共查询到18条相似文献，搜索用时 203 毫秒
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尼帕病毒病（Nipah virus disease,NV)是一个新近被认识的人畜共患病，该病于1999年3月首次被分离。人和家畜通过接触感染动物而被感染，依其在马来西亚最初被检测到的地名而将其命名为尼帕病毒病（NV），它和另一个新近认识的病毒－亨得拉病毒（Hendra ivrus，HIV)具有一定的同源关系。HIV于1994年在澳大利亚亨得拉镇首次发现并以此地而命名。NV和HV都属于副粘病毒科家族成员，虽然这些病毒仅仅能引起一些病例的爆发，但因它们具有感染突主范围广，感染人类能引起高死亡率等生物特性，已引起了公众对尼帕病毒的重视及对基对公司健康影响的关注。 相似文献
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尼帕病毒病是由尼帕病毒（Nipah virus）感染引起的人畜共患病。其特征为急性发热性脑炎和高死亡率。病原体是副粘病毒科副粘病毒亚科的亨尼帕属,毒力强。本文就尼帕病毒病样品采集技术进行简要概述。 1 采集样品 可疑动物的脑、肺、。肾、脾、肝、淋巴结都应采样送检。采集的样品应在低温和密封状态下运输到实验室。 相似文献
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尼帕病毒病是由尼帕病毒（Nipah virus,Ni V）引起的人畜共患病。尼帕病毒主要侵害中枢神经系统和呼吸系统,引起多种动物和人类严重脑炎和呼吸系统疾病,出现急性发热、头痛和不同程度的意识障碍。由于发病率和死亡率高,因此,Ni V被美国疾病控制中心列为最危险的生物安全4（P—4）级病原。 相似文献
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Tanimura N Imada T Kashiwazaki Y Shamusudin S Syed Hassan S Jamaluddin A Russell G White J 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2004,66(10):1263-1266
The immunohistochemical reactivity of seven clones of mouse monoclonal antibodies raised to Nipah virus antigens were investigated using formalin-fixed, paraffin embedded porcine and equine lung tissues from experimental Nipah and Hendra virus infection, respectively. Either microwave irradiation or enzymatic digestion effectively unmasked the viral antigens in formalin-fixed, paraffin-embedded tissue sections. Four clones showed positive reaction to both Nipah virus-infected porcine lung tissue and Hendra virus-infected equine lung tissue. Two clones (11F6 and 13A5) reacted with Nipah virus-infected porcine lung tissue, but not with Hendra virus-infected equine lung tissue. These Nipah virus-specific monoclonal antibodies may therefore be useful for immunohistological diagnosis of Nipah virus infection and for further research on Nipah virus pathogenesis. 相似文献
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尼帕病毒(Nipah virus,NiV)是新近发现的引发脑部炎症或呼吸道疾病等重症的新型人畜共患病病毒,该病毒最初于1999年马来西亚尼帕镇的1名脑炎患者脑脊液中分离获得,至今已经历了数次大的流行,造成严重的经济损失和人员伤亡.该病毒可由动物传播给人,也可直接人与人传播,并且能够在猪等动物身上引起严重疾病,狐蝠科的果蝠是该病毒的天然宿主.NiV感染人后的病死率极高,并且目前还没有有效的疫苗和治疗措施,生物危害性极大,被列为生物安全4级病原(BSL4).笔者从NiV的分类及分型、基因和蛋白质组、流行和分布、疫苗研制、临床和病理变化以及实验室诊断技术等方面对NiV做简单的概述. 相似文献
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尼帕病毒(Ni V)和亨德拉病毒(HeV)属于副黏病毒亚科的亨尼帕病毒属的成员。Ni V和HeV感染引起新的两种重要的人兽共患传染病。有关APMV-1(NDV)的发病和流行以及病原学研究认为APMV-1不断发生演化,新的基因型不断产生,对不同宿主的致病力不断变化,病毒感染的宿主谱不断扩大。本文简要介绍两种新的人兽共患传染病和APMV-1对鹅、鸭、猪的感染研究现状,就APMV-1宿主感染谱与演化加以分析,思考新的动物副黏病毒病防控对策。 相似文献
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P T Hooper M M Williamson 《Veterinary Clinics of North America: Equine Practice》2000,16(3):597-603, xi
The most important clinical and pathological manifestation of Hendra virus infection in horses and humans is that of severe interstitial pneumonia caused by viral infection of small blood vessels. The virus is also capable of causing nervous disease. Hendra virus is not contagious in horses and is spread by close contact with body fluids, such as froth from infected lungs. Diagnosis should be based on the laboratory examination of blood, lung, kidney, spleen, and, if nervous signs are present, also of the brain. Evidence of infection with the more recently identified and related Nipah virus was found in the brain of one horse in which there was inflammation of the meningeal blood vessels. Fruit bats, especially Pteropus s., have been incriminated as the natural and reservoir hosts of both Hendra and Nipah viruses. 相似文献
