共查询到20条相似文献，搜索用时 15 毫秒
1.
Cho AK 《Science (New York, N.Y.)》1990,249(4969):631-634
Ice, which has been described as the drug of the 1990s, is a pure form of (+)methamphetamine hydrochloride; it is more dangerous because of its purity and because it can be inhaled. Taken by this route, the drug causes an effect similar to that from an intravenous dose, and much more intense than that from ingestion. The detailed mechanism of action differs from that of cocaine, but the overall stimulant effect of methamphetamine is similar. Methamphetamine effects, however, persist for hours, whereas cocaine effects are over in minutes. Ice is, therefore, just another agent for abuse by those seeking psychostimulation and, as with cocaine, compulsive abusers of amphetamines consume the drug repeatedly and continuously. Unlike cocaine, methamphetamine is a synthetic compound and is manufactured in illicit laboratories within the United States. 相似文献
2.
Xue YX Luo YX Wu P Shi HS Xue LF Chen C Zhu WL Ding ZB Bao YP Shi J Epstein DH Shaham Y Lu L 《Science (New York, N.Y.)》2012,336(6078):241-245
Drug use and relapse involve learned associations between drug-associated environmental cues and drug effects. Extinction procedures in the clinic can suppress conditioned responses to drug cues, but the extinguished responses typically reemerge after exposure to the drug itself (reinstatement), the drug-associated environment (renewal), or the passage of time (spontaneous recovery). We describe a memory retrieval-extinction procedure that decreases conditioned drug effects and drug seeking in rat models of relapse, and drug craving in abstinent heroin addicts. In rats, daily retrieval of drug-associated memories 10 minutes or 1 hour but not 6 hours before extinction sessions attenuated drug-induced reinstatement, spontaneous recovery, and renewal of conditioned drug effects and drug seeking. In heroin addicts, retrieval of drug-associated memories 10 minutes before extinction sessions attenuated cue-induced heroin craving 1, 30, and 180 days later. The memory retrieval-extinction procedure is a promising nonpharmacological method for decreasing drug craving and relapse during abstinence. 相似文献
3.
Cocaine abuse has reached epidemic proportions in the United States, and the search for an effective pharmacotherapy continues. Because primates self-administer most of the drugs abused by humans, they can be used to predict the abuse liability of new drugs and for preclinical evaluation of new pharmacotherapies for drug abuse treatment. Daily administration of buprenorphine (an opioid mixed agonist-antagonist) significantly suppressed cocaine self-administration by rhesus monkeys for 30 consecutive days. The effects of buprenorphine were dose-dependent. The suppression of cocaine self-administration by buprenorphine did not reflect a generalized suppression of behavior. These data suggest that buprenorphine would be a useful pharmacotherapy for treatment of cocaine abuse. Because buprenorphine is a safe and effective pharmacotherapy for heroin dependence, buprenorphine treatment may also attenuate dual abuse of cocaine and heroin. 相似文献
4.
Dalley JW Fryer TD Brichard L Robinson ES Theobald DE Lääne K Peña Y Murphy ER Shah Y Probst K Abakumova I Aigbirhio FI Richards HK Hong Y Baron JC Everitt BJ Robbins TW 《Science (New York, N.Y.)》2007,315(5816):1267-1270
Stimulant addiction is often linked to excessive risk taking, sensation seeking, and impulsivity, but in ways that are poorly understood. We report here that a form of impulsivity in rats predicts high rates of intravenous cocaine self-administration and is associated with changes in dopamine (DA) function before drug exposure. Using positron emission tomography, we demonstrated that D2/3 receptor availability is significantly reduced in the nucleus accumbens of impulsive rats that were never exposed to cocaine and that such effects are independent of DA release. These data demonstrate that trait impulsivity predicts cocaine reinforcement and that D2 receptor dysfunction in abstinent cocaine addicts may, in part, be determined by premorbid influences. 相似文献
5.
