Interleukin 11 expression in the normal canine eye     

Tara R. Richards  Jessica H. H. Mortlock  Chantale L. Pinard  Nick C. Whelan  Tamas Revay  Jonathan LaMarre 《Veterinary ophthalmology》2014,17(1):46-56

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Daily chemical variability of domestic septic tank effluent     

B. R. Whelan  Z. V. Titamnis 《Water, air, and soil pollution》1982,17(2):131-139

Effluent from the septic tanks of five households was sampled daily for 15 days. Temperature, redox potential, conductivity and biochemical oxygen demand (BOD₅) were measured and samples were analyzed for N, P, Ca, Mg, Na, K, Zu, Zn, Cd, Cr, Pb, Mg, and linear alkylate sulphonate (LAS). Samples from the five households differed in the values obtained but the differences were small. Little daily variation occurred in the effluent from any one household. The effluent was in a reduced and anaerobic condition with almost all the N and P occurring in the inorganic form in solution. The effluent concentration N was about 100 mg l^?1 and P concentration about 15 mg l^?1. The mean annual N and P loading in the effluent over the five households was 3.8 kg N/head yr and 0.6 kg P/head · yr. Copper and Zn were the only trace metals of any significance and their concentrations were less than in tap water. The chemical composition of the effluent was very similar to that found in New Zealand, Canada, and U.S.A.  相似文献   

Reproductive success and pollinator effectiveness differ in common and rare Persoonia species (Proteaceae)     

Paul D. Rymer  Robert J. Whelan  Peter H. Weston 《Biological conservation》2005,123(4):521-532

In plants, understanding the interactions between breeding systems and pollination ecology may enable us to predict the impacts of rarity. We used a comparative approach to test whether rarity is associated with reproductive biology in two closely-related species pairs. This system has been recently altered by changes in fire regimes and the introduction of European honeybees. More than 35% of flowers matured fruits in the common species after natural-pollination compared to <20% of flowers in the rare species. All species were obligate outcrossers in each of the study populations, but only the two rare species were pollen-limited, having significantly lower fruit-set on open-pollinated flowers than those cross-pollinated by hand (mean ± SE; 0.18 ± 0.02 vs. 0.42 ± 0.05; p < 0.001). Native bees (Leioproctus species) and introduced honeybees (Apis mellifera) visited all species. The native bees visited fewer flowers within a plant and moved greater distances between plants while foraging than honeybees, so the native bees are expected to be more effective in promoting outcrossing. While honeybees were the most frequent visitors to flowers of all species, native bees made more visits to common than rare species (0.65 ± 0.20 vs. 0.20 ± 0.09). Our results suggest that the poorer reproductive success in rare Persoonia species is associated with lower pollinator effectiveness, which is exacerbated by frequent fires and introduced honeybees. If this is a causal relationship, this may increase the probability of extinction in populations of these species.  相似文献   

Influence of compost amendments on the hydraulic functioning of brownfield soils     

A. Whelan  C. Kechavarzi  F. Coulon  R. Sakrabani  R. Lord 《Soil Use and Management》2013,29(2):260-270

This study assessed the impact of compost on the hydraulic properties of three soils (sandy loam, clay loam and diesel‐contaminated sandy loam) with relatively poor physical quality typical of brownfield sites. Soils were amended with two composts at 750 t/ha. Samples were also collected from a clay‐capped brownfield site, previously amended with 250, 500 or 750 t/ha of compost. Water‐release characteristics and saturated hydraulic conductivity were determined for all soils and physical quality indicators derived. Unsaturated flow in field profiles after compost application with two depths of incorporation and two indigenous subsoils was simulated using Hydrus‐1D. Compost generally increased water retention. Hydraulic conductivity tended to decrease following compost application in sandy loam but increased in clay and clay loam, where compost addition resulted in a larger dominant pore size. Although compost improved physical quality indicators, they remained suboptimum in clay and clay loam soil, which exhibited poor aeration, and in the contaminated sandy loam, where available water capacity was limited, possibly due to changes in wettability. Increasing application rates in the field enhanced water retention at low potentials and hydraulic conductivity near saturation but did not alter physical quality indicators. Numerical simulation indicated that the 500 t/ha application resulted in the best soil moisture regime. Increasing the depth of incorporation in the clay cap improved drainage and reduced waterlogging, but incorporation in more permeable subsoil resulted in prolonged dry conditions to greater depths.  相似文献   

