Evaluation of compliance among nursing staff in administration of prescribed analgesic drugs to critically ill dogs and cats     

Armitage EA  Wetmore LA  Chan DL  Lindsey JC 《Journal of the American Veterinary Medical Association》2005,227(3):425-429

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Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis     

Föger N  Rangell L  Danilenko DM  Chan AC 《Science (New York, N.Y.)》2006,313(5788):839-842

The evolutionarily conserved actin-related protein (Arp2/3) complex is a key component of actin filament networks that is dynamically regulated by nucleation-promoting and inhibitory factors. Although much is known about actin assembly, the physiologic functions of inhibitory proteins are unclear. We generated coronin 1-/- mice and found that coronin 1 exerted an inhibitory effect on cellular steady-state F-actin formation via an Arp2/3-dependent mechanism. Whereas coronin 1 was required for chemokine-mediated migration, it was dispensable for T cell antigen receptor functions in T cells. Moreover, actin dynamics, through a mitochondrial pathway, was linked to lymphocyte homeostasis.  相似文献   

Liver lobe torsion in dogs: 13 cases (1995-2004)     

Schwartz SG  Mitchell SL  Keating JH  Chan DL 《Journal of the American Veterinary Medical Association》2006,228(2):242-247

OBJECTIVE: To determine history, results of diagnostic testing, surgical findings, complications, and outcome for dogs with liver lobe torsion (LLT). DESIGN: Retrospective case series. ANIMALS: 12 dogs (1 with 2 episodes). PROCEDURE: Signalment, clinical signs, clinicopathologic findings, radiographic and ultrasonographic findings, surgical and histologic findings, complications, and hospitalization time were evaluated. RESULTS: The most common clinical signs were nonspecific abnormalities (eg, vomiting, lethargy, and anorexia) of acute or chronic duration. All dogs were large-breed dogs (median body weight, 37.2 kg [82 lb]). Biochemical abnormalities included high alanine amino-transferase (n = 12) and aspartate aminotransferase (11) activities. Results of abdominal ultrasonography were supportive of the diagnosis in 5 of 8 cases. Affected lobes included the left medial lobe (n = 4), left lateral lobe (3), papillary process of the caudate lobe (2), caudate lobe (1), and right lateral lobe (1). Exploratory celiotomy and liver lobectomy were performed in 12 of 13 cases, and in 11 of those 12 cases, the dog survived. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that development of nonspecific clinical signs of vomiting, lethargy, and anorexia in conjunction with high serum hepatic enzyme activities and mature neutrophilia in a medium-sized or large-breed dog should increase the index of suspicion for LLT. Abdominal ultrasonography with Doppler assessment may be useful in establishing the diagnosis. The long-term outcome for dogs that survive the hospitalization period is excellent.  相似文献   

Effects of mutations in Drosophila nicotinic acetylcholine receptor subunits on sensitivity to insecticides targeting nicotinic acetylcholine receptors     

Trent PerryJanice Q. Chan  Phil BatterhamGerald B. Watson  Chaoxian GengThomas C. Sparks 《Pesticide biochemistry and physiology》2012,102(1):56-60

Several strains of Drosophila melanogaster possess mutant alleles in nicotinic acetylcholine receptor (nAChR) subunits, Dα1 and Dβ2 that confer resistance to neonicotinoids such as imidacloprid and nitenpyram, and Dα6, that confers resistance to spinosyns. These mutant strains were bioassayed with a selected set of nAChR active insecticides including neonicotinoids, spinosad, and sulfoxaflor, a new sulfoximine insecticide. All of the neonicotinoids examined, except dinotefuran showed reduced insecticidal efficacy on larvae of the Dα1 mutant, suggesting that this subunit may be important in the action of these insecticides. All of the neonicotinoids, including dinotefuran, showed reduced insecticidal efficacy on larvae possessing the Dβ2 mutation. A similar pattern of broad neonicotinoid resistance to that of Dβ2 alone was also observed for larvae with both the mutations (Dα1 + Dβ2). The Dβ2 mutation exhibited a lower level of cross-resistance to sulfoxaflor (<3-fold) than to any of the neonicotinoids (>13-fold). In contrast, there was no cross-resistance for any of the neonicotinoids or sulfoxaflor in adult flies with the Dα6 mutation, which confers high levels of resistance to spinosad. Thus in the D. melanogaster strains studied, target site resistance observed for the neonicotinoids and the spinosyns does not translate directly to resistance towards sulfoxaflor.  相似文献   

