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Ali R. Nourian Paul C. Mills Christopher C. Pollitt 《Veterinary journal (London, England : 1997)》2010,183(1):22-26
Microdialysis (MD) was used for continuous monitoring of the lamellar extracellular fluid (ECF) in six mature healthy Standardbred horses. MD probes were introduced into the lamellar tissue under local anaesthesia. Following intravenous injection of gentamicin (5 mg/kg), MD and serum samples were collected for 24 h and analysed using a sensitive ELISA test for gentamicin and fluorescence polarization immunoassay for urea concentrations. Calibration of probes was performed through in vivo urea recovery and in vitro gentamicin and urea recovery. Data obtained from different body compartments were compared statistically. The concentration of gentamicin was significantly higher in serum than lamellar ECF for the first 8 h (P < 0.05), but remained above the minimum inhibitory concentration (MIC) in the ECF for a further 4 h. The method will be useful to monitor changes in the lamellar ECF during laminitis and the local kinetics of drugs used therapeutically for this condition. 相似文献
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DN Basov SI Woods AS Katz EJ Singley RC Dynes M Xu DG Hinks CC Homes M Strongin 《Science (New York, N.Y.)》1999,283(5398):49-52
Analysis of the interlayer infrared conductivity of cuprate high-transition temperature superconductors reveals an anomalously large energy scale extending up to midinfrared frequencies that can be attributed to formation of the superconducting condensate. This unusual effect is observed in a va- riety of materials, including Tl2Ba2CuO6+x, La2-xSrxCuO4, and YBa2Cu3O6.6, which show an incoherent interlayer response in the normal state. Midinfrared range condensation was examined in the context of sum rules that can be formulated for the complex conductivity. One possible interpretation of these experiments is in terms of a kinetic energy change associated with the superconducting transition. 相似文献
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Brian P. Grossbard DVM Catherine A. Loughin DVM Diplomate ACVS ACCT Leonard J. Marino MD FAAP Joseph Sackman Scott E. Umbaugh BSE MSEE PhD Patrick S. Solt BSEE MSCS Jakia Afruz BSAPECE MSAPECE Peter Leando PhD DSc DAc Martin L. Lesser PhD EMT‐CC Meredith Akerman MS 《Veterinary surgery : VS》2014,43(7):869-876
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REASONS FOR PERFORMING STUDY: Experimental induction of equine laminitis with a reliable and clinically relevant model should facilitate understanding of the disease. Successful induction with oligofructose (OF) could link pasture consumption to laminitis. OBJECTIVES: To determine whether alimentary administration of OF induces laminitis. METHODS: Twelve horses were dosed with OF and 6 received a sham (placebo) treatment. Clinical observations were made and blood collected at 4 h intervals over a 48 h study period. Stained sections of the hoof wall lamellae, examined by light microscopy, were graded for laminitis severity. RESULTS: All horses administered OF, but no sham-treated controls, developed clinical and histological laminitis. CONCLUSIONS AND POTENTIAL RELEVANCE: Alimentary overload with OF is a valid induction model for studying the pathogenesis of laminitis. A link is therefore established between field cases of laminitis and pasture fructan content. 相似文献