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1.
Left dorsal displacement of the large colon is a condition unique to the horse that results in an obstruction of the colon and signs of colic. This condition may be successfully treated medically with analgesia, i.v. or oral fluids and feed restriction, exercise with or without administration of phenylephrine, or rolling under general anaesthesia with or without administration of phenylephrine, or a combination of these conservative options. Surgical correction via standing left flank laparotomy or, more commonly, ventral midline laparotomy under general anaesthesia, is required in cases where conservative therapy is unsuccessful. Recurrence rates range from 3.2% to 21%. Surgical attempts to prevent recurrence of this condition include large colon resection, colopexy, and ablation of the nephrosplenic space. 相似文献
2.
M W Riggs 《Veterinary Clinics of North America: Equine Practice》1987,3(3):515-528
Currently recognized equine immune deficiency disorders include failure of passive colostral immunoglobulin transfer, combined immunodeficiency, selective IgM deficiency, transient hypogammaglobulinemia, and agammaglobulinemia. Additional equine immune deficiency disorders probably exist. Immune deficiency should be suspected in any horse experiencing persistent or recurrent infections that are not responsive to conventional therapy. 相似文献
3.
Cotovio M Monreal L Navarro M Segura D Prada J Alves A 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2007,21(2):308-313
BACKGROUND: In humans and experimental animals, disseminated intravascular coagulation (DIC) causes fibrin deposition in several organs, which eventually leads to ischemia and multiorgan failure. HYPOTHESIS: Horses who died or were euthanized for severe gastrointestinal disorders could have fibrin deposits in different tissues. ANIMALS: Tissue-organ samples collected during postmortem examinations on 66 colic horses with poor prognoses (eg, severe intestinal ischemia, enteritis, peritonitis), from 11 colic horses with good prognoses (eg, large-colon obstruction or displacement), and from 16 slaughter horses. METHODS: Tissue samples (kidney, lung, liver) were stained with hematoxylin and eosin, and phosphotungstic acid hematoxylin for a blinded histologic examination. A fibrin score (grades 0 to 4) was established for each tissue sample and for each horse. RESULTS: Fibrin deposits were found in tissue specimens of 11 of 27 of horses (40.7%) in the ischemic group, 8 of 21 in the enteritis group (38.1%), and 7 of 18 in the peritonitis group (39.0%), whereas none of the horses in the obstructive group (n = 11) and only 1 horse in the slaughter group (n = 16) had fibrin deposits in their tissues. In addition, the mean fibrin score values for the ischemic, enteritis, and peritonitis groups (1.3 +/- 1.7, 1.1 +/- 1.6, and 0.9 +/- 1.3, respectively) were statistically higher than those for the obstructive and slaughter groups (0.0 +/- 0.0 and 0.1 +/- 0.5, respectively). The largest fibrin deposits were found in the lungs. Conclusions and Clinical Importance: Horses with severe gastrointestinal disorders have fibrin deposits that are consistent with capillary microthrombosis, multiorgan failure, and DIC. 相似文献
4.
M J Kemen D S McClain J G Matthysse 《Journal of the American Veterinary Medical Association》1978,172(3):360-362
Equine infectious anemia virus was transmitted from an acutely ill and an inapparently infected pony to uninfected ponies by the interrupted feeding of horse flies (tabanids). Transmission from acutely ill ponies was not accomplished following: (1) the interrupted feeding of a single horse fly, (2) bites of horse flies that had fed on an acutely affected pony 24 hours earlier, (3) bites of horse flies that had oviposited after feeding on an acutely affected pony, or (4) the inoculation of larval material derived from horse flies that had fed to repletion. It was concluded that horse fly transmission of equine infectious anemia virus is mechanical only and that infected horses that are free of clinical signs can be a source of virus for insect transmission. 相似文献
5.
In summary, important events of ejaculation include emission of sperm and the accessory gland fluids into the urethra, simultaneous closure of the bladder neck, and forceful ejaculation of the combined semen through the urethra. Emission and bladder neck closure are primarily alpha-adrenergically mediated thoracolumbar sympathetic reflex events with supraspinal modulation. Ejaculation is a sacralspinal reflex mediated by the pudendal nerve. In stallions, the most common ejaculation disorders are emission and ejaculation failure, and urine contamination of semen. Rare disorders are azoospermia and premature ejaculation. In a large percentage of cases, an ejaculation appears to be a result of musculoskeletal disorders or to be psychogenic in nature rather than attributable to specific ejaculatory dysfunction. Traditional therapeutic approaches for accommodating deficits can extend the breeding life of many stallions. Pharmacologic aids may be useful. 相似文献
6.
