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1.
脂肪肝出血综合征(Fatty liver haemorrhagic syndrome，FLHS)，是高能低蛋白日粮导致的脂肪代谢障碍，使肝脏脂肪过度沉积所致的肝细胞变性、血管擘变脆而发生的肝脏出血；临床上多发生于蛋鸡，尤其是笼养蛋鸡产蛋高峰期的炎热季节，其次是肉鸡和鸭，有的 相似文献
2.
《中国兽医学报》2020,(10)
为了比较高能低蛋白日粮诱导的脂肪肝出血综合征(FLHS)蛋鸡脂肪组织代谢的差异,将海兰褐蛋鸡分为对照组与病理组,每组40只,对照组饲喂基础日粮,病理组饲喂高能低蛋白日粮。饲养80 d后,采集肝脏和脂肪组织进行HE染色观察,同时测定血清中白细胞介素6(IL-6)的水平并通过实时荧光定量PCR测定IL-6在脂肪组织中的表达差异变化。HE染色结果表明,通过给予高能低蛋白日粮可成功建立FLHS模型;所建立FLHS组(病理组)脂肪组织出现脂质代谢异常,其脂滴(LDs)直径明显(P0.01)大于对照组LDs。FLHS组中IL-6在脂肪组织中的表达水平与血清水平均显著高于(P0.05或P0.01)对照组,提示患FLHS的蛋鸡脂肪组织代谢失常导致机体IL-6水平升高,从而对肝脏的肿大、出血等症状呈正向诱导。 相似文献
3.
《广东饲料》2016,(4)
脂肪肝出血综合症(FLHS)是小鸡及其他鸟类由于不同的营养状况、激素水平、环境及代谢因素等导致的一种代谢疾病。本试验研究不同的日粮组成对单冠白来杭(WL)蛋鸡FLHS诱导的影响。选取76只26周龄和69只84周龄相同品种不同周龄的WL蛋鸡,各分为4个组饲喂4种不同的试验日粮。各组日粮如下:对照组(C):17.5%蛋白(CP),3.5%脂肪(F);高脂组(HF):17.5%CP,7%F;低蛋白组(LP):13%CP,3.5%F;低蛋白高脂肪组(LPHF):13%CP,6.5%F。高脂肪组代谢能水平为3000 kcal/kg,普通脂肪组代谢能水平为2750kcal/kg。检测主要指标为:日产蛋重(HDEP)、平均日采食量(ADFI)、体重(BW)、蛋重、血浆中与肝损伤相关酶类(碱性磷酸酶(ALP);天冬氨酸氨基转移酶AST;γ谷氨酰胺转移酶(GGT)、肝腹脂重、肝脏颜色评分(LCS)、肝脏出血性评分(LHS)、肝脏脂肪含量(LFC)、肝脏组织学检测、脂质过氧化产物及肝脏炎症相关基因的表达等。结果表明:LPHF组HDEP,ADFI,BW及蛋重均显著下降,同时LP组蛋重也显著降低(P0.05)。年轻母鸡LPHF组在日粮处理30天后,ALP显著高于其他组(P0.05),整个试验期虽然差异不显著,但数值一直高于其他组;日粮处理105天后AST显著高于其他组(P0.05)。年轻母鸡LPHF组中LCS,LHS及LFC均显著高于其他组(P0.05)。肝脏组织学检测表明LPHF组形成更多的脂肪空泡。LP组及HF组对LFC,LHS,或LCS均没有影响。综上所述,日粮中低蛋白及高脂肪引起的高能可能是诱导蛋鸡FLHS的一个因素。 相似文献
4.
