Simultaneous application of the vascular endothelial growth factor (VEGF) receptor inhibitor PTK787/ZK 222584 and ionizing radiation does not further reduce the growth of canine oral melanoma xenografts in nude mice     

Inteeworn N  Ohlerth S  Höpfl G  Guscetti F  Bley CR  Wergin MC  Roos M  Gassmann M  Kaser-Hotz B 《Veterinary journal (London, England : 1997)》2007,173(3):564-570

PTK787/ZK 222584 is an inhibitor of the vascular endothelial growth factor (VEGF) receptor tyrosine kinases. In this study, the effectiveness of PTK787/ZK 222584 and radiation on canine oral melanoma xenografts was assessed. Xenografts were treated with radiotherapy (4x6Gy), or with PTK787/ZK 222584, or with a combination of both. Treatment efficacy was assessed using a tumour growth delay assay, serial power Doppler and pO(2) measurements during and after therapy. There was a significant growth delay for the group treated with radiation alone and for the combined treatment group. However, tumour growth delay was similar in both groups. Tumours were hypoxic before irradiation and no significant re-oxygenation occurred during therapy. In all tumours, vascularity and perfusion were significantly lower at the end of the study but no significant differences in perfusion, vascularity and oxygenation status were observed between and within treatment groups. The combination of PTK787/ZK 222584 and radiotherapy did not perform better than radiotherapy alone in this model.  相似文献   

A molecular and multivariate approach to the microbial community of a commercial shallow raceway marine recirculation system operating with a Moving Bed Biofilter     

Ana Matos  Maria‐Teresa Borges  Carla Peixe  Isabel Henriques  Carlos M Pereira  Paula M L Castro 《Aquaculture Research》2011,42(9):1308-1322

  相似文献   

Functional Feeds to Tackle Meagre (Argyrosomus regius) Stress: Physiological Responses under Acute Stressful Handling Conditions     

Marta Monteiro  Carla Sousa  Filipe Coutinho  Carolina Castro  Filipa Fontinha  Inês Guerreiro  Pedro Pouso  Elisabete Matos  Patrícia Díaz-Rosales  Aires Oliva-Teles  Paula Enes  Ana Couto 《Marine drugs》2021,19(11)

Marine algae are recognised sources of bioactive compounds that have attracted great interest as nutritional supplements for aquaculture fish. Intensive rearing conditions often expose fish to husbandry-related stressors, rendering fish more susceptible to disease and reducing production yields. The present work evaluated the potential of two marine algae extracts (Fucus vesiculosus and Nannochloropsis gaditana) as nutritional supplements to mitigate stress effects in meagre (Argyrosomus regius) exposed to an acute handling stress (AS). A plant-based diet was used as a control, and three other diets were prepared, which were similar to the control diet but supplemented with 1% of each algal extract or a combination of the two extracts (0.5% each). The effects of supplemented diets on stress biomarkers, antioxidant enzyme activities, and immune response were analysed in fish exposed to AS after 4 weeks of feeding. Supplemented diets did not affect growth performance but the inclusion of F. vesiculosus promoted higher feed efficiency, as compared to the control group. Dietary algal extracts supplementation reduced plasma glucose levels, increased white blood cell counts, and reduced the expression of pro-inflammatory genes when compared with the control. N. gaditana supplementation led to a reduction in hepatic antioxidant enzyme activity and glutathione levels, while F. vesiculosus supplementation increased muscle glutathione reductase activity and reduced lipid peroxidation. These findings support the potential of algal extracts as nutraceuticals in aquafeeds to enhance the ability of fish to cope with husbandry-related stressful conditions and ultimately improve fish health and welfare.  相似文献   

Haematologic and immunologic parameters of bullfrogs,Lithobates catesbeianus,fed probiotics     

Danielle de Carla Dias  Marta Verardino De Stéfani  Cláudia Maris Ferreira  Fernanda Menezes França  Maria José Tavares Ranzani‐Paiva  Antenor Aguiar Santos 《Aquaculture Research》2010,41(7):1064-1071

The effects of two probiotics (P₁–Lactobacillus acidophilus, Bifidobacterium bifidum and Enterococcus faecium and P₂–Bacillus subtilis) supplemented to commercial feed (40% crude protein) on the haematological and immunological parameters of the bullfrog Lithobates catesbeianus were studied. Two doses of each probiotic (5 and 10 g kg^?1 of food) were added to the diets and fed to frogs, totalling five treatments over 112 days. Haematological analyses consisted of total and differential leucocyte counts, erythrocyte and thrombocyte counts, haematocrit, haemoglobin levels and RBC indices (mean corpuscular volume, mean corpuscular haemoglobin – and mean corpuscular haemoglobin concentration) and the immunological parameters included phagocytic capacity and phagocytic index of peritoneal phagocytes. The results showed that the probiotics did not significantly influence any of the haematological parameters measured. However, immunological assays showed that the probiotics had an immunostimulating effect. The greatest effects were seen with probiotic P₁ fed at a dose of 10 g kg^?1 of diet and probiotic P₂ fed at 5 g kg^?1 of diet.  相似文献   

STAR: An integrated and standardized procedure to evaluate the ecological status of coralligenous reefs     

