Phytochemical Characterization and Effects on Cell Proliferation of Lentisk (Pistacia lentiscus) Berry Oil: a Revalued Source of Phenolics     

Siano  Francesco  Cutignano  Adele  Moccia  Stefania  Russo  Gian Luigi  Volpe  Maria Grazia  Picariello  Gianluca 《Plant foods for human nutrition (Dordrecht, Netherlands)》2020,75(4):487-494

Plant Foods for Human Nutrition - The ethno-pharmaceutical use of the edible fixed oil produced from lentisk (Pistacia lentiscus) berries covers a long tradition in several Mediterranean regions....  相似文献   

Biotechnological production of vitamin B2-enriched bread and pasta     

Capozzi V  Menga V  Digesu AM  De Vita P  van Sinderen D  Cattivelli L  Fares C  Spano G 《Journal of agricultural and food chemistry》2011,59(14):8013-8020

Lactic acid bacteria (LAB) were obtained from durum wheat flour samples and screened for roseoflavin-resistant variants to isolate natural riboflavin-overproducing strains. Two riboflavin-overproducing strains of Lactobacillus plantarum isolated as described above were used for the preparation of bread (by means of sourdough fermentation) and pasta (using a prefermentation step) to enhance their vitamin B2 content. Pasta was produced from a monovarietal semolina obtained from the durum wheat cultivar PR22D89 and, for experimental purposes, from a commercial remilled semolina. Several samples were collected during the pasta-making process (dough, extruded, dried, and cooked pasta) and tested for their riboflavin content by a high-performance liquid chromatography method. The applied approaches resulted in a considerable increase of vitamin B2 content (about 2- and 3-fold increases in pasta and bread, respectively), thus representing a convenient and efficient food-grade biotechnological application for the production of vitamin B2-enriched bread and pasta. This methodology may be extended to a wide range of cereal-based foods, feed, and beverages. Additionally, this work exemplifies the production of a functional food by a novel biotechnological exploitation of LAB in pasta-making.  相似文献   

PML regulates apoptosis at endoplasmic reticulum by modulating calcium release     

Giorgi C  Ito K  Lin HK  Santangelo C  Wieckowski MR  Lebiedzinska M  Bononi A  Bonora M  Duszynski J  Bernardi R  Rizzuto R  Tacchetti C  Pinton P  Pandolfi PP 《Science (New York, N.Y.)》2010,330(6008):1247-1251

The promyelocytic leukemia (PML) tumor suppressor is a pleiotropic modulator of apoptosis. However, the molecular basis for such a diverse proapoptotic role is currently unknown. We show that extranuclear Pml was specifically enriched at the endoplasmic reticulum (ER) and at the mitochondria-associated membranes, signaling domains involved in ER-to-mitochondria calcium ion (Ca(2+)) transport and in induction of apoptosis. We found Pml in complexes of large molecular size with the inositol 1,4,5-trisphosphate receptor (IP(3)R), protein kinase Akt, and protein phosphatase 2a (PP2a). Pml was essential for Akt- and PP2a-dependent modulation of IP(3)R phosphorylation and in turn for IP(3)R-mediated Ca(2+) release from ER. Our findings provide a mechanistic explanation for the pleiotropic role of Pml in apoptosis and identify a pharmacological target for the modulation of Ca(2+) signals.  相似文献   

High tolerance of European plum varieties to plum leptonecrosis   总被引：1，自引：0，他引：1  

Luigi Carraro  Nazia Loi  Paolo Ermacora  Ruggero Osler 《European journal of plant pathology / European Foundation for Plant Pathology》1998,104(2):141-145

A 13 year comparative study was carried out on the behaviour of four European and two Japanese plum varieties grown in adjacent rows in an area of northern Italy where plum leptonecrosis is epidemic. Within seven years, 100% of the Japanese plum trees became symptomatically infected. Nine years after planting, five trees of each of the European cvs, which were asymptomatic, were top-grafted with healthy buds of the cv Ozark Premier, which is an indicator for plum leptonecrosis. Based on the results of PCR analysis, DAPI staining and on the reaction of the top-grafted Ozark Premier indicators, 50% of the European plum trees, despite their healthy appearance, were shown to be infected with plum leptonecrosis. The detectable presence and graft transmissibility of the plum leptonecrosis phytoplasma in the asymptomatic European plum trees means that the European plum trees are not resistant to the infection but that they are tolerant. The active presence of a still unknown vector/s in the investigated area is stressed as well as the important role of Prunus domestica L. played in the conservation and spread of plum leptonecrosis.  相似文献   

