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1.
猪呼吸道病综合征(PRDC)是一种由多因素引起的呼吸道疾病的总称,是生长育成猪普遍存在的疾病.PRDC病因复杂,涉及的病原体繁多,没有明确的定论.猪支原体、猪繁殖与呼吸障碍综合征病毒、猪传染性胸膜肺炎放线杆菌、猪伪狂犬病病毒、猪流行性感冒病毒、猪圆环病毒、猪呼吸道冠状病毒、猪瘟病毒、多杀性巴氏杆菌、猪源链球菌、副猪嗜血杆菌、猪霍乱沙门氏菌、棒状杆菌等病原微生物都有一定的关联;此外,也与一些寄生虫性病原和环境应激因素有关. 相似文献
2.
海南省规模化猪场主要呼吸道病原的血清流行病学调查 总被引：2，自引：0，他引：2
猪呼吸道疾病综合征(PRDC )已上升为规模化猪场的主导疾病,发病率30%～80%,死亡率在5%～30%或以上,造成了严重的经济损失[1-2].PRDC是一种多因子疾病,因为在典型的病例中可以检出多种病原.猪繁殖与呼吸综合征病毒(PRRSV)、猪肺炎支原体(MH)、猪圆环病毒2型(PCV2)、猪瘟病毒(CSFV)、猪伪狂犬病病毒(PRV)、猪传染性胸膜肺炎放线杆菌(APP)、猪多杀性巴氏杆菌(PM)、猪副猪嗜血杆菌(HP)等是PRDC最常见几种病原[3]. 相似文献
3.
副猪嗜血杆菌病 (一)该病当前流行特点在猪群发生高热综合征时,猪只感染蓝耳病病毒、圆环病毒2型,伪狂犬病病毒,猪流感病毒和猪瘟病毒后,常见继发感染副猪嗜血杆菌,并与巴氏杆菌、链球菌,传染性胸膜肺炎放线杆菌与支原体等混合感染,使疾病多样化,病情复杂化,大大地增高了发病率和死亡率,造成很大的经济损失. 相似文献
4.
猪传染性胸膜肺炎是由猪胸膜肺炎放线杆菌(Actinobacillus Pleuropeumoniae,APP)引起的一种危害较为严重的高度接触传染性、致死性呼吸系统传染病。临床上以体温升高、呼吸困难、肺炎、胸膜炎为特征,近年来随着疫病的复杂化,本病经常与猪繁殖与呼吸综合征、猪圆环病毒病、猪伪狂犬病、支原体肺炎、副猪嗜血杆菌、多杀性巴氏杆菌等混合感染,对养猪业的危害日趋严重。 相似文献
5.
芮志立 《河南畜牧兽医(综合版)》2015,36(6)
猪高热病是由病毒、细菌、血原虫等混合感染引起的以高热、高发病率和高死亡率为特征的呈流行或暴发流行的传染病.病毒包括猪瘟病毒、猪繁殖与呼吸综合征病毒、猪流感病毒、伪狂犬病病毒、猪圆环病毒2型.细菌包括猪胸膜肺炎放线杆菌、猪链球菌属2型、副猪嗜血杆菌病、多杀性巴氏杆菌、猪支原体肺炎等.寄生虫包括猪弓形体、附红细胞体等,夏季高温季节多发易发. 相似文献
6.
5省区规模猪场猪呼吸道病综合征病原学调查的统计分析 总被引：1，自引：0，他引：1
对5省区规模猪场猪呼吸道病综合征(PRDC)的2 184份血清检测结果进行分析、归纳,结果显示,其主要病原是猪繁殖与呼吸综合征病毒、圆环病毒2型和伪狂犬病病毒,其中猪繁殖与呼吸综合征病毒阳性率为34.80%,圆环病毒2型阳性率为58.24%,伪狂犬病病毒阳性率为27.79%,而猪瘟病毒和猪流感病毒的感染率较低;上海市病料的主要病因是肺炎支原体(57.50%)和猪繁殖与呼吸综合征病毒(45.83%),海南省血清的主导病原是圆环病毒2型(90.5%)、胸膜肺炎放线杆菌(72.7%),说明肺炎支原体和胸膜肺炎放线杆菌的感染可能有一定的地域性;PRDC的混合感染率较高(广西43.77%,云南35.75%)。 相似文献
7.