Retrograde amnesia produced by electroconvulsive shock after reactivation of a consolidated memory trace 总被引：11，自引：0，他引：11
Rats had a memory loss of a fear response when they received an electroconvulsive shock 24 hours after the fear-conditioning trial and preceded by a brief presentation of the conditioned stimulus. No such loss occurred when the conditioned stimulus was not presented. The memory loss in animals given electroconvulsive shock 24 hours after conditioning was, furthermore, as great as that displayed in animals given electroconvulsive shock immediately after conditioning. This result throws doubt on the assertion that electroconvulsive shock exerts a selective amnesic effect on recently acquired memories and thus that electroconvulsive shock produces amnesia solely through interference with memory trace consolidation. 相似文献
6.
Both impulsivity and novelty-seeking have been suggested to be behavioral markers of the propensity to take addictive drugs. However, their relevance for the vulnerability to compulsively seek and take drugs, which is a hallmark feature of addiction, is unknown. We report here that, whereas high reactivity to novelty predicts the propensity to initiate cocaine self-administration, high impulsivity predicts the development of addiction-like behavior in rats, including persistent or compulsive drug-taking in the face of aversive outcomes. This study shows experimental evidence that a shift from impulsivity to compulsivity occurs during the development of addictive behavior, which provides insights into the genesis and neural mechanisms of drug addiction. 相似文献
7.
J H Hollis 《Science (New York, N.Y.)》1968,159(3822):1487-1489
A retarded child with a high stereotyped rocking rate was conditioned to pull a ball on a reinforcement schedule in which the fixed ratio aof rewarded to nonrewarded responses was 100. Results show no rocking movements during ball-pulling; but when ball-pulling was on extinction, rocking returned to its original rate. Chlorpromazine blocked rocking movements during extinction, but had no effect on ball-pulling. Delivery of one free reinforcer was sufficient to reinstate ball-pulling after extinction, but the stimulus properties of the free reinforcer were not affected by the drug. 相似文献
8.
When rats are treated with an antihistamine prior to being given sublethal doses of ionizing radiation, the formation of a conditioned saccharin aversion is completely inhibited. A profound aversion could be conditioned with histamine diphosphate as the aversive stimulus. The increase in histamine production after radiation exposure represents the physiological basis of radiation-induced taste aversions. 相似文献
9.
Associative learning has been demonstrated in a reduced siphon, mantle, gill, and abdominal ganglion preparation of Aplysia. The preparations learned to respond to a previously neutral stimulus as a consequence of training in a classical conditioning paradigm. Backward conditioning, presentation of the conditioned stimulus alone, or presentation of the unconditioned stimulus at some random interval after presentation of the conditioned stimulus failed to produce conditioning. This model system can be used to study the neural mechanisms underlying associative learning. 相似文献
10.
Rats were trained with a tone being followed by either food or electric shock, on alternate days. Unit activity during application of the conditioned stimulus was recorded from the dorsal hippocampus. The results indicate differentiation of the hippocampal system. Dentate units respond by augmentation to a conditioned stimulus which leads to food and by inhibition to the same stimulus when it precedes electric shock. The hippocampus proper responds by augmentation in both situations. The intensity of the hippocampal response to the conditioned stimulus on the first day of training is higher if the unconditioned stimulus is food than if it is electric shock. These data cast light on the functions of the dorsal dentate-hippocampal connections and the hippocampus proper during aversive and appetitive conditioning. 相似文献
11.
Cocaine addiction: psychology and neurophysiology 总被引：30，自引：0，他引：30
F H Gawin 《Science (New York, N.Y.)》1991,251(5001):1580-1586
Cocaine was considered incapable of producing dependence in 1980 but was recently proclaimed the drug of greatest national health concern. Recent clinical and preclinical investigations demonstrate that cocaine produces unique abuse and withdrawal patterns that differ from those of other major abused drugs and suggest that long-term cocaine abuse produces neurophysiological alterations in specific systems in the central nervous system that regulate the capacity to experience pleasure. It will be necessary to develop clinically pertinent research models before these findings can be considered definitive, but these evolving ideas have already led to applications of promising experimental treatments for cocaine abuse. 相似文献
12.
