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1.
Transplantation of normal bone marrow cells to a gray collie dog with cyclic neutropenia resulted in normal granulocytopoiesis. The finding suggests that cyclic neutropenia occurs because the hematopoietic stem cells are defective. Because of the similarity of human and canine cyclic neutropenia, it also suggests that the human disease may be curable by marrow transplantation. 相似文献
2.
Streptomycin varying in potency from 100 to 500 units/mg. has been administered to 14 dogs intravenously, intramuscularly, and orally in amounts of 100,000 to 420,000 units. High blood levels of streptomycin were observed after parenteral administration and 23 to 65 per cent was excreted in the urine of normal dogs. After 4 or 5 hours only small amounts were detected in the blood. The maintenance of blood levels was no better with intramuscular than with intravenous administration. Following the oral administration of as much as 420,000 units of streptomycin, it could not be detected in the plasma, but up to 3.9 per cent was recovered from the urine. 相似文献
3.
There is evidence that the golden hamster (Cricetus auratus) is the animal of choice for the isolation of leptospirae, especially of the Leptospira canicola type since young guinea pigs and mice are resistant to infection and rats are entirely refractory. Both the classical strain, L. icterohaemorrhagiae and L. canicola on isolation have been found to produce a fatal infection in hamsters. The present report deals with the isolation of L. canicola in two instances by the injection intraperitoneally into hamsters of urine obtained from dogs ill with suspected leptospirosis. Each of the dogs was apparently the source of infection for a human case of Canicola leptospirosis. The classical strain L. icterohaemorrhagiae was isolated from the dog for the first time in the United States. In this instance the organism was isolated by injecting both whole blood and urine from the patient intraperitoneally into young hamsters. The injection into hamsters of suitable material from patients infected with L. canicola and L. icterohaemorrhagiae is followed by a fatal leptospirosis in the test animal. 相似文献
4.
NAHAS GG 《Science (New York, N.Y.)》1959,129(3351):782-783
The compound 2-amino-2(hydroxymethyl)1,3-propane diol was administered intravenously to apneically oxygenated dogs over a 1-hour period. Arterial blood pH remained normal, and an estimated 18 to 28 percent of the CO(2) produced during apnea was recovered in the urine. 相似文献
5.
12条健康幼犬经血液学检查确认无附红细胞体感染后,随机分为对照组和消化道接种组,将奶牛附红细胞体阴性菌血和阳性菌血分别经呼吸道接种对照组和消化道接种组各犬,逐日采血,测定其红细胞感染率,并在红细胞感染率最高的时候,测定其生理指标、血液常规指标及血液生化指标。本试验结果表明,消化系统接种组接种前后各犬体温、脉搏、呼吸、血红蛋白和一分钟胆红素无明显差异(P>0.05);红细胞感染率、红细胞总数、白细胞总数和总胆红素差异显著(P<0.05),红细胞感染率最高可达30%。对照组没有明显变化。试验结果表明,消化道可以感染该病。 相似文献
6.
R M Weinshilboum F A Raymond L R Elveback W H Weidman 《Science (New York, N.Y.)》1973,181(103):943-945
Dopamine-beta-hydroxylase activity is released into the blood with catecholamines from the adrenal medulla and sympathetic nerves. This enzyme activity has been measured in the blood of 317 normal children and 227 normal adults. A significant sibling-sibling correlation of serum dopamine-beta-hydroxylase values was found in the 94 sibling pairs tested. Frequency distributions of serum enzyme values in both children and adults suggest the existence of two populations with regard to serum activity of this enzyme. 相似文献
7.
Cerebrospinal fluid production by the choroid plexus and brain 总被引：7，自引：0，他引：7
T H Milhorat M K Hammock J D Fenstermacher V A Levin 《Science (New York, N.Y.)》1971,173(994):330-332
The production of cerebrospinal fluid and the transport of (24)Na from the blood to the cerebrospinal fluid were studied simultaneously in normal and choroid plexectomized rhesus monkeys. Choroid plexectomy reduced the production of cerebrospinal fluid by an average of 33 to 40 percent and the rate of appearance of (24)Na in the cerebrospinal fluid and its final concentration were proportionately reduced. In both normal and plexectomized animals, (24)Na levels were found to be markedly greater in the gray matter surrounding the ventricles and in the gray matter bordering the subarachnoid space. That sodium exchanges in these two general areas of the brain may be linked to the formation of the cerebrospinal fluid is discussed here. 相似文献
8.
Plasma natriuretic activity was evoked in cows and dogs by infusion of saline with or without dextran. Deproteinized samples were fractionated on both Sephadex and Bio-Gel columns; the activity was separated, the approximate molecular weight being in the region of 1000. Incubation with chymotrypsin destroyed the activity, suggesting that it might be a polypeptide. A similar activity in blood resulted from intracarotid injection of either oxytocin or either of two synthetic analogs. Possibly the latter are saluretic by virtue of a releasing action on some intracranial structure for another natriuretic peptide. 相似文献
9.