David S. Kronfeld PhD DSc MVSc MRCVS DipACVN DipACVIM 《Journal of Equine Veterinary Science》2001,21(8)
Athletic performance is initially enabled but then becomes limited by changes in body fluids. This review deals with potentially beneficial interventions replacement strategies. It is the second of a trilogy on exercise with a focus on body fluids. The first part (published previously in this Journal) concerned physiological changes in body fluids likely to affect performance. These changes are certain to tax the homeostatic capacity of a competitive horse, which may be supported by supplementation with water and electrolytes before, during or after an event. The simplest replacement strategy is to completely offset depletion, so as to maintain or restore the resting status. A preferred replacement strategy emphasizes more frequent and smaller doses during an event, so as to avoid over-riding the initial beneficial changes in body fluids. Because the turning points from enabling to limiting are not well established, effective electrolyte replacement currently depends as much on the rider's development of a specific dosage regimen (amounts and times) for an individual horse as on any scientist's rational design of a flexible formula for all horses.Marketedformulas are based on sweat loss and changes in plasma. Most contain Na, K and Cl; some also have Ca, Mg, P, glucose and nutraceuticals. Attention to hyperkalemia at speeds over 4 m/s suggests the need for two formulas—one without potassium for use during an event, the other with potassium for use before and after. Illustrative studies are examined for the validity of their physiological interpretations and their practicalimplications. They indicate various advantages from the administration of hypertonic mixtures of electrolytes in pastes or slurries a few hours before as well as during and after an event, provided that the horse has ample opportunity to drink. Nevertheless, the physiology of absorption suggests that hypertonic mixtures should be regarded as unsuitable for a clinically hypohydrated horse until shown otherwise. The third part of this series will discuss the influence of nutrition and feeding management on body fluids and performance. 相似文献
7.
J L Traub-Dargatz A O McKinnon M A Thrall R L Jones W Bruyninckx A M Blancquaert D A Dargatz 《American journal of veterinary research》1992,53(10):1908-1916
We evaluated the efficacy of 3 treatments for chronic obstructive pulmonary disease in horses: prednisone (400 mg/horse, PO, daily; n = 7), methyl sulfonmethane (10 g/horse, PO, q 12 h; n = 6), and clenbuterol hydrochloride (0.4 mg/horse, PO, q 12 h; n = 7). A fourth group acted as controls (n = 6) and was not treated. The treatment period lasted 10 days. Each horse was a member of 2 different groups for 10 days, separated by an 18-day interval of no treatment. All horses were housed together in an outdoor pen without bedding. Horses were fed alfalfa/grass hay mix ad libitum from a large feeder. The same batch of hay was fed throughout the study. Multiple physical and laboratory variables were monitored prior to, during, and at the end of each 10-day trial period. Changes in lung sounds, respiratory effort, degree of anal movement, nasal discharge, temperature, respiratory rate, or heart rate were not significant. Changes in arterial blood gas tensions, tracheal wash or bronchoalveolar lavage cytologic findings, or phagocyte function were not significant. All horses were tachypneic and most were tachycardic. The median value for PaO2 was below normal for all horses. All tracheal wash and most bronchoalveolar lavage cytologic findings represented a suppurative response. Negative linear correlation was observed between PaO2 and degree of respiratory effort in these horses (eg, as PaO2 decreased, the degree of respiratory effort increased). 相似文献
8.
《Clinical Techniques in Equine Practice》2003,2(2):130-137
Colloids are fluids containing large molecular weight molecules that do not readily cross the capillary membrane. Colloid replacement is becoming increasingly more common in the equine intensive care unit. Advantages of colloid therapy include improved oncotic pressure, rapid intravascular volume replacement, and improved microvascular perfusion. Edema formation is minimized through the use of colloids, rather than crystalloids, in the volume resuscitation of hypoproteinemic animals. Available colloids include both natural (biologic) and synthetic formulations. Plasma is the most common biologic colloid utilized in horses, and offers the advantage of providing a broad range of proteins in addition to its principle colloid, albumin. These additional proteins include coagulation factors, antithrombin, and immunoglobulins. The most widely used synthetic colloid in horses is hydroxyethyl starch (hetastarch). Side effects of hetastarch include dose-dependent effects on coagulation, primarily because of decreases in factor VIII and von Willebrand factor concentrations. Other synthetic or semisynthetic colloids include pentastarch, dextrans, and a polymerized ultrapurified bovine hemoglobin product. Monitoring of patients receiving colloid therapy should include direct colloid osmometry. Indirect estimates of colloid osmotic pressure are not reliable in critically ill patients and in those receiving synthetic colloids. Total protein measurements do not account for the oncotic contribution of synthetic colloids. 相似文献
9.
