Wilderness Medicine Within Global Health: A Strategy for Less Risk and More Reward     

Jay Lemery  Dana Sacco  Amita Kulkarni  Liz Francis 《The Forestry Chronicle》2012,23(1):84-88

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Projected impacts of climate change on stream salmonids with implications for resilience‐based management          下载免费PDF全文

Andrew K. Carlson  William W. Taylor  Kelsey M. Schlee  Troy G. Zorn  Dana M. Infante 《Ecology of Freshwater Fish》2017,26(2):190-204

The sustainability of freshwater fisheries is increasingly affected by climate warming, habitat alteration, invasive species and other drivers of global change. The State of Michigan, USA, contains ecologically, socioeconomically valuable coldwater stream salmonid fisheries that are highly susceptible to these ecological alterations. Thus, there is a need for future management approaches that promote resilient stream ecosystems that absorb change amidst disturbances. Fisheries professionals in Michigan are responding to this need by designing a comprehensive management plan for stream brook charr (Salvelinus fontinalis), brown trout (Salmo trutta) and rainbow trout (Oncorhynchus mykiss) populations. To assist in developing such a plan, we used stream‐specific regression models to forecast thermal habitat suitability in streams throughout Michigan from 2006 to 2056 under different predicted climate change scenarios. As baseflow index (i.e., relative groundwater input) increased, stream thermal sensitivity (i.e., relative susceptibility to temperature change) decreased. Thus, the magnitude of temperature warming and frequency of thermal habitat degradation were lowest in streams with the highest baseflow indices. Thermal habitats were most suitable in rainbow trout streams as this species has a wider temperature range for growth (12.0–22.5 °C) compared to brook charr (11.0–20.5 °C) and brown trout (12.0–20.0 °C). Our study promotes resilience‐based salmonid management by providing a methodology for stream temperature and thermal habitat suitability prediction. Fisheries professionals can use this approach to protect coldwater habitats and drivers of stream cooling and ultimately conserve resilient salmonid populations amidst global change.  相似文献   

Neutrophil extracellular traps in stored canine red blood cell units     

Erin R. McQuinn  Stephanie A. Smith  Austin K. Viall  Chong Wang  Dana N. LeVine 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2020,34(5):1894-1902

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Effect of Dorsal Acetabular Rim Loss on Stability of the Zurich Cementless Total Hip Acetabular Cup in Dogs          下载免费PDF全文

Dana M. DeSandre‐Robinson DVM  Stanley E. Kim BVSc  MS  Diplomate ACVS  Jeffrey N. Peck DVM  Diplomate ACVS  Jason D. Coggeshall DVM  Giovanni Tremolada DMV  PhD  Antonio Pozzi DMV  MS  Diplomate ACVS 《Veterinary surgery : VS》2015,44(2):195-199

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Efficacy of Florfenicol for Control of Mortality Associated with Edwardsiella ictaluri in Three Species of Catfish     

Patricia S. Gaunt  Nagaraj Chatakondi  Dana Gao  Richard Endris 《Journal of aquatic animal health》2015,27(1):45-49

The efficacy of florfenicol for control of mortality associated with Edwardsiella icatluri was studied in fingerlings of Channel Catfish Ictalurus puntatus (Delta strain), Blue Catfish I. furcatus (D&B strain), and a hybrid catfish (Delta strain Channel Catfish × D&B strain Blue Catfish). On day 0, fish were immersion challenged in 65-L aquaria. For each of the three species of catfish, 10 aquaria were randomly assigned to two treatment groups, either treated with florfenicol at 0 mg/kg of body weight (unmedicated feed) or at 10 mg/kg (medicated feed). Fish were treated for 10 consecutive days, monitored for mortality during this treatment period, and observed for 14 d afterwards. Post observation, all survivors were humanely euthanized in tricaine methanesulfonate, cultured for E. ictaluri, and examined for gross pathology. The mean cumulative percent mortality from enteric septicemia of catfish (ESC) challenge among the three genotypes of catfish did not differ between Blue Catfish, hybrid, and Channel Catfish in treated or control groups. However, the florfenicol-treated fish had a significantly lower mean cumulative mortality (6%) than the controls (78%). All genotypes of catfish tested were responsive to treatment with florfenicol-medicated feed for control of mortality associated with ESC. There were no significant differences in mortality associated with hybrid catfish, blue catfish, and Channel Catfish (Delta strain).