猪呼吸道综合征 (PRDC)的防治是目前养猪业的难点之一 ,特别是高密度饲养的大型猪场 ,猪的呼吸道综合征问题显得更突出。其原发性病原包括猪繁殖与呼吸综合征病毒(PRRSV)、猪圆环病毒 2型 (PCV 2 )、猪瘟病毒 (HCV)、伪狂犬病病毒 (PrV)和猪气喘病等 ;继发性病原有副猪嗜血菌、胸膜肺炎放线杆菌和链球菌等。有报道认为 ,猪肺炎支原体和PRRSV是引起猪呼吸道疾病的主要元凶 ,也是最多发和最常见的病原。这 2个病原同时感染 ,往往出现严重的呼吸道症状。据报道支原体疫苗免疫接种会大大减少发生PRRSV所致肺炎的可能性 ,也会降低支原… 相似文献
8.
猪呼吸道病综合征的防制 总被引：1，自引：0，他引：1
<正>猪呼吸道病综合征(PRDC)是一种由病毒、细菌、支原体感染及环境应激和猪抵抗力降低等诸多因素相互作用引起的呼吸道疾病的总称。呼吸道病是许多因素综合作用的结果,目前以猪蓝耳病为主继发圆环病毒2型、猪瘟、伪狂犬病、副猪嗜血杆菌病、气喘病、猪传染性胸膜肺炎病、猪附红细胞体、 相似文献
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1发病原因1．1病原因素病毒类主要有猪瘟病毒、伪狂犬病病毒、蓝耳病病毒、网环病毒Ⅱ型、流感病毒等；细菌类主要有链球菌、副猪嗜血杆菌、胸膜肺炎放线杆菌、多杀性巴氏杆菌、沙门氏菌、化脓棒状杆菌、支气管败血波氏杆菌、肺炎支原体、霍乱沙门氏菌等； 相似文献
11.
Immunology of the porcine respiratory disease complex. 总被引：1，自引：0，他引：1
E L Thacker 《Veterinary Clinics of North America: Food Animal Practice》2001,17(3):551-565
PRDC is a multifactorial respiratory syndrome that includes several respiratory pathogens. As can be observed in this article, although the pathogenesis of some of the respiratory pathogens of pigs is fairly well defined, the host response and the immune response necessary to control the pathogen often remain unclear. As our ability to evaluate the porcine immune system and its ability to respond to disease improves, the knowledge of how each of these respiratory pathogens alter and evade the immune system will increase. The pathogens most commonly isolated from pigs with clinical signs of PRDC either infect the cells of the immune system or induce significant immunopathology. Thus, PRRSV and M. hyopneumoniae, the two most common pathogens associated with PRDC, alter the ability of the respiratory immune system to respond to their presence and the presence of other pathogens. By changing the respiratory immune system, these two common pathogens increase the susceptibility to the many other pathogens associated with PRDC. As we learn more about the pathogens of the respiratory system, their interactions with each other, and the mechanisms by which they modulate the immune system, our ability to develop effective control measures will improve. 相似文献
12.
A retrospective study was performed on natural cases of porcine respiratory disease complex (PRDC) to determine the association and prevalence of PRDC with porcine circovirus 2 (PCV2) and other co-existing pathogens in Korea. Histologically, alveolar septa were markedly thickened by infiltrates of mononuclear cells. Moderate to marked multifocal peribronchial and peribronchiolar fibrosis were present and often extended into the airway lamina propria. Among the 105 pigs with PRDC, 85 were positive for PCV2, 66 were positive for porcine reproductive and respiratory syndrome virus (PRRSV), 60 were positive for porcine parvovirus (PPV), and 14 were positive for swine influenza virus (SIV). There were 80 co-infections and 25 single infections. A co-infection of PCV2 with another additional bacterial pathogen is frequently diagnosed in PRDC. The combination of PCV2 and Pasteurella multocida (38 cases) was most prevalent followed by PCV2 and Mycoplasma hyopneumoniae (33 cases). The consistent presence of PCV2, but lower prevalence of other viral and bacterial pathogens in all pigs examined with PRDC, has led us to speculate that PCV2 plays an important role in PRDC. 相似文献
13.
