Corepressor-dependent silencing of chromosomal regions encoding neuronal genes     

Lunyak VV  Burgess R  Prefontaine GG  Nelson C  Sze SH  Chenoweth J  Schwartz P  Pevzner PA  Glass C  Mandel G  Rosenfeld MG 《Science (New York, N.Y.)》2002,298(5599):1747-1752

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What price the perfect baby?     

L R Kass  B Glass 《Science (New York, N.Y.)》1971,173(992):103-104

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A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation   总被引：38，自引：0，他引：38  

J C Loftus  T E O'Toole  E F Plow  A Glass  A L Frelinger  M H Ginsberg 《Science (New York, N.Y.)》1990,249(4971):915-918

The ligand-binding function of integrin adhesion receptors depends on divalent cations. A mutant alpha IIb beta 3 integrin (platelet gpIIb/IIIa) that lacks ligand recognition shows immunologic evidence of a perturbed interaction with divalent cations. This was found to be caused by a G----T mutation that resulted in an Asp119----Tyr119 substitution in the beta 3 subunit. This residue is proximal to bound ligand and is in a conserved region among integrins that are enriched in oxygenated residues. The spacing of these residues aligns with the calcium-binding residues in EF hand proteins, suggesting interaction with receptor-bound divalent cation as a mechanism of ligand binding common to all integrins.  相似文献   

Brain abscess in seven cats due to a bite wound: MRI findings, surgical management and outcome     

Costanzo C  Garosi LS  Glass EN  Rusbridge C  Stalin CE  Volk HA 《Journal of Feline Medicine and Surgery》2011,13(9):672-680

PRESENTATION AND LESION LOCALISATION: Seven adult domestic shorthair cats were presented with a 1- to 6-day history of progressive neurological signs. A focal skin puncture and subcutaneous swelling over the dorsal part of the head were detected on physical examination. Neurological examination indicated lesion(s) in the right forebrain in four cats, multifocal forebrain in one cat, left forebrain in one cat, and multifocal forebrain and brainstem in the remaining cat. In all cats, magnetic resonance imaging revealed a space-occupying forebrain lesion causing a severe mass effect on adjacent brain parenchyma. CLINICAL APPROACH AND OUTCOME: All cats were managed with a combination of medical and surgical treatment. At surgery a small penetrating calvarial fracture was detected in all cats, and a tooth fragment was found within the content of the abscess in two cats. The combination of surgical intervention, intensive care and intravenous antimicrobials led to a return to normal neurological function in five cats. PRACTICAL RELEVANCE: As this series of cases indicates, successful resolution of a brain abscess due to a bite injury depends on early recognition and combined used of antimicrobials and surgical intervention. A particular aim of surgery is to remove any skull and foreign body (tooth) fragments that may represent a continuing focus of infection.  相似文献   

Science education--process or content?     

Glass B 《Science (New York, N.Y.)》1971,171(3974):851

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谈谈学分制下如何做好学生党建工作     

沈兆 梅  尤德 胜 《安徽农业大学学报》2007,(5):110-112

全面推行学分制是高校教学改革的深化, 是教育和教学改革的一个发展阶段。但由于学分制所带来的思想教育、学生党建等新情况、新问题, 应值得所有教育者认真思考和研究的。本文围绕学分制实行后给学生党建工作带来的“四难”以及如何应对提出了一些理论和实践的思考。  相似文献   

Utilization index: A modified approach to the estimation and comparison of nutrient utilization efficiency in plants     

M. Yaeesh Siddiqi  Anthony D.M. Glass 《Journal of plant nutrition》2013,36(3):289-302

The disadvantages of using utilization quotient (biomass per unit amount of nutrient present in biomass) in comparing nutrient utilization efficiencies of different varieties and species are discussed. A modified approach to the estimation of utilization efficiency is presented. A comparison of efficiencies of two plants calculated by this method gives an index which is the ratio of biomass ratio: tissue nutrient concentration ratio. Theoretical validity and advantages in practical application of this approach are discussed.  相似文献   

The effect of colour on the appearance of monofilament nylon under water     

C.S. Wardle  G. Cui  W.R. Mojsiewicz  C.W. Glass 《Fisheries Research》1991,10(3-4):243-253

Monofilament nylon line can be made more or less visible when viewed in the sea or in green light in tanks by the use of coloured dye. The undyed line, although least visible when perpendicular to the sea surface, shows a bright jewel-like glint when parallel to it. There is also a bright glint in the knots of netting, being brightest where the line is oriented parallel to the sea surface. The glint changes from mainly a surface reflection in air to an internal glow when immersed in water due to a lengthening of the focal length of the nylon cylinder. However, because in the sea the glint is derived from green downwelling light that has passed into the nylon cylinder, it is reduced by pale dye colours that remove a proportion of the green light. This allows a controlled reduction of the glint and a closer match with the water background when viewed horizontally.  相似文献   

Distribution of prion protein genotypes in breeds of sheep in New Zealand     

MA Lee  TR Manley  BC Glass  RM Anderson  SJ Wilson  JS O'Keefe 《New Zealand veterinary journal》2013,61(5):222-227

AIM: To use an established high through-put genotyping procedure to gain an estimate of the frequency of alleles of the prion protein (PrP) gene in some common sheep breeds in New Zealand.

METHODS: Using a genotyping procedure based on matrix-assisted laser desorption ionisation-time of flight (MALDI-TOF), DNA samples from 3,024 sheep from New Zealand, including breeds such as Romney, Texel, Coopworth, Merino and mixedbreed, were isolated, genotyped and the results analysed.

RESULTS: The 15 scrapie genotypes commonly reported, and derived from the five commonly reported allelic variants (ARR, ARQ, AHQ, ARH and VRQ), were all observed in the samples analysed. The estimates were indicative of the frequencies in the population of alleles present in breeds of sheep in New Zealand. There was a significant difference between the frequencies of alleles between breeds, but the ARQ, followed by the ARR allele, were, except in Carwell sheep, the most common alleles present.

CONCLUSION: This study gave an indication of the percentages of PrP gene alleles in sheep in New Zealand, including data previously unreported from breeds in this country. It is of interest because of the relatively large size of the sheep population in New Zealand compared with many countries, and it provides some useful information on the genetic susceptibility or resistance of the sheep population in New Zealand to scrapie. The frequencies of the alleles can be different for an individual breed compared between countries.  相似文献   

Topical hypertonic saline as a treatment for ocular and nasal hirudiniasis in a dog     

EN Perry  C Davies  PMG McCarthy 《Australian veterinary journal》2023,101(7):279-281

This case report describes ocular and nasal leech infestation (hirudiniasis) in a dog. The patient presented for a suspected ocular foreign body. The patient was sedated to allow proper examination, which revealed a leech foreign body attached to the bulbar conjunctiva adjacent to the inferotemporal limbus of the left eye. A 3.5% hypertonic saline solution was applied topically to the eye in four sequential drops, until the leech detached itself and was removed with a cotton bud. The affected eye was found to have a small corneal ulcer, a small area of scleral haemorrhage, and prominent lymphoid follicles within the third eyelid. Approximately 5 min after the leech was removed, another leech emerged from the left nostril. The patient was sent home on chloramphenicol ointment for treatment of the corneal ulcer, was rechecked 4 days later by an American Board of Veterinary Ophthalmology resident (PM) and found to have a normal ocular exam. This case report highlights that topical hypertonic saline solution (3.5%) can be an effective and easily prepared treatment for ocular and nasal hirudiniasis in veterinary patients.  相似文献