Cyanophora paradoxa genome elucidates origin of photosynthesis in algae and plants     

Price DC  Chan CX  Yoon HS  Yang EC  Qiu H  Weber AP  Schwacke R  Gross J  Blouin NA  Lane C  Reyes-Prieto A  Durnford DG  Neilson JA  Lang BF  Burger G  Steiner JM  Löffelhardt W  Meuser JE  Posewitz MC  Ball S  Arias MC  Henrissat B  Coutinho PM  Rensing SA  Symeonidi A  Doddapaneni H  Green BR  Rajah VD  Boore J  Bhattacharya D 《Science (New York, N.Y.)》2012,335(6070):843-847

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How cells know the size of their organelles     

YH Chan  WF Marshall 《Science (New York, N.Y.)》2012,337(6099):1186-1189

Cells have developed ways to sense and control the size of their organelles. Size-sensing mechanisms range from direct measurements provided by dedicated reporters to indirect functional readouts, and they are used to modify organelle size under both normal and stress conditions. Organelle size can also be controlled in the absence of an identifiable size sensor. Studies on flagella have dissected principles of size sensing and control, and it will be exciting to see how these principles apply to other organelles.  相似文献   

Neuroscience. Revitalizing remyelination--the answer is circulating     

Redmond SA  Chan JR 《Science (New York, N.Y.)》2012,336(6078):161-162

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气候变暖对宜阳县朝天椒种植的影响研究     

夏婵 《现代农业科技》2012,(10):302-304

通过对朝天椒大田生产的气候、生态环境特征的分析,选取气温、降水、日照和相对湿度这4个对朝天椒生产影响最大的气象因子,分析各因子的变化特点。结果表明:气候变暖和日照增加有利于朝天椒的种植发展,但降雨量减少会影响朝天椒的生产。据此提出相关对策,如温棚育苗、提早播种、加强田间管理、做好人工增雨和蓄水准备,以应对气候变暖的影响。  相似文献   

The immunopathology of sepsis: pathogen recognition, systemic inflammation, the compensatory anti-inflammatory response, and regulatory T cells     

Lewis DH  Chan DL  Pinheiro D  Armitage-Chan E  Garden OA 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2012,26(3):457-482

Sepsis, the systemic inflammatory response to infection, represents the major cause of death in critically ill veterinary patients. Whereas important advances in our understanding of the pathophysiology of this syndrome have been made, much remains to be elucidated. There is general agreement on the key interaction between pathogen-associated molecular patterns and cells of the innate immune system, and the amplification of the host response generated by pro-inflammatory cytokines. More recently, the concept of immunoparalysis in sepsis has also been advanced, together with an increasing recognition of the interplay between regulatory T cells and the innate immune response. However, the heterogeneous nature of this syndrome and the difficulty of modeling it in vitro or in vivo has both frustrated the advancement of new therapies and emphasized the continuing importance of patient-based clinical research in this area of human and veterinary medicine.  相似文献   

血清10型鸭疫里默氏杆菌灭活油乳剂疫苗的研制     

王小兰  刘蕾  刘海文  苗双  胡青海  韩先干  丁铲  于圣青 《中国家禽》2012,34(15):29-32

鸭疫里默氏杆菌(Riemerella anatipestifer,RA)感染是主要危害2~8周龄雏鸭的高致病性细菌性传染病。为研制血清10型RA灭活油乳剂疫苗,选取10株血清10型RA分离株进行动物体复壮、分离和鉴定后,分别对部分毒株进行了毒力测定和灭活油乳剂疫苗的研制。结果表明,所有试验用分离株对7日龄雏鸭均具有较强的致病力。分离株YXL1和HXb2的半数致死量分别为2.8×108 cfu和82 cfu,不同菌株之间的毒力差异很大。用研制的灭活油乳剂疫苗对雏鸭进行2次免疫后,免疫鸭可获得高水平的特异性抗体,并可抵抗强毒RA的攻击,以HXb2免疫后的攻毒保护性最好。抗体水平检测和攻毒保护试验结果表明,用血清10型RA分离株HXb2制备的油乳剂灭活疫苗具有良好的免疫保护作用。  相似文献