Although the voluntary intake of drugs of abuse is a behavior largely preserved throughout phylogeny, it is currently unclear whether pathological drug use ("addiction") can be observed in species other than humans. Here, we report that behaviors that resemble three of the essential diagnostic criteria for addiction appear over time in rats trained to self-administer cocaine. As in humans, this addiction-like behavior is present only in a small proportion of subjects using cocaine and is highly predictive of relapse after withdrawal. These findings provide a new basis for developing a true understanding and treatment of addiction. 相似文献
13.
THOMPSON R 《Science (New York, N.Y.)》1960,132(3439):1551-1553
Rats trained to make a jumping response to the onset of a visual stimulus lost the habit after damage to the interpeduncular nucleus of the midbrain. It was noted, however, that the majority of the operated animals showed perfect retention of the "fear" response to the conditioned stimulus. 相似文献
14.
Rats showed amnesia for conditioned fear training if given an electroconvulsive shock immediately after training. Retention was unimpaired, however, when the electroconvulsive shock treatment was given 1 day after training immediately after the presentation of the stimulus used in the fear conditioning training. These results support the view that electroconvulsive shock disrupts memory trace consolidation but does not disrupt a recently reactivated memory trace. 相似文献
15.
Weakly electric fish of the African family Mormyridae emit pulses at variable intervals with a distribution skewed toward longer intervals. Fourteen specimens of the genera Mormyrops, Gnathonemus, and Marcusenius were classically conditioned to increase briefly their discharge frequency. The unconditioned stimulus was electric shock and the conditioned stimulus was light. These results are novel in that the overt conditioned response involves neither secretion nor movement. 相似文献
16.
Koekkoek SK Hulscher HC Dortland BR Hensbroek RA Elgersma Y Ruigrok TJ De Zeeuw CI 《Science (New York, N.Y.)》2003,301(5640):1736-1739
Mammals can be trained to make a conditioned movement at a precise time, which is correlated to the interval between the conditioned stimulus and unconditioned stimulus during the learning. This learning-dependent timing has been shown to depend on an intact cerebellar cortex, but which cellular process is responsible for this form of learning remains to be demonstrated. Here, we show that protein kinase C-dependent long-term depression in Purkinje cells is necessary for learning-dependent timing of Pavlovian-conditioned eyeblink responses. 相似文献
17.
Subjects conditioned concurrently to two different conditioned stimuli, light and tone, exhibited a significantly higher level of conditioning to the stimulus paired with a strong unconditioned stimulus than to the stimulus paired with a weak one. The findings suggest that habit strength in aversive conditioning varies with the intensity of the unconditioned stimulus. 相似文献
18.
Heart rate: changes during conditioned suppression in rats 总被引：1，自引：0，他引：1
Heart rate of rats was recorded in the Estes-Skinner conditioned emotional response situation. Response to the conditioned stimulus was a decrease in rate. The change in heart rate was conditioned more slowly than suppression of bar-pressing; it was of shorter duration and was more variable than suppression. 相似文献
19.
Conditioned leg-flexion responses in dogs were developed with electric shock as an unconditioned stimulus and intestinal stimulation or the effects of injections of various drugs as conditioned stimuli. It is concluded that physiological effects can play a role in the development and maintenance of conditioned avoidance behavior. 相似文献
20.
A technique is described for self-infusion of pharmacologic agents in solution through a permanently indwelling jugular catheter in the rhesus monkey. The results of an experiment utilizing this technique demonstrate that an instrumental lever response can be conditioned, extinguished, reconditioned, and brought under stimulus control and reward-schedule control with saline self-infusion as the reinforcing stimulus. 相似文献