共查询到20条相似文献，搜索用时 515 毫秒
1.
Xylazine＋DDHE合剂对大鼠的ED50值测定及剂量确定 总被引：2，自引：0，他引：2
以翻正反射消失和痛阈增加３０％为指标,应用序贯法测定ｘｙｌａｚｉｎｅ＋ＤＨＥ合剂腹腔给药对大鼠的麻醉半数有效量和镇衮地数有效量;在此基础上,确定给药剂量并检验给药剂量是否合理。结果表明,ｘｙｌａｚｉｎｅ＋ＤＨＥ合剂对大鼠的麻醉ＥＤ５０为８．３６４ｍｇ／ｋｇ,镇痛ＥＤ５０为７．８０２ｍｇ／ｋｇ;确定麻醉剂量为１５．００ｍｇ／ｋｇ,镇痛剂量为１０．０００ｍｇ／ｋｇ。进一步的麻醉和镇痛实验显示,麻醉剂量 相似文献
2.
二甲苯胺噻嗪对大鼠镇痛和麻醉的ED50及时效的测定 总被引：1，自引：0，他引：1
大鼠腹腔注射二甲苯胺噻嗪（ｘｙｌａｚｉｎｅ）后,采用序贯法（ＳｅｑｕｅｎｔｉａｌＡｎａｌｙｓｉｓ）测定对大鼠镇痛和麻醉的半数有效量（Ｍｅｄｉａｎ Ｅｆｆｅｃｔｉｖｅ Ｄｏｓｅ,ＥＤ５０）结果,镇痛的ＥＤ５０值１５．５２４ｍｇ／ｋｇ麻醉的ＥＤ５０值为４５．０９６ｍｇ／ｋｇ,在增加一个公比（ｒ镇痛＝１．５０７,ｒ麻醉＝１．１４３）的基础上,我们取２５．０ｍｇ／ｋｇ和５５ｍｇ／ｋｇ用于镇痛和麻醉实验,结 相似文献
3.
给大鼠腹腔注射二氢埃托啡（ＤＨＥ），应用序贯法测定ＤＨＥ对大鼠的镇痛ＥＤ５０值，同时应用热甩尾法观察了大鼠在镇痛状况下痛阈的变化，以及不同剂量的ＤＨＥ对大鼠痛阈的影响。 相似文献
4.
速眠新与异戊巴比妥钠对大鼠的麻醉试验 总被引：1，自引：0，他引：1
用生理盐水１０倍稀释速眠新，麻醉Ｗｉｓｔａｒ大鼠，并与０．３％的异戊巴比妥钠配合麻醉，适于大鼠全胰十二指肠移植的单方及配合麻醉的有效麻醉剂量为０．４５－０．６０ｍｌ／ｋｇ速眠新；０．２ｍｌ／ｋｇ速眠新配合６０ｍｇ／ｋｇ异戊巴比妥钠；０．３ｍｌ／ｋｇ速眠速新配合４０－４５ｍｇ／ｋｇ异戊巴比妥钠；０．４ｍｌ／ｋｇ速眠新配合３０ｍｇ／ｋｇ异戊巴比妥钠。本试验还筛选出适于２０－９０分钟内手术的麻醉剂量，为 相似文献
5.
盐酸双氟沙星对大鼠致畸胎试验 总被引：5，自引：1，他引：4
本试验研究了盐酸双氟沙星对ＳＤ大鼠的致畸性。剂量分别为３００ｍｇ／ｋｇ，ｂ．ｗ．；１５０ｍｇ／ｋｇ．ｂ．ｗ．和５０ｍｇ／ｋｇ ｂ．ｗ．，于大鼠受孕７至１５ｄ经口给药，３００ｍｇ／ｋｇ ｂ．ｗ．和１５０ｍｇ／ｋｇ．ｂ．ｗ．剂量的盐酸双氟沙星显著影响胚胎的生长发育，引起胎鼠死亡和骨骼畸形，其严重程度具有剂量效应关系。 相似文献
6.
