Standing myotomy to treat fibrotic myopathy: 22 cases (2004–2016)     

Charlene V. Noll  Isabelle Kilcoyne  Betsy Vaughan  Larry D. Galuppo 《Veterinary surgery : VS》2019,48(6):997-1004

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Equine idiopathic hemorrhagic cystitis: Clinical features and comparison with bladder neoplasia          下载免费PDF全文

Fauna L. Smith  K. Gary Magdesian  Adam O. Michel  Betsy Vaughan  Christopher M. Reilly 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(3):1202-1209

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Evaluation of clinical characteristics, diagnostic test results, and outcome in horses with internal infection caused by Corynebacterium pseudotuberculosis: 30 cases (1995-2003)     

Pratt SM  Spier SJ  Carroll SP  Vaughan B  Whitcomb MB  Wilson WD 《Journal of the American Veterinary Medical Association》2005,227(3):441-448

OBJECTIVE: To determine clinical signs, results of diagnostic testing, and outcome in horses with internal Corynebacterium pseudotuberculosis infection. DESIGN: Retrospective study. ANIMALS: 30 horses. PROCEDURE: Information pertaining to clinical data, results of diagnostic tests, and costs of hospitalization and treatment was extracted from medical records of affected horses. RESULTS: Internal C. pseudotuberculosis infection was diagnosed on the basis of clinical signs, diagnostic imaging, and clinicopathologic data, including results of serologic tests and bacterial culture. The most common clinical signs were concurrent external abscesses, anorexia, fever, lethargy, weight loss, and signs of respiratory tract disease or abdominal pain. Clinicopathologic abnormalities included a geometric mean reciprocal serum synergistic hemolysin inhibition titer > or = 512, leukocytosis with neutrophilia, hyperglobulinemia, hyperfibrinogenemia, and anemia. Specific organ involvement was diagnosed in 27 of 30 horses. Affected organs included the liver (18 horses), lungs (12), kidneys (7), and spleen (3); multiple organs were affected in 10 horses. Treatment with antimicrobials for a median of 36 days (range, 7 to 97 days) was usually successful, yielding an overall survival rate of 71%. CONCLUSIONS AND CLINICAL RELEVANCE: Early diagnosis and long-term antimicrobial treatment were important for a successful outcome in horses with internal C. pseudotuberculosis infection. Ultrasonographic imaging was an important technique for identifying specific organs affected, aiding in obtaining samples for a definitive diagnosis, and monitoring response to treatment. Pregnant mares with internal infections are at risk for fetal loss. Preexisting chronic organ disease may be associated with a poor prognosis.  相似文献   

Absolute and relative cell counts for synovial fluid from clinically normal shoulder and stifle joints in cats     

Pacchiana PD  Gilley RS  Wallace LJ  Hayden DW  Feeney DA  Jessen CR  Aird B 《Journal of the American Veterinary Medical Association》2004,225(12):1866-1870

OBJECTIVE: To determine absolute and relative cell counts for synovial fluid from grossly, radiographically, and histologically normal shoulder and stifle joints in healthy cats. DESIGN: Clinical study. ANIMALS: 52 cats scheduled to be euthanatized for unrelated reasons. PROCEDURE: Arthrocentesis of the shoulder and stifle joints was performed bilaterally, and synovial fluid was analyzed for absolute WBC count, WBC morphology, and percentages of neutrophils and mononuclear cells. Joints were examined grossly and radiographically, and synovial membrane specimens were submitted for histologic examination. Synovial fluid samples that were contaminated with blood and samples from joints with any gross, radiographic, or histologic abnormalities were excluded. RESULTS: 82 of the 208 synovial fluid samples were excluded because abnormalities were identified during physical examination; the volume of fluid obtained was insufficient for analysis; there was evidence of blood contamination; or the joint had gross, radiographic, or histologic abnormalities. Median WBC count for the remaining 126 synovial fluid samples was 91 cells/microL (96.4% mononuclear cells and 3.6% neutrophils); WBC count was not significantly different between left and right joint samples or between shoulder and stifle joint samples. Body weight was associated with synovial fluid WBC count, with WBC count increasing as body weight increased. Sixteen of the 52 (30%) cats had radiographic evidence of osteoarthritis involving at least 1 joint. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that synovial fluid can be obtained reliably from shoulder and stifle joints in cats.  相似文献   

Antiplatelet effects and pharmacodynamics of clopidogrel in cats     

Hogan DF  Andrews DA  Green HW  Talbott KK  Ward MP  Calloway BM 《Journal of the American Veterinary Medical Association》2004,225(9):1406-1411

OBJECTIVE: To evaluate antiplatelet effects and pharmacodynamics of clopidogrel in cats. DESIGN: Original study. ANIMALS: 5 purpose-bred domestic cats. PROCEDURE: Clopidogrel was administered at dosages of 75 mg, p.o., every 24 hours for 10 days; 37.5 mg, p.o., every 24 hours for 10 days; and 18.75 mg, p.o., every 24 hours for 7 days. In all cats, treatments were administered in this order, with at least 2 weeks between treatments. Platelet aggregation in response to ADP and collagen and oral mucosal bleeding times (OMBTs) were measured before and 3, 7, and 10 days (75 and 37.5 mg) or 7 days (18.75 mg) after initiation of drug administration. Serotonin concentration in plasma following stimulation of platelets with ADP or collagen was measured before and on the last day of drug administration. Platelet aggregation, OMBT, and serotonin concentration were evaluated at various times after drug administration was discontinued to determine when drug effects were lost. RESULTS: For all 3 dosages, platelet aggregation in response to ADP platelet aggregation in response to collagen, and serotonin concentration were significantly reduced and OMBT was significantly increased at all measurement times during drug administration periods. All values returned to baseline values by 7 days after drug administration was discontinued. No significant differences were identified between doses. None of the cats developed adverse effects associated with drug administration. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that administration of clopidogrel at dosages ranging from 18.75 to 75 mg, p.o., every 24 hours, results in significant antiplatelet effects in cats.  相似文献   

