Risk factors for recurrence of clinical signs associated with thoracolumbar intervertebral disk herniation in dogs: 229 cases (1994-2000)     

Mayhew PD  McLear RC  Ziemer LS  Culp WT  Russell KN  Shofer FS  Kapatkin AS  Smith GK 《Journal of the American Veterinary Medical Association》2004,225(8):1231-1236

OBJECTIVE: To assess risk factors for recurrence of clinical signs associated with thoracolumbar intervertebral disk disease (IVDD) in dogs that had decompressive laminectomy without attempted prophylactic treatment of other disk spaces. DESIGN: Retrospective study. ANIMALS: 229 dogs. PROCEDURE: Medical records of dogs that had decompressive laminectomy without prophylactic fenestration for a first episode of IVDD and were available for follow-up were reviewed. Information on 7 clinical and 8 radiographic potential risk factors were recorded. RESULTS: Clinical signs associated with recurrence of IVDD developed in 44 (19.2%) dogs. Ninety-six percent of recurrences developed within 3 years after surgery. Recurrence developed in 25% of Dachshunds and 15% of dogs of other breeds combined. Number of opacified disks was a significant risk factor for recurrence. Risk increased with number of opacified disks in an almost linear manner; each opacified disk increased risk by 1.4 times. Dogs with 5 or 6 opacified disks at the time of first surgery had a recurrence rate of 50%. CONCLUSIONS AND CLINICAL RELEVANCE: When all likely episodes of recurrence are considered and a long follow-up period is achieved, true rate of recurrence of IVDD appears to be higher than in many previous reports. Dogs with multiple opacified disks at the time of first surgery should be considered a high-risk subpopulation.  相似文献   

Evaluation of parameters obtained from two systems of gait analysis     

ND Assaf  SC Rahal  LR Mesquita  WT Kano  RB Abibe 《Australian veterinary journal》2019,97(10):414-417

  相似文献   

Feline visceral hemangiosarcoma     

Culp WT  Drobatz KJ  Glassman MM  Baez JL  Aronson LR 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2008,22(1):148-152

BACKGROUND: Feline visceral hemangiosarcoma (HSA) is an uncommon tumor, and the clinical progression and outcome are rarely reported. HYPOTHESIS: The prognosis of feline visceral HSA is poor because of severe clinical signs, anemia, and a high rate of metastasis. ANIMALS: The medical records of 26 client-owned cats with visceral HSA were reviewed. METHODS: Multi-institutional retrospective study. RESULTS: The most common historical findings and clinical signs included lethargy, anorexia, respiratory difficulty, collapse, and vocalizing. Eighty-two percent of cats were anemic, and aspartate transaminase was increased in 53% of the study population. Metastatic lung disease was noted in 33% of affected cats. In 75% of the cats, abdominal ultrasonography identified a specific location of HSA. However, ultrasound identification of all multifocal lesions was successful only in 3/9 cats (33%). Tumor location was identified in the following organs: liver (35%), small intestine (31%), large intestine (31%), abdominal lymph node (31%), mesentery (27%), spleen (23%), lung (19%), omentum (12%), brain (8%), pancreas (8%), and diaphragm (8%). Multifocal HSA was noted in 77% of cats. Three cats received adjuvant chemotherapy (doxorubicin). Seventy-one percent of euthanized cats were euthanized within 1 day of diagnosis. The median survival time of the remaining cats (n = 6) was 77 days (range, 23-296 days). CONCLUSION AND CLINICAL IMPORTANCE: Feline visceral HSA is most often multifocal at the time of diagnosis. The prognosis appears poor, and the number of cats receiving chemotherapy is low.  相似文献   

Is the caudal auricular axial pattern flap robust? A multi‐centre cohort study of 16 dogs and 12 cats (2005 to 2016)     

J. L. J. Proot  N. Jeffery  W. T. N. Culp  P. Buracco  B. de la Puerta  J. M. Williams  J. F. Ladlow  E. J. Field  P. Nelissen  R. A. Ragni  J. F. A. Pope  S. J. Baines  J. M. Liptak  I. Nicholson 《The Journal of small animal practice》2019,60(2):102-106