复合不育剂对高原鼠兔种群控制作用的研究 总被引：11，自引：1，他引：10
通过室内试验选定致高原鼠兔雌性和雄性不育或抗生育作用且对环境低污染或无污染的不育剂各一种。雌性不育剂的半致死剂ＬＤ５０为８．６８ｍｇ／ｋｇ，半不育剂量ＥＤ５０为２．１１ｍｇ／ｋｇ。雄性不育剂的半致死剂量ＬＤ５０为１２１．４２ｍｇ／ｋｇ，半不育剂量ＥＤ５０为４３．７ｍｇ／ｋｇ。前者的主要作用特点是导致子宫内膜出血、体重下降，从而引起胚胎流产或吸收，而后者的作用部分是睾丸，对曲细精小管内精子、精子细胞 相似文献
7.
8.
对一群经两次检疫均为结核菌素阳性并经临床学、病理解剖学和细菌学证实为结核杆菌感染奶牛，随机选择２０头奶，每日按２５ｍｇ／ｋｇ体重投与异烟肼复合剂，连服６０日，接着再按上述剂量每隔一天给药一次连服６０次。结果感染牛在治疗后的７０天转阴率为５０％；治疗后１６５天转阴率为８０．１％；未经治疗的７头对照牛仍呈阳性。 相似文献
9.
对５头驴先后用０．０１，０．０１５，０．０２ｍｌ／ｋｇ体重剂量的８４６合剂麻醉３０ｍｉｎ后的血气和酸碱值进行研究。结果：０．０１５ｍｌ／ｋｇ，和０．０２ｍｌ／ｋｇ体重剂量使血液ＰＨ，ＢＥ，ＳＢＣ值极显著升高，ＳＢＥ值显著升高，而０．０１ｍｌ／ｋｇ体重剂量对上述４项指标无显著影响；三种剂量的８４６合剂对ＰＯ２，ＰＣＯ２，ＨＣＯ３，ＳＯ２％，ＣＯ２ＣＴ均无显著影响。 相似文献
10.
鸡胆汁对鼠的抗疲劳,耐缺氧及体重的影响 总被引：1，自引：0，他引：1
本文首次揭示了鸡胆汁对动物抗疲劳，耐缺氧及体重的影响，实验结果表明：鸡胆汁按０．２ｇ／ｋｇ和０．５ｇ／ｋｇ剂量口服给药，能明显延长小鼠的爬杆时间，显著抑制小鼠和大鼠的增重率及日增重，而对小鼠的游泳时间和组织耐缺氧则无明显影响，鸡胆汁经口服给药的小鼠急性ＬＤ５０，大于１０５６０ｍｇ／ｋｇ，属实际无毒者。 相似文献
11.
12.
The effect of opioid and acepromazine premedication on the anesthetic induction dose of propofol in cats 
下载免费PDF全文
下载免费PDF全文 Hall TL Duke T Townsend HG Caulkett NA Cantwell SL 《The Canadian veterinary journal. La revue veterinaire canadienne》1999,40(12):867-870
The median effective dosage (ED50) for induction of anesthesia with propofol was determined by using the up-and-down method in 31 unpremedicated cats, in 30 cats premedicated with butorphanol, 0.4 mg/kg body weight (BW), and acepromazine, 0.1 mg/kg BW, intramuscularly, and in 30 cats premedicated with morphine, 0.2 mg/kg BW, and acepromazine, 0.1 mg/kg BW, intramuscularly. The dose required for a satisfactory anesthetic induction in 50% of unpremedicated cats (ED50) was 7.22 mg/kg BW and of premedicated cats was 5.00 mg/kg BW. The reduction in dose was statistically significant in both premedicated groups compared with no premedication. There was no significant difference in ED50 between premedication regimes. Cyanosis was the most common adverse effect observed in all groups following anesthetic induction with propofol. 相似文献
13.
Five adult dogs were used to determine whether acepromazine maleate (ACP), administered IM, decreases the maintenance requirement of halothane and to measure any decrease for the ACP dosages of 0.02, 0.04, 0.06, 0.08, 0.10, and 0.20 mg/kg. The value minimal alveolar concentration, a measure of anesthetic potency, was used as the measure of anesthetic requirement of halothane before and after ACP was administered. All dogs were randomly exposed to each dosage of ACP, as well as to control of 0.2 ml of sterile water. At all dosages of ACP, the decrease in the minimal alveolar concentration of halothane was significant (P less than or equal to 0.05) when compared with that of the control. The decreases at the 0.04 and 0.20 mg/kg dosages were significantly (P less than or equal to 0.05) greater than those at the 0.02 and 0.06 mg/kg dosages. Halothane requirements at all other ACP dosages (0.08 and 0.10 mg/kg) were not significantly different from each other or from those at any of the other dosages. The percentage of decrease in anesthetic requirement after ACP was administered varied from 34% to 46%, with a mean decrease of 40%. The largest decrease was recorded at the dosage of 0.04 mg/kg. 相似文献
14.