Saddle fitting,recognising an ill‐fitting saddle and the consequences of an ill‐fitting saddle to horse and rider 
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下载免费PDF全文 A saddle that does not fit either a horse or a rider correctly has potentially far reaching consequences for both horse and rider health. The saddle should be assessed off and on the horse, without and with a rider. The fit of the saddle for both the horse and rider must be evaluated. A well‐fitted saddle should distribute weight evenly via the panels to the horse's thoracic region, with complete clearance of the spinous processes by the gullet. The saddle should remain fairly still during ridden exercise at all paces. The saddle must also fit the rider to enable them to sit in balance. Signs of an ill‐fitting saddle include equine thoracolumbar pain, focal swellings under the saddle, ruffling of the hair, dry spots under the saddle immediately after exercise surrounded by sweat, and abnormal hair wear. If a saddle does not fit the rider, the rider may not be able to ride in balance with the horse, and this may induce equine thoracolumbar pain. A saddle of inappropriate size and shape for the rider may induce rider back pain, ‘hip’ pain, sores under the ‘seat bones’ and perineal injuries. 相似文献
10.
Equine gastrointestinal motility is a central issue in cases of equine colic, post operative convalescence and alimentary conditions encountered in practice. There are significant syndromes of intestinal dysmotility in the horse such as obstructive disorders and post operative ileus that are still poorly understood. This review describes the various areas of research that aim to elucidate the pathogenesis of intestinal hypo- or hypermotility by research methods, which include studies at the cellular level, and those that employ in vitro or in vivo techniques of evaluating the physiology and mechanical means of ingesta transit through the alimentary tract. The review discusses future directions for studies which will hopefully lead to better understanding and appropriate measures for diagnosis, therapy and prevention of ileus and other motility disorders. 相似文献
11.
Misato NAKAMURA Marin MATSUSHIRO Masatoshi TSUNOKAWA Seiya MAEHARA Takanori KOORIYAMA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(7):1075
Pinnipeds have evolved enlarged ocular bulbs to catch fish in the dark. However, their large protruding eyes are easily damaged, which increases the risk of blindness and death in these animals. In captivity, ophthalmic disorders, manifested as keratitis and cataracts, are common among pinnipeds. In this study, we investigated symptoms of ophthalmic disorders in pinniped species using a questionnaire distributed to 32 zoos and aquariums throughout Japan. We conducted this study in cooperation with the Japanese Association of Zoos and Aquariums. The survey included 295 pinnipeds from four otariid species, five phocid species, and one odobenid species. Of these, 43.1% of the pinnipeds had diseases affecting the lens, cornea, and/or other eye parts. Age was positively associated with lens disorders in California sea lions, South American sea lions, and spotted seals. Conflicts and public appearances were also associated with corneal and/or lens disorders in California sea lions. Treatments were evaluated as effective for corneal disorders and conjunctivitis. The results of this study indicate that ophthalmic disorders in pinnipeds are related to the conditions of their captive environment. Aquariums and zoos should be encouraged to share information regarding optimal maintenance practices to improve the living conditions of pinnipeds. 相似文献
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13.