Luigi Piazzi  Paola Gennaro  Monica Montefalcone  Carlo Nike Bianchi  Enrico Cecchi  Carla Morri  Fabrizio Serena 《水产资源保护:海洋与淡水生态系统》2019,29(2):189-201

  相似文献   

Dietary β‐carotene improves growth performance and antioxidant status of juvenile Piaractus mesopotamicus     

Carla Bacchetta  Andrea S. Rossi  Raúl E. Cian  Silvina R. Drago  Jimena Cazenave 《Aquaculture Nutrition》2019,25(4):761-769

This study was conducted to investigate the effects of dietary synthetic β‐carotene on growth performance, haematological and immunological parameters, energy reserves and antioxidant status of juvenile fish Piaractus mesopotamicus. Two hundred and ten fish (12.24 ± 2.98 g) were fed with a control extruded feed (CEF) and the same diet supplemented with β‐carotene (BEF) for 90 days. A higher weight gain and specific growth rate were found in fish fed BEF in comparison with those fed CEF. In addition, BEF‐fed fish showed lower liver somatic index and a higher percentage of eosinophils. No statistical differences were found in energy reserves, except for plasma triglycerides which decreased in fish fed with BEF. Regarding oxidative stress markers, decreased activities of antioxidant enzymes were found in intestine and gills of BEF‐fed fish (SOD and GST, respectively). In the liver, both LPO levels and CAT activity decreased in fish fed with BEF. Additionally, lower brain LPO levels without changes in the antioxidant enzymes were observed in BEF‐fed fish. The inclusion of dietary synthetic β‐carotene improved growth and antioxidant status, and had a plasma triglyceride‐lowering effect in juvenile P. mesopotamicus.  相似文献   

Physicochemical property guidelines for modern agrochemicals          下载免费PDF全文

Yu Zhang  Beth A Lorsbach  Scott Castetter  William T Lambert  Jeremy Kister  Nick X Wang  Carla J R Klittich  Joshua Roth  Thomas C Sparks  Mike R Loso 《Pest management science》2018,74(9):1979-1991

The relentless need for the discovery and development of new agrochemicals continues as a result of driving forces such as loss of existing products through the development of resistance, the necessity for products with more favorable environmental and toxicological profiles, shifting pest spectra, and the changing agricultural needs and practices of the farming community. These new challenges underscore the demand for novel, high‐quality starting points to accelerate the discovery of new agrochemicals that address market challenges. This article discusses the efforts to identify the optimum ranges of physicochemical properties of agrochemicals through analysis of modern commercial products. Specifically, we reviewed literature studies examining physicochemical property effects and analyzed the properties typical of successful fungicides, herbicides, and insecticides (chewing and sap‐feeding pests). From the analysis, a new set of physicochemical property guidelines for each discipline, as well as building block class, are proposed. These new guidelines should significantly aid in the discovery of next‐generation agrochemicals. © 2018 Society of Chemical Industry  相似文献   

Effects of Agave fructans (<Emphasis Type="Italic">Agave tequilana</Emphasis> Weber var. azul) on Body Fat and Serum Lipids in Obesity     

Eduardo Padilla-Camberos  Carla P. Barragán-Álvarez  Nestor E. Diaz-Martinez  Vineet Rathod  José Miguel Flores-Fernández 《Plant foods for human nutrition (Dordrecht, Netherlands)》2018,73(1):34-39

Obesity affects millions of people worldwide, constituting a public health problem associated with premature mortality. Agave fructans decrease fat mass, body and liver weight, and generate satiety in rodents. In the present study the effects of agave fructans on weight control, lipid profile, and physical tolerability were evaluated in obese people. Twenty-eight obese volunteers were randomly divided into two groups. In the first group, 96 mg/bw of agave fructans was administered for 12 weeks; in the second group, maltodextrin as a placebo was administered for 12 weeks. All participants consumed a low-calorie diet of 1500 kcal/day. Anthropometric and biochemical measurements were taken at baseline and at the end of the study. The body mass index (BMI) of the agave fructans treated group was reduced significantly from the baseline to the final measurements. Hip and waist circumferences decreased statistically in both groups. A decrease of 10% in total body fat was observed in the agave fructans treated group, resulting in a statistically significant difference in the final versus baseline measurements between the Agave fructans treated group and the placebo treated group. Triglycerides were reduced significantly in the agave fructans treated group. Glucose values did not change in either group. Agave fructans intake was safe and well tolerated throughout the study. The results showed that the ingestion of agave fructans enhanced the decrease in BMI, the decrease in total body fat, and the decrease in triglycerides in obese individuals who consume a low-calorie diet.  相似文献   

Intraguild predation of Geocoris punctipes on Eretmocerus eremicus and its influence on the control of the whitefly Trialeurodes vaporariorum          下载免费PDF全文

Lourdes Bao‐Fundora  Ricardo Ramirez‐Romero  Carla V Sánchez‐Hernández  José Sánchez‐Martínez  Nicolas Desneux 《Pest management science》2016,72(6):1110-1116

  相似文献   

Controlling Dactylopius opuntiae with Fusarium incarnatum–equiseti species complex and extracts of Ricinus communis and Poincianella pyramidalis     

Ana Carla da Silva Santos  Rafael Leão Soares Oliveira  Antonio Félix da Costa  Patricia Vieira Tiago  Neiva Tinti de Oliveira 《Journal of pest science》2016,89(2):539-547

  相似文献