Polymicrobial respiratory disease in pigs 总被引：2，自引：0，他引：2
Opriessnig T Giménez-Lirola LG Halbur PG 《Animal health research reviews / Conference of Research Workers in Animal Diseases》2011,12(2):133-148
Respiratory disease in pigs is common in modern pork production worldwide and is often referred to as porcine respiratory disease complex (PRDC). PRDC is polymicrobial in nature, and results from infection with various combinations of primary and secondary respiratory pathogens. As a true multifactorial disease, environmental conditions, population size, management strategies and pig-specific factors such as age and genetics also play critical roles in the outcome of PRDC. While non-infectious factors are important in the initiation and outcome of cases of PRDC, the focus of this review is on infectious factors only. There are a variety of viral and bacterial pathogens commonly associated with PRDC including porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus (SIV), porcine circovirus type 2 (PCV2), Mycoplasma hyopneumoniae (MHYO) and Pasteurella multocida (PMULT). The pathogenesis of viral respiratory disease is typically associated with destruction of the mucocilliary apparatus and with interference and decrease of the function of pulmonary alveolar and intravascular macrophages. Bacterial pathogens often contribute to PRDC by activation of inflammation via enhanced cytokine responses. With recent advancements in pathogen detection methods, the importance of polymicrobial disease has become more evident, and identification of interactions of pathogens and their mechanisms of disease potentiation has become a topic of great interest. For example, combined infection of pigs with typically low pathogenic organisms like PCV2 and MHYO results in severe respiratory disease. Although the body of knowledge has advanced substantially in the last 15 years, much more needs to be learned about the pathogenesis and best practices for control of swine respiratory disease outbreaks caused by concurrent infection of two or more pathogens. This review discusses the latest findings on polymicrobial respiratory disease in pigs. 相似文献
14.
副猪嗜血杆菌的分离鉴定 总被引：1，自引：0，他引：1
副猪嗜血杆菌(Hps)为猪呼吸道疾病综合征(PRDC)的重要病原之一。在对广西65个猪场281份病猪组织样品进行PRDC病原学调查的基础上,对PCR检测的Hps阳性样品进行了细菌分离,并进行了生化特性、药敏试验、16 S RNA基因片段序列分析和基因组DNA的PCR指纹图谱分析。结果显示,11份(3.91%)检测样品为Hps阳性,且均为混合感染;从南宁市四塘、桂林市永福、玉林市容县和钦州市浦北分离出5株Hps,分离菌株的生化鉴定结果均符合Hps生化特性,且对头孢噻呋和头孢菌素高度敏感;其中3株为血清5型,1株为血清12型,另1株未能定型;分离菌株16 S RNA基因片段之间及与GenBank其他一些代表菌株的核苷酸同源性在99%以上。 相似文献
15.
The role of swine torque teno sus viruses (TTSuVs) as co-factors in disease syndromes involving porcine circovirus strain 2 (PCV2) and porcine reproductive and respiratory disease syndrome virus (PRRSV) has been a debatable subject. In this study, the prevalence of TTSuVs in Iowa, the leading pork producing state in the U.S., was estimated by a duplex PCR. The PCR is capable of simultaneously detecting both teno sus viruses 1 and 2 (TTSuV1 and 2). Based on an analysis of 300 random samples representing six major geographical regions of the state, the overall prevalence rates for TTSuV1 and 2 were 47.34% and 24.67% respectively while the combined prevalence rate was 52.33%. The epidemiological association of TTSuV1 and 2 with the common etiological agents of the porcine respiratory disease complex (PRDC) namely porcine PRRSV, PCV2, Mycoplasma hyopneumoniae and swine influenza virus (SIV) was estimated in lung tissue derived from 45 pigs showing clinical signs of PRDC. Notably, 86.67% of the PRDC-suspect samples were positive for TTSuV1 in comparison to the baseline population prevalence rate of 47.34%. However, the prevalence of TTSuV2 (26.67%) was not significantly different. TTSuV1 was detected in 80.00%, 81.81%, 75.00% and 77.78% of the PRRSV, SIV, M. hyopneumoniae and PCV2 positive PRDC-suspect samples respectively. Our results indicate that TTSuV1 is strongly associated with clinical PRDC and support the hypothesis that TTSuVs might function as co-factors in PRDC. Further studies to define their possible role in the pathogenesis of swine respiratory diseases are warranted. 相似文献
16.
广西规模猪场猪呼吸道疾病综合征的病原学调查 总被引：1，自引：0，他引：1
为了解猪呼吸道疾病综合征(PRDC)在广西规模场猪群中的感染状况,采用PCR和RT-PCR方法,对2007～2009年期间采自广西13个市65个规模猪场的281份疑似PRDC感染组织样品进行了12种病原体检测。结果显示:73.85%(48/65)的猪场和71.87%(202/281)的组织样品为PRDC感染,其中,被猪繁殖与呼吸综合征病毒(PRRSV)、猪圆环病毒2型(PCV2)、猪瘟病毒(CSFV)、猪链球菌(SS)、猪伪狂犬病毒(PRV)、败血性波氏杆菌(Bb)、猪附红细胞体(E-su is)、猪流感病毒(SIV)、产毒素多杀性巴氏杆菌(T+PM)、副猪嗜血杆菌(HP)、猪细小病毒(PPV)和猪传染性胸膜肺炎放线杆菌(APP)感染(包括混合感染)的阳性样品分别占49.11%(138/281)、34.52%(97/281)、9.60%(27/281)、8.19%(23/281)、6.41%(18/281)、6.41%(18/281)、6.05%(17/281)、6.14%(15/281)、4.63%(13/281)、3.91%(11/281)、0.36%(1/281)和0.00%(0/281);单纯感染占28.11%(79/281);混和感染占43.77%(123/281)。二重、三重和四重混合感染分别占28.11%(79/281)、12.46%(35/281)和3.20%(9/281)。其中,以PRRSV+PCV2(+其他)混合感染形式较多见,占所有混合感染样品的52.03%(64/123)。细菌性病原体感染样品占20.28%(57/281),其中19.22%(54/281)为混合感染。可见:广西地区规模猪场普遍存在PRDC感染,其中PRRSV和PCV2是引起PRDC的主要病原;感染类型复杂多样,以PRRSV+PCV2(+其他)混合感染最为常见。 相似文献
17.
