Development of Immediate Release Tablets Containing Calcium Lactate Synthetized from Black Sea Mussel Shells     

Magdalena Mititelu  Elena Moro&#x;an  Anca Cecilia Nicoar&#x;  Ana Andreea Sec&#x;reanu  Adina Magdalena Musuc  Irina Atkinson  Jeanina Pandele Cusu  George Mihai Niulescu  Emma Adriana Ozon  Iulian Sarbu  Teodora Dalila Balaci 《Marine drugs》2022,20(1)

Nowadays, the use of marine by-products as precursor materials has gained great interest in the extraction and production of chemical compounds with suitable properties and possible pharmaceutical applications. The present paper presents the development of a new immediate release tablet containing calcium lactate obtained from Black Sea mussel shells. Compared with other calcium salts, calcium lactate has good solubility and bioavailability. In the pharmaceutical preparations, calcium lactate was extensively utilized as a calcium source for preventing and treating calcium deficiencies. The physical and chemical characteristics of synthesized calcium lactate were evaluated using Fourier Transform Infrared Spectroscopy, X-ray diffraction analysis and thermal analysis. Further, the various pharmacotechnical properties of the calcium lactate obtained from mussel shells were determined in comparison with an industrial used direct compressible Calcium lactate DC (PURACAL^®). The obtained results suggest that mussel shell by-products are suitable for the development of chemical compounds with potential applications in the pharmaceutical domain.  相似文献   

CRISPR-based genetic control strategies for insect pests          下载免费PDF全文

Ying YAN  Roswitha A. AUMANN  Irina H?CKER  Marc F. SCHETELIG 《农业科学学报》2023,22(3):651-668

Genetic control strategies such as the sterile insect technique have successfully fought insect pests worldwide. The CRISPR(clustered regularly interspaced short palindromic repeats) technology, together with high-quality genomic resources obtained in more and more species, greatly facilitates the development of novel genetic control insect strains that can be used in area-wide and species-specific pest control programs. Here, we review the research progress towards state-of-art CRISPR-based gen...  相似文献   

Unilateral twin pregnancy: A non-infectious factor required for the etiological diagnosis of abortion in dairy herds     

Fernando L PEZ-GATIUS  Irina GARCIA-ISPIERTO  Christian HANZEN 《The Journal of reproduction and development》2021,67(6):337

Twin pregnancies are classified into bilateral (one fetus in each uterine horn: 44%) and unilateral (both fetuses in the same uterine horn, right or left: 56%). The incidence of abortion during mid- to late gestation is approximately 1% in cows carrying bilateral twins and more than 40% in cows carrying unilateral twins. In this period, abortion seems most commonly associated with infectious agents. However, although this imbalanced abortion rate may imply that unilateral twin pregnancy is a non-infectious abortion factor, few available data can describe the cause of abortions in twin pregnancies. The current findings suggest that unilateral twin pregnancy is a non-infectious factor required for the etiological diagnosis of abortion in dairy herds.  相似文献   

Deep-Sea Anemones Are Prospective Source of New Antimicrobial and Cytotoxic Compounds     

Aleksandra Kvetkina  Elena Kostina  Irina Gladkikh  Victoria Chausova  Ekaterina Yurchenko  Irina Bakunina  Mikhail Pivkin  Stanislav Anastyuk  Roman Popov  Margarita Monastyrnaya  Emma Kozlovskaya  Marina Isaeva  Pavel Dmitrenok  Elena Leychenko 《Marine drugs》2021,19(12)

The peculiarities of the survival and adaptation of deep-sea organisms raise interest in the study of their metabolites as promising drugs. In this work, the hemolytic, cytotoxic, antimicrobial, and enzyme-inhibitory activities of tentacle extracts from five species of sea anemones (Cnidaria, orders Actiniaria and Corallimorpharia) collected near the Kuril and Commander Islands of the Far East of Russia were evaluated for the first time. The extracts of Liponema brevicorne and Actinostola callosa demonstrated maximal hemolytic activity, while high cytotoxic activity against murine splenocytes and Ehrlich carcinoma cells was found in the extract of Actinostola faeculenta. The extracts of Corallimorphus cf. pilatus demonstrated the greatest activity against Ehrlich carcinoma cells but were not toxic to mouse spleen cells. Sea anemones C. cf. pilatus and Stomphia coccinea are promising sources of antimicrobial and antifungal compounds, being active against Gram-positive bacteria Bacillus subtilis, Staphylococcus aureus, and yeast Candida albicans. Moreover, all sea anemones contain α-galactosidase inhibitors. Peptide mass fingerprinting of L. brevicorne and C. cf. pilatus extracts provided a wide range of peptides, predominantly with molecular masses of 4000–5900 Da, which may belong to a known or new structural class of toxins. The obtained data allow concluding that deep-sea anemones are a promising source of compounds for drug discovery.  相似文献   

桦褐孔菌菌核提取物对细菌抑菌活性研究   总被引：1，自引：1，他引：0  

刘迎秋  熊红霞  包海鹰  李玉 《中国食用菌》2009,28(2)

采用纸片法研究了桦褐孔菌的水、甲醇、丙酮、氯仿、石油醚提取物对大肠杆菌ERcat、EnR￡、ATCC25923和金黄色葡萄球菌ATCC25923、O41ermc的抑制作用。结果表明:桦褐孔菌各提取物对大肠杆菌ERcat、ATCC25923和金黄色葡萄球菌O41ermc均有不同程度的抑制作用。其中甲醇提取物在10mg·mL-1浓度下对大肠杆菌ERcat的抑菌效果最好,抑制率高达84.1%;石油醚提取物对除大肠杆菌EnR￡以外的其它供试菌株均表现出显著的抑菌活性。另外,浓度为10mg·mL-1的丙酮提取物对大肠杆菌EnR￡的生长有一定的抑制作用;浓度2.5mg·mL-1的甲醇提取物和浓度10mg·mL-1的石油醚提取物对金黄色葡萄球菌ATCC25923的抑菌作用较为明显。  相似文献   