蛋鸡脂肪肝出血综合征(FLHS)是常发生于高产蛋鸡的营养代谢病,其临床表现主要为蛋鸡脂质代谢紊乱引起的肝脏脂质沉积、产蛋量骤降及急性死亡,造成严重经济损失,是当前集约化养殖需要重点关注的疾病。肠道微生物作为参与机体生长发育、免疫代谢的重要角色,参与宿主的脂质合成与转运,保持肠道屏障的完整性以避免有害物质通过血液循环损伤肝脏并影响其功能,同时肠道微生物代谢产物的丰减与转化方向也会对肝脏健康产生或好或坏的影响。目前认为FLHS的发病机制主要包括营养、遗传、激素、肠道微生物等多种因素,“肠-肝轴”也受到当前治疗肝脏疾病的广泛关注。作者以肠道微生物为切入点,通过对蛋鸡常见肠道微生物及其与脂质代谢相关的功能进行总结,回顾了肠道微生物在脂质代谢与FLHS方面的相关研究,着重介绍了肠道微生物及其代谢产物在FLHS发生发展过程中可能产生的作用机理,以期从肠道微生物的角度解释FLHS的可能发病机制,并在生产实践中找到通过调节肠道微生物预防或治疗FLHS的方法,推动养禽业的发展。 相似文献
5.
脂肪肝综合症(FLHS)是高能低蛋白日粮引起的脂肪代谢障碍,使肝脏脂肪过度沉积所致的肝细胞与血管壁变脆而发生的肝脏出血,因此统称脂肪肝、肝破裂、肝出血症。本病多发生于体质肥胖的蛋鸡,尤以笼养鸡的产蛋高峰期或高峰过后多见。其发病率因鸡的品种、日粮组成、饲养管理和环境等因素而有差异,一般为5%~7%,高的10%以上,根据何维明(1991)的调查,有的鸡场发病率高达30%,病死率30%~40%,给养鸡业造成严重的经济损失。该病一年四季均有发生,以夏季居多。其发生因素较多,主要有下述几方面。1发病因素1.1高能低蛋白日粮是本病发生的主要饲料因素… 相似文献
6.
蛋鸡脂肪肝综合征（FLS）又叫脂肪肝出血综合征（FLHS），是由于营养障碍、内分泌失调、脂肪代谢紊乱导致脏脂肪过度沉积于肝脏，从而导致肝细胞及血管壁质地变脆而发生的肝出血的症状[1-2]。 相似文献
7.
蛋鸡脂肪肝综合征是蛋鸡养殖业中常见疾病之一,以肝脏脂肪含量升高为主要特征。营养失衡、激素水平、脂质过氧化损伤及应激等因素都可引起蛋鸡脂肪肝综合症的发生。介绍了蛋鸡脂肪肝综合征的临床症状、病理变化,并分析了该病的病因,提出了预防和治疗该病的具体措施。 相似文献
8.
蛋鸡脂肪肝综合征的防治 总被引：1，自引：0，他引：1
蛋鸡脂肪肝综合征是蛋鸡养殖业中常见疾病之一,以肝脏脂肪含量升高为主要特征.营养失衡、激素水平、脂质过氧化损伤及应激等因素都可引起蛋鸡脂肪肝综合症的发生.介绍了蛋鸡脂肪肝综合征的临床症状、病理变化,并分析了该病的病因,提出了预防和治疗该病的具体措施. 相似文献
9.
蛋鸡脂肪肝出血综合症的诊治 总被引：2，自引：0，他引：2
脂肪肝出血综合症是高能低蛋白日粮引起的脂肪代谢障碍,使肝脏脂肪过度沉积所致的肝细胞与血管壁变脆而：殳生的肝脏出血。多发生于蛋鸡,尤其是笼养蛋鸡的产蛋高峰期。本病可引起产蛋大幅度下降,死亡率增高,造成很大的经济损失。2003年4月在河北省廊坊市某鸡场发生一起蛋鸡脂肪肝出血综合症的病例,现将结果报告如下。 相似文献
10.
脂肪肝综合症主要发生在产蛋性能良好的鸡群,绝大部分患鸡体质状况良好,没有特别的临床症状,仅表现产蛋量下降;有少量患鸡会因肝脏破裂引起急性出血而突然死亡。剖检可看到肝脏因脂肪大量沉积而肥大呈黄褐色且表面有小点出血,体腔内和肠表面有大量的脂肪沉积。 笼养蛋鸡发生脂肪肝综合症主要是日粮中营养不平衡所致,如产蛋鸡饲喂低蛋白高能量的日粮以及日粮中氨基酸含量不平衡,缺乏蛋 相似文献
11.
