Pharmacokinetics of orally administered tramadol in Muscovy ducks (Cairina moschata domestica)     

Ryan S. Bailey  Julie D. Sheldon  Matthew C. Allender  Mark G. Papich  Sathya K. Chinnadurai 《Journal of veterinary pharmacology and therapeutics》2019,42(4):380-384

This study documents the pharmacokinetics of oral tramadol in Muscovy ducks. Six ducks received a single 30 mg/kg dose of tramadol, orally by stomach tube, with blood collection prior to and up to 24 hr after tramadol administration. Plasma tramadol, and metabolites O‐desmethyltramadol (M1), and N,O‐didesmethyltramadol (M5) concentrations were determined by high‐pressure liquid chromatography (HPLC) with fluorescence (FL) detection. Pharmacokinetic parameters were calculated using a one‐compartment model with first‐order input. No adverse effects were noted after oral administration. All ducks achieved plasma concentrations of tramadol above 0.10 μg/ml and maintained those concentrations for at least 12 hr. Elimination half‐life was 3.95 hr for tramadol in ducks, which is similar to other avian species. All ducks in this study produced the M1 metabolite and maintained plasma concentrations above 0.1 μg/ml for at least 24 hr.  相似文献   

Analyses of oviposition times and intervals in a wide range of layer flocks under normal and continuous lighting regimes     

B. H. Yoo  B. L. Sheldon  R. N. Podger 《British poultry science》1986,27(2):267-287

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Effects of magnesium with or without boron on headshaking behavior in horses with trigeminal‐mediated headshaking     

Shara A. Sheldon  Monica Aleman  Lais R. R. Costa  Kalie Weich  Quinn Howey  John E. Madigan 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2019,33(3):1464-1472

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Diffusion model based on Fick’s second law for the moisture absorption process in wood fiber-based composites: is it suitable or not?     

Sheldon Q. Shi 《Wood Science and Technology》2007,41(8):645-658

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Everted third eyelid cartilage in a cat: a case report and literature review     

Williams D  Middleton S  Caldwell A 《Veterinary ophthalmology》2012,15(2):123-127

An 8-year-old neutered female British Blue cat was presented with a presumed diagnosis of a prolapsed nictitans gland and associated ocular irritation and epiphora. However, during surgery, the apparent nictitans gland protrusion was determined to be an everted cartilage of the nictitating membrane. The scrolled portion of the cartilage was removed through an incision through the conjunctiva on the bulbar aspect of the third eyelid, as previously described in the dog. This operation resolved the ocular irritation occurring, and the third eyelid returned to its anatomically correct position.  相似文献   

Gonadectomy in Cats and Dogs: A Review of Risks and Benefits     

IM Reichler 《Reproduction in domestic animals》2009,44(S2):29-35

The necessity, and in particular the timing, of gonadectomy in dogs and cats is still controversial. This is mainly because gonadectomy confers a mixture of benefits and adverse effects that depend upon the age at neutering, sex, species and breed. In this paper, the long-term risks and benefits of gonadectomy, at various ages, in dogs and cats are reviewed using data describing the effects of desexing on the urogenital tract and on other medical conditions, such as orthopaedic diseases, immune-mediated diseases, tumour development and behaviour.  相似文献   

Feline intracranial neoplasia: retrospective review of 160 cases (1985-2001)     

Troxel MT  Vite CH  Van Winkle TJ  Newton AL  Tiches D  Dayrell-Hart B  Kapatkin AS  Shofer FS  Steinberg SA 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2003,17(6):850-859

The purpose of this study was to determine the frequency of different tumor types within a large cohort of cats with intracranial neoplasia and to attempt to correlate signalment, tumor size and location, and survival time for each tumor. Medical records of 160 cats with confirmed intracranial neoplasia evaluated between 1985 and 2001 were reviewed. Parameters evaluated included age, sex, breed, FeLV/FIV status, clinical signs, duration of signs, number of tumors, tumor location(s), imaging results, treatment, survival times, and histopathologic diagnosis. Most of the cats were older (11.3 +/- 3.8 years). Primary tumors accounted for 70.6% of cases. Metastasis and direct extension of secondary tumors accounted for only 5.6 and 3.8% of cases, respectively. Twelve cats (7.5%) had 2 or more discrete tumors of the same type, whereas 16 cats (10.0%) had 2 different types of intracranial tumors. The most common tumor types were meningioma (n = 93, 58.1%), lymphoma (n = 23, 14.4%), pituitary tumors (n = 14, 8.8%), and gliomas (n = 12, 7.5%). The most common neurological signs were altered consciousness (n = 42, 26.2%), circling (n = 36, 22.5%), and seizures (n = 36, 22.5%). Cats without specific neurological signs were common (n = 34, 21.2%). The tumor was considered an incidental finding in 30 (18.8%) cats. In addition to expected relationships (eg, meninges and meningioma, pituitary and pituitary tumors), we found that lesion location was predictive of tumor type with diffuse cerebral or brainstem involvement predictive of lymphoma and third ventricle involvement predictive of meningioma.  相似文献   

Effect of experimentally induced metritis on uterine involution,acute phase protein response and PGFM secretion in the postpartum ewe     

Regassa F  Sheldon M  Noakes DE 《The Veterinary record》2002,150(19):605-607

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Reproduction seminar     

Sheldon M  Lanyon L  Howard C 《The Veterinary record》2002,151(2):64

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Pig feeding practice and veterinary problems. IV. The veterinary surgeon, the compounder and the farmer. 1. The compounder's point of view     

R S Sheldon 《The Veterinary record》1966,78(13):447-448

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