10.
由于DEA1.1血型是临床上犬最常见和最具免疫原性的血型,因此发达国家很重视DEA1.1血型的调查研究,但鲜有中国本土犬血型调查研究的报道.该研究通过血型鉴定卡法和抗体法调查了236条中华田园犬的血型,发现54.2%中华田园犬的血型为DEA1.1~+(128/236),45.8%的犬血型为DEA1.1~-(108/236).相对于雄性(48.1%),雌性中华田园犬DEA1.1的阳性率较高,达到了67.1%.研究结果表明,由于DEA1.1血型在输血中的重要意义和其在中华田园雄性犬中较低的出现率,建议可将雄性纯种中华田园犬作为紧急献血犬;在给其他犬种输血之前需要进行DEA1.1血型鉴定. 相似文献
11.
[目的]评价中药处方犬粮的安全性及其对犬创伤恢复能力的影响。[方法]选取1龄中华田园犬8只,随机分为试验组和对照组,每组4只、雌雄各半。预试1周后,对照组饲喂普通犬粮、试验组饲喂中药处方犬粮4周,于试验开始前和结束后测定体重并采血,分析体重和血液指标的变化。对试验犬进行腹壁切开术,观察各组犬创口愈合情况。[结果]中药处方犬粮能极显著提高犬体重和增加犬血液中红细胞、白细胞、中性粒细胞、淋巴细胞数目(P0.01),显著增加血红蛋白和单核细胞数目(P0.05)。试验前后,试验组犬碱性磷酸酶含量显著增加(P0.01),其他血液生化指标变化不显著(P0.05)。剖腹伤口愈合时间试验组显著短于对照组(P0.05)。[结论]该处方犬粮可安全用于宠物临床,对创口愈合具有一定的促进作用。 相似文献
12.
Cyclic adenosine monophosphate and hypertension in rats 总被引：7，自引：0，他引：7
M S Amer 《Science (New York, N.Y.)》1973,179(75):807-809
Aortas from spontaneously hypertensive and stress hypertensive rats contained significantly lower intracellular concentrations of cyclic adenosine monophosphate than did their respective controls. Adenylate cyclase activity was normal but was less responsive to stimulation, while phosphodiesterase activity (especially the low Michaelis-Menten constant form) was significantly elevated. Human aortas contained two forms of phosphodiesterase that were similar to those in rat aortas. 相似文献
13.
将明胶墨汁溶液注入到15例狗脊髓动脉系统内,观察其灰质内动脉构筑,结果如下:供应脊髓灰质内的动脉分别自脊髓背外侧动脉、沟动脉和周缘支发出。背角内侧动脉和背角外侧动脉分布于背角的头和颈部。中间外侧动脉发出分支到灰质侧角。供应灰质腹角的动脉有腹角外侧、腹侧和内侧动脉。中间内侧动脉分布于灰质中间带的内侧2/3。背连合动脉供应背侧灰质连合。在中央管两侧各有一条中央管旁动脉,纵向将各沟连合动脉串连一起。分布于灰质内的相邻各动脉间均存在吻合,构成灰质内动脉网。 相似文献
14.
通过透皮给药.考察雷公藤多苷纳米乳(TWP-NE)治疗SD大鼠佐荆性关节炎的增效减毒作用.用TWP-NE和雷公藤多苷片(TWP)对SD大鼠佐剂性关节炎进行治疗,每隔4 d测量足部体积,28d后测定血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、尿素氮(BUN)和尿液中尿蛋白含量,并取肝、肾进行组织病理学观察.结果显示:TWP-NE对佐荆性关节炎的治疗效果优于TWP.与空白对照组相比,TWP-NE组血清ALT、AST,BUN以及尿液中尿蛋白含量无显著性差异:TWP组血清ALT、AST、BUN以及尿液中尿蛋白含量显著升高.病理组织学观察显示TWP组肝、肾的损伤更严重.说明用纳米乳对雷公藤多苷进行包合可以提高药效并降低其对肝、肾的毒性. 相似文献
15.
Vitamin A deficiency effect on retina: dependence on light 总被引：3，自引：0，他引：3
The effects of vitamin A deficiency in the rat eye, as measured by the electroretinogram and changes in rhodopsin content, are critically dependent upon the levels of illumination to which the animals are exposed daily. Depleted animals kept in darkness maintained virtually normal electroretinogram function and rhodopsin content for 5 to 6 months while those kept in weak cyclic light lost rhodopsin continuously. A fraction of the retinol released from rhodopsin during illumination disappears presumably from the pigment epithelium into the blood and becomes unavailable for rhodopsin regeneration. A sequence of three first-order reactions was assumed to estimate the rate constant of this disappearance (0.03 per hour). Computer simulation supporting the experimental data illustrates the dependence of the retinal abnormalities on light. 相似文献
16.