1. Two long-term experiments were conducted with Single Comb White Leghorn (SCWL) hens (line UCD-003) predisposed to fatty liver haemorrhagic syndrome (FLHS). The first investigated the effect of adding a fatty liver supplement to the diet of laying hens prior to the onset of lay, and continuing either until peak production or throughout 39 weeks into lay. The second experiment, lasting 9 months into lay, investigated the effect of adding a fatty liver supplement, with or without 100 g/kg dietary ground flaxseed, to the diet. Body weight, feed intake, plasma triglycerides (in experiment 2) and egg production were measured throughout the experiment. Liver weight, liver fat content, liver malondialdehyde (MDA) content and liver haemorrhage score and fatty acid content of liver fat (in experiment 2) were measured at the end of each experiment. 2. In experiment 1, hens given diets containing the fatty liver supplement had higher egg production and eggshell strength, but there was no difference in liver parameters including MDA content or haemorrhage score compared with controls. 3. At the end of experiment 2, hens on 100 g/kg flaxseed diets had lower body weight, liver weight, liver dry matter and fat content, and plasma triglyceride concentrations than hens given the control diets. 4. Liver haemorrhage score was positively correlated with liver weight, but not with liver fat content, plasma triglyceride concentration or liver MDA content. This suggests that reducing the liver lipid content or feeding fatty liver supplements may not be as effective in controlling FLHS as controlling the size of the liver. 相似文献
12.
Gang Peng Enfu Huang Jiming Ruan Liumei Huang Haiping Liang Qing Wei Xianhua Xie Qingjie Zeng Jianzhen Huang 《Animal Science Journal》2019,90(2):247-254
Cidea and Cidec are two members of Cell death‐inducing DNA fragmentation factor‐alpha‐like effector family proteins, which could be involved in lipid or fat metabolism. To better understand the roles of Cidea and Cidec in fatty liver hemorrhagic syndrome (FLHS), 150 healthy 155‐day‐old Hyline Brown laying hens were randomly divided into control group (fed with basic diet) and experimental group (fed with high‐energy low‐protein [HELP] diet). Analysis of the liver by tissue sectioning and hematoxylin and eosin staining showed that the HELP diet induced micro‐vesicular steatosis in laying hens. Subsequently, based on the liver color scores and the range of lipid accumulation observed in histological examination, we classified livers with <50% vacuolization as mild FLHS and >50% as severe FLHS. The results showed that the levels of Cidea and Cidec mRNA expression were markedly elevated in the liver and adipose tissues with FLHS and the levels of Cidea and Cidec mRNA expression in the liver with severe FLHS were significantly higher than that in the liver with mild FLHS. Thus, the present study revealed that the Cidea and Cidec genes may be involved in pathways of FLHS formation. 相似文献
13.
本试验旨在研究甜菜碱对蛋鸡脂肪肝出血综合征的预防效果。选用300日龄海蓝褐蛋鸡120只,随机分为3组,每组4个重复,每个重复10只,在自由采食、饮水和光照16 h的条件下,分别饲喂正常日粮（代谢能11.30 MJ/kg,粗蛋白质17.20%）、高能量低蛋白质日粮（代谢能12.81 MJ/kg,粗蛋白质13.04%）和添加1000 mg/kg甜菜碱的高能量低蛋白质日粮60 d。于试验期第1、30、60天,每组取8只鸡采血制备血清和采集肝脏样品及腹脂,测定血脂含量、肝脂率和腹脂率,结合产蛋性能及病理学变化,综合判定脂肪肝出血综合征(fatty liver hemorrhagic syndrome,FLHS)的发生及甜菜碱的预防效果。结果表明,与对照组相比,饲喂高能量低蛋白质日粮30 d即可引发FLHS,饲喂60 d则病情进一步加重;而在高能量低蛋白质日粮中添加1000 mg/kg甜菜碱后,饲喂30 d时甜菜碱可显著抑制FLHS的发生,具有很好的预防作用,但饲喂60 d时甜菜碱的预防作用减弱。 相似文献
14.
