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鸡白痢沙门菌病是危害养鸡行业最严重的疾病之一。抗生素的过度使用导致动物源性细菌产生耐药性。而中药复方替代抗生素已成为相关研究的重点和热点。中药复方“四神丸加减”(Sishen Wan Plus and Minus, SSJ)具有涩肠止泻、益气活血、清热利湿解毒等功能,但是SSJ对鸡白痢沙门菌病的影响尚缺乏研究。本研究旨在研究SSJ对感染白痢沙门菌雏鸡的免疫功能和肠道菌群的影响。将90只1日龄雏鸡均分为6组,空白对照组、鸡白痢沙门菌组、SSJ低剂量治疗组(0.4 g/kg)、SSJ中剂量治疗组(0.8 g/kg)、SSJ高剂量治疗组(1.6 g/kg)、抗生素组。通过16S rRNA测序和ELISA等技术探究SSJ对鸡白痢沙门菌病的影响。研究结果显示,SSJ能够显著降低由白痢沙门菌引起的雏鸡绒毛长度降低以及炎性因子水平的升高(P<0.05)。此外,SSJ也能显著缓解由白痢沙门菌引起的雏鸡免疫球蛋白指数的显著降低(P<0.05)。16S rRNA测序结果显示,高剂量SSJ能够显著增加菌群的多样性以及有益菌的丰度。以上结果证实,添加SSJ能够改善白痢沙门菌感染引起的雏鸡免疫功能减... 相似文献
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"雏痢净"对人工感染雏鸡白痢的疗效研究 总被引：1，自引：0，他引：1
对人工感染鸡白痢的艾维茵雏鸡,采用“雏痢净”按高(0.5g/只)、中(0.4g/只)和低(0.3g/只)三个剂量混饲治疗,用2%甲磺酸培氟沙星(药物对照组)、感染不用药(阳性对照组)、不感染不用药(阴性对照组)作为对照。结果:“雏痢净”高、中、低剂量组与2%甲磺酸培氟沙星组对雏鸡白痢均有较高的疗效,其中“雏痢净”高、中剂量组与2%甲磺酸培氟沙星组的治疗效果最好,但三者差异不显著(P>0.05);“雏痢净”各组与2%甲磺酸培氟沙星组的相对增重率极显著高于感染不用药组(P<0.01)。表明:“雏痢净”高、中剂量用药后症状明显减轻且渐恢复,体重也明显增加,其疗效与2%甲磺酸培氟沙星相当。 相似文献
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以鸡白痢沙门氏菌为菌种，对２～３日龄雏鸡进行了人工感染致病的分组药物治疗比较试验。取２１０只雏鸡随机分成７组，除阴性对照组外，每组都接种鸡白痢沙门氏菌，每只鸡的接种量按最小致死量给予。阳性对照组不给药治疗，其中５组分别用泻痢安糖糊高剂量、中剂量、低剂量、中药鸡痢灵和西药可溶性氟哌酸给予治疗，连续用药４ｄ，停药观察７ｄ。结果表明，泻痢安中剂量组的存活率达９０％，即泻痢安中剂量对雏鸡鸡白痢的治疗效果可列各组之首。 相似文献
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将头孢噻呋混悬剂以高、中、低(10、52、.5 mg/kg)3个剂量组,分别肌肉注射治疗仔猪黄白痢,每24 h用药1次,连用3次,同时设对照组。结果表明,头孢噻呋混悬剂3个剂量组和头孢噻呋钠注射液对照组对仔猪黄白痢均有明显的治疗效果,成活率可达80%~100%,极显著的高于感染对照组(P<0.01)。头孢噻呋混悬剂中、高剂量组成活率显著高于头孢噻呋混悬剂低剂量组及头孢噻呋钠注射液组(P<0.01)。表明头孢噻呋混悬剂能减少大肠埃希菌人工感染引起的临床症状,降低病死率。作为注射剂治疗仔猪黄白痢,剂量以5 mg/kg~10 mg/kg为佳。 相似文献
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对人工感染鸡白痢的艾维茵雏鸡,采用"雏痢净"按高(0.5/只)、中(0.4/只)和低(0.3/只)三个剂量混饲治疗,用2%甲磺酸培氟沙星(药物对照组)、感染不用药(阳性对照组)、不感染不用药(阴性对照组)作为对照.结果"雏痢净"高、中、低剂量组与2%甲磺酸培氟沙星组对雏鸡白痢均有较高的疗效,其中"雏痢净"高、中剂量组与2%甲磺酸培氟沙星组的治疗效果最好,但三者差异不显著(P＞0.05);"雏痢净"各组与2%甲磺酸培氟沙星组的相对增重率极显著高于感染不用药组(p0.01).表明"雏痢净"高、中剂量用药后症状明显减轻且渐恢复,体重也明显增加,其疗效与2%甲磺酸培氟沙星相当. 相似文献
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《养殖与饲料．饲料世界》2016,(3)
为了研究禽病清散治疗鸡白痢的效果,选取270只雏鸡,随机平均分成6组,每组45只,分别给予每组不同的治疗方案,并比较每组治疗方案的治疗效果。结果显示,用禽病清散治疗的高剂量组治疗效果显著优于其他组。说明禽病清散应用在鸡白痢的治疗中具有效果明显、见效快的优点,可以广泛应用。 相似文献
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为了检测发酵马齿苋对雏鸡白痢的防治效果,设置发酵马齿苋高、中、低剂量组,非发酵马齿苋高、中、低剂量组,氟苯尼考组与阳性、阴性对照组,检测各组人工感染雏鸡的发病数、死亡数和治愈数。发现4g/L发酵马齿苋与氟苯尼考对雏鸡白痢防治效果相当(P>0.05),两者与阳性对照组相比,在预防试验中能显著抑制雏鸡的发病率和死亡率(P<0.05);在治疗试验中能显著提高雏鸡的治愈率(P<0.05),并降低雏鸡的死亡率(P<0.05)。在雏鸡白痢防治上,4g/L发酵马齿苋效果明显,可代替氟苯尼考作为养禽业的新型绿色开口药。 相似文献
