共查询到20条相似文献，搜索用时 171 毫秒
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益生素与免疫刺激作用 总被引：11，自引：0，他引：11
胃肠道中作为益生菌的微生物通过三条途径刺激动物的免疫系统。其一 ,它们能作为活细胞在动物胃肠道表面定植与繁殖 ,增殖到一定数目 ,刺激动物免疫系统 ;其二 ,由死细胞释放出来的抗源物质(包括脂多糖、肽聚糖和ＤＮＡ等大分子物质 )被动物吸收后直接刺激动物免疫系统。其三 ,乳杆菌 (Ｌａｃ ｔｏｂａｃｉｌｌｕｓ)通过影响胃肠道中微生物菌群组成来间接影响免疫系统。目前来说这三种方法哪一种被广泛采用还没有定论 ,但显而易见的是某一菌株的定植、繁殖能力以及其在动物胃肠道存在的数量同它的免疫刺激能力的强弱是相关联的。益生菌对动… 相似文献
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A. Schoster J.S. Weese L. Guardabassi 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2014,28(6):1640-1652
The gastrointestinal microbiota is extremely important for human and animal health. Investigations into the composition of the microbiota and its therapeutic modification have received increasing interest in human and veterinary medicine. Probiotics are a way of modifying the microbiota and have been tested to prevent and treat diseases. Probiotics are proposed to exert their beneficial effects through various pathways. Production of antimicrobial compounds targeting intestinal pathogens, general immune stimulation, and colonization resistance are among these mechanisms. Despite widespread availability and use, scientific, peer‐reviewed evidence behind commercial probiotic formulations in horses is limited. Additionally, quality control of commercial over‐the‐counter products is not tightly regulated. Although promising in vitro results have been achieved, in vivo health benefits have been more difficult to prove. Whether the ambiguous results are caused by strain selection, dosage selection or true lack of efficacy remains to be answered. Although these limitations exist, probiotics are increasingly used because of their lack of severe adverse effects, ease of administration, and low cost. This review summarizes the current evidence for probiotic use in equine medicine. It aims to provide veterinarians with evidence‐based information on when and why probiotics are indicated for prevention or treatment of gastrointestinal disease in horses. The review also outlines the current state of knowledge on the equine microbiota and the potential of fecal microbial transplantation, as they relate to the topic of probiotics. 相似文献
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微生态制剂作为一种新型的饲料添加剂,适量、合理地应用可以促进动物生长、提高饲料转化率及动物免疫力,因其无毒副作用,目前已被广泛用于多种动物的养殖中。主要介绍了近年来微生态制剂在现代畜牧业中应用的成果,并对微生态制剂的应用前景进行了展望。 相似文献
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益生菌在犬猫上的应用研究进展 《畜牧与饲料科学》2022,43(3):46-52
益生菌是一种定植于宿主肠道,能够调节肠道微生态平衡,提高宿主机体健康水平的活菌制剂。目前益生菌已被证实能够对动物起到多种有益的作用。随着宠物医疗行业的快速发展,犬猫的健康越来越受到主人的重视,益生菌被广泛添加到宠物食品以及营养补充剂中,通过维持肠道微生态的平衡达到预防肠道疾病或提高肠道免疫力的目的。对益生菌的定义、种类和作用机制,以及益生菌在犬猫上的应用研究进展进行综述,以期为犬猫益生菌制剂的开发以及益生菌在宠物医疗行业的应用提供参考。 相似文献
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益生菌对畜禽健康的影响及作用机制研究进展 《畜牧与饲料科学》2016,37(6):117-117
益生菌是一种通过改善肠道菌群平衡而对动物机体进行调节的活性微生物。近年来,益生菌作为微生物饲料添加剂广泛运用于动物生产中。就益生菌对畜禽生产性能、畜产品品质等方面的影响及可能的作用机制进行了综述,旨在为其今后在畜牧生产上的科学应用提供参考。 相似文献
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It is now widely recognized that probiotics have health-beneficial effects on humans and animals. Probiotics should survive in the intestinal tract to exert beneficial effects on the host's health. To keep a sufficient level of probiotic bacteria in the gastrointestinal tract, a shorter interval between doses may be required. Although adherence to the intestinal epithelial cell and mucus is not a universal property of probiotics, high ability to adhere to the intestinal surface might strongly interfere with infection of pathogenic bacteria and regulate the immune system. The administration of probiotic Lactobacillus stimulated indigenous Lactobacilli and the production of short-chain fatty acids. This alteration of the intestinal environment should contribute to maintain the host's health. The immunomodulatory effects of probiotics are related to important parts of their beneficial effects. Probiotics may modulate the intestinal immune response through the stimulation of certain cytokine and IgA secretion in intestinal mucosa. The health-beneficial effects, in particular the immunomodulation effect, of probiotics depend on the strain used. Differences in indigenous intestinal microflora significantly alter the magnitude of the effects of a probiotic. Specific probiotic strains suitable for each animal species and their life stage as well as each individual should be found. 相似文献
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ZHANG Man JIN Xin TIAN Qiao-zhen LIU Jiao WANG Yun-he ZHANG Zhao-yi YANG Yin-feng 《中国畜牧兽医》2017,44(12):3656-3662
Probiotics are a kind of living microorganism which can be administered in feed and confer numerous health benefits to animals. Probiotics play a key role in maintaining the microbial balance of gastrointestinal, immunomodulation and pathogen defense, specific probiotics show certain degree of potential to reinforce the integrity of intestinal epithelium and regulate some immune components. The mechanism of probiotic action is an area of interest. Among all possible routes of modulation by probiotics of intestinal mediated defense responses, modulations of intestinal barrier function, innate and adaptive mucosal immune responses as well as signaling pathways are considered to play an important role in the intestinal defense responses against pathogenic bacteria. This review summarizes how probiotic bacteria interact with goblet cell-derived mucins, trefoil factors (TFFs),defensins, Toll-like receptors (TLRs), secretory immunoglobulin A (sIgA), heat shock proteins (HSPs) and P-glycoproteins (P-gp) in the gut to regulate the intestinal innate defense responses,which is regarded as the scientific basis for the future detailed study of benefits of probiotics towards the health of intestine and also dietary intervention against intestinal exposure to pathogens. 相似文献
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益生菌是可添加在饲料中对动物健康产生很多益处的活微生物,其在维持胃肠道微生物平衡、免疫调节和病原体防御中起关键作用,某些特定的益生菌菌株对加强肠上皮的完整性和调节一些免疫组分也显示出一定程度的潜力。有关益生菌的作用机制是当前研究的热点,其中,在益生菌调节肠道介导的防御反应的所有可能途径中,肠屏障功能、先天和适应性黏膜免疫反应及信号传导途径被认为在针对病原菌的肠防御反应中起重要作用。作者主要针对益生菌如何与肠道内的杯状细胞黏蛋白、三叶因子（trefoil factors,tffs）、防御素、Toll样受体（Toll-like receptors,TLRs）、分泌型免疫球蛋白A（secretory immunoglobulin A,sIgA）、热休克蛋白（heat shock proteins,HSPs）和P-糖蛋白（P-glycoprotein,P-gp）相互作用而起到调节肠道先天防御反应的作用进行了概述,以期为今后研究益生菌对肠道健康及对感染病原体的肠道如何起到有益作用奠定基础。 相似文献
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