1. Two experiments were carried out to investigate the effect of dietary flaxseed, flax oil and n-3 fatty acid supplementation (Dry n-3) on hepatic fat content, plasma triglycerides, hepatic haemorrhage score, egg production, food intake and body weight in an inbred line of Single Comb White Leghorns (UCD-003) predisposed to fatty liver haemorrhagic syndrome (FLHS) and normal SCWL hens. 2. Feeding diets containing 100 g/kg ground flaxseed, 40 g/kg flax oil, or 100 g/kg Dry n-3 reduced body weight and significantly reduced hepatic fat content compared to feeding the control diet with animal and vegetable oil as a fat source. 3. Hepatic malondialdehyde, an indicator of lipid peroxidation within the liver, was not significantly affected by dietary treatment. 4. Normal SCWL hens tended to have higher egg production, greater body weight, greater food intake and higher blood triglyceride concentrations than UCD-003 hens, although the strain effects were not significant. Liver weight as a percent of body weight was significantly lower in normal SCWL hens. Treatments by strain interactions were not found. 5. The result suggested that dietary flaxseed, flax oil and Dry n-3 decrease hepatic fat content and reduce body weight, 2 of the predisposing factors believed to contribute to FLHS onset. However, haemorrhages were still apparent in both strains regardless of treatment, indicating that other unknown underlying mechanisms may also be responsible for FLHS. 相似文献
15.
本试验旨在研究苜草素对产蛋后期蛋鸡脂肪肝出血综合征(FLHS)的预防作用。选用500日龄京红1号产蛋鸡1 008只,随机等分为7组,每组6个重复,每个重复24只鸡。Ⅰ组为对照组,饲喂常规饲粮(代谢能11.10 MJ/kg,粗蛋白质17.68%);Ⅱ~Ⅶ组为试验组,饲喂高能低蛋白质饲粮(代谢能12.87 MJ/kg,粗蛋白质13.84%),并分别在饲粮中添加0、200、400、600、800、1 000 mg/kg苜草素。试验期60 d。结果表明:1)与对照组相比,高能低蛋白质饲粮组(Ⅱ组)蛋鸡第30天时即可表现出明显的FLHS病理特征,第1~30天平均日采食量、产蛋率、蛋重、产蛋量显著降低(P0.05),料蛋比显著升高(P0.05),第1~60天趋势更加显著(P0.05);第42天蛋白高度和哈氏单位显著降低(P0.05)。2)在高能低蛋白质饲粮中添加不同梯度的苜草素均能降低FLHS发生率,提高第1~60天的平均日采食量、产蛋率、产蛋量,降低料蛋比;提高第42天的蛋白高度、哈氏单位。由此可见,高能低蛋白质饲粮能够诱导蛋鸡FLHS,补充苜草素具有预防作用。 相似文献
16.
选用300日龄健康海蓝褐蛋鸡90羽,随机分为对照组、病理组、防治组3组（每组3个重复,每个重复10只）,分别饲喂正常日粮（代谢能11.30MJ/kg,粗蛋白质17.00%）、高能量低蛋白质日粮（代谢能12.81MJ/kg,粗蛋白质12.90%）和添加0.3mg/kg生物素的高能量低蛋白质日粮,试验期60d,分别于试验的1,30,60d,每组选取体质量相近的试验蛋鸡6羽,采血制备血清和采集肝脏样品及腹脂,测定血脂含量、肝脂率和腹脂率,观察其病理学变化。结果表明,与对照组相比,试验30,60d,高能量低蛋白质日粮组鸡产蛋性能、HDL-C含量显著降低,TG、TC、LDL-C、ALT、AST、肝脂率和腹脂率显著升高,肝脂肪变性明显。试验30d,与对照组比较,防治组鸡产蛋性能、HDL-C、TG、TC、LDL-C、ALT、AST、肝脂率和腹脂率差异不显著,肝脏脂肪变性不明显;与高能量低蛋白质日粮组比较,防治组鸡产蛋性能、HDL-C含量显著升高,TG、TC、LDL-C、ALT、AST、肝脂率和腹脂率显著降低。60d时,与对照组相比,防治组鸡产蛋性能、HDL-C显著降低,TG、TC、LDL-C、ALT、AST、肝脂率和腹脂率显著升高,肝脏呈现一定的脂肪变性;与高能量低蛋白质日粮组比较,防治组鸡产蛋性能、HDL-C含量显著升高,TG、TC、LDL-C、ALT、AST、肝脂率和腹脂率显著降低。结果提示,采用高能低蛋白日粮饲喂蛋鸡可以成功的建立蛋鸡脂肪肝出血征病理模型;在高能量低蛋白质日粮中添加0.3mg/kg生物素后,可显著影响蛋鸡的脂肪肝出血征蛋鸡脂类代谢,一定程度上对其具有预防作用。 相似文献
17.
