Evaluation of hemostatic derangements associated with canine anaphylaxis and the relationship to syndrome severity     

M. Ryan Smith DVM  DACVECC  Virginie A. Wurlod MS  Dr vet med  DACVECC  DECVECC  Chin-Chi Liu MS  MApStat  PhD 《Journal of Veterinary Emergency and Critical Care》2023,33(6):648-655

Objective

To describe hemostatic derangements associated with canine anaphylaxis and to assess for association with syndrome severity.

Design

Prospective observational study.

Setting

University teaching hospital.

Animals

Twenty-seven client-owned dogs, recruited from November 2018 to January 2022, diagnosed with anaphylaxis of varying severity were included. Study inclusion required presentation <6 hours after initiation of clinical signs, no medications or history of illness within the prior 2 weeks, lack of comorbidities expected to affect hemostasis, and lack of a disease state that could alternatively explain the clinical presentation.

Interventions

Blood samples were collected within the first hour of presentation for CBC, serum biochemistry, prothrombin time (PT), activated partial thromboplastin time (aPTT), and viscoelastic coagulation testing for use with a cartridge-based point-of-care device.

Measurements and main results

Clotting time and clot formation time were prolonged, alpha angle and maximum clot firmness were decreased, PT and aPTT were prolonged, and platelet counts were lower in severe cases compared to mild and moderate cases. There were no differences for any parameter between mild and moderate cases. The presence or absence of abdominal effusion was not associated with hemostatic status.

Conclusions

Global hemostatic derangements consistent with hypocoagulability are a prominent feature of severe anaphylaxis in dogs and should be considered for routine evaluation.  相似文献   

Retrospective evaluation of indications,transfusion protocols,and acute transfusion reactions associated with the administration of lyophilized canine albumin: 53 cases (2009–2020)     

Emilia Terradas Crespo LV  MS  DACVECC  Linda G. Martin DVM  MS  DACVECC  Elizabeth B. Davidow DVM  DACVECC 《Journal of Veterinary Emergency and Critical Care》2023,33(5):567-576

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Effects of intra-articular injection of an acellular equine liquid amniotic allograft in healthy equine joints     

Danica D. Wolkowski DVM  Robert D. McCarthy DVM  Mike J. Schoonover DVM  MS  DACVS-LA  DACVSMR  Jared D. Taylor DVM  MPH  PhD  DACVIM  DACVPM  Timothy G. Eastman DVM  MS  DACVS 《Veterinary surgery : VS》2023,52(1):62-68

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Comparison of two postoperative complication grading systems after treatment of stifle and shoulder instability in 68 dogs     

Faolain M. Barrett BVM&S  Jason A. Bleedorn DVM MS  DACVS-SA  Kyle D. Hutcheson DVM  DACVS-SA  Bryan T. Torres DVM PhD  DACVS-SA  DACVSMR  Derek B. Fox DVM  PhD  DACVS 《Veterinary surgery : VS》2023,52(1):98-105

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Serum acute-phase protein concentrations following uncomplicated total hip arthroplasty in dogs     

Jose L. Carvajal DVM  MS  Stanley E. Kim BVSc  MS  DACVS-SA 《Veterinary surgery : VS》2023,52(1):81-86

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Estimating evapotranspiration in the Padova Botanical Garden   总被引：1，自引：0，他引：1  

Francesco Morari  Luigi Giardini 《Irrigation Science》2001,20(3):127-137

In 1996, intensive building operations near the botanical garden of Padova, the oldest botanical garden in the world, altered a long-established equilibrium between groundwater and plants and threatened the lives of some of them. To avoid water stress, an advanced irrigation system was installed. For design purposes, better knowledge of the water cycle and the monthly average evapotranspiration (ET) in the area was needed. Due to the complex canopy stand of the site, ET was estimated using the water balance method, integrating mathematical models with the Arc/Info Geographical Information System. The water balance was estimated in 1997 and 1998, and results were used to derive an empirical mean crop coefficient of the botanical garden, to simulate the long-term water requirements using the product of reference ET and the apparent crop coefficient to estimate ET from the garden. Two types of hydrological behaviour were identified: one in the central area of the garden, where reduced ground cover diminishes ET and increases runoff and percolation. In the external area, the ET was higher because of the presence of many trees. The empirical mean monthly crop coefficient ranged between 0.56 and 0.83, indicating that ET in the entire area is always less than grass reference ET.  相似文献   

Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes     

Marilia Barreca  Virginia Span  Alessandra Montalbano  Mercedes Cueto  Ana R. Díaz Marrero  Irem Deniz  Ayegül Erdoan  Lada Luki&#x; Bilela  Corentin Moulin  Elisabeth Taffin-de-Givenchy  Filippo Spriano  Giuseppe Perale  Mohamed Mehiri  Ana Rotter  Olivier P. Thomas  Paola Barraja  Susana P. Gaudêncio  Francesco Bertoni 《Marine drugs》2020,18(12)

The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestrial counterparts, thus producing unique chemicals with a broad diversity and complexity. So far, more than 36,000 compounds have been isolated from marine micro- and macro-organisms including but not limited to fungi, bacteria, microalgae, macroalgae, sponges, corals, mollusks and tunicates, with hundreds of new marine natural products (MNPs) being discovered every year. Marine-based pharmaceuticals have started to impact modern pharmacology and different anti-cancer drugs derived from marine compounds have been approved for clinical use, such as: cytarabine, vidarabine, nelarabine (prodrug of ara-G), fludarabine phosphate (pro-drug of ara-A), trabectedin, eribulin mesylate, brentuximab vedotin, polatuzumab vedotin, enfortumab vedotin, belantamab mafodotin, plitidepsin, and lurbinectedin. This review focuses on the bioactive molecules derived from the marine environment with anticancer activity, discussing their families, origin, structural features and therapeutic use.  相似文献   

Symbiosis disruption in the olive fruit fly,Bactrocera oleae (Rossi), as a potential tool for sustainable control     

Martina Sinno  Annie Bzier  Francesco Vinale  David Giron  Stefania Laudonia  Antonio P Garonna  Francesco Pennacchio 《Pest management science》2020,76(9):3199-3207

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Effect of apple cultivars and storage periods on the virulence of Neofabraea spp.     

A. Di Francesco  I. Cameldi  F. Neri  L. Barbanti  A. Folchi  A. Spadoni  E. Baraldi 《Plant pathology》2019,68(8):1525-1532

Bull’s eye rot is a typical quiescent postharvest apple disease in major fruit-growing areas. The susceptibility of different apple cultivars to Neofabraea spp. (N. vagabunda and N. malicorticis) was assessed, with Granny Smith showing the most resistance and Cripps Pink the most susceptibility. To assess the factors involved in conidial germination, Neofabraea spp. were grown on crude protein extracts (CPEs) collected from apple fruits at different storage periods. Fungal germ tube growth rate and pathogenic enzyme (cellulase and xylanase) activity were assessed. Results showed that CPEs collected after 2 and 4 months of storage progressively stimulated conidial germination and germ tube elongation, while a lesser effect was observed from CPEs after 1 month of storage. Xylanase proved to be the main degrading enzyme secreted by all the isolates, while cellulase was produced only by N. vagabunda isolates. Overall, the isolate ID02 was the most virulent, based on more rapid germ tube elongation and greater activity of the lytic enzymes.  相似文献   

The effects of starving and feeding on Dover sole (Solea solea,Soleidae, Linnaeus, 1758) stress response and early larval development          下载免费PDF全文

Chiara Carla Piccinetti  Marco Donati  Giuseppe Radaelli  Giovanni Caporale  Gilberto Mosconi  Francesco Palermo  Lina Cossignani  Roberto Salvatori  Rocio Penuela Lopez  Ike Olivotto 《Aquaculture Research》2015,46(10):2512-2526

In the view of an urgent necessity to improve the quantity and the quality of farmed fish species, there is a strong need to improve our basic knowledge on the effects of first feeding during the developmental stages of fish larvae. High mortality, mainly due to food deprivation or inappropriate food quality, has been observed in many larval fish species, but knowledge about the morphological, biochemical and molecular processes related to this topic is still poorly understood. The understanding of the early larval ontogeny as well as the larval nutritional requirements and the molecular and cellular mechanisms elicited by fish larvae during food deprivation and starvation are thus of primary importance. At this regard, this study investigates, in Dover sole larvae, the effects of starvation and starving/re‐feeding procedures at a morphological, histological, biochemical and molecular level. The results evidenced that starved larvae progressively decrease in growth, lipid content, affected their gastrointestinal tract and muscle development and increased cortisol and heat shock protein 70 levels. On the contrary, starved and re‐fed larvae showed, after the restoration of a favourable feeding condition, a compensatory growth. In conclusion, this is the first study analysing through a multidisciplinary approach the effects of food deprivation on the development of an important economic species, the Dover sole.  相似文献