猪呼吸道疾病综合征（PRDC）在养猪业中广泛流行,发病原因复杂,由多种细菌、病毒、寄生虫及环境应激等因素共同引发,普遍造成猪生长迟缓和猪肉品质下降,还有相当比例的病猪死亡,严重影响养猪业的发展。胸膜肺炎放线杆菌（APP）、副猪嗜血杆菌（Hps）、链球菌（SS）是常见的细菌性病原,而猪繁殖与呼吸障碍综合征病毒（PRRSV）、猪圆环病毒2型（PCV2）、伪狂犬病毒（PRV）是常见的病毒性病原,合理用药防治PRDC十分关键。头孢喹肟、氟苯尼考及加米霉素等抗生素因抗菌谱广、抗菌活性强、在猪体内药代动力学特征优良等优点被广泛用于防控细菌性感染的猪呼吸道疾病。对于病毒性感染的猪呼吸道疾病,常用的抗病毒药物有细胞因子及中药,尤其是中药,不仅可以抗病毒还可增强机体免疫力,应用前景非常广阔。文章系统地阐述了上述抗菌药物的抗菌机理、药效学及药动学,详细介绍了上述抗病毒药物的抗病毒机理及其在病毒性猪呼吸道疾病上的应用,以期为合理用药防控PRDC提供一定的建议。 相似文献
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Deblanc C Gorin S Quéguiner S Gautier-Bouchardon AV Ferré S Amenna N Cariolet R Simon G 《Veterinary microbiology》2012,157(1-2):96-105
Swine influenza virus (SIV) and Mycoplasma hyopneumoniae (Mhp) are widespread in farms and are major pathogens involved in the porcine respiratory disease complex (PRDC). The aim of this experiment was to compare the pathogenicity of European avian-like swine H1N1 and European human-like reassortant swine H1N2 viruses in na?ve pigs and in pigs previously infected with Mhp. Six groups of SPF pigs were inoculated intra-tracheally with either Mhp, or H1N1, or H1N2 or Mhp+H1N1 or Mhp+H1N2, both pathogens being inoculated at 21 days intervals in these two last groups. A mock-infected group was included. Although both SIV strains induced clinical signs when singly inoculated, results indicated that the H1N2 SIV was more pathogenic than the H1N1 virus, with an earlier shedding and a greater spread in lungs. Initial infection with Mhp before SIV inoculation increased flu clinical signs and pathogenesis (hyperthermia, loss of appetite, pneumonia lesions) due to the H1N1 virus but did not modify significantly outcomes of H1N2 infection. Thus, Mhp and SIV H1N1 appeared to act synergistically, whereas Mhp and SIV H1N2 would compete, as H1N2 infection led to the elimination of Mhp in lung diaphragmatic lobes. In conclusion, SIV would be a risk factor for the severity of respiratory disorders when associated with Mhp, depending on the viral subtype involved. This experimental model of coinfection with Mhp and avian-like swine H1N1 is a relevant tool for studying the pathogenesis of SIV-associated PRDC and testing intervention strategies for the control of the disease. 相似文献
20.
猪呼吸道疾病综合征是一种由病毒、细菌、环境应激和猪体免疫力低下等多因素相互作用引起的呼吸道疾病。2009年2～4月,上海农场某猪场一批育肥猪出现疑似病例,表现为食欲下降,咳嗽,呼吸困难,生长缓慢和料肉比降低。本研究在流行病学调查的基础上,剖检8头病猪观察其病理变化,主要表现为肺脏弥慢性实变,弹性降低,间质增宽,有的水肿、气肿,或纤维素性胸膜肺炎。病原检测结果显示,该发病猪群主要病原为猪繁殖与呼吸综合征病毒、猪圆环病毒2型和副猪嗜血杆菌。本研究为猪呼吸道疾病综合征的防治提供了依据。 相似文献