Around 30% of European agricultural landscapes are classified as high nature value (HNV) farmlands. Current policies emphasize the multifunctionality of these landscapes, but little is known about the positive and negative associations of multiple ecosystem services within HNV farmland.
Objectives
This study aims to identify perceived ecosystem services synergies, trade-offs, and bundles in agricultural landscapes of HNV from a socio-cultural perspective.
Methods
We performed a participatory mapping survey of 10 ecosystem services categories among 2301 rural residents in 13 European sites. We analyzed bivariate synergies and trade-offs between perceived ecosystem services through nonparametric correlation analyses. Spatial bundles of perceived ecosystem services were identified through hierarchical cluster analysis. Multinomial logit models were used to assess the influence of land cover on generating associations of ecosystem services.
Results
We find two strong and 16 moderate synergies of perceived ecosystem services (out of 46 possible ecosystem services pairs), mainly among different cultural ecosystem services. We do not reveal moderate or strong trade-offs. We identify five spatial bundles of ecosystem services, termed “Ecosystem services coldspots”, “Wild harvesting ranges”, “Nature areas”, “Recreational spaces”, and “Ecosystem services hotspots”. Of all land-cover co-variates, natural areas, urban areas, and roads have the strongest explanatory power.
Conclusions
Our study complements prevailing biophysical and economic analyses of ecosystem services synergies, trade-offs and bundles by a spatially explicit, socio-cultural perspective. We conclude that socio-cultural mapping of ecosystem services is useful for understanding the perceived multifunctionality of a landscape.
Efficacy and mechanism of action of marine alkaloid 3,10-dibromofascaplysin (DBF) were investigated in human prostate cancer (PCa) cells harboring different levels of drug resistance. Anticancer activity was observed across all cell lines examined without signs of cross-resistance to androgen receptor targeting agents (ARTA) or taxane based chemotherapy. Kinome analysis followed by functional investigation identified JNK1/2 to be one of the molecular targets of DBF in 22Rv1 cells. In contrast, no activation of p38 and ERK1/2 MAPKs was observed. Inhibition of the drug-induced JNK1/2 activation or of the basal p38 activity resulted in increased cytotoxicity of DBF, whereas an active ERK1/2 was identified to be important for anticancer activity of the alkaloid. Synergistic effects of DBF were observed in combination with PARP-inhibitor olaparib most likely due to the induction of ROS production by the marine alkaloid. In addition, DBF intensified effects of platinum-based drugs cisplatin and carboplatin, and taxane derivatives docetaxel and cabazitaxel. Finally, DBF inhibited AR-signaling and resensitized AR-V7-positive 22Rv1 prostate cancer cells to enzalutamide, presumably due to AR-V7 down-regulation. These findings propose DBF to be a promising novel drug candidate for the treatment of human PCa regardless of resistance to standard therapy. 相似文献
Grain yield and its component traits are essential targets in maize breeding. These traits are genetically complex and controlled by a large number of quantitative trait loci (QTL). The aim of this study was to compile reported QTL and major genes for grain yield and its component traits in a QTL atlas, as a valuable resource for the maize community. To this end, 1,177 QTL related to maize yield were collected from 56 studies published between 1992 and 2018. These QTL were projected to genetic map “IBM2 2008 Neighbors”, which led to the identification of 135 meta-QTL. Some genomic regions appear to be hotspots for yield-related meta-QTL, often affecting more than one of the investigated traits. Moreover, we catalogued 20 major maize loci associated with yield and identified 65 maize homologs of 21 rice yield-related genes. Interestingly, we found that a significant proportion of them are located in meta-QTL regions. Collectively, this study provides a reference for QTL fine-mapping and gene cloning, as well as for molecular marker-assisted breeding of yield-related traits in maize. 相似文献
Distribution and connectivity of suitable habitat for species of conservation concern is critical for effective conservation planning. Capercaillie (Tetrao urogallus), an umbrella species for biodiversity conservation, is increasingly threatened because of habitat loss and fragmentation.
Objective
We assessed the impact of drastic changes in forest management in the Carpathian Mountains, a major stronghold of capercaillie in Europe, on habitat distribution and connectivity.
Methods
We used field data surveys with a forest disturbance dataset for 1985–2010 to map habitat suitability, and we used graph theory to analyse habitat connectivity.
Results
Climate, topography, forest proportion and fragmentation, and the distance to roads and settlements best identified capercaillie presence. Suitable habitat area was 7510 km2 in 1985; by 2010, clear-cutting had reduced that area by 1110 km2. More suitable habitat was lost inside protected areas (571 km2) than outside (413 km2). Habitat loss of 15 % reduced functional connectivity by 33 % since 1985.
Conclusions
Forest management, particularly large-scale clear-cutting and salvage logging, have substantially diminished and fragmented suitable capercaillie habitat, regardless of the status of forest protection. Consequently, larger areas with suitable habitat are now isolated and many patches are too small to sustain viable populations. Given that protection of capercaillie habitat would benefit many other species, including old-growth specialists and large carnivores, conservation actions to halt the loss of capercaillie habitat is urgently needed. We recommend adopting policies to protect natural forests, limiting large-scale clear-cutting and salvage logging, implementing ecological forestry, and restricting road building to reduce forest fragmentation.