Received July 20, 2014; accepted October 10, 2014  相似文献   

The fatty acid binding protein 6 gene (Fabp6) is expressed in murine granulosa cells and is involved in ovulatory response to superstimulation     

Raj DUGGAVATHI  Dayananda SIDDAPPA  Yasmin SCHUERMANN  Melissa PANSERA  Isabelle J. MENARD  Dana PRASLICKOVA  Luis B. AGELLON 《The Journal of reproduction and development》2015,61(3):237-240

The fatty acid binding protein 6 (Fabp6) is commonly regarded as a bile acid binding protein found in the distal portion of the small intestine and has been shown to be important in maintaining bile acid homeostasis. Previous studies have also reported the presence of Fabp6 in human, rat and fish ovaries, but the significance of Fabp6 in this organ is largely unknown. Therefore, we surveyed murine ovaries for Fabp6 gene expression and evaluated its role in ovarian function using mice with whole body Fabp6 deficiency. Here we show that the Fabp6 gene is expressed in granulosa and luteal cells of the mouse ovary. Treatment with gonadotropins stimulated Fabp6 gene expression in large antral follicles. The ovulation rate in response to superovulatory treatment in Fabp6-deficient mice was markedly decreased compared to wildtype (C57BL/6) mice. The results of this study suggest that expression of Fabp6 gene in granulosa cells serves an important and previously unrecognized function in fertility.  相似文献   

Longitudinal assessment of B-RAF V595E levels in the peripheral cell-free tumor DNA of a 10-year-old spayed female Korean Jindo dog with unresectable metastatic urethral transitional cell carcinoma for monitoring the treatment response to a RAF inhibitor (sorafenib)     

Jung-Hyun Kim  Dana Hyunjung Ahn  Je-Sung Moon  Hyun-Jung Han  Kieun Bae  Kyong-Ah Yoon 《The Veterinary quarterly》2021,41(1):153

Transitional cell carcinoma (TCC) is the most common malignant tumor of the canine urinary tract. In this case study, a dog with metastatic urethral TCC was treated with sorafenib. The tumor expression levels of receptor tyrosine kinase genes, including VEGFR-1, VEGFR-2, PDGFR-α, PDGFR-β, ALK, EGFR, ErbB2, and B-RAF, were analyzed. VEGFR was overexpressed in tumor tissues compared to the normal tissues. Considering the high frequency of B-RAF mutation in canine urological tumors, the B-RAF gene was examined, and the B-RAF V595E mutation was detected in the tumor tissue. Therefore, the antitumor effect of sorafenib, a multi-tyrosine kinase inhibitor, on unresectable metastatic urethral TCC characterized by B-RAF V595E was evaluated and circulating cell-free tumor DNA (ctDNA) was assessed for monitoring the treatment response. After the initiation of oral sorafenib therapy (4 mg/kg/day escalated to 10 mg/kg/day), the dysuria was alleviated gradually, and the patient remained stable for 3 months. During that treatment period, the patient showed various levels of changes associated with B-RAF V595E mutation in ctDNA as evident from longitudinal plasma samples after initiation of sorafenib therapy. The findings of this study suggest that ctDNA may serve as a useful non-invasive tool for monitoring the treatment response to anticancer drugs.  相似文献   

Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan     

Girardin SE  Boneca IG  Carneiro LA  Antignac A  Jéhanno M  Viala J  Tedin K  Taha MK  Labigne A  Zähringer U  Coyle AJ  DiStefano PS  Bertin J  Sansonetti PJ  Philpott DJ 《Science (New York, N.Y.)》2003,300(5625):1584-1587

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RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites     

Sobhian B  Shao G  Lilli DR  Culhane AC  Moreau LA  Xia B  Livingston DM  Greenberg RA 《Science (New York, N.Y.)》2007,316(5828):1198-1202

Mutations affecting the BRCT domains of the breast cancer-associated tumor suppressor BRCA1 disrupt the recruitment of this protein to DNA double-strand breaks (DSBs). The molecular structures at DSBs recognized by BRCA1 are presently unknown. We report the interaction of the BRCA1 BRCT domain with RAP80, a ubiquitin-binding protein. RAP80 targets a complex containing the BRCA1-BARD1 (BRCA1-associated ring domain protein 1) E3 ligase and the deubiquitinating enzyme (DUB) BRCC36 to MDC1-gammaH2AX-dependent lysine(6)- and lysine(63)-linked ubiquitin polymers at DSBs. These events are required for cell cycle checkpoint and repair responses to ionizing radiation, implicating ubiquitin chain recognition and turnover in the BRCA1-mediated repair of DSBs.  相似文献   

Number theory. Prime-number proof's leap falls short     

Mackenzie D 《Science (New York, N.Y.)》2003,300(5622):1066

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