Egg hatching rate and fatty acid composition of Acartia bilobata (Calanoida,Copepoda) across cold storage durations     

Yen‐Ju Pan  Anissa Souissi  Irina Sadovskaya  Jiang‐Shiou Hwang  Sami Souissi 《Aquaculture Research》2019,50(2):483-489

To investigate egg storage capacity of the copepod Acartia bilobata for aquaculture interest, we tested hatching success rate (HSR) of inclusive eggs (mixture of all egg types) after 4°C storage. The HSR peaked after 14 days storage when incubating at 28°C for 48 hr (85.8 ± 1.6%) and 72 hr (87.6 ± 0.9%), then gradually declined until 1 year (48 hr: 7 ± 0.6%; 72 hr: 19.4 ± 3.9%). Reallocation of fatty acid profile suggests that docosahexaenoic acid (DHA) is correlated with the HSR of A. bilobata eggs. Additionally, we investigated the HSR of diapausing eggs (unhatched eggs after 72 hr incubation of the inclusive eggs) after 4°C storage. Their HSR peaked after 14 days storage (48 hr:75.3 ± 3.5%; 72 hr:78.2 ± 2.1%), then gradually declined until 60 days (48 hr HSR:42.1 ± 2.3%; 72 hr HSR:53.0 ± 3.2%). Overall, we illustrated the hatchability of diapausing and quiescent eggs of A. bilobata after 4°C storage. The cold storage capacities were low (<60% HSR after 60 days), and it could be limited by the egg DHA content. Our findings provide implications for future studies aiming to improve cold storage techniques of tropical copepod eggs for aquaculture applications.  相似文献   

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Yen‐Ju Pan  Anissa Souissi  Irina Sadovskaya  Jiang‐Shiou Hwang  Sami Souissi 《Aquaculture Research》2019,50(2):i-i

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New approaches for evaluation of soil health,sensitivity and resistance to degradation     

Yakov KUZYAKOV  Anna GUNINA  Kazem ZAMANIAN  Jing TIAN  Yu LUO  Xingliang XU  Anna YUDINA  Humberto APONTE  Hattan ALHARBI  Lilit OVSEPYAN  Irina KURGANOVA  Tida GE  Thomas GUILLAUME 《农业科学与工程前沿(英文版)》2020,7(3):282

Assessment of soil health requires complex evaluation of properties and functions responsible for a broad range of ecosystem services. Numerous soil quality indices (SQI) have been suggested for the evaluation of specific groups of soil functions, but comparison of various SQI is impossible because they are based on a combination of specific soil properties. To avoid this problem, we suggest an SQI-area approach based on the comparison of the areas on a radar diagram of a combination of chemical, biological and physical properties. The new approach is independent of the SQI principle and allows rapid and simple comparison of parameter groups and soils. Another approach analyzing the resistance and sensitivity of properties to degradation is suggested for a detailed evaluation of soil health. The resistance and sensitivity of soil properties are determined through comparison with the decrease of soil organic carbon (SOC) as a universal parameter responsible for many functions. The SQI-area and resistance/sensitivity approaches were tested based on the recovery of Phaeozems and Chernozems chronosequences after the abandonment of agricultural soils. Both the SQI-area and the resistance/sensitivity approaches are useful for basic and applied research, and for decision-makers to evaluate land-use practices and measure the degree of soil degradation.  相似文献   

Strawberry recovers from iron chlorosis after foliar application of a grass‐clipping extract     

Maribela Pestana  Irina Domingos  Florinda Gama  Susana Dandlen  Maria Graça Miguel  João Castro Pinto  Amarilis de Varennes  Pedro José Correia 《植物养料与土壤学杂志》2011,174(3):473-479

Bare‐root transplants of strawberry (Fragaria × ananassa Duch. cv. Selva) were transferred to nutrient solutions with or without iron. After 35 d of growth, plants in the solution without iron became chlorotic and had morphological changes in roots typical of iron‐deficiency chlorosis (IDC). Acidification of the nutrient solution was also observed. We tested a grass‐clipping extract to correct IDC in strawberry plants by foliar application to some chlorotic plants. We also assessed the effects of this product on plant growth, Fe allocation, as well as morphological and physiological parameters related with IDC. After the second spray, leaf chlorophyll increased in the youngest expanded leaves. The total content of iron in plants increased from 1.93 mg to 2.37 mg per plant after three sprays, accounting for 80% of the total iron supplied by the extract. Newly formed roots from sprayed plants had a normal morphology (no subapical swollen zone) but a higher ferric chelate–reductase (FC‐R; EC 1.16.1.17) activity per root apex compared with roots from plants grown with iron or untreated chlorotic plants. Acidification of the nutrient solution continued in sprayed recovered plants. The results suggest an uncoupling of the regulation of morphological and physiological mechanisms related to IDC: FC‐R activity seems to be controlled by roots on their own or together with shoots, while morphological changes in roots are apparently regulated only by the level of iron in shoots.  相似文献   

Regional and socio-economic differences in food, nutrient and supplement intake in school-age children in Germany: results from the GINIplus and the LISAplus studies     

Sausenthaler S  Standl M  Buyken A  Rzehak P  Koletzko S  Bauer CP  Schaaf B  von Berg A  Berdel D  Borte M  Herbarth O  Lehmann I  Krämer U  Wichmann HE  Heinrich J;GINIplus  the LISAplus Study Groups 《Public health nutrition》2011,14(10):1724-1735

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