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为验证"乳源康"对奶牛乳房炎的疗效,以青、链霉素为对照药,乳房灌注给药,在奶牛场试用3年,"乳源康"治疗组共收治各类型临床乳房炎病牛1 638头次,2 203个乳区,治愈率为93.3%,总有效率为96.7%,平均疗程4.5 d.青、链霉素对照组共收治各类型临床乳房炎病牛276头次,359个乳区,治愈率为56.3%,总有效率为77.4%,平均疗程12 d;用"乳源康"治疗隐性乳房炎4 031例,用药1次～2次临床治愈率为100%;通过对56个患病乳区"乳源康"用药前后的细菌削减状况的检查,细菌转阴率为71.74%.因此,用"乳源康"治疗奶牛乳房炎安全、高效. 相似文献
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通过对１１种畜禽常见致病菌的药敏试验表明，氟呢酸的ＭＩＣ１００为０．１～３．１３ｕｇ／ｍｌ，是庆大霉素的１／２～１／６４，痢菌净的１／４～１／６４。氟派酸的ＭＢＣ１００为０．２～６．２５ｕｇ／ｍｌ，与其ＭＩＣ１００相差悬殊，杀菌性不好。 相似文献
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高生俊 《青海畜牧兽医杂志》2005,35(5):22-22
选用本地小尾寒羊60只,随机分为试验1组、试验2组、对照组3组,每组20只.试验1组在饲喂基础日粮中每只添加“牛羊壮”20g;试验2组在同等条件下,每只添加“牛羊肥”20g;对照组只喂基础日粮.试验表明,在试验期间,试验1组比试验2组平均多增重3.55kg,试验1组比试验2组经济效益多增28.98元. 相似文献
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The possible remedial effect of Persicaria senegalense in bovine subclinical mastitis was studied by in vitro and in vivo antimicrobial tests, using crude extracts and the leaf in different forms. The in vitro test showed that isolates of Staphylococcus aureus, Candida albicans and Corynebacterium bovis from subclinical cases and an isolate of Pseudomonas aeruginosa from a clinical case of mastitis were all inhibited by the three crude extracts at 820 g concentration. An in vivo trial feeding 1.5 kg of the cooked leaf per day for 5 days did not give a significant cure rate, whereas a second trial in which 0.77 kg of leaf powder, equivalent to 3 kg of wet leaf, was fed per day for 5 days resulted in an apparent cure rate of 92.8% (52.8% actual as there was a 40% spontaneous cure rate in the negative control group, in contrast to 80% (40% actual) in the positive control group treated with an intramammary antibiotic preparation. The difference in cure rate between the negative control group and the experimental group given 0.77 kg leaf powder was significant (p = 0.008). 相似文献
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A number of immuno-competent Blackface lambs were infected with 10,000 Haemonchus contortus third stage larvae and were later challenged with a second dose of 10,000 H. contortus third stage larvae. One group of lambs was treated with dialysed transfer factor prior to the second challenge dose. Histological changes in the abomasal wall, reductions in abomasal worm burdens at slaughter and faecal egg counts monitored throughout the experiment suggested the presence in some animals of an innate resistance, a "self curing" effect, an enhancement of this "self curing" effect in the transfer factor treated group and a response in one transfer factor treated animal comparable to "classical self cure". 相似文献
