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Objective To examine the effect of dose and route of administration on the sedative‐hypnotic effects of midazolam. Design Prospective randomized controlled study Animals Six indigenous, African bred goats. Methods Pilot studies indicated that the optimum dose of midazolam for producing sedation was 0.6 mg kg?1 for intramuscular (IM) injection, while the optimum intravenous (IV) doses causing hypnosis without, and with loss of palpebral reflexes were 0.6 mg kg?1 and 1.2 mg kg?1, respectively. These doses and routes of administration were compared with a saline placebo in a randomized block design in the main experiment, and the sedative‐hypnotic effects evaluated according to pre‐determined scales. Results Intramuscular midazolam produced sedation with or without sternal recumbency in all animals with the peak effect occurring 20 minutes after administration. The scores for IM sedation with midazolam were significantly different (p < 0.05) from placebo. Intravenous midazolam at 0.6 mg kg?1 resulted in hypnosis, and at 1.2 mg kg?1 increased reflex suppression was observed. The maximum scores for hypnosis at both doses were obtained 5 minutes after IV injection. The mean (± SD) duration of lateral recumbency was 10.8 (± 3.8) minutes after IV midazolam (0.6 mg kg?1) compared to 20 (± 5.2) minutes after midazolam at 1.2 mg kg?1. Compared to baseline, the heart rate increased significantly (p < 0.05) after high dose IV midazolam. Conclusion Intramuscular midazolam (0.6 mg kg?1) produced maximum sedation 20 minutes after injection. Intravenous injection produced maximum hypnosis within 5 minutes. Increasing the IV dose from 0.6 to 1.2 mg kg?1 resulted in increased reflex suppression and duration of hypnosis. Clinical relevance For a profound effect with rapid onset midazolam should be given IV in doses between 0.6 and 1.2 mg kg?1.  相似文献   
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Abstract

Extract

Madam:– In 1984 Bedford(l Bedford, P.G.C. 1984. Retinal pigment epithelial dystrophy (CPRA): study of the disease in the Briard. J. Small Anim. Pract., 25: 129129.  [Google Scholar]) described a retinal pigment epithelial dystrophy (RPED) in the Briard breed in Great Britain. In a five year survey involving approximately 70% of the Briard popula'tion in Great Britain, 31 % of dogs 18 months of age or older were affected with a primary retinal pigment dystrophy which causes secondary neuroretinal degeneration and in some dogs subsequent blindness. The age of onset of the condition in the British dogs was extremely variable. The majority developed the disease during the two to six year period of their lives but dogs as young as 17 months and as old as nine years were found to be affected for the first time.  相似文献   
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