Prospective trial of metronomic chlorambucil chemotherapy in dogs with naturally occurring cancer     

Leach TN  Childress MO  Greene SN  Mohamed AS  Moore GE  Schrempp DR  Lahrman SR  Knapp DW 《Veterinary and comparative oncology》2012,10(2):102-112

The purpose of this study was to assess the toxicoses and antitumor activity of metronomic chlorambucil at a dosage of 4 mg m(-2) daily in dogs with naturally occurring cancer. Thirty-six dogs were enrolled in the study. The protocol was well tolerated with no grade 3 or 4 toxicoses noted. Complete remission was achieved, and lasted over 35 weeks in three dogs (mast cell tumour, soft tissue sarcoma and thyroid carcinoma). Partial remission was noted in 1 dog with histiocytic sarcoma (39 weeks duration) for an overall remission rate of 11% (4 of 36). Stable disease was noted in 17 dogs (47%) with various other cancers. The median progression-free interval was 61 days, and the median survival time was 153 days. Chlorambucil given in a metronomic protocol showed antitumor activity in dogs with a variety of naturally occurring cancers.  相似文献   

Role of genetically engineered animals in future food production     

KA McColl  B Clarke  TJ Doran 《Australian veterinary journal》2013,91(3):113-117

Genetically engineered (GE) animals are likely to have an important role in the future in meeting the food demand of a burgeoning global population. There have already been many notable achievements using this technology in livestock, poultry and aquatic species. In particular, the use of RNA interference (RNAi) to produce virus‐resistant animals is a rapidly‐developing area of research. However, despite the promise of this technology, very few GE animals have been commercialised. This review aims to provide information so that veterinarians and animal health scientists are better able to participate in the debate on GE animals.  相似文献   

An outbreak of severe tracheobronchitis in racing greyhounds in New Zealand     

KA Potter  C Morley  D Angove  AC Johnstone 《New Zealand veterinary journal》2013,61(1)

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Heat stress as a manageable risk factor to mitigate pneumonia in lambs     

H Black  MR Alley  KA Goodwin-Ray 《New Zealand veterinary journal》2013,61(1):91-92

Abstract

Extract

The paper by Goodwin et al (2004 Goodwin, KA, Jackson, R, Brown, C, Davies, PR, Morris, RS and Perkins, NR. 2004. Pneumonic lesions in lambs in New Zealand: patterns of prevalence and effects on production. New Zealand Veterinary Journal, 52: 175–9. [Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) which appeared in the August 2004 issue of the New Zealand Veterinary Journal highlighted the prevalence and costs to the sheep industry of pneumonia in lambs. The costs are considerable, and the article begs the question, “what can sheep farmers do to reduce the effects of pneumonia in lambs?”  相似文献   

Preliminary evaluation of exotic tick species and exotic pathogens imported on migratory birds into the British Isles     

Pietzsch ME  Mitchell R  Jameson LJ  Morgan C  Medlock JM  Collins D  Chamberlain JC  Gould EA  Hewson R  Taylor MA  Leach S 《Veterinary parasitology》2008,155(3-4):328-332

Field studies were carried out to determine whether ticks are being imported into the British Isles on migratory birds. During spring and autumn migration 2004, ticks were collected from ringed birds at 11 bird observatories and 3 inland Riparia riparia colonies. A total of 38 ticks of 4 species (Ixodes ricinus, I. frontalis, I. lividus, I. arboricola) were collected from 12 species of bird. Ticks were tested for viruses in the Flavivirus and Nairovirus genera, with no positives found. This data demonstrates that ticks are being imported into the British Isles on migratory birds with future work recommended to determine the quantity of ticks imported and to detect low prevalence pathogens.  相似文献   

Hypoventilation,cardiac dysrhythmia,and cardiac arrest following acute Brunfelsia species (Yesterday,today, tomorrow) intoxication in a dog     

JD Crowley  KA Thomas  SL Donahoe  G Child  MC Hickey  ET Mooney 《Australian veterinary journal》2019,97(6):202-207

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Tissue culture method affects ex vitro growth and development of loblolly pine     

Frampton  L. John  Amerson  Henry V.  Leach  Gregory N. 《New Forests》1998,16(2):125-138

Loblolly pine (Pinus taeda L.) propagules initiated adventitiously from cotyledons and via axillary-fascicular micropropagation from epicotyls were compared to seedlings grown from the same open-pollinated seedlot. Greenhouse and early field results indicate that unlike tissue culture propagules of cotyledon-origin, propagules originating via axillary-fascicular micropropagation from epicotyls do not display early reduced growth relative to seedlings. Further, axillary-fascicular micropropagules derived from cotyledon-origin adventitious shoots displayed early reduced growth. Early reduced growth and other differences between tissue culture propagules and seedlings previously observed in field plantings appear to be inherent to the cotyledon system of propagation and do not necessarily occur when other tissue culture procedures are used for propagation.  相似文献   

Spray-drying of the microalga Dunaliella salina: effects on beta-carotene content and isomer composition.     