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Pharmacokinetics of norfloxacin and its N-desethyl- and oxo-metabolites in broiler chickens. 总被引：3，自引：0，他引：3
A Anadón M R Martinez-Larra?aga C Velez M J Díaz P Bringas 《American journal of veterinary research》1992,53(11):2084-2089
Norfloxacin was given to 2 groups of chickens (8 chickens/group) at a dosage of 8 mg/kg of body weight, IV and orally. For 24 hours, plasma concentration was monitored serially after each administration. Another group of chickens (n = 30) was given 8 mg of norfloxacin/kg orally every 24 hours for 4 days, and plasma and tissue concentrations of norfloxacin and its major metabolites desethylenenorfloxacin and oxonorfloxacin were determined serially after the last administration of the drug. Plasma and tissue concentrations of norfloxacin, desethylenenorfloxacin, and oxonorfloxacin were measured by use of high-performance liquid chromatography. Pharmacokinetic variables were calculated, using a 2-compartment open model. For norfloxacin, the elimination half-life (t1/2 beta) and the mean +/- SEM residence time for plasma were 12.8 +/- 0.59 and 15.05 +/- 0.81 hours, respectively, after oral administration and 8.0 +/- 0.3 and 8.71 +/- 0.23 hours, respectively, after IV administration. After single oral administration, norfloxacin was absorbed rapidly, with Tmax of 0.22 +/- 0.02 hour. Maximal plasma concentration was 2.89 +/- 0.20 microgram/ml. Oral bioavailability of norfloxacin was found to be 57.0 +/- 2.4%. In chickens, norfloxacin was mainly converted to desethylenenorfloxacin and oxonorfloxacin. Norfloxacin parent drug and its 2 major metabolites were widely distributed in tissues. Considerable tissue concentrations of norfloxacin, desethylenenorfloxacin, and oxonorfloxacin were found when norfloxacin was administered orally (8 mg/kg on 4 successive days). The concentration of the parent fluoroquinolone in fat, kidneys, and liver was 0.05 micrograms/g on day 12 after the end of dosing. 相似文献
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90只小白鼠随机分为9组每组10只。除对照组外,其余8组分别以绵羊每日正常用药量的1．5^u等比级数递增剂量,一次给小白鼠灌服定量“棘防E号”,连续观察14天,以测定“棘防E号”对小白鼠口服的LD50。同时,按最大无作用剂量(101.25mg／BW、正常剂量(20．00mg／kg.BW、最大无作用剂量的1／30(3．375mg／kg．BW)给小白鼠饮用“棘防E号”,观察对小白鼠繁殖机能的影响。结果表明,当小白鼠服用绵羊正常用药量的17倍时,不出现半数死亡,说明“棘防E号”对小白鼠的LD50大于绵羊正常用药量的10倍,是完全安全性的药物;最大无作用剂量、正常剂量、最大无作用剂量的1／30对小白鼠怀孕率和胎儿畸形与对照组没有明显的区别。 相似文献