E A Hoover J I Mullins 《Journal of the American Veterinary Medical Association》1991,199(10):1287-1297
Feline leukemia virus is a naturally occurring, contagiously transmitted and oncogenic immunosuppressive retrovirus of cats. The effects of FeLV are paradoxical, causing cytoproliferative and cytosuppressive disease (eg, lymphoma and myeloproliferative disorders vs immunodeficiency and myelosuppressive disorders). In the first few weeks after virus exposure, interactions between FeLV and hemolymphatic system cells determine whether the virus or the cat will dominate in the host/virus relationship--persistent viremia and progressive infection or self limiting, regressive infection will develop. The outcome of these early host/virus interactions is revealed in the diagnostic assays for FeLV antigenemia and viremia. The latter, in turn, predict the outcome of FeLV infection in cats. Known host resistance factors include age and immune system functional status. Known virus virulence factors are magnitude of exposure and virus genotype. Molecular analysis of FeLV strains indicated that natural virus isolates exist as mixtures of closely related virus genotypes and that minor genetic variations among FeLV strains can impart major differences in pathogenicity. The genetic coding regions responsible for cell targeting and specific disease inducing capacity (eg, thymic lymphoma, acute immunosuppression, or aplastic anemia) have been mapped to the virus surface glycoprotein and/or long terminal repeat regions for several FeLV strains. Infection by specific FeLV strains leads to either malignant transformation or cytopathic deletion of specific lymphocyte and hemopoietic cell population, changes that prefigure the onset of clinical illness. Another notable feature of the biology of FeLV is that many cats are able to effectively contain and terminate viral replication, an important example of host immunologic control of a retrovirus infection and a process that can be selectively enhanced by vaccination. Thus, FeLV infection serves as a natural model of the multifaceted pathogenesis of retroviruses and as a paradigm for immunoprophylaxis against an immunosuppressive leukemogenic retrovirus. 相似文献
14.
《Clinical Techniques in Equine Practice》2003,2(2):199-211
Mortality rates for healthy horses undergoing general anesthesia for routine procedures have been reported to range from 0.6% to 1.8%; these numbers increase as high as 5% when systemically ill horses are included in calculations. Anesthesia of intensivecare equine patients should first include critical assessment of the need for versus risk of anesthetic intervention. When general anesthesia cannot be avoided, the following measures should be considered and addressed throughout the perianesthetic period: preanesthetic assessment and cardiopulmonary stabilization, perianesthetic oxygen supplementation and ventilatory support, vigilant monitoring of the cardiopulmonary system, supportive therapy (ie, inotropic agents, fluids) to promote adequate cardiac output, use of perioperative adjunct systemic and/or regional agents to reduce inhalant requirements, close observation and assistance during recovery, and postoperative analgesia. 相似文献
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16.
SUMMARY: Free radical oxidation products, namely conjugated dienes, ultraviolet fluorescence (excitation 325 nm, emission 395 nm) and visible fluorescence (excitation 360 nm, emission 460 nm) were measured in equine synovial fluid exposed to free radicals In vitro and in the plasma and synovial fluids of horses with synovial effusions. The synovial effusions were induced by intra-articularly administered carrageenin (0.3 ml, 1%), which rarely resulted in clinical lameness. The free radicals were generated In vitro by mixtures of iron and ethylene diamine tetra acetate (Fe/EDTA) or mixtures of hypoxanthine and xanthine oxidase (HX/XO). The conjugated diene concentrations and intensity of ultraviolet fluorescence were negligible in plasma and synovial fluid specimens. No increase resulted from incubation of synovial fluids with either a free radical generating system or as a result of the induced inflammation. The intensity of visible fluorescence did not increase in specimens incubated with Fe/EDTA. However, the intensity of visible fluorescence increased in specimens incubated with HX/XO, in synovial effusions induced by carrageenin, in plasma and in synovial fluids aspirated from saline injected controls. The results indicate that the intensity of visible fluorescence of equine synovial fluid increases after exposure to free radicals and during synovitis in the horse, suggesting a possible role for free radicals in the pathogenesis of equine inflammatory joint diseas 相似文献
17.
S Dyson 《Equine veterinary journal》1983,15(1):25-30
Thirty cases of peritonitis, in which the diagnosis was based on a peritoneal fluid white blood cell count in excess of 10 x 10(9)/litre, are described. Colic, ileus, pyrexia, weight loss and diarrhoea were common presenting signs. Treatments included intravenous fluids, anti-inflammatory analgesics, broad spectrum antibiotics and anthelmintics. Duration of treatment was determined by the clinical condition of the horse and sequential analyses of the peritoneal fluid and the haemogram. In the majority of cases the primary cause of peritonitis was not accurately determined, but 21 horses (70 per cent) recovered. All the horses with diarrhoea were killed after marked deterioration in their clinical condition despite intensive treatment. No individual laboratory parameter was of value in determining prognosis, although of the eight (27 per cent) horses from which bacteria were identified in the initial peritoneal fluid by Gram stain, four (50 per cent) were subsequently killed. 相似文献
18.