Experimentally induced canine dermatophilosis     

J L Richard  A C Pier  S J Cysewski 《American journal of veterinary research》1973,34(6):797-799

  相似文献   

Effect of aflatoxin and aspergillosis on turkey poults   总被引：1，自引：0，他引：1  

J L Richard  A C Pier  S J Cysewski  C K Graham 《Avian diseases》1973,17(1):111-121

  相似文献   

The fine structure of the male genital organs of Allacma fusca (L.) (Collembola, Symphypleona)     

Romano Dallai  Vittoria Cavallo  Luigi Federico Falso  Pietro Paolo Fanciulli 《Pedobiologia》2000,44(3-4)

The fine structure of the male reproductive system of Allacma fusca (L.) is described. The system consists of testes, deferent ducts, seminal vesicles, ejaculatory duct and accessory glands. The nature of each part is established. Secretions from the seminal vesicles are stored in the lumen of these organs, then flow into the ejaculatory duct and are used to produce spermatophores. The epithelium of this tract has secretory activity and osmoregulatory function. Secretions and spermatozoa are stored into two distinct parts of the ejaculatory duct, divided by a transverse cuticular septum.  相似文献   

Effects of Dietary Protein Source and Feeding Regime on Growth Performance,Nutrient Digestibility,Fatty Acids,and Quality Characteristics of Rainbow Trout,Oncorhynchus mykiss,Fillets          下载免费PDF全文

Francesco Gai  Pier Giorgio Peiretti  Alberto Brugiapaglia  Laura Gasco 《Journal of the World Aquaculture Society》2016,47(4):496-507

This study investigated the effects of dietary protein source and feeding regime (apparent satiation and rationed) on growth performance, nutrient digestibility, fatty acid (FA) profile, and fillet quality traits in rainbow trout. A stock of 1200 juvenile trout (mean weight 114.6 ± 0.2 g) were randomly distributed into 24 fiberglass tanks (four diets × three replications × two feeding regimes). The experimental diets were formulated to be isoproteic and isoenergetic based on bacterial protein meal (BPM), pea protein concentrate (PPC), mixture thereof (MIX), and fish meal (FM), respectively. The feeding trial lasted 77 d with water temperature of 13 C. Statistical differences appeared among the diets only in terms of crude protein digestibility. Growth performance and somatic indexes were significantly affected by the diet, while only the condition factor was influenced by the feeding regime. None of the parameters appeared to be affected by the interaction effects. Differences appeared between the FA profiles of the dorsal muscle. Oleic, linoleic, α‐linolenic, and docosahexaenoic acid contents were influenced by diet, while only minor FAs were influenced by feeding regime. In conclusion, growth performance and nutrient digestibility resulted lower in fish fed BPM diet than other groups, while PPC group was similar to FM group.  相似文献   

Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification     

Ruggero D  Grisendi S  Piazza F  Rego E  Mari F  Rao PH  Cordon-Cardo C  Pandolfi PP 《Science (New York, N.Y.)》2003,299(5604):259-262

Mutations in DKC1 cause dyskeratosis congenita (DC), a disease characterized by premature aging and increased tumor susceptibility. The DKC1 protein binds to the box H + ACA small nucleolar RNAs and the RNA component of telomerase. Here we show that hypomorphic Dkc1 mutant (Dkc1m) mice recapitulate in the first and second generations (G1 and G2) the clinical features of DC. Dkc1m cells from G1 and G2 mice were impaired in ribosomal RNA pseudouridylation before the onset of disease. Reductions of telomere length in Dkc1m mice became evident only in later generations. These results suggest that deregulated ribosome function is important in the initiation of DC, whereas telomere shortening may modify and/or exacerbate DC.  相似文献   

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor   总被引：1，自引：0，他引：1  

Di Croce L  Raker VA  Corsaro M  Fazi F  Fanelli M  Faretta M  Fuks F  Lo Coco F  Kouzarides T  Nervi C  Minucci S  Pelicci PG 《Science (New York, N.Y.)》2002,295(5557):1079-1082

  相似文献