  相似文献   

PROSPECTIVE COMPARISON OF TUMOR STAGING USING COMPUTED TOMOGRAPHY VERSUS MAGNETIC RESONANCE IMAGING FINDINGS IN DOGS WITH NASAL NEOPLASIA: A PILOT STUDY          下载免费PDF全文

Cassie N. Lux  William T. N. Culp  Lynelle R. Johnson  Michael Kent  Philipp Mayhew  Lise A. Daniaux  Alaina Carr  Sarah Puchalski 《Veterinary radiology & ultrasound》2017,58(3):315-325

Identification of nasal neoplasia extension and tumor staging in dogs is most commonly performed using computed tomography (CT), however magnetic resonance imaging (MRI) is routinely used in human medicine. A prospective pilot study enrolling six dogs with nasal neoplasia was performed with CT and MRI studies acquired under the same anesthetic episode. Interobserver comparison and comparison between the two imaging modalities with regard to bidimensional measurements of the nasal tumors, tumor staging using historical schemes, and assignment of an ordinal scale of tumor margin clarity at the tumor‐soft tissue interface were performed. The hypotheses included that MRI would have greater tumor measurements, result in higher tumor staging, and more clearly define the tumor soft tissue interface when compared to CT. Evaluation of bone involvement of the nasal cavity and head showed a high level of agreement between CT and MRI. Estimation of tumor volume using bidimensional measurements was higher on MRI imaging in 5/6 dogs, and resulted in a median tumor volume which was 18.4% higher than CT imaging. Disagreement between CT and MRI was noted with meningeal enhancement, in which two dogs were positive for meningeal enhancement on MRI and negative on CT. One of six dogs had a higher tumor stage on MRI compared to CT, while the remaining five agreed. Magnetic resonance imaging resulted in larger bidimensional measurements and tumor volume estimates, along with a higher likelihood of identifying meningeal enhancement when compared to CT imaging. Magnetic resonance imaging may provide integral information for tumor staging, prognosis, and treatment planning.  相似文献   

M_(99-1)引诱剂诱捕松墨天牛等松甲虫的研究   总被引：8，自引：1，他引：8       下载免费PDF全文

赵锦年  林长春  姜礼元  吴沧松  姚剑飞  俞盛明 《林业科学研究》2001,(5)

报道了松墨天牛成虫活动期间 ,在马尾松 -栎类次生混交林、马尾松 -湿地松人工林和黄山松天然林 3种不同林分中 ,应用 M99-1引诱剂诱捕钻蛀性松甲虫种类、主要钻蛀性松甲虫成虫种群数量及其比率和不同诱捕期松墨天牛雌成虫孕卵量及其比率的情况。研究结果显示 ,M99-1引诱剂诱获鞘翅目害虫达 2 6种 ,其中钻蛀性松甲虫达 14种 ,占诱获种类的 5 3.8%。马尾松角胫象、松墨天牛种群数量比率最高 ,分别达 5 7.3%～ 69.8%和 2 7.2 %～ 2 9.3%。 3种不同松林林分中 ,短角幽天牛、褐幽天牛、薄翅锯天牛等其它主要钻蛀性害虫的数量比率也较高。不同诱捕期松墨天牛雌成虫平均孕卵量及其比率 ,以活动前期 (6月下旬前 )为最高 ,分别达 16.9粒和 4 1.9%。 M99-1引诱剂诱捕是监测松林钻蛀性松甲虫种群动态和降低其虫口密度的重要方法  相似文献   

Early Tumor Response to Intraarterial or Intravenous Administration of Carboplatin to Treat Naturally Occurring Lower Urinary Tract Carcinoma in Dogs          下载免费PDF全文

W.T.N. Culp  C. Weisse  A.C. Berent  J.A. Reetz  E.L. Krick  D.E. Jackson  P.H. Kass  C.A. Clifford  K.U. Sorenmo 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2015,29(3):900-907

Background

Survival times and tumor responses associated with malignant neoplasia of the lower urinary tract are poor despite the vast array of current treatments. Therefore, the evaluation of alternative treatments, such as intraarterial administration of chemotherapy (IAC) should be considered.