LIN KLEIN VMD NANCY AILES BA GUSTAVE E. FACKELMAN DVM DiplomateACvs ELEANOR KELLON VMD HENRY ROSENBERG MD 《Veterinary surgery : VS》1990,18(6):479-482
Signs of malignant hyperthermia, including progressive increases in PaCO2 , skin temperature and heart rate, and elevated serum levels of potassium, inorganic phosphate, and creatine kinase, were identified in a halothane-anesthetized horse. Treatment was discontinuing halothane administration, applying ice and cold fluids, and hyperventilating with 100% oxygen. After an initial recovery, bilateral hindlimb myopathy and pigmenturia developed. The myopathy resolved after treatment with oral dantrolene, IV fluids, and hydrocortisone. Results of caffeine-halothane challenge, using semimembranosus muscle collected 2 weeks after the episode, were considered within normal limits for horses. The intraoperative abnormalities were evidently predictive of postanesthetic myopathy but the cause in this horse remained unclear. 相似文献
19.
Lalko CC Deppe E Ulatowski D Lutgen A Hart AP Patton EA Lunn DP Suresh M Darien BJ 《Veterinary immunology and immunopathology》2003,91(2):119-134
Acute inflammatory diseases, such as colic, septicemia and endotoxemia are common in equines and have been shown to be correlated to vascular injury and thrombosis. In humans with similar thrombotic conditions, P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1)-mediated platelet-leukocyte adhesion contributes to the pathogenesis of these disorders through the generation of inflammatory mediators and tissue factor. As such, we hypothesized that a P-selectin-PSGL-1 (platelet-leukocyte) interaction, similar to that in humans, may also exist in the horse. The objective of this study was to investigate phenotypic and morphological properties of equine platelet activation with a focus on CD62P (P-selectin) expression and CD62P mediated platelet-leukocyte interactions. To study high levels of platelet activation, we used 1 U/ml thrombin to induce secondary, irreversible aggregation in both human and equine platelets. Addition of glycyl-L-prolyl-L-arginyl-L-proline amide (GPRP) prior to thrombin activation blocked fibrin polymerization, allowing the use of flow cytometry to study alpha-granule expression as a measure of platelet activation. Thrombin activation resulted in high levels of activation, measured as P-selectin expression, in both humans and equines. Interestingly, our research illustrates that in healthy horses, P-selectin is also constitutively expressed on 20-25% of resting platelets. This finding is in direct contrast to humans, in which P-selectin expression is negligible (<5%) in the absence of agonist activation. The high baseline level of P-selectin expression among equine platelets may suggest that they are primed for leukocyte adhesion, possibly resulting in prothrombotic conditions. This phenomenon could be of significant clinical relevance, as it may be related to the rapid clinical decline often seen in equine patients with colic and endotoxemia, where vascular injury and thrombotic complications compromise patient survival. Based on these findings, further investigation into the mechanisms of platelet P-selectin-mediated inflammation and platelet-leukocyte mediated vascular injury in the horse appears warranted. 相似文献
20.
In the Swiss horse population, the prevalence of conspicuous behaviours (behavioural disorders and stable vices) was recorded with a written questionnaire in a representative survey among 1861 horse yards, and the occurrence of the stereotypic behavioural disorders crib-biting, weaving and boxwalking was analysed with emphasis on their association with horse specific (breed, age, sex) and environmental factors (e.g. housing system, nutrition, management and utilisation). 622 horse yards with a total number of 2536 horses answered to the questionnaire, and conspicuous behaviours were described for 418 horses (16.5%). Thereof, the most common stereotypic behavioural disorders with a potential negative impact on animal welfare, crib-biting, weaving, and/or boxwalking were named for 89 horses (3.5%). Stable vices (e.g. shying, bucking, aggressivity against humans) were noted for 47 horses (1.9%). For 281 horses (11.1%) conspicuous behaviours such as pawing, lip-liking, head shacking, kicking stall were given; these can be categorised as behavioural disorders or as stable vices depending on their intensity and causation. Data analysis data revealed a number of statistically significant associations between genetic factors (breed), housing, management practices, utilisation and the three stereotypies. The strongest influence on the degree of behavioural disorders had the breed as well as the extent of direct social contact with other horses, free movement on pasture, feeding pattern and regular utilisation. 相似文献