为提供胃动力注射液的安全性毒理学评价资料,本试验采用改良Ｋａｒｂｅｒ法测定小鼠ＬＤ５０;以剂量递增法测定蓄积性和耐受性,分别以剂量１．３８１,０．５８２,０．２７６ｍｇ／ｋｇ为３个试验组,设阴性和阳性对照组进行小鼠骨髓微核试验,分别以剂量２．１５４,１．０７７,０．５３９ｍｇ／ｋｇ为３个剂量组,设阴性和阳性对照组进行了有子畸形试验,结果表明：其ＬＤ５０为２．７６２ｍｇ／ｋｇ,蓄积系数大于５．３,无明显蓄积毒性和耐受性（Ｐ〉０．０５）,小鼠骨髓微核试验和精子畸形试验结果均为阴性。 相似文献
15.
为了探索速眠新Ⅱ与舒泰复合麻醉剂对比格犬的麻醉效果,选用健康比格犬20只,用速眠新Ⅱ(0.6mg/kg)与舒泰(0.75mg/kg)混合肌注诱导麻醉,30min后给予该混合制剂静脉维持麻醉(每小时速眠新Ⅱ0.2mg/kg,舒泰0.3mg/kg),随麻醉时间延长逐渐减量。结果显示,速眠新Ⅱ与舒泰复合麻醉剂,诱导麻醉迅速,维持麻醉效果安全、稳定,镇痛及肌松等效果良好,麻醉期间能保证动物的正常心肺功能。试验表明该复合麻醉剂是一种理想的麻醉剂,能满足各种外科手术操作需求。 相似文献
16.
盐酸赛拉嗪对家兔麻醉效果的研究 《畜牧与饲料科学》2022,43(6):114-118
[目的]探究盐酸赛拉嗪对家兔的麻醉效果。[方法]选取新西兰兔12只,随机分为耳缘静脉注射（IV）保定组、臀部肌肉注射（IM）保定组、IV未保定组、IM未保定组,每组3只;按照不同给药途径给予家兔3 mg/（kg·BW）盐酸赛拉嗪,给药后保定处理方式为仰卧保定四肢及头部,未保定的家兔自然俯卧;第1次给药后30 min,再以相同给药途径给予家兔2 mg/（kg·BW）盐酸赛拉嗪;于给药前10 min以及第2次给药后5、30、60 min监测家兔基本生命体征及麻醉反应指标。[结果]给予盐酸赛拉嗪后不同时间,4组家兔呼吸频率和脉搏次数与给药前相比均显著（P<0.05）或极显著（P<0.01）降低;给药后60 min IM保定组脉搏次数最低,显著（P<0.05）低于IV未保定组。4组家兔给药后30 min直肠温度与给药前相比均显著（P<0.05）降低;除IV未保定组外,给药后60 min各组家兔直肠温度与给药前相比极显著（P<0.01）降低;给药后60 min IM保定组的直肠温度最低,极显著（P<0.01）低于IV未保定组。IM保定组家兔给药后不同时间均未出现翻正反射、睫毛反射和疼痛反射;IV未保定组在给药后60 min,3只家兔均出现翻正反射、睫毛反射和疼痛反射。IM保定组家兔的麻醉期最长,显著（P<0.05）长于IV保定组,极显著（P<0.01）长于IV未保定组和IM未保定组。[结论]用盐酸赛拉嗪麻醉家兔时应使用IM给药途径,推荐首次给药剂量为3 mg/（kg·BW）,之后30 min再补充2 mg/（kg·BW）,给药后应即刻保定确实。 相似文献
17.
