Prophylactic use of a lyophilized platelet product for rhinoscopic diagnosis and treatment of sinonasal aspergillosis in a dog with a P2Y12 platelet receptor mutation     

Laura R. Van Vertloo DVM  MS  DACVIM  Alexandra Z. Portanova DVM  Elle K. Donnini DVM  DACVIM  Anne S. Hale DVM  Dana N. LeVine DVM  PhD  DACVIM 《Journal of Veterinary Emergency and Critical Care》2023,33(2):242-246

Objective

To describe the periprocedural use of a lyophilized platelet product during rhinoscopic diagnosis and treatment of sinonasal aspergillosis in a Greater Swiss Mountain Dog with a P2Y12 platelet receptor disorder.

Case Summary

After the development of severe epistaxis, a Greater Swiss Mountain Dog was diagnosed with thrombopathia secondary to a P2Y12 receptor gene mutation. Concurrent primary nasal disease was also suspected due to persistent mucopurulent nasal discharge. One month after the initial presentation for epistaxis, the dog was readmitted for workup of nasal disease. Computed tomography of the head showed turbinate lysis and regional lymphadenopathy. Because of concern for a high risk of bleeding in a thrombopathic patient subjected to rhinoscopy and nasal biopsies, a lyophilized platelet product was administered prior to the procedure. Rhinoscopic exam revealed fungal plaques consistent with Aspergillus spp. that were later confirmed on fungal culture to be Aspergillus fumigatus. Rhinoscopic biopsies were performed as well as debridement of the fungal plaques, followed by topical administration of clotrimazole solution. Bleeding was minimal during and after the procedure, and the dog recovered uneventfully.

New or Unique Information Provided

This is the first report of the prophylactic use of lyophilized platelets in a thrombopathic patient undergoing an invasive procedure with potential for significant hemorrhage. Minimal bleeding occurred during the procedure, suggesting that lyophilized platelets could be used for the prevention of bleeding in thrombopathic patients undergoing invasive procedures.  相似文献   

Prevalence of antibodies against Saint Louis encephalitis and Jamestown Canyon viruses in California horses     

Nelson DM  Gardner IA  Chiles RF  Balasuriya UB  Eldridge BF  Scott TW  Reisen WK  Maclachlan NJ 《Comparative immunology, microbiology and infectious diseases》2004,27(3):209-215

Jamestown Canyon (JC) and Saint Louis encephalitis (SLE) viruses are mosquito-transmitted viruses that have long been present in California. The objective of this study was to determine the seroprevalence of these two viruses in horses prior to the introduction of West Nile (WN) virus. Approximately 15% of serum samples collected in 1998 from 425 horses on 44 equine operations horses throughout California had serum antibodies to JC virus, whereas antibodies were not detected to SLE virus. The results indicate that horses in California were commonly infected prior to 1998 with mosquito-transmitted Bunyaviruses that are identical or closely related to JC virus, but not with SLE virus. The different seroprevalence of SLE and JC viruses in horses likely reflects the unique ecology of each virus, and it is predicted that WN virus will have a wider distribution in California than closely related SLE virus.  相似文献   

Transrectal stapling for colonic resection and anastomosis (10 cases)     

Banz WJ  Jackson DJ  Richter K  Launer DP 《Journal of the American Animal Hospital Association》2008,44(4):198-204

The purpose of this retrospective study was to determine the feasibility of using the end-to-end anastomosis (EEA) stapling device transrectally for managing distal colonic disease in clinical veterinary cases. Ten animals met the criteria of having distal colonic or rectal resection and anastomosis with the EEA stapling device. The only complications seen after discharge from the hospital were colonic stricture at the anastomosis site in two animals and transient colitis in two animals. The stapled anastomosis has good success when properly applied, and the incidences of stricture formation, leakage, and other potential complications can be kept to a minimum.  相似文献   

Pyogranulomatous panophthalmitis with systemic coronavirus disease in a domestic ferret (Mustela putorius furo)          下载免费PDF全文

Dana M. Lindemann  David Eshar  Loni L. Schumacher  Kelli M. Almes  Amy J. Rankin 《Veterinary ophthalmology》2016,19(2):167-171

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ACVIM consensus statement on the diagnosis of immune‐mediated hemolytic anemia in dogs and cats     

Oliver A. Garden  Linda Kidd  Angela M. Mexas  Yu‐Mei Chang  Unity Jeffery  Shauna L. Blois  Jonathan E. Fogle  Amy L. MacNeill  George Lubas  Adam Birkenheuer  Simona Buoncompagni  Julien R. S. Dandrieux  Antonio Di Loria  Claire L. Fellman  Barbara Glanemann  Robert Goggs  Jennifer L. Granick  Dana N. LeVine  Claire R. Sharp  Saralyn Smith‐Carr  James W. Swann  Balazs Szladovits 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2019,33(2):313-334

