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为制备抗菌活性较好的肽粉乳基料,以新鲜牛乳为原料提取酪蛋白,以酪蛋白酶解物对大肠杆菌、沙门氏菌和金黄色葡萄球菌的抑菌圈直径为指标,从木瓜蛋白酶、碱性蛋白酶、中性蛋白酶和胰蛋白酶中筛选出一种蛋白酶水解牛乳酪蛋白,并通过单因素试验和正交试验确定该酶水解牛乳酪蛋白优化水解条件。结果表明：木瓜蛋白酶水解牛乳酪蛋白,其酶解物对3种菌均有较好的抑制作用;优化水解工艺条件为：酶解温度50℃、酶解时间4.5h、加酶量4500U/g、pH5.5、底物质量浓度6g/100mL;牛乳酪蛋白酶解物及初级肽粉乳基料稳定性均较好。 相似文献
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目的：观察牦牛乳酪蛋白降血压肽对应激性高血压大鼠（stress induced hypertensive rats,SIHR）和正常Wistar大鼠的降压效果,并与降压药物厄贝沙坦（irbesaran）和卡托普利（Captopril）的作用效果进行比较。方法：采用木瓜蛋白酶、中性蛋白酶水解制备牦牛乳酪蛋白降血压肽,分别以20 mg/kg、40 mg/kg和60 mg/kg剂量的牦牛乳酪蛋白降血压肽一次灌胃,每隔2 h测量SIHR收缩压（SBP）,连续测量8 h;长期实验持续6周,每天60 mg/kg一次灌胃,每隔1周测量SBP一次。结果：SIHR给予牦牛乳酪蛋白降血压肽后,血压均显著下降（P〈0.05）,并均在灌胃后3-6 h达最低,血压下降最大幅度为（27±5.13）mmHg,呈现一定的量效关系;而正常大鼠给予牦牛乳酪蛋白降血压肽后血压无显著变化,服用厄贝沙坦和卡托普利后血压则保持显著下降的趋势。长期灌胃牦牛乳酪蛋白降血压肽可使SIHR血压明显下降（P〈0.05）,并且降压效果稳定。结论：牛乳酪蛋白降血压肽对SIHR有明显的体内降压效果,长期服用可稳定血压,对正常大鼠血压无明显影响。 相似文献
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CPPs的功能及其在饲料工业上的应用 总被引：2，自引：0，他引：2
生物活性肽酪蛋白磷酸肽CPPs是牛乳酪蛋白经酶水解，分离，纯化而得到的一类富含磷酸丝氨酸的肽类化合物，据研究发现，它含有成簇的磷酸丝氨酸，无高级结构，具有多种生物学功能，在生产上应用前景非常广阔。 相似文献
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《黑龙江畜牧兽医》2014,(15)
为了探明蛋白酶水解作用对牛乳酪蛋白(CN)致敏性或者抗原性的影响,试验采用小鼠动物模型从体外和体内2个方面研究了水解作用对牛乳酪蛋白抗原性的影响。结果表明:胰蛋白酶水解的最适条件为50℃,E/S为0.5%下水解2 h;此水解条件下酪蛋白的总致敏性降低最多,α-酪蛋白(α-CN)抗原性降低率为81.59%,β-酪蛋白(β-CN)抗原性降低率为62.69%。酶解组小鼠过敏症状比未水解的牛乳酪蛋白组相比明显减轻;与未水解酪蛋白相比,酶解物显著抑制特异性免疫球蛋白E(IgE)的产生;酶解物显著降低血浆中组胺的释放。说明胰蛋白酶能够有效降低牛乳酪蛋白的抗原性。 相似文献
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正牛初乳所含各种蛋白本身不仅具有生理活性,同时,在其大分之内部还存在许多具有生理活性的蛋白肽,在蛋白质被水解之前它们是以非活性状态隐藏在蛋白质分子中,当蛋白质被水解后,这些肽的活性被释放出来。自从1979年Brant从牛乳β-酪蛋白的水解物中分离出β-阿片样肽至今,已经从牛乳酪蛋白的水解中发现了多种活性肽,例如:阿片样肽、抗血压升高肽、酪蛋白磷酸肽、免疫多肽、抗血栓肽等。 相似文献
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生物活性肽——酪蛋白磷酸肽(CPPs)是以牛乳酪蛋白为原料,经单一酶或复合酶水解,再对其产物进行分离提纯而得到的含有成簇磷酸丝氨酸的多肽,具有促进矿物元素吸收,增强动物机体免疫力,改善繁殖性能等多种生物学功能。本文综述了CPPs的结构、功能、作用机理及应用前景。 相似文献
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酪蛋白磷酸肽(Cpps)是从牛乳酪蛋白中分离得到的一种磷酸肽,近年来研究发现其具有促进猪的免疫功能的作用.本文综述了最近的有关研究结果. 相似文献
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Beran GW 《Preventive veterinary medicine》2008,86(3-4):198-207
When early people made their appearance, zoonotic infectious diseases were already waiting, but epidemic diseases did not appear in human history until people began to live in large numbers under conditions of close contact, mainly during the last 10,000 years. Disease has decimated urban populations, conquered armies, and disrupted society. The focus here is on (1) the plague of Athens and the Black Death; (2) smallpox, influenza, and rabies; (3) avian influenza prion diseases, and foot & mouth disease; and (4) emerging and re-emerging diseases. All have veterinary public health associations. In Athens, Greece, in 430 BC, when the Spartans ravaged the countryside, hordes crowded into Athens so that orderly movements, space in which to live, and adequate supplies of food became impossible. Crowding