E7 (1057ΔTA) mutation of the acidic α‐glucosidase gene causes Pompe's disease in Droughtmaster cattle          下载免费PDF全文

RE Lyons  DJ Johnston  MR McGowan  A Laing  B Robinson  H Owen  BD Hill  BM Burns 《Australian veterinary journal》2017,95(5):138-142

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Mixed infections of Vibrio cholerae O1 Ogawa EL Tor with Shigella dysenteriae     

Gharibi O  Mirzaei K  Karimi A  Darabi H 《Pakistan journal of biological sciences: PJBS》2010,13(22):1110-1112

Mixed infections caused by enteric pathogens such as bacteria, virus, protozoa and helminthes were reported in different literatures. This report also describes the co-infections caused by Vibrio cholerae O1 Ogawa EL Tor with Shigella dysenteriae in a patient. A 36-year-old man was admitted in Fatemeh Zahra Hospital of Bushehr Iran with fever, vomiting and dysentery. His stool sample was cultured, for identification purposes TCBS, XLD and other media were used. V. cholerae and S. dysenteriae were identified. Both species were resistant to ampicillin and sensitive to nalidixic acid and trimethoprim-sulfamethoxazol. Shigella was resistant to tetracycline. The results of the study showed that places where diarrheal diseases especially cholera are endemic, it is better to examine for those patients with dysentery for the presence of the V. cholerae O1. That will prevent the spread of pathogenic organism in the community.  相似文献   

Digestive proteolytic and amylolytic activities of Helicoverpa armigera in response to feeding on different soybean cultivars     

Bahram Naseri  Yaghoub Fathipour  Saeid Moharramipour  Vahid Hosseininaveh  Angharad MR Gatehouse 《Pest management science》2010,66(12):1316-1323

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Original Study: Comparison of three intraosseous access techniques in cats     

Alex Bukoski PhD  DVM  Matthew Winter DVM  DACVR  Carsten Bandt DVM  DACVECC  Mary Wilson RT  CV  MR  CT  Andre Shih DVM  DACVA 《Journal of Veterinary Emergency and Critical Care》2010,20(4):393-397

Objective – To compare the placement feasibility and amount of bone trauma induced by 3 intraosseous (IO) access techniques in cats: an automatic impact penetration device (A), an automatic rotary insertion device (B), and a manual IO needle (C). Design – Prospective ex vivo study. Setting – University. Animals – Eighteen adult mixed breed feline cadavers. Interventions – Cadavers provided 72 total IO insertion locations divided equally between the right and left humerus and tibia. The 3 IO techniques were randomly allocated to these locations. Time to successful insertion, ease of insertion, and success rate were recorded. Each insertion site was analyzed for the number of bone fragments and defect diameter by computed tomography. Measurements and Main Results – Device B had lower time of insertion (P=0.01) compared with devices A and C. Device B had better ease of insertion scores (P<0.01) compared with devices A and C. No differences were detected between insertion sites (tibia versus humerus). No differences in the number of bone fragments, defect diameter, or success rate were detected among devices (P=0.06, 0.31, and 0.14, respectively). Conclusions – All 3 IO access methods evaluated yield acceptable results. Device B is significantly faster and easier to place in cat cadavers when compared with other methods.  相似文献   

Response of Thawed Epidi dymal Red Deer Spermatozoa to Increasing Concentrations of Hydrogen Peroxide,and Importance of Individual Male Variability     

AE Domínguez‐Rebolledo  F Martínez‐Pastor  AF Bisbal  JL Ros‐Santaella  O García‐Álvarez  A Maroto‐Morales  AJ Soler  JJ Garde  MR Fernández‐Santos 《Reproduction in domestic animals》2011,46(3):393-403

Oxidative stress represents a challenge during sperm manipulation. We have tested the effect of increasing hydrogen peroxide (H₂O₂) levels on red deer spermatozoa after cryopreservation, and the role of male‐to‐male variation in that response. In a first experiment, eight thawed samples were submitted to 0, 25, 50, 100 and 200 μm H₂O₂ for 2 h at 37°C. Intracellular reactive oxygen species (H₂DCFDA‐CM) increased with H₂O₂ concentration, but we only detected a decrease in sperm function (motility by CASA and chromatin damage by sperm chromatin structure assay) with 200 μm . Lipoperoxidation assessed by the thiobarbituric acid reactive substance (TBARS) method increased slightly with 50 μm H₂O₂ and above. In a second experiment, samples from seven males were submitted to 0 and 200 μm H₂O₂ for 2 h, triplicating the experiment within each male. Males differed at thawing and regarding their response to incubation and H₂O₂ presence. We found that the kinematic parameters reflected male‐to‐male variability, whereas the response of the different males was similar for lipid peroxidation and viability. A multiparametric analysis showed that males grouped differently if samples were assessed after thawing, after incubation without H₂O₂ or after incubation with H₂O₂. Red deer spermatozoa are relatively resilient to H₂O₂ after thawing, but it seems to be a great male‐to‐male variability regarding the response to oxidative stress. The acknowledgement of this individual variability might improve the development of optimized sperm work protocols.  相似文献   