Feline intracranial neoplasia: retrospective review of 160 cases (1985-2001)     

Troxel MT  Vite CH  Van Winkle TJ  Newton AL  Tiches D  Dayrell-Hart B  Kapatkin AS  Shofer FS  Steinberg SA 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2003,17(6):850-859

The purpose of this study was to determine the frequency of different tumor types within a large cohort of cats with intracranial neoplasia and to attempt to correlate signalment, tumor size and location, and survival time for each tumor. Medical records of 160 cats with confirmed intracranial neoplasia evaluated between 1985 and 2001 were reviewed. Parameters evaluated included age, sex, breed, FeLV/FIV status, clinical signs, duration of signs, number of tumors, tumor location(s), imaging results, treatment, survival times, and histopathologic diagnosis. Most of the cats were older (11.3 +/- 3.8 years). Primary tumors accounted for 70.6% of cases. Metastasis and direct extension of secondary tumors accounted for only 5.6 and 3.8% of cases, respectively. Twelve cats (7.5%) had 2 or more discrete tumors of the same type, whereas 16 cats (10.0%) had 2 different types of intracranial tumors. The most common tumor types were meningioma (n = 93, 58.1%), lymphoma (n = 23, 14.4%), pituitary tumors (n = 14, 8.8%), and gliomas (n = 12, 7.5%). The most common neurological signs were altered consciousness (n = 42, 26.2%), circling (n = 36, 22.5%), and seizures (n = 36, 22.5%). Cats without specific neurological signs were common (n = 34, 21.2%). The tumor was considered an incidental finding in 30 (18.8%) cats. In addition to expected relationships (eg, meninges and meningioma, pituitary and pituitary tumors), we found that lesion location was predictive of tumor type with diffuse cerebral or brainstem involvement predictive of lymphoma and third ventricle involvement predictive of meningioma.  相似文献   

Pericardial effusion due to primary cardiac lymphosarcoma in a dog     

Sims CS  Tobias AH  Hayden DW  Fine DM  Borjesson DL  Aird B 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2003,17(6):923-927

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Behavioral training and hydraulic chute restraint enables handling of eland antelope (Taurotragus oryx) without general anesthesia.     

Gemechu Wirtu  Alexander Cole  C Earle Pope  Charles R Short  Robert A Godke  Betsy L Dresser 《Journal of zoo and wildlife medicine》2005,36(1):1-11

Difficulties and risks associated with restraining large nondomestic ungulates are limiting factors toward developing and applying assisted reproductive technologies, such as artificial insemination and embryo transfer. In this study on 10 female eland (Taurotragus oryx), we evaluated the use of behavioral training and handling handling in a hydraulic chute to perform transvaginal ultrasound-guided oocyte retrieval and other clinical procedures. Nine females were conditioned to associate specific sound cues with food treats. The interval from the audio cue until acceptance of handheld treats varied among females (1.8-58.3 min). Animals also differed in their response to training for voluntary entry into the chute. Handling eland for oocyte retrieval in the hydraulic chute required xylazine sedation. During sedation and handling, eland undergoing oocyte retrieval procedures had higher blood glucose levels (14.4 +/- 3.1) than females handled similarly but without oocyte retrieval (9.3 +/- 2.7 mmol/L). Plasma osmotic pressure, hematocrit, and creatine phosphokinase activity were similar between these two groups. Females that were more difficult to train had higher blood glucose levels than the more cooperative animals. Cooperative females had fewer vertical stripes on their sides. More than 40 procedures were conducted without complications or mortality. The combination of behavioral conditioning-training and restraint of sedated eland in a hydraulic chute was a reliable and repeatable method for performing minimally invasive assisted reproductive techniques.  相似文献   

PCR as a diagnostic tool for brucellosis   总被引：11，自引：0，他引：11  

Bricker BJ 《Veterinary microbiology》2002,90(1-4):435-446

Numerous PCR-based assays have been developed for the identification of Brucella to improve diagnostic capabilities. Collectively, the repertoire of assays addresses several aspects of the diagnostic process. For some purposes, the simple identification of Brucella is adequate (e.g. diagnosis of human brucellosis or contamination of food products). In these cases, a genus-specific PCR assay is sufficient. Genus-specific assays tend to be simple, robust, and somewhat permissive of environmental influences. The main genetic targets utilized for these applications are the Brucella BCSP31 gene and the 16S–23S rRNA operon.

Other instances require identification of the Brucella species involved. For example, most government-sponsored brucellosis eradication programs include regulations that stipulate a species-specific response. For epidemiological trace back, strain-specific identification is helpful. Typically, differential PCR-based assays tend to be more complex and consequently more difficult to perform. Several strategies have been explored to differentiate among Brucella species and strains, including locus specific multiplexing (e.g. AMOS-PCR based on IS711), PCR-RFLP (e.g. the omp2 locus), arbitrary-primed PCR, and ERIC-PCR to name a few. This paper reviews some of the major advancements in molecular diagnostics for Brucella including the development of procedures designed for the direct analysis of a variety of clinical samples. While the progress to date is impressive, there is still room for improvement.  相似文献   

Diagnostic strategies used for the identification of Brucella     

Bricker BJ 《Veterinary microbiology》2002,90(1-4):433-434

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