Serum antibody responses to vaccinal antigens in lean and obese geriatric dogs     

John Ellis  Sheryl Gow  Carrie Rhodes  Stacey Lacoste  Lyndsay Kong  Kristyna Musil  Elisabeth Snead 《The Canadian veterinary journal. La revue veterinaire canadienne》2016,57(5):531-534

The immune responses in control dogs [1 to 4 years of age, body condition score (BCS): 4 to 5 out of 9] were compared to those of aging dogs (based on breed and body size) either categorized as lean (BCS: 4 to 5 out of 9) or obese (BCS: 8 to 9 out of 9). Of interest were the serum titers to the following common agents found in vaccines, canine parainfluenza virus (CPIV), canine parvovirus (CPV), canine distemper virus (CDV), canine respiratory coronavirus (CRCoV), and Bordetella bronchiseptica. There were no statistical differences in the antibodies to CPIV, B. bronchispetica, and CRCoV, among the age/weight categories, nor among the age/weight categories and the time, in days, between the date of sample collection and the date of the last recorded vaccination for CPIV, B. bronchiseptica, CPV, and CDV. For CPV, the control dogs had significantly (P < 0.002) higher serum neutralization (SN) titers than the lean geriatric dogs and the obese geriatric dogs. For CDV SN titers, the only statistically significant (P = 0.01) difference was that the control dogs had higher SN titers than the lean geriatric dogs.  相似文献   

Surgical implantation of temperature‐sensitive transmitters and data‐loggers to record body temperature in koalas (Phascolarctos cinereus)          下载免费PDF全文

D Adam  SD Johnston  L Beard  V Nicholson  A Lisle  J Gaughan  R Larkin  P Theilemann  A Mckinnon  W Ellis 《Australian veterinary journal》2016,94(1-2):42-47

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Evaluation of a Permanent Synthetic Osteochondral Implant in the Equine Medial Femoral Condyle          下载免费PDF全文

Kirsty A. Husby  Shannon K. Reed  David A. Wilson  Keiichi Kuroki  John R. Middleton  Natalie C. Hoepp  Elizabeth M. Charles  James L. Cook 《Veterinary surgery : VS》2016,45(3):364-373

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Letter to Editor          下载免费PDF全文

Chand Khanna DVM  PhD  DACVIM  David Vail DVM  DACVIM  Mona Rosenberg DVM  DACVIM 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2016,30(1):9-9

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Planetary science. As tiny worlds turn     

Rubincam DP  Paddack SJ 《Science (New York, N.Y.)》2007,316(5822):211-212

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Climate change. Why is it hard to predict the future of ice sheets?     

Vaughan DG  Arthern R 《Science (New York, N.Y.)》2007,315(5818):1503-1504

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Research funding. UC balks at campus-wide ban on tobacco money for research     

Grimm D 《Science (New York, N.Y.)》2007,315(5811):447-448

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Neutrophil myeloperoxidase measurements in plasma, laminar tissue, and skin of horses given black walnut extract     

Riggs LM  Franck T  Moore JN  Krunkosky TM  Hurley DJ  Peroni JF  de la Rebière G  Serteyn DA 《American journal of veterinary research》2007,68(1):81-86

OBJECTIVE: To compare measurements of myeloperoxidase (MPO) in plasma, laminar tissues, and skin obtained from control horses and horses given black walnut heartwood extract (BWHE). ANIMALS: 22 healthy 5- to 15-year-old horses. PROCEDURES: Horses were randomly assigned to 4 groups as follows: a control group given water (n = 5) and 3 experimental groups given BWHE (17) via nasogastric intubation. Experimental groups consisted of 5, 6, and 6 horses that received BWHE and were euthanatized at 1.5, 3, and 12 hours after intubation, respectively. Control horses were euthanatized at 12 hours after intubation. Plasma samples were obtained hourly for all horses. Laminar tissue and skin from the middle region of the neck were harvested at the time of euthanasia. Plasma and tissue MPO concentrations were determined via an ELISA; tissue MPO activity was measured by use of specific immunologic extraction followed by enzymatic detection. RESULTS: Tissues and plasma of horses receiving BWHE contained significantly higher concentrations of MPO beginning at hour 3. Laminar tissue and skin from horses in experimental groups contained significantly higher MPO activity than tissues from control horses. Concentrations and activities of MPO in skin and laminar tissues were similar over time. CONCLUSIONS AND CLINICAL RELEVANCE: In horses, BWHE administration causes increases in MPO concentration and activity in laminar tissue and skin and the time of increased MPO concentration correlates with emigration of WBCs from the vasculature. These findings support the hypothesis that activation of peripheral WBCs is an early step in the pathogenesis of acute laminitis.  相似文献   