Antagonism of ketamine-xylazine (85 mg of ketamine/kg of body weight and 15 mg of xylazine/kg, IM) anesthesia in rats by yohimbine (YOH; 1, 5, 10, and 20 mg/kg, IP), tolazoline (TOL; 10, 20, or 50 mg/kg, IP), 4-aminopyridine (4-AP; 1 or 5 mg/kg, IP), or a combination of yohimbine and 4-aminopyridine (YOH:4-AP, 1 mg/kg:1 mg/kg or 5 mg/kg:1 mg/kg, IP) was studied. All dosages of YOH, TOL, 4-AP, and YOH:4-AP reduced the time to appearance of corneal and pedal reflexes. Only TOL was effective in reducing time to appearance of the crawl reflex and recovery time. Yohimbine, 4-AP, YOH:4-AP, and TOL were effective in reversing respiratory depression caused by ketamine-xylazine anesthesia, but anesthetic-induced hypothermia was not antagonized. When given to non-anesthetized rats, the antagonists had little influence on respiratory rate, but all antagonists caused significant (P less than 0.05) reduction in core body temperature for at least 90 minutes. When YOH was used as an anesthetic antagonist at dosage of 20 mg/kg, 20% mortality was observed and was attributable to acute respiratory arrest. The use of 4-AP and YOH:4-AP at the dosages studied induced moderate to severe muscular tremors. In conclusion, TOL at dosage of 20 mg/kg given IP, appears to be an appropriate antagonist for ketamine-xylazine anesthesia in rats. 相似文献
18.
探讨Ca2＋，Mg2＋-ATP酶与小型猪复合麻醉剂全麻作用的关系，以判断该酶是否为该制剂作用的靶位之一。选取84只SD大鼠，先随机抽取12只为对照组，其余随机均分为高剂量小型猪复合麻醉剂组（腹腔注射7．5mg／kg）和低剂量小型猪复合麻醉剂组（腹腔注射5mg／kg），每个剂量组又随机均分为麻醉组、恢复I组和恢复Ⅱ组等3个亚纽。对照组腹腔注射生理盐水10mL／kg，5min后断头取材；麻醉组、恢复I组和恢复Ⅱ组分别在翻正反射消失即刻、翻正反射恢复即刻和大鼠可直线爬行后断头取材，在生理盐水冰面上取脑，用4℃生理盐水将脑上的血迹冲洗干净，迅速分离双侧大脑皮层、海马、小脑、脑干、丘脑，立即液氮冷冻。制备脑粗突触体，采用比色法测定ca2＋，Mg2-ATP酶活性。结果表明，小型猪复合麻醉剂的全麻作用与抑制小脑和丘脑突触体Ca2＋，Mg2＋-ATP酶活性相关，此酶可能是小型猪复合麻醉剂全麻作用的靶位之一。 相似文献
19.
Oku K Ohta M Yamanaka T Mizuno Y Fujinaga T 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2005,67(6):569-575
To investigate an adequate infusion rate of propofol for total intravenous anesthesia (TIVA) in horses, the minimum infusion rate (MIR) comparable to the minimum alveolar anesthetic concentration (MAC) of inhalation anesthetic was determined under constant ventilation condition by intermittent positive pressure ventilation (IPPV). In addition, arterial propofol concentration was measured to determine the concentration corresponding to the MIR (concentration preventing reaction to stimulus in 50% of population, Cp(50)). Further, 95% effective dose (ED(95)) was estimated as infusion rate for acquiring adequate anesthetic depth. Anesthetic depth was judged by the gross purposeful movement response to painful stimulus. MIR and Cp(50) were 0.10 +/- 0.02 mg/kg/min and 5.3 +/- 1.4 microg/ml, respectively. ED(95) was estimated as 0.14 mg/kg/min (1.4MIR). 相似文献
20.
B L Blagburn C M Hendrix D S Lindsay J L Vaughan D I Hepler J C Wright 《American journal of veterinary research》1992,53(4):513-516
The efficacy of milbemycin oxime was evaluated at dosages of 0.25, 0.50, and 0.75 mg/kg of body weight in dogs naturally infected with mature Ancylostoma spp, at a dosage of 0.50 mg/kg in dogs with experimentally induced immature and mature A caninum, and at dosages of 0.55 to 0.86 mg/kg in dogs naturally infected with mature Trichuris vulpis. Milbemycin oxime was 95 and 99% effective against mature Ancylostoma spp at dosages of 0.50 and 0.75 mg/kg, respectively, but only 49% effective at a dosage of 0.25 mg/kg. Efficacy was 49% against pulmonary L3-L4 stages of A caninum (36 hours after inoculation), greater than 80% against L4 (120 hours after inoculation) and early L5 stages (216 hours after inoculation), and greater than 90% against experimentally induced mature stages (360 hours after inoculation). Milbemycin oxime was also 97% effective in the removal of mature Tr vulpis from naturally infected dogs. Adverse reactions were not observed following treatment in any of the dogs. 相似文献