Isolation of viral haemorrhagic septicaemia virus from muskellunge, Esox masquinongy (Mitchill), in Lake St Clair, Michigan, USA reveals a new sublineage of the North American genotype     

Elsayed E  Faisal M  Thomas M  Whelan G  Batts W  Winton J 《Journal of fish diseases》2006,29(10):611-619

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Efficacy of tropicamide,homatropine, cyclopentolate,atropine and hyoscine as mydriatics in Angora goats     

NC Whelan  F Castillo-Alcala  I Lizarraga 《New Zealand veterinary journal》2013,61(6):328-331

Abstract

AIM: To document the efficacy of five commercially available mydriatics for their potential for diagnostic and therapeutic use in Angora goats.

METHODS: Over 8 weeks, the mydriatic effects of 1% tropicamide, 2% homatropine, 1% cyclopentolate, 1% atropine and 0.25% hyoscine were evaluated. Given as block treatments, drugs were applied randomly to one eye of 10 Angora goats, and the contralateral eye served as a control. Vertical and horizontal pupil diameters were measured to document onset ofeffect, time to reach a difference of 5 mm in the vertical/horizontal pupil diameter between eyes, time to maximum pupillary dilation, and duration of mydriatic action.

RESULTS: Onset of mydriasis for all drugs occurred within 15 minutes. Time to reach a difference of 5 mm in the vertical pupil diameter between eyes was shortest for 1% tropicamide and 0.25% hyoscine (0.5 h), then 2% homatropine and 1% atropine (0.75 h), and longest for 1% cyclopentolate (1.5 h). The maximum vertical pupillary dilation occurred earliest with 1% tropicamide and 1% atropine (2 h), followed by 0.25% hyoscine (3 h), 2% homatropine (4 h), and latest with 1% cyclopentolate (8 h). The duration of vertical dilation of the pupil was shortest with 1% tropicamide (6 h), then 2% homatropine (12 h), 1% cyclopentolate (12 h), 1% atropine (24 h), and longest for 0.25% hyoscine (96 h).

The time to reach maximum horizontal dilation of the pupil in treated eyes was shortest with 1% cyclopentolate (1 h), followed by 1% tropicamide (1.5 h), 0.25% hyoscine (3 h), 2% homatropine (3.5 h), and 1% atropine (4 h). The duration of horizontal pupil dilation was shortest with 1% tropicamide (4.5 h), and longest with 0.25% hyoscine (48 h).

CONCLUSION: All five mydriatics induced clinical dilation. Tropicamide (1%) had the shortest duration of effect, but gave incomplete dilation. Good dilation was achieved with 1% cyclopentolate and 2% homatropine, but took too long to reach maximum dilation for routine mydriasis. The largest vertical dilation of the pupil was achieved with 1% atropine and 0.25% hyoscine, but pupils remained dilated for more than 24 h.

CLINICAL RELEVANCE: For routine mydriasis in goats, it is recommended that 1% tropicamide be used, though there may be incomplete dilation. For a longer duration of mydriasis, such as in the treatment of anterior uveitis, 1% atropine or 0.25% hyoscine would be the drugs of choice.  相似文献   

An integrated framework for software to provide yield data cleaning and estimation of an opportunity index for site-specific crop management     

Wei Sun  Brett Whelan  Alex B. McBratney  Budiman Minasny 《Precision Agriculture》2013,14(4):376-391