Objective

To describe a technique for superselective catheterization for IAC and to evaluate initial tumor response by ultrasonography after both IAC and intravenous administration of chemotherapy (IVC).

Animals

Client‐owned dogs with lower urinary tract neoplasia treated with either IVC (n = 15) or IAC (n = 11).

Methods

Retrospective study. An arterial approach via the carotid or femoral artery was utilized to obtain superselective access and administer chemotherapy in the IAC cases. Medical record review was performed, data were recorded, and recorded variables were evaluated statistically.

Results

Intraarterial chemotherapy was successfully administered in all cases. There was a significantly greater decrease in longest unidimensional measurement in the IAC group as compared to the IVC group (P = .013). The IAC group was also significantly more likely to have a tumor response as assessed by modified RECIST guidelines (P = .049). Dogs in the IAC group were significantly less likely to develop anemia (P = .001), lethargy (P = .010) and anorexia (P = .024).

Conclusion and Clinical Importance

This study demonstrated the feasibility and efficacy of performing IAC for lower urinary tract neoplasia. Further investigation is necessary as the follow‐up time was short and the impact on long‐term outcome and survival was not determined.  相似文献   

Evaluation of Weight Change During Carboplatin Therapy in Dogs With Appendicular Osteosarcoma          下载免费PDF全文

A.L. Story  S.E. Boston  J.J. Kilkenny  A. Singh  J.P. Woods  W.T.N. Culp  K.A. Skorupski  X. Lu 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2017,31(4):1159-1162

  相似文献   

Comparisons of the effects of acupuncture, electroacupuncture, and transcutaneous cranial electrical stimulation on the minimum alveolar concentration of isoflurane in dogs     

Culp LB  Skarda RT  Muir WW 《American journal of veterinary research》2005,66(8):1364-1370

OBJECTIVE: To compare the effects of acupuncture (AP), electroacupuncture (EA), and transcutaneous cranial electrical stimulation (TCES) with high-frequency intermittent currents on the minimum alveolar concentration (MAC) of isoflurane and associated cardiovascular variables in dogs. ANIMALS: 8 healthy adult female Beagles. PROCEDURE: Each dog was anesthetized with isoflurane on 4 occasions, allowing a minimum of 10 days between experiments. Isoflurane MAC values were determined for each dog without treatment (controls) and after treatment with AP and EA (AP points included the Large Intestine 4, Lung 7, Governing Vessel 20, Governing Vessel 14, San Tai, and Baihui) and TCES. Isoflurane MAC values were determined by use of noxious electrical buccal stimulation. Heart rate, mean arterial blood pressure (MAP), arterial blood oxygen saturation (Spo2) measured by use of pulse oximetry, esophageal body temperature, inspired and expired end-tidal isoflurane concentrations, end-tidal carbon dioxide concentration, and bispectral index (BIS) were monitored. Blood samples were collected for determination of plasma cortisol concentration. RESULTS: Mean +/- SD baseline MAC of isoflurane was 1.19 +/- 0.1%. Acupuncture did not significantly change MAC of isoflurane. Treatments with EA and TCES significantly lowered the MAC of isoflurane by 10.1% and 13.4%, respectively. The Spo2, heart rate, MAP, BIS, esophageal body temperature, and plasma cortisol concentration were not significantly different after AP, EA, TCES, and control treatments at any time interval. CONCLUSIONS AND CLINICAL RELEVANCE: Use of EA and TCES decreased MAC of isoflurane in dogs without inducing adverse hemodynamic effects. However, the reduction in isoflurane MAC by EA andTCES treatments was not considered clinically relevant.  相似文献   

Ostrich anaesthesia: xylazine premedication followed by alphaxalone/alphadolone and isoflurane     

LK CULLEN  MA GOERKE  RA SWAN  WT CLARK  D NANDAPI  C COLBOURNE 《Australian veterinary journal》1995,72(4):153-154

  相似文献