A prospective study was conducted to determine the sensitivity and specificity of diagnosis of portosystemic shunts (PSS) and the accuracy of anatomically locating single congenital PSS in dogs using magnetic resonance angiography (MRA). MRA was performed on 10 normal dogs and 23 dogs with PSS. Sensitivity and specificity of MRA to diagnose any shunt among all dogs were 80% and 100%, respectively. Among dogs identified with PSS, sensitivity and specificity of MRA for diagnosis of multiple extrahepatic shunts were 63% and 97%, respectively, and for diagnosis of single congenital shunts were 79% and 100%, respectively. Using MRA, radiologists correctly identified shunts as extrahepatic or intrahepatic in 83% of patients and correctly identified the origin and insertion of the shunts in 57% and 97% of patients, respectively. Use of MRA is specific for diagnosis of PSS and is a sensitive indicator of anatomic location of single congenital portosystemic shunts. 相似文献
Despite regular reforms, problems under the EU's Common Fisheries Policy (CFP) persist. In order to identify priorities for future reforms of the policy, we developed an analytical framework consisting of 17 criteria and specifying indicators, derived from scientific, wider fisheries, and common resources literature. We applied the framework to the CFP governance system, its regulations, institutions, and processes at EU as well as member state level. The results show that the CFP does not fully meet any of the 17 criteria for an effective resource policy. Its performance was assessed as “neutral” regarding 10 criteria and “negative” regarding seven criteria. Trend analysis shows that there is a slightly positive trend regarding the CFP's performance, with five criteria trending positively, 11 showing a neutral trend and only one criterion trending negatively (simplicity of rules). The analysis identified five criteria which are performing badly and have not improved over time: simplicity of rules, user‐pays principle, resource efficiency, accountability, and compliance mechanisms. Future reforms of the CFP should first and foremost address these criteria while continuing efforts to improve the CFP's performance regarding other criteria. The evaluation of the CFP demonstrates the applicability of the analytical framework which can also be applied to other multilevel fisheries governance systems. Moreover, the results can inform reforms of Regional Fisheries Management Organisations. Like the CFP, these institutions manage transboundary fisheries and have not effectively addressed the issues of resource rent capture and resource efficiency. 相似文献
Eurasian perch is generally only considered to be a candidate for freshwater aquaculture even though wild populations are found in estuarine and brackish water habitats. Little knowledge exists on two issues a) the effect of temperature on the salinity tolerance of perch and b) the long-term effects of brackish water on their overall growth performance. The present study addresses these two questions.
Firstly, the effect of temperature (12, 15, 20 and 25°C) on perch survival of a salinity challenge at either 13 or 18‰ was determined. Survival was unaffected by 13‰ at the two lowest temperatures whereas higher temperature and higher salinities had a dramatic detrimental effect (at 25°C, 50% mortality was reach at 62h and 39h for 13‰ and 18‰, respectively). Secondly, we examined the effect of salinity on growth, which was assessed by measuring standard length and body weight at regular intervals for 130days. In addition, Specific growth rate (SGR), Fulton's condition factor (K) and food conversion ratio (FCR) were also calculated as was the effect of salinity on plasma osmolality, blood ion content (Na+, Cl−, K+) and muscle water content at the termination of the experiment. The optimum growth for this study was seen in the lowest salinities at 0 and 4‰. Surprisingly, even small increases in salinity were detrimental to perch growth. At 10‰, growth in terms of body weight was reduced by about 50% after 130days compared to perch reared in freshwater.
Interest in brackish water production of perch would be most likely served best by selecting a strain of perch that is adapted to saline conditions, as found in the lower Baltic region. Further studies are required to understand the potential for brackish water perch production. 相似文献
Agricultural management is a major factor driving the change of faunal richness in anthropogenic landscapes. Thus, there is
an urgent need to develop tools that allow decision-makers to understand better intended and unintended effects of agricultural
policy measures on biodiversity. Here we demonstrate the potential of such a tool by combining a socio-economic model with
the biodiversity model GEPARD to forecast the response of bird and carabid species richness to two scenarios of agricultural
subsidies: (1) subsidies based on production levels and prices and (2) direct income support that is independent of production
levels. We focussed on farmland of the Lahn-Dill area, Germany, as an example of European regions with low intensity farming.
GEPARD predicts faunal richness and is based on multi-scaled resource-selection functions. Under both scenarios the area of
predicted losses in species richness of birds and carabids was larger than the area of predicted gains in species richness.
However, the area with predicted losses of avian richness was smaller under the direct income support scenario than under
the production-based subsidy scenario, whereas the area with predicted losses of carabid species richness was smaller under
the production-based subsidy scenario than under the direct income support. Yet locally, richness gains of up to four species
were predicted for carabids under both scenarios. We conclude that the sometimes contrasting and heterogeneous responses of
birds and carabids at different localities suggest the need for spatially targeted subsidy schemes. With the help of the GIS-based
approach presented in this study, prediction maps on potential changes in local and regional species richness can be easily
generated. 相似文献