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OBJECTIVE: To examine piggeries in Queensland for evidence of infection with Hendra virus and Nipah virus. DESIGN: A serological survey was designed to provide 99% confidence of detecting at least one infected pig herd in Queensland, assuming that for each virus, at least 5% of herds would have been exposed to virus and that at least 40% of the finisher pigs in these herds would have detectable antibodies to virus. PROCEDURE: A two stage sampling regimen was used. All samples were tested with serum neutralisation tests developed and performed at the Australian Animal Health Laboratory. RESULTS: There was no evidence of antibody to either virus in the 500 samples collected from 100 herds. CONCLUSION: The results of the survey support a case that commercial pigs in Queensland are free of both Hendra virus and Nipah virus infections. 相似文献
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Imada T Abdul Rahman MA Kashiwazaki Y Tanimura N Syed Hassan S Jamaluddin A 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2004,66(1):81-83
Eight clones of monoclonal antibodies (Mabs) to Nipah virus (NV) were produced against formalin-inactivated NV antigens. They reacted positive by indirect immunofluorescent antibody test, and one of them also demonstrated virus neutralizing activity. They were classified into six different types based on their biological properties. These Mabs will be useful for immunodiagnosis of NV infections in animals and further research studies involving the genomes and proteins of NV. 相似文献
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Raj Kumar Singh Ruchi Tiwari Senthilkumar Natesan Rekha Khandia 《The Veterinary quarterly》2019,39(1):26-55
Nipah (Nee-pa) viral disease is a zoonotic infection caused by Nipah virus (NiV), a paramyxovirus belonging to the genus Henipavirus of the family Paramyxoviridae. It is a biosafety level-4 pathogen, which is transmitted by specific types of fruit bats, mainly Pteropus spp. which are natural reservoir host. The disease was reported for the first time from the Kampung Sungai Nipah village of Malaysia in 1998. Human-to-human transmission also occurs. Outbreaks have been reported also from other countries in South and Southeast Asia. Phylogenetic analysis affirmed the circulation of two major clades of NiV as based on currently available complete N and G gene sequences. NiV isolates from Malaysia and Cambodia clustered together in NiV-MY clade, whereas isolates from Bangladesh and India clusterered within NiV-BD clade. NiV isolates from Thailand harboured mixed population of sequences. In humans, the virus is responsible for causing rapidly progressing severe illness which might be characterized by severe respiratory illness and/or deadly encephalitis. In pigs below six months of age, respiratory illness along with nervous symptoms may develop. Different types of enzyme-linked immunosorbent assays along with molecular methods based on polymerase chain reaction have been developed for diagnostic purposes. Due to the expensive nature of the antibody drugs, identification of broad-spectrum antivirals is essential along with focusing on small interfering RNAs (siRNAs). High pathogenicity of NiV in humans, and lack of vaccines or therapeutics to counter this disease have attracted attention of researchers worldwide for developing effective NiV vaccine and treatment regimens. 相似文献