This paper proposes an integrated framework for software that provides yield data cleaning and yield opportunity index (Y _i ) calculation for site-specific crop management (SSCM). The artifacts in many yield data sets, which inevitably occur, can pose a significant effect on the validity of Yi. Automated and standardised yield correction procedures were designed to improve the data quality by removing: (1) unreasonable outliers; (2) distribution outliers (globally and locally); and (3) position errors. The calculation of Yi uses two aspects of crop yield assessment, the magnitude of yield variation and the spatial structure of the variation. The cleaning algorithms were applied to four yield data sets with known integrity issues to demonstrate effectiveness. Approximately 13–20 % of the original yield data were removed, and this resulted in an increased mean yield of 0.13 t/ha (average). The semivariograms of cleaned data were shown to possess smaller nugget values compared with the original data. The opportunity index calculation algorithm was demonstrated on a field with nine seasons of yield data. The results demonstrated that using a ranking of Yi provides a rational, agronomic assessment of the opportunity for SSCM based on the quantity and pattern of production variability displayed in yield data sets. This provides farm managers with a rapid way to assess whether the observed variability deserves further investigation and eventual investment in SSCM operations.  相似文献   

Factor VIII inhibitors complicating treatment of postoperative bleeding in a dog with hemophilia A     

Benjamin M. O'Kelley  DVM    Megan F. Whelan  DVM  DACVECC    Marjory B. Brooks  DVM  DACVIM 《Journal of Veterinary Emergency and Critical Care》2009,19(4):381-385

Objective – To describe the clinical course of a dog with hemophilia A and circulating factor VIII inhibitors complicating the treatment of postoperative hemorrhage.
Case Summary – A 7-year-old castrated male Japanese Chin with hemophilia A, weighing 6 kg, was presented for dental cleaning, polishing, and extractions. Despite presurgical administration of cryoprecipitate, continuous oral bleeding occurred. Circulating factor VIII inhibitors were detected, and the postoperative hemorrhage was subsequently managed with extensive and prolonged blood component transfusion. The dog was discharged after a full clinical recovery.
New or Unique Information Provided – This case report describes the clinical consequences and successful treatment of postoperative hemorrhage in a dog with hemophilia A and circulating factor VIII inhibitors. A relevant discussion of the management of human patients with circulating factor VIII inhibitors is included.  相似文献   

Effects of methionine on muscle protein synthesis and degradation pathways in broilers     

Johanna O. Zeitz  Sarah Mohrmann  Stella C. Kding  Murat Devlikamov  Ines Niewalda  Rose Whelan  Ariane Helmbrecht  Klaus Eder 《Journal of animal physiology and animal nutrition》2019,103(1):191-203

This study investigated the hypothesis that supplementation of methionine (Met) to broiler diets increases muscle growth due to regulation of molecular pathways related to protein synthesis and degradation depending on the Met source. Day‐old male Cobb‐500 broilers (n = 240) were phase‐fed three different wheat–soya bean meal‐based basal diets during days 1–10, 11–21 and 22–35. Basal diets (Met‐ group, Met + Cys concentration 15% below NRC recommendations) were supplemented with 0.10% or 0.40% Met either as DL‐Met (DLM) or DL‐2‐hydroxy‐4‐(methylthio) butanoic acid (DL‐HMTBA) (equimolar comparison). Breast muscle weights were lower in the Met‐ group compared to all Met‐supplemented groups and were lower in broilers supplemented with 0.10% of DL‐HMTBA compared to the other groups fed Met‐supplemented diets. However, the expression of genes or relative phosphorylation and thus activation state of proteins involved in the somatotropic axis, the mammalian target of rapamycin (mTOR) pathway of protein synthesis, the ubiquitin–proteasome pathway (UPP) and autophagy–lysosomal pathway of protein degradation, the GCN2/eIF2a pathway involved in the inhibition of protein synthesis and in the myostatin–Smad2/3 pathway involved in myogenesis were not affected by Met source. Feeding diets with suboptimum Met + Cys concentrations, however, decreased expression of GHR and IGF1 in liver and muscle and increased that of MURF1 involved in the UPP in the broiler's muscle at day 10 and 21, while that of FOXO and atrogin‐1 and FOXO phosphorylation remained unaffected. Additionally, suboptimum dietary Met concentrations increased expression of the autophagy‐related genes ATG5 and BECN1 at day 35. Met supplementation neither affected gene expression nor phosphorylation of proteins involved in the GNC2/eIF2a and mTOR pathways. These data indicate that protein synthesis was not affected on the molecular level, while protein degradation was marginally affected by dietary Met dosage.  相似文献   

Songbird ecosystem function and conservation     

Whelan CJ  Marquis RJ 《Science (New York, N.Y.)》1995,268(5215):1263

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