Studies were carried out to investigate whether the administration of oestradiol to laying hens induced fatty liver-haemorrhagic syndrome (FLHS). Short term oestradiol administration (up to 6 d) significantly increased liver size and plasma lipid concentration but had no effect on liver lipid concentration or hepatic lipogenic enzyme activities. Longer-term hormone treatment (up to 28 d) again significantly increased liver size and plasma lipid concentration. Liver lipid concentration was substantially reduced and lipogenic enzyme activity significantly reduced in oestradiol-treated birds. These effects had some similarities to those seen in oestrogenised immature birds and were additive to the effects of endogenous oestrogen in the laying bird. There were no deaths from FLHS and oestradiol treatment did not cause liver haemorrhages or affect egg production. 相似文献
18.
1. The rate of thrombin generation in plasma from Fatty Liver Haemorrhagic Syndrome-susceptible laying hens (FLHS, UCD-003) is more rapid than in plasma from age-matched normal Single Comb White Leghorn (SCWL) laying hens. 2. The rate of thrombin generation in plasma was determined by measuring the biological activity of the specific coagulation proteins, Factors V, VII, VIII, IX and X. 3. The higher activity of Factors V, VII and X in FLHS-susceptible laying hens compared with normal SCWL hens remained consistent after plasma lipid concentrations were reduced. 4. Analysis of the fatty acid composition of plasma phospholipids showed that in normal SCWL laying hens phosphatidylethanolamine contained C18:3n3 whereas it contained C20:3n3 in FLHS-susceptible laying hens. 5. The results suggest that alterations in the composition of the phospholipids that are essential cofactors in the biochemical reactions involved in thrombin generation may be a contributing factor in the development of FLHS. 相似文献
19.
肝脏是鸡进行脂质代谢的重要场所,脂肪肝综合征是产蛋期母鸡常见的一种亚临床生理性代谢综合征,脂肪肝综合征呈渐进性发展,特别是进入产蛋后期会严重影响母鸡的健康和生产性能,给养殖业带来经济损失。雌激素水平与母鸡产蛋和肝脏脂肪代谢功能密切相关,雌激素的作用主要由雌激素受体(ER)介导。大量的数据表明,ERα和ERβ在哺乳动物的脂质代谢和脂质沉积中扮演不同的角色,但雌激素-ER通路对母鸡脂肪肝发生、发展的影响尚不明确。本文概述了卵黄前体物质合成对肝脏脂肪代谢的影响、雌激素对脂肪肝发生的可能影响以及雌激素-ER通路在母鸡脂肪肝发生过程中的可能分子机制。 相似文献
20.
Effects of age and diet on the lipid content and composition of gallbladder bile, liver and serum in laying strains of hen 总被引：1，自引：0，他引：1
1. Changes in lipid content and composition of liver and bile during pre- and post-laying periods were investigated in hens of a laying strain. 2. The large increase in liver lipid concentration, particularly triacylglycerols, at the onset of laying was accompanied by the appearance of triacylglycerols in the bile. 3. Accumulation of triacylglycerol in the liver was increased by a diet containing maize and soyabean meal. This was associated with increases in the triacylglycerol concentration in both serum and bile. 4. Liver microsomal phosphatidate phosphohydrolase activity was positively correlated with liver triacylglycerol content in birds given the maize/soyabean meal diet. 5. The time course of triacylglycerol accumulation in the liver and associated changes in the bile triacylglycerol concentration in laying strain hens were different to those previously observed in broiler hens. 6. Over the lifetime of the bird, secretion of triacylglycerols into bile may play an important role in the prevention of fatty liver syndromes. 相似文献