Phenytoin as a novel anti-vitiligo weapon     

MR Namazi 《Journal of Autoimmune Diseases》2005,2(1):11

Vitiligo is a psychologically devastating clinical conundrum which affects approximately 1% of the general population. The exact cause of the illness is an enigma, but several hypotheses about its pathogenesis are advanced.The autoimmune hypothesis proposes an autoimmune attack against melanocytes. Although anti-melanocyte autoantibodies have been demonstrated in vitiligo, recent research casts doubt on their pathogenic role and instead supports the involvement of cell-mediated autoimmune response in the pathobiology of this disorder, which is characterized by increase of suppressor T-cells and decrease of the helper/suppressor ratio in association with the presence of type-1 cytokine secreting cytotoxic T cells in the vicinity of disappearing melanocytes.The neural hypothesis proposes that increased release of norepinephrine, a melanocytotoxin, from the autonomic nerve endings in the microenvironment of melanocytes injures these cells. Moreover, norepinephrine induces the catecholamine degrading enzyme monoamine oxidase (MAO), which favors the formation of toxic levels of hydrogen peroxide in the vicinity of melanocytes.Another theory suggests that abnormal permeability of melanosome membrane, which normally prevents the diffusion of toxic melanin precursors into the cytoplasm, may cause melanocyte damage.Phenytoin, the widely-used anticonvulsant, has been employed both topically and systemically in the treatment of some dermatological disorders. The drug has been shown to significantly suppress mitogen-induced activation of lymphocytes and cytotoxic T lymphocyte activity and to polarize the immune response toward the type-2 pathway. It also significantly decreases suppressor T cells and increases the helper/suppressor ratio.At high concentrations, the drug inhibits the release of norepinephrine and the activity of MAO. Moreover, phenytoin is suggested to interact with membrane lipids, which may promote stabilization of the membranes.The hydantoin moiety of phenytoin exerts a direct stimulatory action on melanocytes; facial hyperpigmentation is a recognized side effect of orally administered phenytoin.Altogether, the above evidence suggests that phenytoin could be therapeutically effective against vitiligo. As phenytoin stimulates collagen production and inhibits its breakdown, its concomitant use with topical steroids could prevent steroid-induced skin atrophy while potentiating the anti-vitiligo effect of these agents.  相似文献   

Babesia and Ehrlichia seropositive horses temporarily imported into Australia: Reply     

MR STRAKOSCH 《Australian veterinary journal》2000,78(2):98-98

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Fertility of sows mated on different days of the week     

RJ LOVE  MR WILSON† 《Australian veterinary journal》1990,67(1):1-3

The farrowing rates resulting from matings on different days of the week were determined for a 2800-sow intensive piggery in both 1983 and 1984. The results showed that sows mated early in the week achieved a significantly higher farrowing rate than sows mated late in the week (P less than 0.0001). During the seasonal (summer to autumn) infertility period, Wednesday matings resulted in a poor farrowing rate whereas for the rest of the year farrowing rates following Wednesday matings were similar to those for Sunday Monday and Tuesday matings. Consistent results were obtained for data from both years. It is proposed that the stress of regrouping unmated sows on Wednesday to accommodate newly weaned sows is responsible for this decrease in fertility. This study illustrates how detailed analysis of farrowing rates on a day of mating basis can identify a problem which is otherwise masked by weekly data.  相似文献   

Pyothorax in a Friesian bull     

MW McLENNAN  MR McGOWAN 《Australian veterinary journal》1995,72(3):115-116

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Isolation of Leptospira interrogans serovars hardjo and zanoni from a dairy herd in north Queensland     

CS McCLINTOCK  MR McGOWAN  BG CORNEY  J COLLEY  L SMYTHE  M DOHNT  M WOODROW 《Australian veterinary journal》1993,70(10):393-393

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