S Orset  G C Leach  R Morais  A J Young 《Journal of agricultural and food chemistry》1999,47(11):4782-4790

The effects of spray-drying of the unicellular microalga Dunaliella salina on its beta-carotene content and geometric isomer composition have been studied. The efficacy of a range of synthetic and natural antioxidants in preventing degradation of beta-carotene has been determined. Losses of beta-carotene and isomerization were minimal during processing for both the control (no exogenous antioxidants) and the samples containing butylated hydroxytoluene (BHT) and tert-butylhydroquinone (TBHQ). However, the use of tocopherol-based antioxidants resulted in degradation of 52-72% of beta-carotene during the drying process. All dried powders of Dunaliella proved to be unstable during storage in the presence of light and air, with beta-carotene degraded according to a first-order kinetic model. Of the antioxidants studied, only TBHQ was successful in significantly minimizing degradation (degradation constants of 0.03 and 0.04 days(-)(1), compared to 0.53 days(-)(1) for the respective control). For control powders and those with BHT added to the feed, the degradation constants were reduced to values between 0.27 and 0.37 days(-)(1) by restricting light and flushing with nitrogen; however, storage in the dark alone had no effect. For more slowly degrading powders having TBHQ added to the feed, it was clear that degradation of beta-carotene was influenced by both light and oxygen. During storage the 9-cis isomer of beta-carotene was significantly more unstable than the all-trans form. TBHQ was, however, successful in reducing relative losses of this isomer for samples stored in the dark. The results suggest a dominant photodegradative mechanism for the loss of the 9-cis isomer of beta-carotene.  相似文献   

The influence of diel period on fish assemblage in the unstructured littoral of reservoirs     

M. ŘÍHA  J. KUBEČKA  M. PRCHALOVÁ  T. MRKVIČKA  M. ČECH  V. DRAŠTÍK  J. FROUZOVÁ  E. HOHAUSOVÁ  T. JŮZA  M. KRATOCHVÍL  J. PETERKA  M. TUŠER  M. VAŠEK 《Fisheries Management and Ecology》2011,18(4):339-347

Abstract Diel changes in littoral fish assemblage were studied in four reservoirs in the Czech Republic (Central Europe). The sampling was performed by beach seining in an unstructured littoral zone. Perch, Perca fluviatilis L., roach, Rutilus rutilus (L.), bream, Abramis brama (L.), carp, Cyprinus carpio L., ruffe, Gymnocephalus cernua (L.), pikeperch, Sander lucioperca (L.), eel, Anguilla anguilla (L.) and A. brama × R. rutilus hybrids exhibited higher densities at night. Only bleak, Alburnus alburnus (L.) exhibited higher densities during the day. The number of species was higher in night hauls, and mean body size of roach and bleak was also higher at night. Diel changes in fish densities resulted in the change in species composition between day and night. The study has implication for the sampling design to assess littoral fish assemblages using beach seine netting and recommends night sampling for a representative assessment or sampling during both diel periods for a robust assessment.  相似文献   

Phytosequestration of Carbon in Miscanthus × giganteus and Pinus sylvestris L. in Degraded Zinc Smelter and Post-Mining Soils     

Agnieszka PLACEK  Bal Ram SINGH  Anna GROBELAK  Dariusz W&#;&#;KA  &#;sgeir R. ALM&#;S  Ma lgorzata KACPRZAK 《土壤圈》2018,28(3):555-560

正Dear Editor,Pinus sylvestris L.is one of the most popular and predominant tree species in Central Europe and Scandinavia.Its cultivation depends on atmospheric conditions,soil fertility,use of fertilizers,and individual characteristics of the trees.Pinus sylvestris L.wood,roots,and needles are used for energy production.Pi-  相似文献