of any population fosters disease transmission; chaos and disorder enhance it all the more. Out of northern Egypt came a terrible plague from across the Mediterranean Sea. The identity of the plague of Athens remains unsure, but the well-considered conclusion is Rift Valley Fever, a mosquito borne, viral zoonosis. The Black Death, also called the Plague, raged in Asia for centuries. In 1347, the Black Death was brought by a ship out of Asia to Sicily. The scenes of devastation were repeated throughout Europe, with 90% or more of the people dying in city after city. Influenza, too, has been a cause of periodic human epidemics, but the great pandemic of influenza occurred in the last months of World War I. In the years of highest occurrence, more than half the world's population became clinically infected. If veterinary public health had been born earlier, it could have led to elucidating the epidemiology of influenza and the plagues of Athens, Europe, and Asia. In turn, smallpox had also caused continual tragedy. In 1796, Edward Jenner began to harvest pustules of cowpox from children or infected cows and inject them into susceptible children. In 1980, the World Health Organization declared that smallpox had been eliminated from the world. Rabies, though, still strikes terror. A number of animal diseases, broadly termed emerging and re-emerging diseases, need surveillance because they have the potential to impact human health. From late in 2003 to 2007, the highly pathogenic H5N1 influenza virus in poultry infected at least 121 people and caused 62 deaths in four countries. The prion diseases, too, all have very high numbers in concentrated contacts. To control these diseases, veterinary public health is essential, with diagnosis, epidemiological surveillance, clinical manifestations, and prevention as primary measures. 相似文献
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Dekker A Dercksen D Snoep J van Wuyjckhuise L 《Tijdschrift voor diergeneeskunde》2007,132(18):695-701
On 26th of july 2007 a new case of bluetongue was notified in the Netherlands and on 2nd of august 2007 foot-and-mouth disease was diagnosed in Surrey, England, which raised the threat of having both infections simultaniously in one area. Bluetongue and foot-and-mouth disease have a different pathogenesis, but symptoms may resemble each other at a later stage of infection. The pathogenesis and possible clinical symptoms of both infections are discussed and illustrated with pictures. 相似文献
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在动物的异常行为中以刻板行为最为常见,而咽气癖又是马最常见的口部刻板行为之一。作者就咽气癖在生理方面和心智方面对马体产生的影响、行为基础、诱因的研究进展及常见的防治措施进行综述。 相似文献
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近几年,世界饲用添加剂市场增长较快,预计今后将进一步增长,据世界粮农组织(FAO)首领会议的倡议,到2015年,将使世界营养不良的人口削减一半,其间,肉制品将会以每年2％的速度增长,特别是加快猪肉和禽肉增长。这将促进世界添加剂,尤其是蛋氨酸和赖氨酸需求量的增加。 相似文献
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