THE SPIRIT OF A UNIVERSITY     

Fischer MH 《Science (New York, N.Y.)》1914,40(1031):464-471

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A NEW TRIANGULATION SIGNAL LAMP     

Fischer EG 《Science (New York, N.Y.)》1916,44(1134):430-431

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PREPARATION OF 1-GLYCERIC ALDEHYDE     

Baer E  Fischer HO 《Science (New York, N.Y.)》1938,88(2274):108

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Fashions in Medicine and Science     

Fischer R 《Science (New York, N.Y.)》1953,118(3078):784

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Clan and land     

Fischer JL 《Science (New York, N.Y.)》1977,195(4284):1321-1322

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Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast     

Roguev A  Bandyopadhyay S  Zofall M  Zhang K  Fischer T  Collins SR  Qu H  Shales M  Park HO  Hayles J  Hoe KL  Kim DU  Ideker T  Grewal SI  Weissman JS  Krogan NJ 《Science (New York, N.Y.)》2008,322(5900):405-410

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Experimental identification of downhill protein folding     

Garcia-Mira MM  Sadqi M  Fischer N  Sanchez-Ruiz JM  Muñoz V 《Science (New York, N.Y.)》2002,298(5601):2191-2195

Theory predicts the existence of barrierless protein folding. Without barriers, folding should be noncooperative and the degree of native structure should be coupled to overall protein stability. We investigated the thermal unfolding of the peripheral subunit binding domain from Escherichia coli's 2-oxoglutarate dehydrogenase multienzyme complex (termed BBL) with a combination of spectroscopic techniques and calorimetry. Each technique probed a different feature of protein structure. BBL has a defined three-dimensional structure at low temperatures. However, each technique showed a distinct unfolding transition. Global analysis with a statistical mechanical model identified BBL as a downhill-folding protein. Because of BBL's biological function, we propose that downhill folders may be molecular rheostats, in which effects could be modulated by altering the distribution of an ensemble of structures.  相似文献   

The genomic sequence of the accidental pathogen Legionella pneumophila     

Chien M  Morozova I  Shi S  Sheng H  Chen J  Gomez SM  Asamani G  Hill K  Nuara J  Feder M  Rineer J  Greenberg JJ  Steshenko V  Park SH  Zhao B  Teplitskaya E  Edwards JR  Pampou S  Georghiou A  Chou IC  Iannuccilli W  Ulz ME  Kim DH  Geringer-Sameth A  Goldsberry C  Morozov P  Fischer SG  Segal G  Qu X  Rzhetsky A  Zhang P  Cayanis E  De Jong PJ  Ju J  Kalachikov S  Shuman HA  Russo JJ 《Science (New York, N.Y.)》2004,305(5692):1966-1968

We present the genomic sequence of Legionella pneumophila, the bacterial agent of Legionnaires' disease, a potentially fatal pneumonia acquired from aerosolized contaminated fresh water. The genome includes a 45-kilobase pair element that can exist in chromosomal and episomal forms, selective expansions of important gene families, genes for unexpected metabolic pathways, and previously unknown candidate virulence determinants. We highlight the genes that may account for Legionella's ability to survive in protozoa, mammalian macrophages, and inhospitable environmental niches and that may define new therapeutic targets.  相似文献   

Stable carbon cycle-climate relationship during the Late Pleistocene   总被引：2，自引：0，他引：2  

Siegenthaler U  Stocker TF  Monnin E  Lüthi D  Schwander J  Stauffer B  Raynaud D  Barnola JM  Fischer H  Masson-Delmotte V  Jouzel J 《Science (New York, N.Y.)》2005,310(5752):1313-1317

A record of atmospheric carbon dioxide (CO2) concentrations measured on the EPICA (European Project for Ice Coring in Antarctica) Dome Concordia ice core extends the Vostok CO2 record back to 650,000 years before the present (yr B.P.). Before 430,000 yr B.P., partial pressure of atmospheric CO2 lies within the range of 260 and 180 parts per million by volume. This range is almost 30% smaller than that of the last four glacial cycles; however, the apparent sensitivity between deuterium and CO2 remains stable throughout the six glacial cycles, suggesting that the relationship between CO2 and Antarctic climate remained rather constant over this interval.  相似文献   

Coherent two-dimensional nanoscopy     

Aeschlimann M  Brixner T  Fischer A  Kramer C  Melchior P  Pfeiffer W  Schneider C  Strüber C  Tuchscherer P  Voronine DV 《Science (New York, N.Y.)》2011,333(6050):1723-1726

We introduce a spectroscopic method that determines nonlinear quantum mechanical response functions beyond the optical diffraction limit and allows direct imaging of nanoscale coherence. In established coherent two-dimensional (2D) spectroscopy, four-wave-mixing responses are measured using three ingoing waves and one outgoing wave; thus, the method is diffraction-limited in spatial resolution. In coherent 2D nanoscopy, we use four ingoing waves and detect the final state via photoemission electron microscopy, which has 50-nanometer spatial resolution. We recorded local nanospectra from a corrugated silver surface and observed subwavelength 2D line shape variations. Plasmonic phase coherence of localized excitations persisted for about 100 femtoseconds and exhibited coherent beats. The observations are best explained by a model in which coupled oscillators lead to Fano-like resonances in the hybridized dark- and bright-mode response.  相似文献