superior temporal sulcus of monkeys, a cortical region that plays an important role in analyzing visual motion, was related to the subjective perception of movement during a visual task. Single neurons were recorded while monkeys (Macaca mulatta) discriminated the direction of motion of stimuli that could be seen moving in either of two directions during binocular rivalry. The activity of many neurons was dictated by the retinal stimulus. Other neurons, however, reflected the monkeys' reported perception of motion direction, indicating that these neurons in the superior temporal sulcus may mediate the perceptual experience of a moving object. 相似文献
15.
Rhesus Macaque Genome Sequencing Analysis Consortium Gibbs RA Rogers J Katze MG Bumgarner R Weinstock GM Mardis ER Remington KA Strausberg RL Venter JC Wilson RK Batzer MA Bustamante CD Eichler EE Hahn MW Hardison RC Makova KD Miller W Milosavljevic A Palermo RE Siepel A Sikela JM Attaway T Bell S Bernard KE Buhay CJ Chandrabose MN Dao M Davis C Delehaunty KD Ding Y Dinh HH Dugan-Rocha S Fulton LA Gabisi RA Garner TT Godfrey J Hawes AC Hernandez J Hines S Holder M Hume J Jhangiani SN 《Science (New York, N.Y.)》2007,316(5822):222-234
16.
Implantation of Bacteroides gingivalis in nonhuman primates initiates progression of periodontitis 总被引：38，自引：0，他引：38
Although periodontitis is a bacterial disease, its multidimensional nature and its bacterial complexity have made it difficult to definitively prove that specific microorganisms initiate the disease process. The successful implantation of a rifampin-resistant strain of the putative periodontal pathogen Bacteroides gingivalis into the periodontal microbiota of monkeys (Macaca fascicularis) resulted in an increase in the systemic levels of antibody to the microorganism and rapid and significant bone loss. 相似文献
17.
Sleep patterns of the monkey and brain serotonin concentration: effect of p-chlorophenylalanine 总被引：2，自引：0，他引：2
The amount of time that monkeys (Macaca mulatta) slept was reduced after they were given p-chlorophenylalanine, a selective depletor of serotonin in animal tissues. The time spent in the rapid eye movement stage of sleep was unchanged, but the time in other sleep stages decreased. Seven regions of the brain had a 31 to 46 percent decrease in serotonin content; the concentration of cerebellar serotonin increased by 44 percent. 相似文献
18.
藏酋猴毛干DNA的3种提取方法 总被引：1，自引：0，他引：1
为寻求一种从藏酋猴毛干中提取总DNA的有效方法,从一藏酋猴个体背部剪取数量不等的毛干样品(不含毛囊),经蛋白酶K消化后,分别采用高盐沉淀抽提法、酚氯仿抽提法、纳米磁珠抽提法分离获得用于PCR扩增的模板DNA,通过紫外分光光度计测定OD值并计算出质量浓度,同时进行琼脂糖凝胶电泳和PCR扩增检测,分析3种方法提取藏酋猴毛干DNA的质量差异。每处理设置10个重复。结果表明,纳米磁珠法提取藏酋猴毛干中DNA是一种快捷、简便、经济、高效、安全的有效方法;进行毛发取样时以5～10根较为合适。 相似文献
19.
丙型肝炎动物模型缺乏限制了丙型肝炎的研究,如果与人类基因背景相似的猕猴能作为丙型肝炎动物模型将有重大意义。文章拟通过检测决定HCV感染物种特异性的关键基因OCLN与CD81在猕猴不同组织的表达量,并以HCV易感的人肝癌细胞系Huh 751为对照,来探究猕猴作为丙型肝炎动物模型的可能性。结果表明,OCLN与CD81在猕猴川西亚种的肝脏、脾脏、肺脏、淋巴结和脊髓中均有表达,但表达量均极显著低于在Huh 751细胞系中的表达量（P<0.01）。肝脏中的OCLN表达量略低于肺脏中的表达量,而肝脏CD81的表达量均高于其他组织。并且,OCLN在不同组织中的表达水平与人体OCLN表达规律相符合（脾＜肝＜肺）。该结果提示HCV感染的宿主亲嗜性基因OCLN与CD81在猕猴中的低表达量可能导致HCV不能有效地结合组织靶细胞,因此推测,猕猴不能直接用于丙型肝炎动物造模可能与此有关。今后可通过转基因等技术增强OCLN与CD81基因的表达,从而使猕猴获得直接感染HCV的能力。 相似文献
20.
Thirteen normal monkeys (Macaca mulatta) trained to discriminate between transilluminated figures of equal area and different luminance, and consequently different luminous flux, made similar numbers of errors during training on a new problem with the same luminance values but with targets equated for luminous flux. These findings together with results of "critical trials" suggest that the significant cue in the original problem was luminous flux. This behavior is strikingly similar to what has been reported for the monkey following exclusion of the geniculostriate system. 相似文献