Characterization of protection against systemic infection and disease from experimental bovine viral diarrhea virus type 2 infection by use of a modified-live noncytopathic type 1 vaccine in calves     

Kelling CL  Hunsaker BD  Steffen DJ  Topliff CL  Eskridge KM 《American journal of veterinary research》2007,68(7):788-796

OBJECTIVE: To evaluate protection resulting from use of a modified-live noncytopathic bovine viral diarrhea virus (BVDV) type 1 vaccine against systemic infection and clinical disease in calves challenged with type 2 BVDV. ANIMALS: 10 calves, 5 to 7 months of age. PROCEDURES: Calves were allocated (n = 5/group) to be nonvaccinated or vaccinated SC on day 0 with BVDV 1 (WRL strain). Calves in both groups were challenged intranasally with BVDV type 2 isolate 890 on day 21. Rectal temperatures and clinical signs of disease were recorded daily, and total and differential WBC and platelet counts were performed. Histologic examinations and immunohistochemical analyses to detect lesions and distribution of viral antigens, respectively, were performed. RESULTS: After challenge exposure to BVDV type 2, nonvaccinated calves developed high rectal temperatures, increased respiratory rates, viremia, leukopenia, lymphopenia, and infection of the thymus. Vaccinated calves did not develop high rectal temperatures or clinical signs of respiratory tract disease. Vaccinated calves appeared to be protected against systemic replication of virus in that they did not develop leukopenia, lymphopenia, viremia, or infection of target organs, and infectious virus was not detected in peripheral blood mononuclear cells or the thymus. CONCLUSIONS AND CLINICAL RELEVANCE: The modified-live BVDV type 1 vaccine protected against systemic infection and disease after experimental challenge exposure with BVDV type 2. The vaccine protected calves against infection and viremia and prevented infection of target lymphoid cells.  相似文献   

Effect of maternal cells transferred with colostrum on cellular responses to pathogen antigens in neonatal calves     

Donovan DC  Reber AJ  Gabbard JD  Aceves-Avila M  Galland KL  Holbert KA  Ely LO  Hurley DJ 《American journal of veterinary research》2007,68(7):778-782

OBJECTIVE: To assess the effect of maternal cells or cellular components on neonatal immune responses to intracellular pathogens in calves. ANIMALS: 15 Holstein calves. PROCEDURES: Calves were fed whole colostrum, frozen colostrum, or cell-free colostrum within 4 hours after birth. Leukocytes were obtained from calves before feeding colostrum and 1, 2, 7, 14, 21, and 28 days after ingestion. Proliferative responses against bovine viral diarrhea virus (BVDV) and mycobacterial purified protein derivatives were evaluated. Dams received a vaccine containing inactivated BVDV, but were not vaccinated against mycobacterial antigens. RESULTS: All calves had essentially no IgG in circulation at birth, but comparable and substantial concentrations by day 1. Calves that received whole colostrum had enhanced responses to BVDV antigen 1 and 2 days after ingestion of colostrum. In contrast, calves that received frozen colostrum or cell-free colostrum did not respond to BVDV. No differences were identified among the 3 groups in response to mycobacterial antigens. CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that transfer of live maternal cells from colostrum to neonatal calves enhanced responses to antigens against which the dams had previously responded (BVDV), but not to antigens to which the dams were na?ve (mycobacterial purified protein derivatives). Results suggested that cell-mediated immune transfer to neonates can be enhanced by maternal vaccination.  相似文献