为了进一步开发利用川芎和黄芪,以受孕大鼠为试材,观察川芎、黄芪对大肠杆菌内毒素致妊娠高血压综合征(妊高征)大鼠血压、尿蛋白及胎盘、胎仔发育情况的影响。结果表明:与正常妊娠组比较,妊高征模型对照组尿蛋白和血压水平明显升高,说明造模成功。川芎和黄芪组与模型对照组比较,尿蛋白和血压均降低,硫酸镁阳性对照组血压比模型对照组低,尿蛋白略有下降,但差异无统计学意义。川芎和黄芪组死胎率较模型对照组明显降低,畸胎率亦显著下降。川芎、黄芪能够有效降低妊高征大鼠血压和尿蛋白,促进妊高征大鼠胎盘供血和胚胎发育。 相似文献
17.
An angiotensin II antagonist, [1-sarcosine, 8-alanine]-angiotensin II, was given intravenously to anesthetized dogs with thoracic caval constriction and ascites to investigate the role of angiotensin II in the control of arterial pressure. The antagonist produced a striking fall in arterial pressure and in aldosterone secretion and an accompanying increase in plasma renin activity. In a control experiment, normal anesthetized dogs were given the angiotensin analog, but it failed to reduce arterial pressure or to influence plasma renin activity. In conscious dogs with caval constriction, the antagonist produced essentially the same drop in arterial pressure as observed in anesthetized animals. These results suggest an important role for angiotensin II in the maintenance of arterial pressure by its action on specific receptor sites in arteriolar smooth muscle and in the adrenal cortex. 相似文献
18.
将100羽35日龄伊沙蛋鸡随机均分为高钙高蛋白组(饲喂含钙36.8 g/kg、蛋白242.5 g/kg的日粮)和对照组(饲喂含钙8.5 g/kg、蛋白175.3 g/kg的日粮)。在饲喂高钙高蛋白日粮32 d时,对2组鸡作动脉血血气分析与血清电解质测定,并利用结肠造口术收集尿液,测定鸡尿液中电解质的变化,以探讨高钙高蛋白日粮对青年蛋鸡体液酸碱度和电解质变化的影响。结果表明,高钙高蛋白日粮能致鸡发生高尿酸血症,同时引起鸡腹泻,使鸡尿量增加,尿液pH较对照显著升高。与对照组相比,高钙高蛋白组鸡血液pH、碳酸氢根及剩余碱显著升高,动脉血氧分压、二氧化碳分压和血氧饱和度显著降低;血清无机磷和钾显著降低,血清尿酸、钙显著升高,镁、钠和氯离子稍有变化,但在统计学上差异不显著;尿液中尿酸、钙、氯的相对含量和24 h总量显著升高,镁相对含量和24 h总量显著下降。说明高钙高蛋白日粮在引起青年蛋鸡高尿酸血症的同时,能致鸡代谢性碱中毒和电解质代谢紊乱。 相似文献
19.
[目的]为建立3种毛色貉生物学特性数据库提供理论依据。[方法]以红褐色乌苏里貉、野生乌苏里貉和吉林白貉为研究对象,利用外周血淋巴细胞培养法制备染色体标本,对3种毛色乌苏里貉的染色体数目进行比较。[结果]红褐色乌苏里貉和野生乌苏里貉二倍体细胞染色体数为56的细胞频率分别为86%和83%,表明红褐色乌苏里貉和野生乌苏里貉种群体细胞的染色体众数为56。吉林白貉二倍体细胞的染色体数目为56的细胞频率为70%,低于其他2种貉。[结论]红褐色乌苏里貉和野生乌苏里貉的染色体众数相同,均为56;吉林白貉的染色体众数为56或57,其染色体数目存在多态现象。 相似文献
20.
L Raymond R B Weiskopf M J Halsey A Goldfien E I Eger J W Severinghaus 《Science (New York, N.Y.)》1972,176(40):1250-1252
Breathing a mixture of 75 percent helium and 25 percent oxygen instead of 75 percent nitrogen and 25 percent oxygen reduced the occurrence of dangerous cardiac arrhythmias after ligation of the circumflex coronary artery in open-chest dogs anesthetized with pentobarbital. In dogs not subjected to circumflex ligation, the sensitivity of blood pressure, heart rate, and extrasystoles to epinephrine injected intravenously was not altered by the substitution of helium for nitrogen; however, helium did reduce the baseline heart rate and the concentration of endogenous plasma catecholamines. The antiarrhythmic effect of helium may thus be mediated by changes in sympathetic activity. 相似文献