Immune‐mediated hemolytic anemia (IMHA) is an important cause of morbidity and mortality in dogs. IMHA also occurs in cats, although less commonly. IMHA is considered secondary when it can be attributed to an underlying disease, and as primary (idiopathic) if no cause is found. Eliminating diseases that cause IMHA may attenuate or stop immune‐mediated erythrocyte destruction, and adverse consequences of long‐term immunosuppressive treatment can be avoided. Infections, cancer, drugs, vaccines, and inflammatory processes may be underlying causes of IMHA. Evidence for these comorbidities has not been systematically evaluated, rendering evidence‐based decisions difficult. We identified and extracted data from studies published in the veterinary literature and developed a novel tool for evaluation of evidence quality, using it to assess study design, diagnostic criteria for IMHA, comorbidities, and causality. Succinct evidence summary statements were written, along with screening recommendations. Statements were refined by conducting 3 iterations of Delphi review with panel and task force members. Commentary was solicited from several professional bodies to maximize clinical applicability before the recommendations were submitted. The resulting document is intended to provide clinical guidelines for diagnosis of, and underlying disease screening for, IMHA in dogs and cats. These should be implemented with consideration of animal, owner, and geographical factors.  相似文献   

The prevalence of ultrasonographic abnormalities and histopathologic lesions is high in testes of yearling tropical hair rams     

John Dascanio  Jerry Roberson  Catherine Pfent  Vinayak K. Nahar  Maziel Arauz  Kerry Alexander  Brian Roberts  D. Andrew Cope  Rhett Bridger  Dana Botsko 《Veterinary radiology & ultrasound》2019,60(3):338-345

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Presumed phenobarbital-induced Stevens–Johnson syndrome in a 4-year-old female Great Dane*     

Ine Cornelis  Sophie Vandenabeele  Dana Dunon  Luc Van Ham 《The Veterinary quarterly》2016,36(4):242-246

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The survival of hatchery‐origin pinto abalone Haliotis kamtschatkana released into Washington waters     

Henry S. Carson  Dana J. Morin  Joshua V. Bouma  Michael Ulrich  Robert Sizemore 《水产资源保护:海洋与淡水生态系统》2019,29(3):424-441

Introgressive hybridization between native and non‐local steelhead (Oncorhynchus mykiss) of hatchery origin     

Dana E. Weigel  Jennifer R. Adams  Michael A. Jepson  Lisette P. Waits  Christopher C. Caudill 《水产资源保护:海洋与淡水生态系统》2019,29(2):292-302

Investigation of a novel, heritable bleeding diathesis of Thoroughbred horses and development of a screening assay     

Norris JW  Pratt SM  Auh JH  Wilson SJ  Clutter D  Magdesian KG  Ferraro GL  Tablin F 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2006,20(6):1450-1456

BACKGROUND: Bleeding in racing horses associated with exercise appears to be multifactorial, and clinical investigation into severe cases rarely occurs. Previously, we reported a severe bleeding diathesis in a Thoroughbred mare. Herein, we describe the cellular physiology of this defect, provide a diagnostic tool for identifying it, and demonstrate that the dysfunction is heritable. HYPOTHESIS: The subject has a heritable defect in platelet secretion that reduces thrombin generation in the absence of additional plasma factors and delays the onset of thrombin production even in the presence of these factors. ANIMALS: The study included 3 clinically normal Thoroughbred horses: the subject and her offspring. METHODS: Washed platelets were examined for their ability to (1) translocate phosphatidylserine to the outer leaflet of the platelet membrane as determined by annexin-V binding, (2) generate thrombin as assessed by the activity of the prothrombinase enzyme complex, and (3) bind fibrinogen and form aggregates as determined by flow cytometry. RESULTS: Subject and offspring platelets created procoagulant surfaces by translocating phosphatidylserine. The subject's platelets demonstrated reduced prothrombinase activity, resulting in decreased production of thrombin relative to control platelets. Subject and offspring platelets bound less fibrinogen than control platelets when stimulated with thrombin. CONCLUSIONS AND CLINICAL IMPORTANCE: The subject mare has a transmissible defect that involves reduced generation of thrombin by activated platelets, resulting in decreased aggregation and ineffective clotting. A flow cytometric assay of fibrinogen binding to washed platelets discriminates individuals with this platelet dysfunction and may be useful for discerning subclinical congenital or acquired platelet dysfunctions.  相似文献